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Measles Pathophysiology

Measles is transmitted through droplets from the nose and throat of infected individuals. The measles virus infects epithelial cells in the respiratory tract and multiplies. It then extends to nearby lymph nodes through the lymphatic system. There is an incubation period of 1-10 days, followed by a prodrome period with fever and malaise. Koplik's spots then appear in the mouth, followed by a maculopapular rash that starts on the face and spreads to the rest of the body over several days.

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357 views1 page

Measles Pathophysiology

Measles is transmitted through droplets from the nose and throat of infected individuals. The measles virus infects epithelial cells in the respiratory tract and multiplies. It then extends to nearby lymph nodes through the lymphatic system. There is an incubation period of 1-10 days, followed by a prodrome period with fever and malaise. Koplik's spots then appear in the mouth, followed by a maculopapular rash that starts on the face and spreads to the rest of the body over several days.

Uploaded by

Al Theó
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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PATHOGENESIS OF MEASLES (rubeola)

Transmission
/.,mnbv by Infect epithelial cells
Virus multiplies in the
Droplets of Measles Of the nose and
epithelial cells
Virus (paramyxovirus) conjunctiva

Extends to the regional


Period of Communicability: during period of Lymph nodes by way of
coryza or catarrhal symptoms or 4 days Lymphatic system
Before rash appears- 5 days after rash
appears.
Primary Viremia Occurs Incubation
Period
Koplik’s spot (Graying Specks) describe as tin
Red patches with central white specks in the The virus continue to
1st – 10th day
buccal mucosa in the second molar. replicate in the
epithelial cells and
Reticuloendotheliel
Measles Virus- (-) single stranded RNA,
system
unsegmented,
lipid containing envelope, Helical symmetry and
replicates in the cytoplasm. Secondary Viremia Occurs

Measles Vaccine
(MMR)-Live Infection starts
Attenuated 12-15
mos of age
Fever and Malaise Prodrome
Period
In Biopsy of lymph
Node the presence Coryza, conjunctival
injection, coughs 8st – 12th day
Of Warthin-
finkeldy or the
Multi-nucleated
Koplik’s Spot 8st – 12th day
Giant Cell

Rash erupts
Presence of HA or (macupapular) Centrifugal 8st – 12th day
Hemo agglutin
activity and F
Protein Rash advances to the trunks

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