Code No.

D-8180/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Backlog) Examination, February / March 2022

Subject: Pharmaceutical Biotechnology

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. What are mutants? Types of mutants.

2. Define Immobilization. What are the types of immobilization?
3. Write the differences between Exonucleases and Endonucleases.
4. What are vectors? Write the ideal properties of vectors.
5. Write few applications of hybridoma technology.
6. What are toxins? Explain the method of conversion of toxin to toxoid.
7. Write the preparation and uses of human fibrinogen.
8. Write about types of aerators in Fermentor.
9. What is protein engineering?
10. Differentiate between prokaryotic and Eukaryotic organisms.

PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)

11. Write differences between HLA and MHC. Discuss the structure and function
of MHC.
12. Explain the typical structure of Immunoglobulin with neat labelled diagram and
types and functions of Antibodies.
13. What are plasma substitutes? Explain the manufacturing of plasma
substitutes and standardization.

PART - C
Note: Answer any seven questions: (7 x 5 = 35 Marks)

14. Write a brief notes on Protein Engineering.

15. Explain the working process of polymerase chain reaction.
16. Explain pBR322 and pUC vectors.
17. Discuss the general methods of preparation of vaccines.
18. Explain southern blotting technique.
19. Explain in detail direct and indirect methods of ELISA.
20. What are mutations? Explain the types of mutations.
21. Explain the preparation of dried human plasma and dries human serum.
22. Explain type I and type II hypersensitivity reactions.

*****
 Code No: D-8179/PCI
FACULTY OF PHARMACY
B. Pharmacy VI– Semester (PCI) (Backlog) Examination, February / March 2022
Subject: Bio pharmaceutics and Pharmacokinetics
Time: 3 Hours [Link]
Note: Answer all questions from Part - A, Any two questions from Part - B.
And any seven questions from Part - C
PART – A (10 x 2 = 20 Marks)
1. Write Noyes Whitney equation. And explain the terms.
2. Describe the absorption of a drug on rectal administration.
3. Define apparent volume of distribution.
4. Write a note on excretion of drugs through skin.
5. Define absolute bioavailability and relative bioavailability.
6. Define Cmax, tmax and AUC?
7. If equatin of the curve is C=15.e-0.23t for a drug administered by IV route and
following one compartment open model, then calculate its biological half – life.
8. Write Michaelis menten equation.
9. Describe hepatic clearance.
10. What are the factors for cause of non-linear kinetics?

PART – B (2x10 = 20 Marks)

11. A dose of 500mg of drug was given intravenously to a patient and following
blood data was obtained. Assuming that the drug follows one compartment open
model. Calculate all possible pharmacokinetic parameters.
Time (Hrs) 2 4 6 8 10 12 16 20
Asma Concentration 1.83 1.01 0.58 0.33 0.18 0.10 0.031 0.012
(g/ml)
12. Describe factors influencing absorption of drugs.
13. Describe renal excretion of drugs.
PART – C (7 X 5 = 35Marks)
14. Discuss about pH-partition hypothesis.
15. Describe the absorption of drugs from extravascular routes.
16. Explain briefly about Kinetics of protein binding.
17. Explain biliary excretion of drugs.
18. Discuss about methods to enhance bioavailability of poorly soluble drugs.
19. Describe estimation of Km and Vmax in non-linear kinetics.
20. Derive kinetic parameters for IV bolus administration in two compartment open
model.
21. How do you determine absorption rate constant, Ka by Wagner nelson method?
22. A 650mg I.V. dose of a drug is administered to a 65kg subject, the plasma
drug concentration was found to decline biexponentially. The equation that
best describes.
The drug kinetics C=67.e-14t + 33.e-3t; C is in mg/it Calculate the different volumes
Of distribution VC, VP, Dd, Vdarea, Vdss.
 Code No. D-8178/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (BACKLOG) Examination,
February / March 2022

Subject: Herbal Drug Technology

Time: 3 Hours Max. Marks: 75
PART - A
Note: Answer all questions. (10 x 2 = 20 Marks)

1 Define herbal medicine and herbs.

2 Define bio pesticide bio insecticide.
3 Write the scope of Nutraceuticals.
4 Define herbal drug interaction with suitable examples.
5 Define herbal formulation with example.
6 Define Phytosomes and Microspheres.
7 Define Bio piracy and patent.
8 Write the constitution of ASU DTAB.
9 Write the scope and future prospectus of herbal drug industry.
10 Define schedule T and write objectives of schedule T.

PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)

11 Write an elaborate note on processing of herbal raw materials.

12 Explain in detail about the scope and type of Nutraceutical products available
market.

13 Discuss WHO and ICH guidelines for the assessments of herbal drugs.

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14 Explain the sources of herbs.

15 Write a brief note on organic farming.

16 Write a note on herb drug interactions with suitable exaples.

17 Explain about the side effects and interactions of Hypercom and Kava-Kava.

18 Write a brief note on flavours in herbal preparations.

19 Write a note on Phytosomes.

20 Explain in detail about Patent and IPR.

21 Give a brief note on Schedule Z.

22 Write a brief note on plant based industries and institutions.

 Code No: D-8177/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Backlog) Examination, February 2022
Subject: Pharmacology - III
Time: 3 Hours Max. Marks: 75
Note: Answer all questions from PART-A, and two questions from PART-B,
and any seven questions from PART-C.
PART - A (10 x 2 = 20 Marks)
1) What is circadian thythm?
2) What is a carcinogenicity give example of drugs causing it?
3) What is the treatment for morphine poisoning?
4) What are the adverse effects of tetracycline.
5) Define laxative. Give examples.
6) What are expectorants? Give examples.
7) Write about appetite suppressant drugs.
8) What are mucolytics? Give examples.
9) What are the adverse effects of penicillins?
10) Define Digestant. Give two examples.

PART - B (2 x 10 = 20 Marks)
11) Write about antibiotics used in cancer.
12) Write about anti tubercular drugs.
13) Classify Antiulcer agents? Write the pharmacology of H 2 antagonists.

PART - C (7 x 5 = 35 Marks)
14) What is biological clock? With some examples explain chronotherapy.
15) Explain the pharmacology of Co-trimoxazole.
16) Write a note on symptoms and treatment of arsenic poisoning.
17) Write the pharmacology of any one class of antibiotics.
18) write a note on Urinary antiseptics.
19)Classify antiamoebic agents. Add a note on Metronidazole.
20)Classify Anti-tussives. Add a note on Anti-histaminics.
21) Write a note on Bronchodilators.
22) What is an antiemetic? Classify antiemetics.

*******
 Code No. D8176/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Backlog) Examination, February / March 2022

Subject: Medicinal Chemistry - III

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. Define & classify-lactam antibiotics?

2. Write the structure of Sulbactam & Monobactam?
3. Give the structure and uses of Neomycin?
4. Write the structure of Pyrazinamide & Isoniazid?
5. Write the structure and uses of Dapsone?
6. Define Partition coefficient, Tafts steric parameter?
7. Write the mechanism of action of Tetracyclines?
8. Write the mechanism of action of Macrolides?
9. Define prodrugs?
10. Write the structure and uses of Clindamycin?

PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)

11. Write the various classes of antitubercular drugs. Write the synthesis & mode of
action of Para amino salicylic acid?
12. Write the life cycle of malaria parasite and Write the synthesis and mode of action
of the Chloroquine?
13. Write the mode of action and SAR of Sulphonamides and Write the synthesis of
Sulfacetamide?

PART - C
Note: Answer any seven questions: (7 x 5 = 35 Marks)

14. Write the chemical degradation of Pencillins?

15. Explain the mode of action, SAR and uses of Cephalosporins?
16. Give the structure, synthesis, mode of action and uses of Chloramphenicol?
17. Write a note of Prodrugs?
18. Give the various classes of Antifungal agents & write the synthesis of Miconazole?
19. Write the synthesis, mode of action and uses Diethylcarbamazine citrate?
20. Give a note on liquid phase synthesis in combinatorial chemistry?
21. Write the structure, synthesis and uses of Tolnaftate?
22. Give the various classes of Anti-protozoal agents & write the synthesis of
Metronidazole?
*****
 Code No. D8176/PCI

FACULTY OF PHARMACY
B. Pharmacy VI Semester (PCI) (Backlog) Examination, February / March 2022

Subject: Medicinal Chemistry - III

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. Define & classify-lactam antibiotics?

2. Write the structure of Sulbactam & Monobactam?
3. Give the structure and uses of Neomycin?
4. Write the structure of Pyrazinamide & Isoniazid?
5. Write the structure and uses of Dapsone?
6. Define Partition coefficient, Tafts steric parameter?
7. Write the mechanism of action of Tetracyclines?
8. Write the mechanism of action of Macrolides?
9. Define prodrugs?
10. Write the structure and uses of Clindamycin?

PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)

11. Write the various classes of antitubercular drugs. Write the synthesis & mode of
action of Para amino salicylic acid?
12. Write the life cycle of malaria parasite and Write the synthesis and mode of action
of the Chloroquine?
13. Write the mode of action and SAR of Sulphonamides and Write the synthesis of
Sulfacetamide?

PART - C
Note: Answer any seven questions: (7 x 5 = 35 Marks)

14. Write the chemical degradation of Pencillins?

15. Explain the mode of action, SAR and uses of Cephalosporins?
16. Give the structure, synthesis, mode of action and uses of Chloramphenicol?
17. Write a note of Prodrugs?
18. Give the various classes of Antifungal agents & write the synthesis of Miconazole?
19. Write the synthesis, mode of action and uses Diethylcarbamazine citrate?
20. Give a note on liquid phase synthesis in combinatorial chemistry?
21. Write the structure, synthesis and uses of Tolnaftate?
22. Give the various classes of Anti-protozoal agents & write the synthesis of
Metronidazole?
*****
 Code No: 12285/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main &Backlog) Examination, September 2021
Subject: Medicinal Chemistry-III
Time: 2 Hours Max. Marks: 75
Note: Answer any seven questions from Part –A, Any one questions from Part-
B and Any five questions from Part-C
PART – A (7X3 = 21 Marks)
1. Define & classify - lactam antibiotics?
2. Write the structure of Benzly penicillin & Chlortetracycline?
3. Write the structure and uses of Strptomycin?
4. Write the structure of Isoniazid & Para amino salicylic acid?
5. Write the structure and uses of Dapsone?
6. Define Partition coefficient, Hammet’s electronic parameter?
7. Write the mechanism of action of Tetracycline?
8. Write the mechanism of action of Macrolides?
9. Define prodrugs?
10. Write the - Lactamase inhibitors?

PART- B (1 X 14 = 14 Marks)
11. Enumerate the various classes of antitubercular drugs. Write the synthesis &
mode of action of Isoniazid?
12. Define Beta lactam antibiotics and explain the classification, SAR and mode
faction of cephalosporins?
13. Write the life cycle of malaria parasite and Write the synthesis and mode of action
of the Chloroquine?
PART - C (5 X 8 = 40 Marks)
14. Write the chemical degradation of pencillin?
15. Write the SAR and uses of Tetracycline?
16. Write the structure, synthesis, mode of action and uses of Chloramphenicol?
17. Write a note on Prodrugs?
18. Write the structure, synthesis, mode of action and uses of Nitrofurantion?
19. Write the mode of action and SAR of Sulphonamides?
20. Write a short note on combinatorial chemistry?
21. Write the structure, synthesis, mode of action and uses of Miconazole?
22. Write the structure, synthesis, mode of action and uses of Mebendazole?
 Code No. 12286 / PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, September 2021

Subject: Pharmacology - III

Time: 2 Hours Max. Marks: 75

Note: Answer any seven questions Part – A, any one question from Part – B
and any five questions from Part – C.

PART – A (7 x 3 = 21 Marks)

1 What are antiemetics?

2 What are nasal decongestants?
3 Differentiate between purgatives and laxatives.
4 Define the following terms
a. Circadian rhythm b. circannual rhythm
5 What are fluoroquinolones? Give examples.
6 Enumerate various antidotes available.
7 Define Chronotherapy and write its applications.
8 Write a note on appetite suppressants.
9 What are the cholinesterase reactivators? Give examples.
10 How do carminatives act?

PART- B (1 x 14 = 14 Marks)
11 Classify the agents used in treatment of peptic ulcer disease. Write about the
pharmacological actions and therapeutic uses of Ranitidine and Omeprazole.
12 Write the MOA, adverse effects and therapeutic uses of Reverse transcriptase
inhibitors and cisplastin.
13 Explain the cell cycle. What are fluoroquinolones? Explain their MOA,
therapeutic uses and adverse effects.

PART- C (5 x 8 = 40 Marks)
14 Explain the MOA and adverse effects of aminoglycosides and penicillins.
15 Write short notes on the pharmacology of H 2 receptor blockers.
16 Discuss the symptoms and treatment of heavy metal poisoning.
17 Write a note on antimalarial drugs.
18 What are proteins based drugs? Write short notes on them.
19 Write about urinary tract infections.
20 Classify antifungal drugs. Write the MOA and adverse effects of amphotericin.
21 Discuss the symptoms and treatment of barbiturate poisoning.
22 What are immunosuppressants? Classify them.

