Anatasya Ayu Puspita
185070500111010
Farmasi B 2018
FARMAKOTERAPI INFEKSI, KANKER, DAN GANGGUAN NUTRISI
SELF-ASSESSMENT QUESTION
ANTICANCER
SAQ PPT
1. Paclitaxel (Taxol) inhibits cancer cell replication primarily at the ______ phase of the cell
cycle.
a. M
b. S
c. G1
d. G2
2. Which of the following monoclonal antibodies is not correctly matched with its target
antigen?
a. Rituximab—CD20+
b. Trastuzumab—Her-2
c. Alemtuzumab—CD33+
d. Ibritumomab —CD20+
3. 3. Which of the following therapies targets the mTOR pathway and is used in renal cell
cancer?
a. Sorafenib
b. Bevacizumab
c. Pazopanib
d. Everolimus
4. All of the following would require a dose adjustment (or holding therapy) based on a
bilirubin of 3.0 mg/dL except:
a. Doxorubicin
b. Vinblastine
c. Paclitaxel
d. Methotrexate
5. Don is a 58-year old with metastatic colon cancer. He has a biopsy taken and it is found
that his tumor overexpresses EGFR-1 and VEGF, but it also harbors a KRAS mutation.
Based on this information alone, which of the following agents would be LEAST useful
in treating Don’s tumor?
Anatasya Ayu Puspita
185070500111010
Farmasi B 2018
a. Bevacizumab
b. Irinotecan
c. Cetuximab
d. Oxaliplatin
Penjelasan:
Pasien dapat menggunakan 2 pilihan, yaitu Bevacizumab sebagai anti VEGF atau
cetuximab sebagai anti EGFR. Namun, pemberian terapi anti EGVF hanya akan bekerja
pada pasien dengan KRAS normal, dan tidak memberikan efek pada pasien dengan
mutasi KRAS. Sehingga dipilih terapi Bevacizumab untuk pasien di atas (Nagara et al.,
2008).
Sumber:
Nagara, Utomo, & Sandra. 2008. Efek Mutasi K-RAS pada Kanker Kolorektal terhadap
Terapi Antibodi Monoklonal anti EGFR . Indonesian Journal of Cancer, 4:144-148.
6. Which of the following is a small molecule kinase inhibitor requires testing for the
V600E raf mutation prior to initiating therapy?
a. Crizotinib
b. Lapatinib
c. Vemurafenib
d. Sunitinib
Penjelasan:
7. Rational combination of anticancer drugs is used to:
a) Prevent adverse effects of hypersensitivity
b) Synchronise anticancers with similar half time
c) Provide stimulation of cell differentiation
d) Provide stimulation of cell proliferation
e) Provide synergism resulting from the use of anticancer drugs with different
mechanisms combination
8. Tick the antibody used for anticancer inhibiting angiogenesis:
a) Trastuzmab
b) Alemtuzumab
c) Cetuximab
d) Gemtuzumab
e) Bevacizumab
Anatasya Ayu Puspita
185070500111010
Farmasi B 2018
9. Which of the following statements about the activity of monoclonal antibodies is true
a) antibody-dependent cytotoxicity involves effector cells such as macrophages and
granulocytes
b) These compounds can be given intravenously or orally due to their small molecular
weight.
c) The constant region of the antibody determines its antigen specificity
d) The Fab region of the antibody determines how the immune system processes the
antibody
e) Resistance to their activity can develop due to continuous administration of same
dosage of the drug
10. Which of the following agents requires activation in the liver to form a cytotoxic
alkylating agent and drug resistance is associated with the lack of activation to the active
drug?
a) cyclophosphamide
b) Ara-C (cytarabine)
c) 5-Fluorouracil
d) irinotecan
e) fludarabine
11. Rational combination of anticancer drugs is used to:
a) Prevent adverse effects of hypersensitivity
b) Synchronise anticancers with similar half time
c) Provide stimulation of cell differentiation
d) Provide stimulation of cell proliferation
e) Provide synergism resulting from the use of anticancer drugs with different
mechanisms combination
12. Some anticancer are intercalating agents.. How such agent could effectively damage
DNA:
a) Increases water solubility which allow it to be administered in high dose
b) Interacts with phosphate group of DNA which stabilize intercalaatione
c) Forms complex susceptible to free radical reaction
d) Being protonized whenit enters cells, hence trapped within cells.
