DAFTAR PUSTAKA
1. Dlova, Ncoza C., Akintilo, Lisa O., and Taylor, Susan C., 2019,
Prevalence of Pigmentary Disorders: A Cross-Sectional Study in Public
Hospitals in Durban, South Africa, Int J Womens Dermatol, Dec; 5(5):
345–348
2. Fisk, W. A., Agbai, O., Lev-Tov, H.A., Sivamani, R.K., 2014, The Use of
Botanically Derived Agents for Hyperpigmentation: A Systematic Review,
Journal of The American Academy of Dermatology, Elsevier Inc, 70(2),
pp. 352–365
3. Raikar, D., Javed, M.W., Takalkar, A. A., 2020, A Clinical and
Epidemiological Study of Hyperpigmentary Disorder of Face,
International Journal of Research in Dermatology, Vol 6, No 2. ISSN:
2455-4529
4. Nautiyal, Avni, and Wairkar, Sarika, 2021, Management of
Hyperpigmentation: Current Treatments and Emerging Therapies, Review:
Pigment cell & Melanoma Research Volume 34, Issue 6 p. 1000-1014
5. Azarpira, N., Kavianil, M., Salehi, S., 2015, The Role of Mesenchymal
Stem Cells in Diabetes Mellitus, Int J Stem Cell Res Ther. 2(2): 1-5
6. Kim, Nayoun, and Cho, Seok-Goo., 2013, Clinical Applications of
Mesenchymal Stem Cells, Korean J Intern Med 2013; 28 (4): 387-402
7. Hernanda, Pratika Y., 2017, Pengaruh Lingkungan Mikro terhadap
Perkembangan Jaringan Tumor/Kanker: Peran Sel Punca Mesenkimal,
Bagian Biomedik, Laboratorium Genetika – Pusat Penelitian
Biomolekuler, Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya,
Surabaya, Indonesia. eJKI Vol. 7, No. 1, April 2019. 80-82
8. Perez, ramon L., Brauer, J., ruhle, A., Trinh, T., Sisombath, S., Wuchter,
P., Grosu, A. L., Debus, J., Saffrich, R., Huber, P. E., Nicolay, N. H.,
2019. Human Mesenchymal Stem Cells are Resistant to UV-B Irradiation,
Scientific Reports, Volume 9, Article number: 20000
9. Vizoso, F.J., Eiro, N., Cid, S., Schneider, J. and Perez-Fermamdez, R.,
2017, Mesenchymal Stem Cell Secretome : Toward Cell- Free
Therapeutic Strategies in Regenerative Medicine, International Journal of
molecular Science, 18 (9), p.1852
10. Tan, Kei. X., Chang, T., and Lin, X., 2022, Secretomes as an Emerging
Class of Bioactive Ingredients for Enhanced Cosmeceutical Applications,
Review Article. Experimental Dermatology ;31:674–688
11. Rathee, P., Kumar, S., Kumar, D., Kumari, B., and Yadav, Savita S., 2021,
Skin Hyperpigmentation and Its Treatment with Herbs: an Alternative
Method, Future Journal of Pharmaceutical Sciences, Volume 7,
Article number: 132
12. Almezani, A. M. M., 2018, Knowledge About the Prevalence of Acne
Scars, Skin Hyperpigmentation, Chloasma and Freckles in Hail’s
