Manufacturing Vessel Process Step
Manufacturing Vessel Pressurization Start
Step-1 Open Air Inlet Valve
Step-2 Fill Air inside the Vessel
Step-3 Closed All Other Valves of Vessels
Step-4 Fill Air Till Design Pressure of Testing
Step-5 Wait For 15 Min
Step-6 After 15 Min the Pressure Cycle Complete
Step-7 Release the Air to Depressure the Vessel
End
Manufacturing Vesse Initial Line Drain Start
Step-1 Open Vessel Jacket Valve
Step-2 Water Drain Through Jacket
Step-3 Jacket Volume Completely Drain
Step-4 Close Vessel Jacket Valve
End
Manufacturing Vesse WFI Filling Start
Step-1 Vessel Inlet Valve Open
Step-2 Water Filling in Vessel Through Spray Ball
Step-3 Vessel Volume Achieved
End
Manufacturing Vessel Cooling Step Start
Step-1 Open Cooling water Valve
Step-2 Cooling Vessel till Ambient Temperature
Step-3 Temperature Achieved
Step-4 Continue Till 5 Min
Step-5 Close Cooling water Valve
End
Manufacturing Vessel Heating Step Start
Step-1 Open Steam Valve
Step-2 Heating the Vessel till Heat Setpoint
Step-3 Temperature Achieved
Step-4 Continue Till 5 Min
Step-5 Close Steam Valve
End
Manufacturing Vesse Media Mixing Process For
Batch Start
Step-1 Start Mixer
Step-2 Keep Running
End
Product Transfer From Manufacturing Vessel to
Holding Vessel Start
Step-1 Open Nitogen Valve
Step-2 Purge Nitrogen inside Vessel
Step-3 Open Vessel Bottom Valve
Step-4 Pass Media Through MFG Vessel To Holding Vessel
Step-5 Open Holding Vessel Inlet Valve
Step-6 Media Transfer Completed
Step-7 Nitrogen Flushing Continue
Step-8 Close Vessel Bottom Valve
Step-9 Close Holding Vessel Inlet Valve
End
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SHREE KIRSHNA KESHAV LABORATORIES
Manufacturing Vessel Process Step
Manufacturing Vessel Cleaning with WFI Water Start
Step-1 Vessel Inlet Valve Open
Step-2 WFI Water Filling in Vessel Through Spray Ball
Step-3 Vessel Volume Achieved
Step-4 Start Recirculation with Pump
Step-5 Recirculation for 5 Min
Step-6 Open Vessel Drain Valve
Step-7 Drain Complete Water
End
Manufacturing Vessel Rinsing with WFI Water Start
Step-1 Vessel Inlet Valve Open
Step-2 WFI Water Filling in Vessel Through Spray Ball
Step-3 Vessel Volume Achieved
Step-4 Start Recirculation with Pump
Step-5 Recirculation for 5 Min
Step-6 Open Vessel Drain Valve
Step-7 Drain Complete Water
End
Manufacturing Vessel Air Flushing Start
Step-1 Air Inlet Valve Open
Step-2 Pass Air Through Complete Pipeline and Vessel
Step-3 Air will Dry the Pipeline and Vessel
Step-4 Open All Drain Valve
Step-5 Pass Air for 5 Min
Step-6 Close All Drain Valve
End
Manufacturing Vessel Sterilization Start
Step-1 Open Steam Valve
Step-2 Sterilize the Vessel till 122 Deg.C
Step-3 Temperature Achieved
Step-4 Continue Till 15 Min
Step-5 Close Steam Valve
End
Manufacturing Vessel Drying Start
Step-1 Air Inlet Valve Open
Step-2 Pass Air Through Complete Pipeline and Vessel
Step-3 Air will Dry the Pipeline and Vessel
Step-4 Open All Drain Valve
Step-5 Pass Air for 5 Min
Step-6 Close All Drain Valve
End
Manufacturing Vessel Nitrogen Blanketing Start
Step-1 Nitrogen Inlet Valve Open
Step-2 Fill Nitrogen inside the Vessel
Step-3 Closed All Other Valves of Vessels
Step-4 Fill Nitrogen Till Design Pressure of Testing
Step-5 Waiting Time As per User
Step-6 Release the Air to Depressure the Vessel
End
2of 2 Prepared By:Raviprakash
