ANS

INTRODUCTION

Q.No:01. The communication between nerve cells or between nerve cell and effective organ
occurs through:
a. Agonist drugs.
b. Enzymes.
c. Hormones.
d. Neurotransmitters. (T)
e. Potentiator drugs.

Q.No:02. All receptors of autonomic nervous system are G protein coupled, except ?
a. Alpha receptor.
b. Beta receptor.
c. Dopamine receptor.
d. Muscarinic receptor.
e. Nicotinic receptor. (T)

Q.01: In post gangilionic sympathetic nerve ending the neurotransmitter is N.E

except, at the side of:
a. Heart.
b. Lung.
c. Adrenal Medulla.
d. Blood vessels.
e. Liver.
PARASYMPATHOMIMETICS:

Q.No:01. A mother complains for his 10 years old child to a physician that her child wets
his bed in the night. On examination the child was found fit otherwise. Which of
the following drug would be the appropriate choice for that child?
a. Atropine.
b. Dicyclomine.
c. Cyclopentolate.
d. Hyoscine.
e. Trospium.(T)

Q.No:02. A 30 year old male known case of Myasthenia gravis, on indirectly acting
cholinomimetic therapy. The expected side effect in this patient would be:
a. Blurring of vision.
b. Diarrhea.(T)
c. Tachycardia.
d. Urine retention.
e. Xerostomia.

Q.No:03. A 30 year old male was operated for renal stone under general anesthesia. After 7
hours of surgery patient did not pass urine and GIT sounds were sluggish. Which
of the following drug would be appropriate choice?
a. Demecarium.
b. Echothiophate.
c. Neostigmine.(T)
d. Physostigmine.
e. Rivastigmine.

Q.No:04. Indirectly acting cholinomimetic that can cross the blood brain barrier easily is:
a. Ambenonium.
b. Edrophonium.
c. Neostigmine.
d. Physostigmine. (T)
e. Pyridostigmine.

Q.No:05. Regarding anticholinesterase:

a. They bind covalently to acetylcholinesterase (T)
b. Ambenonium is an irreversible anticholinesterase
c. The binding of Isoflurophate to acetylcholinesterase can be reversed by atropine
d. The inactivation of cholinesterase by isoflurophate can be reversed when the drug is
withdrawn
e. Echothiophate is drug of choice in glaucoma.
Q.No:06. Which one of the following is topically used long acting cholinesterase inhibiters?
a. Echothiophate. (T)
b. Edrophonium.
c. Malathion.
d. Neostigmine.
e. Physostigmine.

Q.No:07. A 50 years old male patient was brought to a physician with complains of
weakness, fatigue, and exhaustion of skeletal muscles. The physician injected him
a drug that resulted in muscle strength within one minute and the patient was
diagnosed as a case of myasthenia gravis. The drug injected was most likely:
a. Bethanecol
b. Edrophonium. (T)
c. Pyridostigmine
d. Pralidoxime
e. Ambenonium.

Q.No:08. Indications of bethanecol include:

a. Bronchial asthma
b. Hyperthyroidism
c. Coronary insufficiency
d. Diabetes mellitus
e. Reflux esophagitis. (T)

Q.No:09. Muscarinic actions of acetylcholine include:

a. Increased heart rate
b. Increased force of contraction
c. Vasoconstriction
d. Contraction of detrusor muscle. (T)
e. Decreased nasopharyngeal secretions.

Q.No:10. During treatment of glaucoma, which drug increases outflow of aqueous humor
a. Timolol
b. Epinephrine
c. Pilocarpine.(T)
d. Acetazolamide
e. Apraclonidine.
Q.No:11. The best drug for distinguishing myasthenia crisis and cholinergic crisis
is:

a) Atropine.
b) Echothiophate.
c) Edrophonium. (T)
d) Physostigmine.
e) Pralidoxime

Q.02: Which one of the following is irreversible anti-cholinesterase agent?

a. Parathion.
b. Endrophonium.
c. Pyridostigmine.
d. Tacrine.
e. Physostigmine.