Community, Saudi Arabia Adnan Meteb Mohamed Almezani, The
Egyptian Journal of Hospital Medicine, Vol. 70 (12), Page 2162-2164
13. Sofiana, R., Wiraguna, A. A. G. P., and Pangkahila, W., 2017, Krim
Ekstrak Etanol Biji Mengkudu (Morinda Citrifolia) Sama Efektifnya
dengan Krim Hidrokuinon dalam Mencegah Peningkatan Jumlah Melanin
Kulit Marmut (Cavia Porcellus) yang Dipapar Sinar Ultraviolet B, Jurnal
e-Biomedik S(eBm), Volume 5, Nomor 1
14. Jusuf, Nelva K., 2017, Pattern of Pigmentation Disorder in Cosmetic
Dermatology Clinic H. Adam Malik General Hospital, Medan, 2012 –
2015, J Gen Proced Dermatol Venereol Indonesia ; 2(1):1-6
15. Lestari, S., 2011, Cosmeceutical Untuk Hiperpigmentasi, Journal of
Cosmetic Dermatology Update Symposium Proceedings
16. Klar, Agnes S., Biedermann, T., Michalak, K., Michalczyk, T., Simmen,
Claudia M., Scherberich, A., Meuli, M., and Reichmann, E., 2017, Human
Adipose Mesenchymal Cells Inhibit Melanocyte Differentiation and The
Pigmentation of Human Skin via Increased Expression of TGF-β1, Journal
of Investigative Dermatology, Volume 137, Issue 12, December, Pages
2464-2466
17. Kumari, S., Thng, S. T. G., Verma, N. K., and Gautam, Hemant K., 2018,
Melanogenesis Inhibitors, Acta Derm Venereol; Vol 98: 924–931
18. Zhu, L., Lin, X., Zhi, L., Fang, y., Lin, K., Li, K., and Wu, L., 2020,
Mesenchymal Stem Cells Promote Human Melanocytes Proliferation and
Resistance to Apoptosis through PTEN Pathway in Vitiligo, Stem Cell Res
Ther; 11: 26
19. Kim, Ji-H., Hong, A., Kim, Yo-H., Yoo, H., Kang, S. W., Chan, Sung
Eun, and Song, Y., 2020, JNK Suppresses Melanogenesis by Interfering
with CREB-Regulated Transcription Coactivator 3-Dependent MITF
Expression, Theranostics ; 10(9):4017-4029
20. Ge, Quanhu, Zhang, H., Hou, J., Wan, L., Cheng, W., Wang, X., Dong,
Dan, Chen, C., Xia, J., Guo, J., Chen, X., and Wu, Xiangwei, 2018,
VEGF Secreted by Mesenchymal Stem Cells Mediates The Differentiation
of Endothelial Progenitor Cells into Endothelial Cells via Paracrine
Mechanisms, Mol Med Rep, Jan; 17(1): 1667–1675
21. Rodrigues, M., and Pandya, A. G., 2019, Fitzpatrick’s Dermatology :
Hypermelanoses. New York: Mcgraw-Hill Education; 1379–1381.e9
22. Kim, Eun Sung, Jeon, H. B., Lim, H., Shin, Ji Hyun, Park, S. J., Jo, Yoon
Kyung, Oh, Wonil, Yang, Y. S., Cho, D. H., and Kim, Ju-Yeon, 2015,
Conditioned Media from Human Umbilical Cord Blood-Derived
Mesenchymal Stem Cells Inhibits Melanogenesis by Promoting
Proteasomal Degradation of MITF, Research Article, PLoS ONE 10(5):