e) Adding methyl group (methylation)
13. Best term to describe bevacizumab mechanism of action is:
a) Antiangiogenesis
b) Antisense agen
Anatasya Ayu Puspita
185070500111010
Farmasi B 2018
c) DNA cutter
d) Toxic against topoisomerase
e) Disruptor of hormonal signaling
14. The commonest adverse effect of anticancer is:
a) Pulmonary fibrosis
b) Myocardial infarct
c) Myelosuppression
d) Hypertension
e) Intratumor bleedings
15. Resistance against cycle-cell specific anticancer may be develop if:
a) Cell proliferation depends on growth hormone
b) Anticancer influx increases
c) Mutation on BCR-ABL
d) HSP-27 expression increases
e) DNA repair increases
16. Which of the following statements about the activity of monoclonal antibodies is true
a) antibody-dependent cytotoxicity involves effector cells such as macrophages and
granulocytes
b) These compounds can be given intravenously or orally due to their small molecular
weight.
c) The constant region of the antibody determines its antigen specificity
d) The Fab region of the antibody determines how the immune system processes the
antibody
e) Resistance to their activity can develop due to continuous administration of same
dosage of the drug
SAQ PDF
1. Which three of the following drugs are antimetabolite chemotherapy agents?
a.Gemcitabine
b.Topotecan
c.Cisplatin
d.Fludarabine
e.Adriamycin
f.Cyclophosphamide
g.Cytosine arabinoside
Anatasya Ayu Puspita
185070500111010
Farmasi B 2018
2. Which of the following applies to intercalating agent in chemotherapy drugs?
a.They act by alkylation of DNA
b.They inhibit RNA synthesis
c.They prevent separation of the DNA strands 20
d.They are topoisomerase inhibitors
e.They include irinotecan
3. Which of the following statements is true regarding chemotherapy agents acting on
mitosis?
a.They interfere with the synthesis of DNA
b.They affect spindle formation
c.They are independent of topoisomerase
d.They include cisplatin
e.They are independent of the cell cycle
4. Which of the following is true of signal transduction inhibitors?
a.They act through tyrosine synthase
b.They can inhibit angiogenesis
c.They include bortezomib
d.They are cell cycle dependent
e.They act on cell division
5. Which three of the following are true of drugs targeting the tumour vasculature?
a.They reduce blood flow to normal tissues
b.They can act through VEGF
c.They include thalidomide
d.They cause extensive thrombosis
e.Their effect is reversed by heparin
f.They can alter blood vessel structure
6. Which three of the following are highly sensitive to chemotherapy?
a.Breast cancer 21
b.Non-Hodgkin lymphoma
c.Small cell lung cancer
d.Neuroblastoma
e.Renal cell carcinoma
f.Phaeochromocytoma
g.Glioblastoma
Anatasya Ayu Puspita
185070500111010
Farmasi B 2018
7. For which three of the following drugs is neurological toxicity a major concern?
a.Cyclophosphamide
b.Carboplatin
c.Paclitaxel
d.Irinotecan
e.Cisplatin
f.Ifosphamide
8. For which of the following drugs must the renal function be measured before
administration?
a.Vincristine
b.Adriamycin
c.Carboplatin
d.Etoposide
e.Epirubicin
9. Which of the following drugs are used for anti-androgen activity?
a.Fluoxetine
b.Tamoxifen
c.Exemestane 22
d.Bicalutamide
e.Cyclophosphamide
10. Which three of the following are the monoclonal antibodies used in cancer treatment?
a.Rituximab
b.Bortezomib
c.Herceptin
d.Lapatinib
e.Erythropoietin
f.Combretastatin
g.Bevacizumab
11. Immunotherapy targets which of the following?
a.EGFR
b.PD-2L
c.VEGF
d.P53
e.PD-L1
Anatasya Ayu Puspita
185070500111010
Farmasi B 2018
f.IL6
12. Which of the following are recognized toxicities of immunotherapy?
a.Bone marrow depression
b.Colitis
c.Encephalopathy
d.Neuropathy
e.Hypopituitarism
