MSN Notes
MSN Notes
MECHANISM OF INFLAMMATION
Undergoes surgery > incision > tissue injury > SNS triggered
> Adrenal Medulla release NE causing Vasoconstriction >
>Norepinephrine >Cortisol
Adrenal Medulla Adrenal Cortex injured tissue release chemical mediators (Ex. Histamine,
->vasoconstriction ->stimulates liver to
Bradikinin, Prostaglandin) causing Vasodilation > more blood
perform gluconeogenesis
will go to the injured site causing Redness and Warmth to
and glycogenolysis
touch because of increase blood supply. > d/t release of
Histamine > increase capillary permeability > albumin goes
>Epinephrine >Aldosterone
out intravascularly to interstitial space thus Swelling happens.
-> Increase HR -> orders renal tubules to
> d/t increase blood suppy there is pressure on the nerve
reabsorb SODIUM ;
endings beneath the skin causing Pain and there is Loss of
where sodium goes water
Function.
follows.
- You have to clean the site very well because they are
>Testosterone
going to create an incision, if it is not clean bacteria
->Sex hormone
will go in.
- Pain is localized
Adrenal cortex
- WBCs phagocytize (a process called endocytosis) > it
- Cortisol will order the liver to peform glycogenolysis
will ingest bacteria in the form of lysosomes
and gluconeogenesis because patient is in NPO >
- Albumin (maintains osmotic pressure) will be
when there is increased stress > hypermetabolism
allowed to go out from the intravascular space to the
occurs > more glucose is needed because cells will
third space > accumulation of albumin in the 3rd space
become hungry.
> osmosis (movement of water from higher to lower
- Glycogenolysis (glycogen-glucose) > glucose is
area of concentrations) > water will go out
released because patient is undergoing surgery >
- Hypertonic solution due to the release of albumin to
under stress > increased metabolism > increasing
the 3rd space.
activity of cells, needing more food > cortisol orders
Blood vessel dysfunction
the liver to produce more glucose > if the liver runs
- The capillaries connect the arterioles and venules
out of glycogen, it will convert fats and proteins to
o This is where exchange of gases occurs
glucose (gluconeogenesis), which is not good.
Functions of the inflammatory
- patient is receiving IV fluids because of this to
- Prevents spread of the damaging agents
counteract loss of glucose
- Disposes of cell debris and pathogen
- aldosterone is a glucocorticoid produced by the
- Sets the stage for repair
adrenal cortex. It will reabsorb more Na (sodium),
- Inflammation sets the stage for healing > vasodilation
where sodium goes water follows.
> good amount of blood will go to the damaged area
- Patient will be bleeding > needing increased volume
> good amount of nutrients, oxygen, and WBCs will
> aside from bleeding client is in NPO, client also
also go to the area > flow in the blood in the wound is
loses fluids through respiration > no fluids are
already preparing the site for healing.
coming in to the client’s body > sodium attracts water
- WBCs are activated during inflammation
to keep fluid balance
- There is increase in heat during inflammation
Difference of aldosterone from ADH (anti-diuretic
because heat will make it hard for the bacteria to
hormone)
survive.
- Anti-diuretic hormone is released by the posterior
o Prevent the spread of damaging agents
pituitary gland. This will order the renal tubules to
reabsorb water decreasing fluid output. o Forms a barrier to prevent the bacteria from
- Aldosterone will reabsorb sodium which will attract metastasizing
water. Histamine – produced by circulating basophils, platelets and
Adrenal Medulla mast cells adjacent to vessels
- Releases two catecholamines: Norepinephrine and - (vasodilation, increased vascular permeability,
Epinephrine endothelial activation)
- Epinephrine increases cardiac rate because patient is Serotonin – produced mainly within platelets dense body
bleeding due to surgery > the heart has to pump granules (vasodilation, increased vascular permeability)
rapidly in order to give more blood to the other
systems of the body (blood contains oxygen and Blood vessel dysfunction
nutrients) - Capillaries leak out their walls
- Norepinephrine causes vasoconstriction - Caused by severe infection (sepsis) and certain
(compensatory mechanism): Blood pressure goes diseases
down (hypotension) due to bleeding ➡️decreasing
Capillary permeability
blood supply to the brain ➡️vasoconstriction ➡️
arteries constricted ➡️no perfused bleeding
- Due to release of histamine of the injured tissue it (inguinal hernia)
will alter capillary permeability and enlarge the pores -satisfies
of the blood vessels. Because of the enlargement of patient’s desires
pores this will cause the protein albumin to go out but not needed to
(albumin is the protein that controls the oncotic preserve life or
pressure inside the vessel) this will cause the water to function.