e0128078
23. Alam, B., Ahmed, A., Motin, A., Kim S., and Lee, S. H., 2018,
Attenuation of Melanogenesis by Nymphaea Nouchali (Burm. F) Fower
Extract through The Regulation of cAMP/CREB/MAPKs/MITF and
Proteasomal Degradation of Tyrosinase, Scientific Reports, 8:13928
Bab 2
24. Amalia, L., Parwati, I., Rizal, A., Panigoro, R., Gamayani, U., Rasyid, A.,
and Atik, N., 2019, Hypoxia Inducible Factor (HIF) 1-Α dan Vascular
Endothelial Growth Factor (VEGF) pada Stroke Iskemik Fase Akut, JNI
2019; 8 (3): 226–32
25. Foxler, D. E., Bridge, K. S., James V., Webb, T.M., Mee, M., Wong, S.
C., Feng Y., Constantin-Teodosiu, D., Petursdottir, T. E., Bjornsson, J.,
Ingvarsson, S., Ratcliffe P. J., Longmore G. D., Sharp T. V., 2018, The
LIMD1 Protein Bridges an Association between The Prolyl Hydroxylases
and VHL to Repress HIF-1 Activity, Nat. Cell Biol, 14:201-208
26. Chen, C., and Lou, T., 2017, Hypoxia Inducible Factors in Hepatocellular
Carcinoma. Oncotarget. 8:46691- 67 46703
27. Almubarak, S., Nethercott, H., Freeberg, M., Beaudon, C., Jha, A.,
Jackson, W., Marcucio, R., Miclau, T., Healy, K., and Bahney, C., 2016,
Tissue Engineering Strategies for Promoting Vascularized Bone
Regeneration, Bone, 83, pp.197–209
28. Kim, Young R., and Hong, Seung H., 2017, Promoter Polymorphisms of
The Vascular Endothelial Growth Factor Gene are Associated with
Metabolic Syndrome Susceptibility in Koreans, Biomed Rep, May; 6(5):
555–560
29. Gurning, Mariati B. R., 2018, Hubungan Kadar Vascular Endothelial
Growth Factor (VEGF) Serum dengan Penyakit Perlemakan Hati
Nonalkoholik, Tesis Magister, Universitas Sumatera Utara
30. Johnson, K. E., and Wilgus, T. A., 2014, Vascular Endothelial Growth
Factor and Angiogenesis in The Regulation of Cutaneous Wound Repair,
Advances in Wound Care, 3(10), 647-661
31. Hoeben, A., Landuyt, B., Highley, M. S., Wildiers, Oosterom, H. A., and
Bruijn, E. A., 2004, Vascular Endothelial Growth Factor and
Angiogenesis, Pharmacol Rev ; 56(4):549–580 dalam
32. Maharaj, A. S. R., and D’Amore, P. A., 2007, Roles for VEGF in Adult,
Microvasc Res : 74(2-3): 100–113
33. Banna, H., Hasan, N., Lee, j., Kim, J., Cao, J., Lee, Eun H., Moon, Hyung
Ryong, Chung, Hae Y., Koo, Jin W., 2018, In Vitro and in Vivo
Evaluation of MHY908-Loaded Nanostructured Lipid Carriers for The
Topical Treatment of Hyperpigmentation, J Drug Deliv Sci Technol
48:457–465
34. Afnan, Q., Kaiser, Peerzada J., Rafiq, Rather A., Nazir, Lone A., Bhushan,
S., Bhardwaj, Subhash, C., Sandhir, R., and Tasduq, and Sheikh A., 2016,
Glycyrrhizic Acid Prevents Ultraviolet-B-Induced Photodamage: A Role
for Mitogen-Activated Protein Kinases, Nuclear Factor Kappa B and
Mitochondrial Apoptotic Pathway, Exp Dermatol 25(6):440–446
35. Park, H. Y., and Yaar, M., 2012, Biology of Melanocytes, dalam:
Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffell, D.J.,
Wolff, K., Fitzpatrick's Dermatology in General Medicine, Edisi ke-8,
New York : McGrawHill; 795–81
36. Suryani, Adelia, 2020, Faktor-Faktor yang Mempengaruhi Pigmentasi
Manusia, Fakultas Kedokteran Universitas Udayana, Denpasar, Bali,
Indonesia, CDK-290/ vol. 47 no. 9
37. Lee, A. Y., 2014, An Updated Review of Melasma Pathogenesis,
Dermatologica Sin 32(4):233–239
38. Nouveau, S., Agrawal, D., Kohli, M., Bernerd, F., Misra, N., and Nayak,
Chitra, S., 2016, Skin Hyperpigmentation in Indian Population: Insights and
Best Practice. Indian J Dermatol; 61(5): 487–495
39. Kwon, S. H., Na, J. I., Choi, J. Y., and Park, K. C., 2019, Melasma:
Updates and Perspectives, Exp Dermatol 28(6):704–708
40. Mahdalena, I., Jusuf, N. K., and Putra, I. B., 2018, Melasma Characteristic
in Hormonal Contraceptive Acceptors at Kelurahan Mangga Kecamatan
Medan Tuntungan, Medan-Indonesia, Bali Med J 7(3):645–649
