BROKENSHIRE COLLEGE SOCKSARGEN, INC.
Name: Resurricon, Ronel D. Date: November 23, 2023
Inclusive Date & Shift : November 22, 2023; 7:00 AM – 3:00 PM Clinical Instructor: Nikki Jad Jugar, RN
Area of exposure: SARMED - WARD
Performed: NA
DRUG STUDY
OMEPRAZOLE
MECHANISM INDICATION AND ADVERSE NURSING
CLASSIFICATION DOSAGE INSIGHTS
OF ACTION CONTRAINDICATION REACTIONS RESPONSIBILITIES
GENERIC: Omeprazole INDICATIONS: DOSAGE AND ROUTE: CNS: Give omeprazole Omeprazole is
OMEPRAZOLE interferes To treat Agitation, before meals, widely used to
BRAND: with gastric symptomatic Mild/Intermittent GERD asthenia, preferably in the treat indigestion
Losec (CAN), acid gastroesophageal (Fewer than 2 Episodes/wk dizziness, morning for once- and heartburn,
Prilosec secretion by reflux disease With no Evidence of EE) drowsiness, daily dosing. and acid reflux.
inhibiting the (GERD). fatigue, It's also taken to
PHARMACOLOGI hydrogen Omeprazole is PO: ADULTS, ELDERLY, fever, If needed, also give prevent and treat
C CLASS: potassium indicated for the CHILDREN WEIGHING headache, an antacid, as stomach ulcers.
Proton Pump adenosine short-term 2O KG OR MORE: 10 mg malaise, prescribed. Omeprazole is a
Inhibitor triphosphatas treatment of peptic once daily. May increase psychic type of medicine
e (H+ K+ - ulcer disease in to 2o mg once daily after disturbance, If needed, open called a proton
THERAPEUTIC ATPase) adults, where most 4-8 wks if necessary. somnolence capsule and sprinkle pump inhibitor
CLASS: enzyme patients heal within Discontinue once CV: Chest enteric-coated (PPI). Proton
Antiulcer drugs system, or four weeks. asymptomatic for 8 wks. pain, granules on pumps are
proton pump, Patients with 10-19 kg: 10 mg/day for 4- hypertension, applesauce or yogurt enzymes in the
in gastric duodenal ulcer 8 wks. 5-9 kg: 5 mg/day peripheral or mix with water or lining of your
parietal cells. disease and H. for 4-8 weks. edema acidic fruit juice, such stomach that
Normally, the pylori infection that EENT: as apple or cranberry help it make acid
proton pump is active for up to Severe and/or Frequent Anterior juice. to digest food.
uses energy one year may GERD (2 or More ischemic
from benefit from Episodes/wk With/Without optic Give immediately. When using
hydrolysis of combination EE) neuropathy, Give drug via NG omeprazole,
adenosine therapy of optic atrophy tube, when needed patients should
triphosphate omeprazole with PO: ADULTS, ELDERLY: or neuritis, by mixing granules in be monitored for
to drive clarithromycin, 20-40 mg once daily. otitis media, acidic juice, because signs and
hydrogen amoxicillin, and Once symptoms are stomatitis enteric coating symptoms of
(H+) and metronidazole. controlled, continue for at ENDO: dissolves in alkaline gastroesophagea
chloride (Cl−) Omeprazole is also least 8 wks. CHILDREN 1- Hypoglycemi pH, or using the l reflux disease
out of parietal indicated for gastric 16 YEARS WEIGHING 2O a delayed-release oral and peptic ulcer
cells and into ulcers in adults. KG OR MORE: 20 GI: suspension form by disease. Should
the stomach Omeprazole is mg/day; WEIGHING 10-19 Abdominal mixing with water. also monitor for
lumen in indicated for KG: 10 mg/day. pain, acid C. difficile-
exchange for gastroesophageal WEIGHING 5-9 KG: 5 regurgitation, Know that because associated
potassium reflux disease in mg/day CHILDREN 1-11 constipation, drug can interfere diarrhea and
(K+), which pediatric and adult MOS WEIGHING 1O KG diarrhea, with absorption of hypomagnesia
leaves the populations. OR MORE: 10 mg/day Clostridium vitamin B12, monitor when patients
stomach Omeprazole is also WEIGHING 5-9 KG: difficile- patient for macrocytic are on
lumen and indicated for healing 5mg/day. WEIGHING 3-4 associated anemia. omeprazole long-
enters erosive esophagitis KG: 2.5 mg/day. diarrhea, term.