go out as well, from the intravascular space to the (cosmetic
third space causing swelling. surgery)
o Hypotonic: albumin inside the capillary
o Hypertonic: albumin outside the capillary SURGICAL PROCEDURES CAN BE BROADLY
o Oncotic: fluid retained in blood vessels CATEGORIZED AS:
because of pressure - ELECTIVE that which is planned
- EMERGENCY that which is unplanned
GENERAL MANIFESTATION OF INFLAMMATION Who is the most important part of the health care team?
>Body weakness - The patient is the most important part of the health
>Loss of Appetite care team.
>Fever - With the patient, nothing will be done or procedure
will not push through
Purposes of surgery
Diagnostics – confirmation of the suspected diagnosis (ex. Perioperative nursing
Biopsy, Endoscopy, Culture) - The Preoperative Phase – decision to proceed w/
- To determine whether disease is benign or malignant. surgical intervention and ends w/ entry in the
- Determines the cause Operating Room
Explorative – confirms the type of and extent of the disease - The Intraoperative Phase – entry in the Operating
(ex. Laboratory) Room to admission of the patient to the Recovery
Reconstructive – repair of physical deformities, improves Room or PACU
appearance. (Ex. Rhinoplasty, Mammoplasty, skin grafting) - The Postoperative Phase – admission of the patient to
Currative – diseased or damaged body organ or structure is the Recovery Room or PACU to discharge of the
removed or repaired. (Ex. Appendectomy, Amputation, patient or follow-up evaluation in clinical setting.
hysterectomy, fixation of fractures)
Palliative – alleviates pain or other disease symptoms; slows Pre-operative phase
progression of disease but does not cure (Ex. Nerve blocks Preoperative interview
placement of feeding tubes) - Meet the patient at eye level & introduce yourself by
- Patient is healthy but there is a problem name & role
o The nurse should ask the patient to tell her
Surgery based on urgency full name rather thin asking if she is a
CLASSIFICATIO INDICATIONS EXAMPLES certain patient because there might be
N another patient by that name on the
Emergent – Px Preserved the -Severe schedule.
requires immediate function of body bleeding - Nurses should not start the physical assessment or ask
attention. ; it may parts or life of -Gunshot the patient’s name without first identifying
be life threatening the patient. -Fracture skull themselves and their role
c/o within 1-2 o To relieve the patient’s anxiety in the new
hours ; w/o delay environment of the surgical experience
Urgent – px c/o within 24-48 -Repair of
requires prompt hours. incision Preoperative assessment
attention -drainage of History of previous surgery
wound - to avoid problems previously encountered
infection o Ex: The patient has one lung left and as a
Required – px Planned -cataracts nurse, emphasize breathing and coughing
needs to have exercises because respiratory complication
surgery is the number one complication of surgery.
This is due to the anesthesia received during
Elective – px The patient is in -repair of scar surgery (exchange of gases will not be
should have optimal health, -vaginal repair good).
surgery. something History of allergies
wrong but can - Patient might be allergic to seafood which contains
wait, done iodine
before the o Disinfectant used in hospitals
disease affects of o Latex allergies
threatens the
quality of life.
Chronic disease history o review the risks, benefits, &
- DM, HPN, Cancer, Asthma alternatives to the planned
- To provide necessary medications procedure
- To be alert for possible complications - If the patient verbalizes that he or she does
not understand the procedure that is planned,
DM: patient is hyperglycemic (blood is filled with sugar), it is the nurse’s responsibility to notify the
wound would not immediately heal surgeon of this lack of understanding
right away
HPN: patient might be taking aspirin which causes bleeding. - The nurse should not teach about the
Should be stopped for five to seven days before surgery procedure; the surgeon needs to do this
Time-out ``
When a “time-out” is called prior to surgery, the surgical team >>>If there will be edema in the eyes -> it will
must:
increase the intraocular pressure -> pressure on
o Read back all prescriptions
the optic nerve happens -> possible the patient to
o Verify the correct site
o Identify the patient again be blind.
o Double check the echocardiogram -If patient will undergo cosmetic surgery it will
increase tension on delicate tissues.