41. Garcia, Rosa M. G., and Molina, Sergio C., 2019, Drug-Induced
Hyperpigmentation: Review and Case Series, The Journal of The American
Board of Family Medicine, 32 (4) 628-638
42. D’Mello, Stacey A. N., Finlay, Graeme J., Baguley, Bruce C., and Amiri,
Marian E. A., 2016, Signaling Pathways in Melanogenesis, Int J Mol Sci,
Jul; 17(7): 1144
43. Maharani, Indah P., Adnan, Zainal A., Arifin, Nurudhin A., 2017,
Modulasi Sel Punca Mesenkimal dalam Menurunkan Kadar High
Sensitivity C-Reactive Protein Sebagai Terapi Nefritis Lupus, Biomedika,
Volume 9 Nomor 1
44. Pawitan, Jeanne A., Pratama, G., Mubarok, W., Jusuf, Ahmad A., Liem,
Isabella K., Mujadid, F., Dilogo, Ismail H., Novialdi, Indrani, Decky J.,
Rizkita, M., and Luviah, E., 2018, Aspek Biologi, Pemrosesan Dan
Aplikasi Klinis Sel Punca Mesenkimal, Stem Cells and Tissue Engineering
Research Center Indonesian Medical Education and Research Institute
(IMERI) Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto
Mangunkusumo, 8-13
45. M.F. Pittenger, A.M. Mackay, S.C. Beck, et al. Multilineage potential of
adult human mesenchymal stem cells Science, 1999, 284, pp. 143, dalam
Pawitan, J. A., et al., 2018 : Aspek Biologi, Pemrosesan Dan Aplikasi
Klinis Sel Punca Mesenkimal, 8
46. Revilla, gusti, 2019, Sel Punca Mesenkimal Untuk Luka Bakar, Andalas
University Press, 14-15
47. Ahangar, P., Mills, Stuart J., and Cowin, Allison J., 2020, Mesenchymal
Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving
Wound Repair, Int. J. Mol. Sci, 21, 7038
48. Caplan, A. I., 2019, Mesenchymal Stem Cells in Regenerative Medicine,
Principles of Regenerative Medicine (Third Edition), Chapter 15,
Academic Press 219-227
49. Murphy, M. B., Moncivais, K., and Caplan, A. I., 2013, Mesenchymal
Stem Cells: Environmentally Responsive Therapeutics for Regenerative
Medicine, Exp Mol Med 45(11): e54
50. Yustianingsih, Vivi, 2018, Pengaruh Pemberian Mesenchymal Stem Cell
Hypoxia Conditioned Medium (Msc-Hcm) terhadap Self-Renewal MSC,
yang Ditandai Ekspresi CD73 CD90 dan CD105, Thesis Magister,
Program Pendidikan Magister Ilmu Biomedik, Fakultas Kedokteran
Universitas Islam Sultan Agung Semarang, 25-62
51. Putra, Agung, 2019, Basic Molecular Stem Cells, Semarang, Unissula
Press, 227-228
52. Widowati, W., Rihibika, Dwi D., Khiong, K., Widodo, M. A., Sumitro,
Sutiman B., and Bachtiar, I., 2017, Hypoxia in Mesenchymal Stem Cell,
In: Hypoxia and Human Disease. IntechOpen, pp. 91-100
53. Kwon, Se Y., Chun, So Y., Ha, Yun S., Kim, Dae H., Kim, J., Song, Phil
H., Kim, Hyun T., Yoo, Eun S., Kim, Bum S., and Kwon, Tae G., 2017,
Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells,
Tissue Eng Regen Med, 14(5)
54. Kim, Dae S., Ko, Young J., Lee, Myoung W., Park, Hyun J., Park, Yoo J.
P., Kim, Dong I., Sung, Ki W., Koo, Hong H., and Yoo, Keon H., 2016,
Effect of Low Oxygen on The Biological Characteristics of Human Bone
Marrow Mesenchymal Stem Cells, Cell Stress and Chaperones, Volume
21, pp. 1089-1099
TABEL
1. Originalitas Penelitian
2. Sistem Skoring Intensity Score dan Proportion Score
3. Sistem IRS / Remmele Score
4. Reagen yang Digunakan dalam Flow Cytometry
GAMBAR
1. Perbandingan Aktivasi HIF-1α pada Keadaan Normoksia dengan Hipoksia
2. – Hidroksilasi HIF-1α oleh Oksigen
3. – Degradasi HIF-1α oleh VHL pada Kondisi Normoksia
4. – Perbandingan Aktivasi HIF-1α pada Keadaan Normoksia dengan
Hipoksia.
5. Struktur Molekul VEGF
6. Ekspresi VEGF
7. Peranan VEGF dalam Proses Kaskade Angiogenesis
8. Hiperpigmentasi kulit
9. Melanogenesis
10. Hasil Kultur MSCs Manusia Akan Terlihat Sel Berbentuk Spindel Seperti
Fibroblas
11. Peran Mesenchymal Stem Cells (MSCs)
12. Konsep MSCs Induced / Soluble Molecule
13. Kaskade Transduksi Sinyal Melanogenesis
14. Degradasi MITF oleh ERK1/2
15. Rancangan Penelitian
16.