Q.01: Predictable signs of muscarinic excess when given in overdosage are all
except:
a. Diarrhea.
b. Sweating.
c. Salivation.
d. Cutaneous vasoconstriction.
e. Branchial constriction.

Q.02: Moderate doses of cholinesterase inhibitors have following not cardio

vascular effects, except:
a. Bradycardia.
b. Fall in cardiac output.
c. Increased vascular resistance.
d. Decrease in blood pressure.
e. Increase in blood pressure.
Q.03: Which one is selective partial agonist at nicotinic receptor used for smoking
cessation?
a. Cevimeline.
b. Varenicline.
c. Sarin.
d. Clonidine.
e. Carbachol.
Q.01: All of direct acting muscarinic drug except?
a. Acetylcholine.
b. Carbacol.
c. Bethancol.
d. Muscarinic.
e. Edrophonium.

Q.02: In Parasympathomimetic which one drug is Alkaloid in natures?

a. Acetylcholine.
b. Carbacol.
c. Neostigmine.
d. Nicotine.
e. Physistigmine.
PARASYMPATHOLYTICS:

Q.No:01. During spraying pesticide, farmer developed bronchoconstriction, lacrimation,

salivation, urination, miosis. Which of the following drug would be administered
as initial treatment to give symptomatic relief?
a. Adrenaline.
b. Atropine.(T)
c. Neostigmine.
d. Pralidoxime.
e. Trimethaphan.

Q.No:02. A 35 year old farmer was brought to emergency department with signs and
symptoms of Bronchoconstriction, miosis, lacrimation, salivation, urination, and
CNS excitation. He was engaged in spraying pesticide on agricultural crop 2 days
back. Which of the following drug would be administered as initial treatment to
give symptomatic relief?
a. Atropine. (T)
b. Neostigmine.
c. Propranolol.
d. Pralidoxime.
e. Trimethaphan.

Q.No:03. A Physician wants to prescribe a drug which could relieve spasm of GIT smooth
muscle without affecting HCl secretion, the choice will be:
a. Atropine. (T)
b. Cyclopentolate.
c. Darifenacin.
d. Ipratropium.
e. Pirenzepine.

Q.No:04. Among the neuromuscular blockers, drug producing depolarizing type of

blockade is:
a. Tubocurarine
b. Rocuronium
c. Gallamine
d. Doxacurium
e. Decamethonium.(T)

Q.No:05. Atropine is contraindicated in:

a. Heart block
b. Biliary colic
c. Chronic obstructive pulmonary disease
d. Prostatic hyperplasia. (T)
e. Parkinsonism
Q.No:06. All of the following cholinoceptor act as antimuscarinic agents, except:
a. Cyclopentolate
b. Pirenzepine
c. Pempidine.(T)
d. Tropicamide
e. Ipratropium.

Q.No:07. At higher concentration which drug shows side effects like Dry as a Bone,
Blind as a Bat, Red as a Beat, Mad as a Hatter?
a. Digitalis
b. Morphine
c. Atropine. (T)
d. Aspirin
e. Alcohol.

Q.No:08. The entry of acetylcholine into vesicle in axon can be blocked by?
a. Hemicholinium
b. Botulinum toxin
c. Vasamicol. (T)
d. Acetylcholinesterase
e. Reserpine.

Q.No:09. Which condition is contraindication for atropine?

a. Vasovagal attack
b. Synechia
c. Parkinson’s disease
d. Pre-anesthetic medication
e. Narrow angle glaucoma. (T)

Q.No:10. Which of the following used as antispasmodics agent?

a. Atropine
b. Cyclopentolate.
c. Pirenzepine
d. Scopolamine. (T)
e. Tropicamide

Q.No:11. All actions of acetylcholine and its congeners at muscarinic receptor are blocked
by:
a. Adrenaline.
b. Atropine. (T)
c. Hexamethonium.
d. Pempidine.
e. Pilocarpine
Q.No:12. Tubocurarine causes hypotension due to:
a. Serotonin release.
b. Histamine release. (T)
c. Alpha reuptake blockage.
d. Ca-channel blockage.
e. Myocardial depression.