*****
 Code No: 12287/PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (Main & Backlog) Examination, September
2021 Subject: Herbal Drug Technology
Time: 2 Hours Max. Marks: 75

Note: Answer any seven questions from Part-A, any one question from
Part-B and any five questions from Part-C.

Part – A (7 x 3 = 21 Marks)

1 Define “IPR” and “Bioprospecting”

2 Write about curcumin
3 Explain soxhlet extraction
4 Differentiate conventional and organic farming
5 Write about any two microbial pesticides
6 Write composition and functions of ASUDCC
7 What are churnas & bhasmas
8 Write about guar gum and saffron
9 Write the underlying principle of homeopathy
10 What are the methods for authentication of a herb

Part – B (1 x 14 = 14 Marks)

11 Write a detailed account of the guidelines for stability testing of herbal

drugs.
12 Write a note on: (a) Vitamins as antioxidants (b) Schedule Z.
13 Write a short note on (a) Herbal drug industry (b) Traditional Knowledge

Part – C (5 x 8 = 40 Marks)

14 Write a note on the role of nutraceuticals in the prevention and management

of cardiovascular diseases.
15 Write about pharmacokinetic herb drug interactions with examples.
16 Present an overview of good agricultural practices.
17 Write an account of plant based research institutes in India.
18 What is bio piracy? Discuss any three bio piracy cases in India.
19 Classify herbal excipients. Write in detail about naturally derived thickening
agents.
20. Write the method of preparation and standardization of churnas.
21. Discuss various methods used for processing of herbal materials.
22. Write a note on omega fatty acids and resveratrol.

*****
 Code No: 12288/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, September 2021
Subject: Biopharmaceutics and Pharmacokinetics
Time: 2Hours Max. Marks: 75
Note: Answer any Seven Questions from Part –A, Any
One Questions from [Link] Any Five Questions from
Part-C PART – A (7X3 = 21 Marks)
1) Define biopharmaceutics
2) Mention factors affecting Ahsorption
3) Differentiate Passive transport and Active transports.
4) Define Absolute bioavailability and relative bioavailability.
5) List the factors affecting elimination of drugs.
6) Explain Flip-flop method in extra vascular administration.
7) What is apparent volume of drug distribution
8) Write the equation for calculating steady state drug concentration for
one compartment open model.
9) What is proties binding. How it affects bio availability
10) Expand the terms: i. AUC, ii. Vd iii. T1/2 IV. Ka v. Kθ vi. CLR
Part - B (1 x 14 = 14 Marks)
11) Write about in-vitro drug dissolution models.
12) How do you estimate the pharmacokinetics parameters (K max and V max)
by using Michaelis – Menton equation.
13) Discuss about factors influencing absorption of drug in GIT

Part - C (5 x 8 = 40 Marks)
14) Write a note on Carrier mediated transport.
15) Describe about the physiological barriers to the distribution of drugs. Any three.
16) Explain the biliary excretion of drugs.
17) Explain the various methods for assessment of bioavailability.
18. Discuss in-Vitro-in-Vivo correlation
19. Explain kinetics of protion binding
20. Write in detail about compartment models.
21) Write a note on non-linear pharmacokinetics.
22) Explain methods of adjustment of dose and dosage regimen in patients
with hepatic failure

*******
 Code No: 12289/PCI

FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Main & Backlog) Examination, September 2021
Subject: Pharmaceutical Biotechnology
Time: 2 Hours Max. Marks: 75
Note: Answer any Seven Questions from Part –A, Any One Question from Part-
B. And Any Five Questions from Part-C PART – A (7X3 = 21 Marks)
1. Define the following:
i) Biotechnology ii) Enzyme immobilization
2. Write the components of Biosensors
3. Write significance of enzyme acting on DNA
i) Restriction end nucleases ii) S1 nuclease
4. Enumerate types of cloning vectors. Add a note on COSMID as vector
5. What is active immunity?
6. Write stability tests defined for official vaccines
7. Give applications involved in Southern blotting technique
8. How will you transfer gene by conjugation method
9. How to control foam during fermentation?
10. Mention six enzymes

PART- B (1 X 14 = 14 Marks)
11. Give the principle of rDNA technology along with significance of enzymes. Enlist
and explain various methods of screening the recombinants.
12. Define vaccine. Write the method of preparation and quality control of bacterial
vaccine
13. Discuss production of Penicillin by fermentation process.

