Cough
1- A 15-year-old female presents to her primary care physician complaining of
runny nose and itchy eyes. She said that she first had these symptoms during the
spring a few years ago, but each year, they have been bothering her more. You
know there are multiple ways to interfere with the signaling that is causing her
symptoms. Which of the following drugs would prevent the release of the main
chemical mediator in her case?
a) Diphenhydramine
b) Loratadine
c) Theophylline
d) Cromolyn sodium
2- A 27-year-old man with recurrent asthma attacks is being considered for
preventative therapy with Nedocromil. This agent is not effective as an acute
treatment of an asthma attack because of the lack of which of the following
properties?
(A) Anti-inflammatory
(B) Bronchodilator
(C) Immune modulator
(D) Mast cell stabilizer
3- A 6-year-old boy presents to his pediatrician for follow up of recurrent hay
fever and asthma. He usually has two to three attacks per week. For symptom
control, he uses an albuterol inhaler, but his parents would like to try something
more. They would like him to take something that would lessen the amount of
attacks he has. Although corticosteroids would probably work best for
prophylaxis, they are contraindicated in children. Which of the following drugs
would decrease the amount of asthma attacks by preventing an arachidonic acid
derivative from binding to its receptor?
(A) Aspirin
(B) Celecoxib
(C) Montelukast
(D) Zileuton
4- A 9-year-old boy is brought to his primary care physician with a history of hay
fever and asthma. He usually has two to three attacks per week. For symptom
control, he uses an albuterol inhaler, but his parents would like to try something
more.. He was also given montelukast to decrease the severity of attacks. How
does montelukast works?
(A) Blocks leukotriene receptors
(B) Blocks muscarinic acetylcholine receptors
(C) Inhibits COX-2 only
(D) Inhibits lipoxygenase
5- A 26-year-old man presents to an urgent care clinic with a dry cough for the
past week. The cough was associated with a fever and chills for 2 days, but he has
since been afebrile. He has no other symptoms. What is most appropriate to treat
this patients’ cough?
(A) Loratadine
(B) Dextromethorphan
(C) Nedocromil
(D) Salbutamol
6- Dextromethorphan is an:
A. Analgesic
B. Antitussive
C. Expectorant
D. Antihistaminic
7- Which of the following is NOT an antitussive:
A. Oxeladin
B. Benzonatate
C. Bromhexine
D. Dextromethorphan
8- A 6-year-old boy returns home from his last day of school before thanksgiving
break. Over the break, he develops a cough, stuffy nose, headache, and fever.
His mother administers a cough syrup containing guaifenesin. Which of the
following effects is likely caused by guaifenesin?
(A) Cough becomes more productive
(B) Cough stops altogether
(C) Fever diminishes
(D) Headache resolves
9- A 16-year-old boy with cystic fibrosis undergoes many types of treatments
intended to loosen and thin the mucus obstructing his airways in order for him to
expel it. He also takes an oral pancreatic enzyme because his pancreas is unable
to secrete sufficient amounts because of mucus obstruction. Which of the
following medications thins cystic fibrosis mucus by cleaving extracellular DNA?
(A) Acetylcysteine
(B) Bromhexine
(C) Dornase alfa
(D) Guaifenesin
10- Bromhexine acts by:
A. Inhibiting cough centre
B. Irritating gastric mucosa and reflexly increasing bronchial secretion
C. Depolymerizing mucopolysaccharides present in sputum.
D. Desensitizing stretch receptors in the lungs
11- Omalizumab is administered in bronchial asthma by which route?
(a) Oral
(b) Intravenous
(c) Subcutaneous
(d) Aerosol
12- Omalizumab is indicated for which of the following conditions:
(a) Multiple myeloma
(b) Psoriasis
(c) Bronchial asthma
(d) Rheumatoid arthritis
Explain
1- Explain why sodium cromoglycate is used for chronic prophylaxis and not for
acute attack of bronchial asthma
2- Explain why ambroxol is used for productive cough not dry cough?
3- Explain why local anesthetics can be used in the management of cough?