Q.No:13. Which of the following is not counted as endogenous ligand?

a. Acetylcholine
b. Serotonin
c. GABA
d. Glutamine
e. Atropine. (T)

Q.No:14. Neuromuscular blocking agents used as component of balanced

anesthesia for:
a. To prevent bradycardia & secretion of fluid into the respiratory tract.
b. To provide the analgesia.
c. To facilitate intubation & relaxation.(T)
d. To relieve Anxiety.
e. To prevent gastric acid secretion

Q.03: Absolute contraindication of Atropine is as a:

a. Pre-anesthetic agent.
b. Anti-peptic ulcer agent.
c. Anti-parkinsonism drugs.
d. Anti-motion sickness agent.
e. Anti-narrow angle glaucoma.
SYMPATHOMIMETICS:

Q.No:01. A 50 years old male brought to cardiac emergency with complains of rapid and
severe left chest pain. For this patient cardiologist must avoid the use of:
a. Adrenaline.(T)
b. Aspirin.
c. Atenolol.
d. Nifedipine.
e. Nitroglycerine.

Q.No:02. The selective Alpha-2 agonist is:

a. Adrenaline.
b. Clonidine. (T)
c. Metaraminol.
d. Methoxamine.
e. Phenyl epinephrine.

Q.No:03. Mixed acting (directly as well as indirectly) sympathomimetic drug is.

a. Epinephrine.
b. Ephedrine.(T)
c. Nor-epinephrine.
d. Salbutamol.
e. Tyramine.

Q.No:04. Activation of prejunctional α-2 receptor on sympathetic neuron ending

is associated with:
a. Activation of adenylyl cyclase.
b. Decrease in cAMP.(T)
c. Increase in IP3
d. Inhibition of protein kinase
e. Opening is Na+/K+ cat ion channel.

Q.No:05. Which of the following selective alpha receptor agonist is used orally for postural
hypotension due to autonomic insufficiency?
a. Methoxamine.
b. Mephentermine.
c. Metaraminol.
d. Midodrine. (T)
e. Oxymetazoline.

Q.No:06. Epinephrine can be administered through the entire of following routes, except:
a. Subcutaneous.
b. Intravenous.
c. Oral. (T)
d. Intramuscular.
e. Topical.
Q.No:07. Dopamine is:
a. A non-catecholamine
b. Among first-line therapy in hypertensive emergencies
c. Very effective in shock. (T)
d. Relatively safer drug, having no adverse effects on CVS
e. Not much effective parenterally.

Q.No:08. Dobutamine is indicated in:

a. Acute congestive heart failure. (T)
b. Tachycardia
c. Cardiac arrhythmias
d. Migraine
e. Parkinsonism.

Q.No:09. Adrenaline in combination with local anesthetics can produce:

a. Cardiac arrest
b. Prolonged action.(T)
c. Urticaria
d. Angioedema
e. Cardiac arrhythmias.

Q.No:10. Based on the mechanism of action all of the following drugs act directly, except:
a. Adrenaline
b. Isoprenaline
c. Amphetamine. (T)
d. Phenylephrine
e. Salbutamol.

Q.No:11. According to chemical nature, among the following adrenoceptor agonists

catecholamine is:
a. Amphetamine
b. Isoprenaline.(T)
c. Phenylephrine
d. Ephedrine
e. Fenoterol.

Q.No:12. By use of Adrenaline:

a. Heart rate increased
b. Conduction increased
c. Diastolic BP increased. (T)
d. Oxygen consumption increased
e. Cardiac out put increased.
Q.No:13. Stimulation of beta-2 receptors will not result in:
a. Vasodilatation in muscles and coronary vessels.
b. Bronchial relaxation
c. Relaxation of pylorus (T)
d. Relaxation of intestine and
e. Hyperglycemia.

Q.No:14. Which action is not related to alph-2 receptor?

a. Inhibition of renin release from the kidney
b. Relaxation of intestine and contraction of pylorus
c. Regulation of adrenaline.(T)
d. Platelet aggregation
e. Depression of central alpha mediated blood pressure.

