cobas* b 123 POC system A cartridge-based blood gas analyzer for your patient care cobas”cobas* b 123 POC system Complete blood gas solution interface [®) * Graphically guided sampling and consumable + Easy installation * Low training needed Immediate control in one screen + Complete overview of operational status + SMART CHIP technology-consumables scan automatically and all important information is stored + Consumable change display 6 Protection = Comprehensive clot protection - eliminating the risk of analyzer downtime, due to clots = Operator lock-out-only train users are allowed « Level of access-certain specially trained users can perform advance function Ready and safe sampling area * Able to choose type of sample container * Lit sample area to facilititate room with low light + Central enclosed port makes left or right handed user comfortable and safe = No needle exposure with closed sample port Result management Customizable out of range values Display of acid/base mapping + Display of patient trendingcobas‘ b 123 POC system Flexsibility 01 Instrument configurations: 02 Sensor configurations: = Without AutoQC and COOX BG +Het = With AutoQe © BG + Het + ISE = With COOX * BG + Het +ISE + Glu = With AutoQC and COOX © BG + Het + ISE + Glu + Lae 03 Fluid Pack Configurations: (04 Automatic quality control + 200 ~ 400 ~ 700 test without COOX + 24 ampoules on three levels + 200 ~ 400 ~700 test with COOX «* Dally/weekly programming BG=pHi,pCO, pO, Electayte=Nat,K*, Cal, Cr AutoQC= automatic quality control system (only in version 2 andl 4) Adapting to your needs * With flexible configurations and a throughput + Flexibility and scalability allows clinically Of up to 30 samples per hou, cabas® b 123 relevant and cost efficient in the management ccan be easily customized according to the of Point of Care Testing nuea needs ofthe critical area and the + All consumables can be interchanged between different eobas® b 123 systems * Thesnll poces” bilza pecemeterpenel * Optional mobile chart, UPS (uninteruptable Fee eee aarpoataat ower source) backup and wireless {Hb 80, 0,11, Hi, CO,Hb, Met, Brubin, tonnecivty enable operation where over Glucose, Lactate. Plus an extensive range of needed calculated parameterscobas* b 123 POC system Clinical value Bilirubin in neonatal caré provide rapid information on the critical care state of new born Immediate monitoring of bilirubin in neonatal care lowers the risk of life-threatening conditions and lasting harm. More than 60 49 of mature healthy newborns develop hypesbilirubinemia, In rare cases, blood biinubin eoncentrations above ‘a cntical value result in kemicterus (encephalopathy), which causes death in 10 % and long-term morbidity in 70 % of cases.1 Whether and when a child receives phototherapy or blood exchange to eliminate neurotoxin and prevent reversible brain damage and neurological development deficits crucially depends on total serum bilirubin (TSB) and age ‘The current guidelines have been developed by the American Academy of Pediatrics (AAP), representing a consensus of the AAP subcommittee on hyperbilirubinemia to update the existing guideline based on a careful review of the ‘evidence by the New England Medical Center Evidence-Based Practice Center's The authors of an AAP technical report conclude high TSB levels exceeding 20 mg/dL to cause kernicterus, with an increasing probability when TSB levels are 2 30 mg/dL. 2 “Give physicians the tools to implement the guidelines: Risk assessment tool at bedside”. fae + Use total bilirubin + Risk factors = soimmune hemolytic disease, G6PD deficiency, asphyxta, significant lethargy, temperature instability, sepsis, acidosis, or albumin < 3.0 gl. (if measured) Lactate: Key parameter in sepsis High lactate is a marker of severe physiological stress and risk of death. It represents the metabolic changes accompanying ‘severe tissue stress and hypoperfusion. Contrary to long-standing belie, lactate is not only a marker of hypoxia but also ‘serves as a metabolic signal The lactate level represents a balance between generation and elimination and so should not be interpreted in isolation from oxygen status and blood pHMeasurement of blood lactate concentrations is therefore a vital addition to the blood gas analysis process. All