parietal cells. in both adults and dyspepsia, Monitor patient for
After this children. Pathologic Hypersecretory elevated liver bone fracture,
exchange, Omeprazole is Conditions enzymes, especially in patients
H+ and Cl− indicated for flatulence, receiving multiple
combine in conditions prone to NOTE: Doses more thant fundic gland daily doses for more
the stomach hypersecretion, 80 mg in divided doses. polyps (long- than a year because
to form such as Zollinger- PO: Adults elderly: Intially, term use), proton pump
hydrochloric Ellison syndrome, 40 mg twice daily. May hepatic inhibitors, such as
acid (HCl), as multiple endocrine titrate up to 180 mg/day. dysfunction omeprazole, increase
shown below adenomas, and or failure, risk for osteoporosis-
left. systemic H. pylori and Duodenal indigestion, related fractures of
Omeprazole mastocytosis inUlcer Disease nausea, the hip, spine, or
irreversibly adults. PO: ADULTS, ELDERLY: pancreatitis, wrist.
blocks the 20 mg or 40 mg twice daily vomiting.
exchange of as part of an appropriate GU: Be aware that long-
intracellular combination regimen with Interstitial term use of
H+ and CONTRAINDICATION antibiotics (dose depends nephritis omeprazole may
extracellular Patients with on the selected regimen). HEME: increase the risk of
K+, as shown Concurrent therapy Agranulocyto gastric carcinoma
below right. with rilpivirine- Peptic Ulcer Disease, sis, anemia, and symptomatic
By containing products; Duodenal / Gastric Ulcer hemolytic response to
preventing hypersensitivity to anemia, omeprazole therapy
H+ from omeprazole, PO: ADULTS, ELDERLY: leukopenia, does not rule out the
entering the substituted 20 mg once daily. Duration leukocytosis, presence of gastric
stomach benzimidazoles, or depends on the size, neutropenia, tumors.
lumen, their components. location, and cause of the pancytopenia
omeprazole DRUG ulcer. Range: 4-8 wks. , Know that
keeps INTERACTION: thrombocyto omeprazole therapy
additional Clopidogrel: OTC use (Frequent penia. may produce false
HCl from Omeprazole could Heartburn) MS: Back elevations of serum
forming. decrease the pain, bone chromogranin levels,
effectiveness of PO: ADULTS, fracture, joint used to help
blood thinners like ELDERLY: 20 mg/day pain. diagnosis presence
Therapeutic clopidogrel. Other for 14 days. May repeat RESP: of neuroendocrine
Effect: drugs, which aren't after 4 mos if needed. Bronchospas tumors.
Prevent blood thinners but m, cough,
Nausea are similarly Dosage in Renal/Hepatic upper If test results are
Vomiting affected by Impairment respiratory high, withhold
omeprazole, include No dose adjustment. infection omeprazole therapy
citalopram, SKIN: temporarily and
Source: cilostazol, Cutaneous repeat test, as
phenytoin, lupus ordered.
https:// diazepam, and erythematosi
reference digoxin. s, erythema Keep in mind that if
.medsca multiforme, omeprazole is given
pe.com/ photosensitiv with antibiotics,
drug/ ity, pruritus, watch for diarrhea
prilosec- rash, from C. difficile.
omepraz Stevens–
ole- Johnson If diarrhea occurs,
341997# syndrome, notify prescriber and
10 toxic expect to withhold
epidermal drug and treat with
necrolysis, electrolytes, fluids,
Saunders urticaria. protein, and an
Nursing Other: antibiotic effective
Drug Anaphylaxis, against C. difficile.
Handboo angioedema,
k 2023, hypomagnes Monitor patient’s
Book 3, emia, urine output because
Page No. hyponatremi omeprazole may
858 a, systemic cause acute
lupus interstitial nephritis.
erythematos
us, vitamin Notify prescriber if
B12 urine output
deficiency decreases or there is
(long-term blood in patient’s
use). urine.
Monitor the patient,
PREGNANCY- especially the patient
LACTATION- on long-term therapy,
REPRODUCTI for
ON hypomagnesemia.
Use during
pregnancy If patient is to remain
only if on omeprazole long
potential term, expect to
benefits monitor the patient’s
justifies risk serum magnesium
to the fetus. level, as ordered,
Drug and if level becomes
appears in low, anticipate
human milk. magnesium
Use replacement therapy
cautiously in and omeprazole to
breastfeedin be discontinued.
g women.
Know that both
cutaneous and
systemic lupus
erythematosus have
occurred within days
to years after proton
pump therapy such
as omeprazole was
initiated.
The most common
symptoms presented
were arthralgia,
cytopenia, and rash.
Report such findings
to prescriber.
Know that proton
pump inhibitors such
as omeprazole
should not be
prescribed longer
than medically
necessary.