Q.No:15. When beta receptors are stimulated, what will happen?

a. Formation of IP3 and DAG, Increased intracellular Calcium.
b. Formation of IP3 and DAG, decreased intracellular Calcium
c. Inhibition of adenylyl cyclase, decreased cAMP
d. Stimulation of adenylyl cyclase, Increased cAMP. (T)
e. Stimulation of adenylyl cyclase, decreased cAMP.

Q.No:16. When alpha- 1 receptors are stimulated, what will happen:

a. Formation of IP3 and DAG, Increased intracellular Calcium. (T)
b. Formation of IP3 and DAG, decreased intracellular Calcium
c. Inhibition of adenylyl cyclase, decreased cAMP
d. Stimulation of adenylyl cyclase, Increased cAMP
e. Stimulation of adenylyl cyclase, decreased cAMP.

Q.No:17. A 20 years young male was brought in casualty with history of drug reaction with
sign and symptoms of cyanosis, dyspnea, palpitation and decreased B.P. Which
one of the following drug is immediately used?
a. Adrenaline. (T)
b. Dobutamine.
c. Dopamine.
d. Isoproterenol.
e. Norepinephrine.

Q.No:18. Dobutamine is direct and selective agonist for:

a. Alpha-1- receptor.
b. Alpha-2- receptor.
c. Beta-1- receptor. (T)
d. Beta-2- receptor.
e. Dopaminergic receptor.
Q.No:19. Epinephrine does not increase the concentration of which of the following:

a) Cyclic AMP in heart.

b) Free fatty acid in blood.
c) Glucose in blood.
d) Lactose in blood.
e) Triglycerides in fat cells.(T)

Q.No:20. Which of the following agents causes increased peripheral resistance

due to the inhibition of reuptake at noradrenergic synapses?

a) Cocaine. (T)
b) Dopamine.
c) Epinephrine.
d) Phenylephrine.
e) Tyramine.

Q.No:21. The use of beta adrenergic agonist in bronchial asthma is mainly

designed to:

a) Compete with alpha adrenergic agonist.

b) Inhibit the airway inflammatory response.
c) Stimulate airway secretion.
d) Manage acute contraction of airway smooth muscle. (T)
e) Prevent awakening during the night.

Q.No:22. Alpha adrenergic blocking agents will convert which of the following
vasoconstrictors to a vasodilator?

a) Cocaine.
b) Dopamine.
c) Epinephrine. (T)
d) Phenylephrine.
e) Tyramine.
Q.No:01. Which sympathomimetic drugs causes relaxing of smooth muscle of
uterus?
 a. β2 Selective.
b. β1 Selective.
c. Reuptake inhibitors.
d. α2 Selective.
e. Non Selective (α2, α2, β1).
Q.04: Adrenergic drug which is clinically use as CNS stimulant is:
a. Dopamine.
b. Isopernaline.
c. Salbutamol.
d. Methamphetamine.
e. Phenylephrine.

Q.10: Regarding epinephrine all are the indications except:

a. Shock.
b. Hypotension.
c. Brancheal Asthma.
d. Hyperthyroidism.
e. Cardiac arrest.

Q.No:01. Which is not direst acting adrenergic agonist?

a. Pirnterol.
b. Clonidine.
c. Formeterol.
d. Cocaine.
e. Salmetrol.

.No:02. Which one from following is not a chatechomine?

a. Epinephrine.
b. Phenylphrine.
c. Norepinephrine.
d. Dopamine.
e. Dobutamine.

Q.No:03. Which one is drug of choice of anaphylactic shock?

a. Dobutamine.
b. Phenylpherine.
c. Epinephrine.
d. Amphetamine.
e. Dopamine.
SYMPATHOLYTICS:

Q.No:01. Use of Timolol in Eye, may causes:

a. Decrease formation of aqueous Humors. (T)
b. Increase blood flow to optic nerve.
c. Increase out flow of aqueous Humors.
d. Miosis.
e. Mydriasis.

Q.No:02. Which one of the following Alpha blocker has longest duration of action?
a. Labetalol.
b. Prazosin.
c. Phentolamine.
d. Phenoxybenzamine. (T)
e. Tolazoline.