patients with a lactate level > 4 mmol/L, whatever their blood pressure is, are entered in the early goal-directed therapy portion of the severe sepsis resuscitation bundle mm Lactic conence 210% fm Lieto cenense «10% a bs 1 1 : - ie 5 Dayscobas°® infinity POC solution Complete remote management —— Screen sharing for complete data management and remote control: + Replacement of device * Calibrations of parameters * Quality Check Simple and self-guided user interface Check your blood gas status. Anytime. Anywhere @ Personalized alert for intellegent management of critical issues + Last access memory * Automatic quality control * Check reagent and fluid pack + Check characteristic parameter a a @ Operator lock-out (ED mutti-site and mutti-analyzer management Proactive and personalized instrument managementcobas* b 123 POC system Product Specification Measured parameters Blood gases Specified range pH 65-80 pCOz 10-150 mmHg (1.33 - 19.95 kPa) pOz 10-700 mmHg (1.33-93.10 kPa) Electrolytes Nat 100-200 mmol/L Kr 1-15 mmol/L Cat 0.1-2.5 mmol/L cr 70-150 mmol/L Het 10-75% Metabolites Lactate 1-20 mmol/L Glucose 1-30 mmol/L CO-Oximetry tHb 4-25 g/dL (25 -15.5 mmol/L) SOz 30-100% OoHb 30-100% COHb 0-70% MetHb 0-70% HHb 0-70% Bilirubin (total) 3-50 mg/dL (51.3-855 umol/L) Calculated parameters H+, cHCOs, ctC02(P), FOzHb, BE, BE«t, BB, S02, Pso, ctO2, ctCO2(B), pHs, CHCOs-xt, PAO2, AaDOz, a/AQ:, avDO», RI, Shunt, nCa*, AG, pH', H*, PCOz!, POz, PAOz', AaDOz', a/AOz, RI, Het(c), MCHC, BOs, BE«t, Osmolality, OER, Heart minute volume (QQ, P/F index, Lactate clearance Sample volume Parameter Volume BG, Het, Electrolytes®, Glu, Lac, COOX 123 pL BG, Hct, Electrolytes, Glu, Lac 102 pl Micro mode ~ BG, Het, COOX 56-122 pL Micro mode - BG only 38-55 pL Micro mode - COOX only Gine. Bilirubin) 25-37 pLSample types Calibration ‘System calibration 1 point-calibration 2 point-calibration Data processing Monitor Thermal printer ‘Supported protocols Electrical requirements Power rating ‘Ambient temperature Relative humidity, not condensed Power cable Options CO-Oximeter ‘AutoQc Barcode scanner Mobile cart UPS (Uninterruptible power supply) Wireless capability Test certificate UL CE conformity Dimension/weight instrument Width Height Depth Weight (without solutions, without AutoQC) Whole blood, aqueous and blood-based QC solutions, and dialysis solution Interval Every 24 hours Every 60 minutes (programmable 30 or 60 minutes) Every 12 hours are programmable for 4, 8 or 12 hours Intel, Celeron M, 800 Hz Built-in color TFT-LCD 10.4 inch flat screen (touchscreen) Built-in, 171 mm width, graphical capability POCTI-A, ASTM 100-240 V, 200 W, 50/60 Hz autoselecting +15 to +32°C (59 to 89.6°F) 15-85% Alocal supply required 512 nm wavelengths ‘Automatic QC system with room for 24 QC ampoules Hand held or benchtop APC BACK-UPs CS 350 VA USB/SERIAL 230 V W-Lan modem recommended UL3101-1 IVD-Directive 98/79/EC (IEC 1010-1 / EN 61010-1 / EN 61010-2-101) 33cm 47cm 32em 18 kg ‘optional / 2scheduled for development / BG = pH, pCOs, pO: / “Electrolytes = Na*, K*, Ca’, ChReferences 1._AAP 2008. ewww sap ora/aualyimprovement/qultvehbmypebil pA, accessed March 2008. 2 Ip.S. Chung, M, Kuli. OBrien, R, Sogo, Reto. 2008). American ‘Academy of Pediatrics, Technical Report, An Evidence-Based Review at Important sues Concerning Neonatal Hypebilirubineia, Peas. 114, 180-2153, 3. Malcle, MJ, Bat, RD, Bhutan, VK, Newman, TB, Palmer, Het a (2004), American Academy of Pediatrie, Cnical Practice Guideline, ‘Management of Hyperlirubinemia in te Newborn Infant 35 or Mere Weeks of Gestation Pacatics 114(1), 207-916 4. Lag, B. Gibot, S, Franck, P,Cravoisy A Bollet, PE (2008). Relation between ‘muscle Na+ K+ ATPase ect and raed lactate concontraone in septic chock: @ prospective study. Lancet 365 (9462), 871-875, 5. Handy, J. 2006), Lactate ~ The bad boy of meteboiam, or simply misunderstood? (Cutrent Anacethesia & Critical Cao. 17.71-76. 5. Sunving Sepsis Campaign. wis survivingsepscorg/bundles/indvidual changes! ‘serum Joctate,aocessed March 2008 © 2020 Roche LT. Roche Indonesia AIA Cental, 3th Floor Jakarta 12030, Indonesia Tel. +92-21-3001 3000 Fax. +62-21-7259 1900 ‘ye diagnostics roche.com wow roche.coid Roche Tre Ral Exper Seton He estou, ‘Wahoo 112 ROID/PMLI8VPOC/v20=0