PART - C (5 X 8 = 40 Marks)
14. Enlist methods of immobilization of enzymes. Add a note on applications of
enzyme Immobilization
15. Explain the applications of Biosensors
16. Write a brief account on production of insulin by rDNA technology
17. Differentiate between ‘type II Hypersensitivity’ the ‘type III Hypersensitivity’.
18. Give role of HAT medium in monoclonal antibody production
19. Write short notes on ELISA technique
20. Differentiate between prokaryote and Eukaryote
21. Describe components and working of fermentor
22. Write short note on vitamin B12 Production by fermentation
 Code No:12007/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021
Subject : Medicinal Chemistry-III
Time: 2 Hours Max. Marks: 75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-
B. And Any Five Questions from Part-C

PART – A (7 X 3 = 21 Marks)
1) Define &classify antibiotics?
2) Write the structure of Sulbactam & Monobactam?
3) Write the structure and uses of Strptomycin?
4) Write the structure of Chloroquine & Ethambutol?
5) Write the structure and uses of Dapsone?
6) Define Partition coefficient, Taft’s steric parameter?
7) Write the mechanism of action of Aminoglycosides?
8) Write the mechanism of action of Macrolides?
9) Define prodrugs?
10) Write the mode of action of anti-fungal agents?

Part - B (1 x 14 = 14 Marks)
11) Write the various classes of antitubercular drugs. Write the synthesis & mode of action of Isoniazid?

12) Define Beta lactam antibiotics and explain the classification, SAR and mode faction of Pencillins?

13)Write the mode of action and SAR of Sulphonamides and Write the synthesis
of Sulfamethoxaole?

Part - C (5x8 = 40 Marks)

14)Write the chemical degradation of Cephalosporins?
15)Write the SAR and uses of Tetracycline?
16) Write the structure, synthesis, mode of action and uses of Chloramphenicol?
17) Write a note on Prodrugs?
18) Write the structure, synthesis, mode of action and uses of Ciprofloxacin?
19) Write the structure, synthesis, mode of action and uses Trimethoprim?
20) Write a short note on combinatorial chemistry?
21) Write the structure, synthesis, mode of action and uses of Tolnaftate?
22) Write the structure, synthesis, mode of action and uses of Mebendazole?
 Code No: 12012/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021
Subject: Quality Assurance
Time: 2 Hours Max. Marks: 75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-B.
And Any Five Questions from Part-C
PART – A (7 X 3 = 21 Marks)
1 Define ISO 14000
2 Define Quality by design (QbD)
3 Define Quality Assurance.
4 Define GMP.
5 Explain out of trend (OOT)?
6 What is Warehousing? Explain.
7 Explain on out of specification.
8 What is Sources of impurities? Explain.
9 What is calibration. Why it should be bone for equipment
10 What is SOP.? Explain.
Part - B (1x 14 = 14 Marks)
11 Write briefly about Quality control test for secondary packing materials.
12 Define ICH. Explain about ICH Guidelines.
13 Write briefly about importance, scope of validation and types of validation.
Part - C (5x 8 = 40 Marks)
14 Describe SOP, Quality audit and Quality Review.
15 Write a short note on Total Quality Management (TQM)
16 List out what are the different analytical instrumentation used in the estimation
of impurities.
17 Explain about validation master plan.
18 Explain about Personnel responsibilities, training, and hygiene
19 Write a short note on ISO 9000 series?
20 Explain about Equipment selection, purchase specifications and maintenance
21 Explain ISO certification procedure and its advantages?
22 Write briefly about Quality control test for containers.
*******
 Code No:
12011/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021
Subject: Pharmaceutical Biotechnology
Time: 2 Hours Max. Marks: 75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-B.
And Any Five Questions from Part-C
PART – A (7 X 3 = 21 Marks)
1 What is biosensor? Write the main components used in biosensor.
2 What is genetic engineering?
3 Explain restriction endonucelases.
4 What are vectors? Write the ideal properties of vectors.
5 Write few applications of hybridoma technology.
6 What are toxins? Explain the method of conversion of toxin to toxoid.
7 Write the preparation and uses of human fibrinogen.
8 Write about types of aerators in Fermentor.
9 Write a brief note on plasmids.
10 Differentiate between prokaryotic and Eukaryotic organisms.