Q.No:03. β-blockers have no role in:

a. Angina Pectoris.
b. Supraventricular tachycardia.
c. Hypothyroidism. (T)
d. Migraine.
e. Glaucoma.

Q.No:04. Among the following, the drug recommended for benign prostatic hyperplasia is:
a. Phenoxybenzamine
b. Tamsulosin. (T)
c. Phentolamine
d. Indoramin
e. Idopamine.

Q.No:05. The entry of dopamine into vesicle in axon can be blocked by?
a. Metyrosine
b. Reserpine. (T)
c. Cocaine
d. Vasamicol
e. Bretylium.

Q.No:06. Which antihypertensive agent act peripherally?

a. Methyldopa
b. Clonidine
c. Indapamide. (T)
d. Guanabenz
e. Guanfacine.
Q.No:07. Which Beta adrenergic blocker also completely blocks Alpha one adrenergic
receptor?
a. Labetalol. (T)
b. Metoprolol.
c. Nadolol.
d. Pindolol.
e. Timolol.

Q.No:08. Which of the following Beta-Blocker has partial agonist activity?

a. Pindolol
b. Propranolol
c. Atenolol
d. Bismolol
e. Cardevolol

Q.No:09. Postural hypotension is a common side effect of which of the following types of
drugs?
a) ACE inhibitors.
b) Alpha receptor blocker. (T)
c) Arteriolar dilators.
d) Beta selective receptor blocker.
e) Non selective beta blockers.

Q.No:10. Which of the following drugs has got complete adrenergic blocking effect?
a) Atenolol.
b) Pindolol.
c) Propranolol.
d) Phentolamine. (T)
e) Labetolol.

Q.No:11. The effectiveness of beta adrenergic agents in treating essential hypertension is most
likely due to:
a) A combination of inhibition of cardiac output and renin release. (T)
b) Inhibition of calcium entry into blood vessels.
c) Stimulation of vagal nerves, leading to increased circulating level of acetylcholine.
d) The direct blockade of angiotension receptors.
e) The production of nitric oxide.
Q.05: Contraindication of Propranolol is:
a. COPD.
b. Myocardial infarction.
c. Cardiac Arrhythmia.
d. Pheochromocytoms.
e. Thyrotoxicosis.

Q.06: Which one of the following drug is useful for the treatment of CCF,
Hypertension, Cardiac Arrhythmia and Angina pectoris?
a. Digoxin.
b. Propranolol.
c. Captopril.
d. Losartan.
e. Furesamide

Q.04: Which one is a patient competitive antagonist at both α 1 and α2 receptors?

a. Terazosin.
b. Phentolamine.
c. Phenoxybenzamine.
d. Butoxamine.
e. Epinephrine.

Q.No:04. Therapeutic use of Phenoxybenzamine is:

a. Hypertension.
b. Glaucoma.
c. Migraine.
d. Angina pectoris.
e. Pheochromocytone.
 ANS

INTRODUCTION

Q.No:01. The communication between nerve cells or between nerve cell and effective organ
occurs through:

PARASYMPATHOMIMETICS:

Q.No:01. A mother complains for his 10 years old child to a physician that her child wets
his bed in the night. On examination the child was found fit otherwise. Which of
the following drug would be the appropriate choice for that child?

Q.No:02. A 30 year old male known case of Myasthenia gravis, on indirectly acting
cholinomimetic therapy. The expected side effect in this patient would be:

Q.No:03. A 30 year old male was operated for renal stone under general anesthesia. After 7
hours of surgery patient did not pass urine and GIT sounds were sluggish. Which
of the following drug would be appropriate choice?

Q.No:04. Indirectly acting cholinomimetic that can cross the blood brain barrier easily is:

Q.No:05. Regarding anticholinesterase:

Q.No:06. Which one of the following is topically used long acting cholinesterase inhibiters?

