Cebu Normal University College of Nursing Osmena Blvd.
Cebu City 6000 DRUG STUDY Name of Patient Diagnosis Doctor Drug Data Generic Name paracetam ol Trade Name Aminofen, Robigesic, Acetamino phen Patients Dose Classificati on Therapeut ic analgesic antipyretic Age Sex Date of Admission Mechanism of Action Pharmacokinetics: A: rapidly absorbed from the gastrointestinal tract following oral administration D: distributed rapidly and evenly throughout most tissues and fluids and binds to red blood cells. It can pass into breast milk M: primarily by the liver E: excreted in the urine as cysteine and mercapturic acid conjugates. Pharmacodynamics: The main mechanism of action of paracetamol is considered to be Indication General Indications It is commonly used for the relief of headaches, other minor aches and pains, and is a major ingredient in numerous cold and flu remedies. Patients Actual Indication to relieve fever Contraindicatio ns Contraindicatio ns Patients hypersensitive to drug Precaution Use cautiously in patients with long-term alcohol use because therapeutic doses cause hepatotoxicity in these patients Drug interaction Drug-Drug: Warfarin- may increase hypoptothromb Height Weight Body Build Adverse Reaction Prolonged daily use increases the risk of upper gastrointestinal complications such as stomach bleeding, and may cause kidney or liver damage. Other side effects include: low fever with nausea, stomach pain, and loss of appetite; dark urine, claycolored stools; or jaundice Nursing Responsibilities Before -Ask if the patient had liver disease -Do not use this medication to patients allergic to acetaminophen or paracetamol. -In children, dont exceed 5 doses in 24 hours. During -Do not give drugs together any other over-the-counter cough, cold, allergy, or pain medication -Give drug with food if GI upset occurs -Dont administer drug for more than 10 days After -Store paracetamol at room temperature away from heat and moisture.
Pharmacol ogic Paraaminophe nol derivative
Minimum Dose Pregnancy risk Category B
Maximum Dose
Contents active metabolite of phenacetin Availability Capsules: 325mg, 500mg Elixir: 160mg/5m l, 325mg/5m l Oral s: 160mg/5m l, 500mg/5m l Sprinkles: 80mg/caps ule, 160mg/cap sule Suppositori es: 80mg, 120 mg, 125mg, 300mg, 325mg, 650mg Tablets: 160mg, 325mg,
the inhibition of cyclooxygenase (COX). Paracetamol reduces the oxidized form of the COX enzyme, preventing it from forming pro-inflammatory chemicals. This leads to a reduced amount of Prostaglandin E2 in the CNS, thus lowering the hypothalamic set-point in the thermoregulatory centre. Onset 11 minutes after administration (PO) Peak -2 hours Duration 3-4 hours Drug Half Life 14 hours.
inemic effects. Zidovudinemay decrease zidovudine effects Barbiturates, carbamazepine : high doses or long-term use of these drugs may decrease therapeutic effects and enhance acetaminophen hepatotoxic effects Drug-food: Caffeine- may enhance analgesic effects of acetaminophen Drug-lifestyle: Alcohol- may increase risk of hepatic damage
-Discontinue drug if hypersensitivity reactions occur -Treatment of overdose: Monitor serum levels regularly,Nacetylcysteine should be available as a specific antidote; basic life support measures may be necessary.
500g, 650mg Tablets (chewable) : 80mg Routes of administra tion P.O., P.R.
Source: Lippincott, Williams, and Wilkins (2008). Nursing 2008 Drug Handbook Ed. 28. pp. 367368
Source: Lippincott, Williams, and Wilkins (2008). Nursing 2008 Drug Handbook Ed. 28. pp. 367368
Source: http://adisonline.com/phar macokinetics/ Abstract/1982/07020/Clinica l_ Pharmacokinetics_of_Parace tamol.1 .aspx
Source: http://en.wikipedia.org/wiki/ Paracetamol
Source Source: Lippincott, http://www.sophar Williams, and ma.com/ Wilkins (2008). paracetamol.phtml Nursing 2008 Drug Handbook Ed. 28. pp. 367-368:
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