Part - B (1 x 14 = 14 Marks)
11 Discuss the structure and function of Major Histocompatability Complex.
12 Explain the typical structure of Immunoglobulin and types of Antibodies.
13 What are plasma substitutes? Explain the manufacturing of plasma substitutes and
standardization.
Part - C (5x 8= 40 Marks)
14 Write a brief notes on Protein Engineering
15 Explain the steps involved in PCR.
16 Explain insertion and replacement vectors (Bacteriophage vector)
17 Discuss the general methods of preparation of vaccines.
18 Explain Southern blotting technique.
19 Explain generalized transduction and specialized transduction.
20 What are mutations? Explain the types of mutations.
21 Draw a neat labelled diagram of a typical fermentor.
22 Explain the aeration and agitation process in fermentation.

*******
 Code No. 12010 / PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021

Subject : Bio pharmaceutics & Pharmacokinetics

Time: 2 Hours Max. Marks: 75

Note: Answer any seven questions Part – A, any one question from Part – B and any five
questions from Part – C.

PART – A (7x3=21 Marks)

1 Define Noyes and Whitney equation and its application.
2 What is Lipinskis rule of five?
3 Differentiate between plasma protein-drug binding and tissue drug binding.
4 Define Microconstants and Hybrid constants and write relationship between them.
5 What is Flip-Flop Phenomenon and how it is useful in method of residual?
6 What are the different methods used to calculate the AUC?
7 Define orange book and objectives of bioavailability studies.
8 Difference between Absolute bioavailability and Relative bioavailability.
9 Define Creatinine and how to calculate the Creatinine Clearance
10 If VD of thiopental is [Link] the amount of drug in the body when
plasma concentration is 2µg/ml.
PART- B (1x14=14 Marks)
11 Define absorption. Write in detail about mechanism of drug absorption with diagram.
12 Explain in detail about Bioequivalence study protocols.
13 Derive Michaelis-Menten equation and how do you estimate Km and Vmax.

PART- C (5x8=40 Marks)

14 Write in detail about pH partition hypothesis and its limitation.
15 Write about Gastric emptying rate and Volume of distribution.
16 Significance and kinetics of protein drug binding.
17 What are the factor causing Non-Linearity?
18 How do you calculate absorption rate constant, Ka by using Wagner Nelson method?
19 Explain the pharmacokinetic parameters of a drug which follows one compartment open
model when given by intravenous bolus with relevant mathematical equations.
20 What are the different methods for Assessment of Bioavailability?
21 Explain various cross over designs in Bioequivalence studies.
22 A 60 kg male received 2mg/kg of a drug orally. The following plasma concentration vs time
data is obtained. Assume the drug follows one compartment open model and it is
completely absorbed. Calculate all possible pharmacokinetic parameters.

Time(hr) 1 2 3 4 5 6 8 10 12 14
Plasma Conc. (µg/ml) 3.2 7.3 9.1 9.7 9.7 9.2 7.1 5.3 4.0 3.0

*****
 Code No: 12009/PCI
FACULTY OF PHARMACY
B. Pharmacy VI-Semester (PCI) (Suppl.) Examination, March 2021

Subject: Herbal Drug Technology

Time: 2 Hours Max. Marks:
75
Note: Answer Any Seven Questions from Part –A, Any one Question from Part-B.
and Any Five Questions from Part-C

PART – A (7 X 3 = 21 Marks)
1 What is Tridosha
2 What are Biopesticides
3 Define the term nutraceuticals
4 Write the health benefits of Amla.
5 What are advantages of Herbal Excipients?
6 Define the term Cosmetics.
7 Define the term patent and farmers right
8 What do you mean by evaluation of drugs?
9 List plant based government research institutes in India.
10 Write a note on Biopiracy.

Part - B (1x 14 = 14 Marks)

11 Briefly explain good agricultural practices in cultivation of medicinal plants.

12 What is traditional knowledge? Explain patenting aspects of Traditional

knowledge and natural products.

13 Briefly explain the objectives and components of Schedule-T.

Part - C (5x 8 = 40 Marks)

14 List the Ayurvedic formulations and write the preparation of Bhasma.
15 Explain the principles of Siddha system of medicine.
16 Discuss the future prospects of Herbal drug industry.
17 Write a detailed account of case study of Neem and Curcuma.
18 Write the methods of stability testing of herbal drugs.
19 Write note on herbal binders and diluents.
20 Write the possible side effects and interactions of garlic and pepper.
21 Write the role of Honey and Alfa alfa as health food.
22 Write about pest management in medicinal plants.

*******