Q.No:07. A 50 years old male patient was brought to a physician with complains of
weakness, fatigue, and exhaustion of skeletal muscles. The physician injected him
a drug that resulted in muscle strength within one minute and the patient was
diagnosed as a case of myasthenia gravis. The drug injected was most likely:

Q.No:08. Indications of bethanecol include:

Q.No:09. Muscarinic actions of acetylcholine include:

Q.No:10. During treatment of glaucoma, which drug increases outflow of aqueous humor
PARASYMPATHOLYTICS:

Q.No:01. During spraying pesticide, farmer developed bronchoconstriction, lacrimation,

salivation, urination, miosis. Which of the following drug would be administered
as initial treatment to give symptomatic relief?

Q.No:02. A 35 year old farmer was brought to emergency department with signs and
symptoms of Bronchoconstriction, miosis, lacrimation, salivation, urination, and
CNS excitation. He was engaged in spraying pesticide on agricultural crop 2 days
back. Which of the following drug would be administered as initial treatment to
give symptomatic relief?

Q.No:03. A Physician wants to prescribe a drug which could relieve spasm of GIT smooth
muscle without affecting HCl secretion, the choice will be:

Q.No:04. Among the neuromuscular blockers, drug producing depolarizing type of

blockade is:

Q.No:05. Atropine is contraindicated in:

Q.No:06. All the following cholinoceptor act as antimuscarinic agents, except:

Q.No:07. At higher concentration which drug shows side effects like Dry as a Bone,
Blind as a Bat, Red as a Beat, Mad as a Hatter?

Q.No:08. The entry of acetylcholine into vesicle in axon can be blocked by?

Q.No:09. Which condition is contraindication for atropine?

Q.No:10. Which of the following used as antispasmodics agent?

Q.No:11. All actions of acetylcholine and its congeners at muscarinic receptor are blocked
by:

Q.No:12. Tubocurarine causes hypotension due to:

Q.No:13. Which of the following is not counted as endogenous ligand?

Q.No:14. Neuromuscular blocking agents used as component of balanced

anesthesia for:
SYMPATHOMIMETICS:

Q.No:01. A 50 years old male brought to cardiac emergency with complains of rapid and
severe left chest pain. For this patient cardiologist must avoid the use of:

Q.No:02. The selective Alpha-2 agonist is:

Q.No:03. Mixed acting (directly as well as indirectly) sympathomimetic drug is.

Q.No:04. Activation of prejunctional α-2 receptor on sympathetic neuron ending

is associated with:

Q.No:05. Which of the following selective alpha receptor agonist is used orally for postural
hypotension due to autonomic insufficiency?

Q.No:06. Epinephrine can be administered through the entire of following routes, except:

Q.No:07. Dopamine is:

Q.No:08. Dobutamine is indicated in:

Q.No:09. Adrenaline in combination with local anesthetics can produce:

Q.No:10. Based on the mechanism of action all of the following drugs act directly, except:

Q.No:11. According to chemical nature, among the following adrenoceptor agonists

catecholamine is:

Q.No:12. By use of Adrenaline:

Q.No:13. Stimulation of beta-2 receptors will not result in:

Q.No:14. Which action is not related to alph-2 receptor?

Q.No:15. When beta receptors are stimulated, what will happen?

Q.No:16. When alpha- 1 receptors are stimulated, what will happen:

Q.No:17. A 20 years young male was brought in casualty with history of drug reaction with
sign and symptoms of cyanosis, dyspnea, palpitation and decreased B.P. Which
one of the following drug is immediately used?

Q.No:18. Dobutamine is direct and selective agonist for:

SYMPATHOLYTICS:

Q.No:01. Use of Timolol in Eye, may causes:

Q.No:02. Which one of the following Alpha blocker has longest duration of action?

Q.No:03. β-blockers have no role in:

Q.No:04. Among the following, the drug recommended in benign prostatic hyperplasia is:

Q.No:05. The entry of dopamine into vesicle in axon can be blocked by?

Q.No:06. Which antihypertensive agent act peripherally?

Q.No:07. Which Beta adrenergic blocker also completely blocks Alpha one adrenergic
receptor?

Q.No:08. Which of the following Beta-Blocker has partial agonist activity?