POST-OPERATIVE PHASE
Cardiovascular complications
- Tachycardia and hypertension
-Increase peripheral resistance causing the blood to be
sluggish resulting to decrease amount of blood going to the
wound thus slow healing of wound and poor oxygenation.
-Post Operative Pain
-Hypothermia
- d/t cold environment it will cause vasoconstriction
- so give additional blanket and lower down the AC
Deep Vein Thrombosis
Tachycardia and hypotension - Clinical Manifestations
- Adverse effect of Anesthesia - Swelling (Unilateral)
- Dehydration d/t bleeding - Warmth to touch
- Hypoglycemia - Redness
- NPO for 6-8 Hours Keep IV Fluids - Pain
- Blood loss during surgery Regulated - Tenderness
- Persistent Pain - Low-Grade Fever
- Cyanosis
Nursing interventions -The Blood is viscous d/t bedridden patient thus
O2 Therapy and IV Fluid Bolus patient is immobilize > no muscular contraction >
- Breathe more deeply and move legs to increase there is vein pooling > there is thrombus > if it goes
venous return. to the blood it will become an embolus > contracting
- Use of elastic bandages for antiembolism stockings the muscle will make the embolus go with the blood
(Squeezes blood veins into the heart) > vein have more blood than arteries > arteries have
- Use of analgesics no valves to prevent backflow > emboli enters the
- Rewarming will correct hypothermia – Induce lungs thus PULMONARY EMBOLISM > if emboli
hypertension is small it will travel and cross the blood brain barrier
- The PR,RR, and BP are recorded at least Q15 for thus resulting in STROKE or CVA.
the 1st hour and Q30 for the next 2 Hours. - Prevention of DVT
- The temperature is monitored Q4 for the first - Use of thrombo-embolic Stockings
24hours. - Elevating the foot of the bed(unless
Hypothermia contraindicated).
- 36*C - Never apply pillow under the knees –> it
- Up to 12 hours duration post operatively will cause pressure in the popliteal vein ->
- d/t effect of anesthesia because of body heat loss of thus blood accumulation happens.
surgical procedure. - compare Circumference, Color and
- Vasoconstriction decreases blood going to the Temperatire (CCT)
injured site so wound will not heal faster. - Leg and Arm exercises.
- Restrain/reduce action of WBC thus patient
becomes prone to infection. Gastrointestinal complications
- Depress cardiac contractility therefore there will be Nausea and Vomiting
less cardiac output (amount of blood being ejected by - It can stress and irritate the abdominal and GI
heart for one minute 5-8L) less blood will go to the wounds
wound site. - Don’t allow the patient to vomit because it can
Mild Elevation increase ICP and IOP
- 38*C - High risk to develop aspiration
- 24-48 hours of this temperature is considered pneumonia/pneumonia
normal due to inflammatory response to surgical stress. - Abdominal distention will happen because of
Above 38.*C decrease peristalsis thus there will be no movement
- Third day or later is due to infection of the intestine then there will be accumulation of
- Wound infection, UTI, or Atelectasis (collapse of gastric secretions in stomach + the swallowed air
the lungs). causing the abdomen to be distented and pain.
Temperature above 37.7*C - Place the patient in an upright position
- Third day or later - Give anti-emetic drugs
- Due to infection - Metoclopramide (Plasil)
- Wound infection - Ondasetron (Zofran)
>UTI - Insertion of NGT for Post-Operative patient who
>Phlebitis undergo abdominal surgery.
>UTI - Auscultation of Bowel Sounds
- Auscultate the 4Quadrants/minute (if you
can’t hear bowel sounds for a minute move
Patient is
Give to another quadrant until you hear)
Perineal Increase Vit.C to
with Care Fluid acidify
catheter given 2x intake to the urine
(Invasive)
- 5-25 bowel sounds/minute (Normal) Four evidence-based strategies for reducing surgical site
- >3 bowel sounds/minute (Hypoactive) infection
- Assess for swallowing reflex 1. Giving antibiotic with 1 hour before surgical incision is
- The best indicator for Peristalsis is the Flatus/Stool made (for 24hrs only)
- Slow Deep Breathing and avoid using - To ensure bactericidal serum and tissue antibiotic
straw levels
- because of the air that a patient can get - Cephalosporin- first and second generation
when using a straw making it distented. - D/C within 24 hours of surgery
- Frequent repositioning.
- Normal Peristalsis returns during the first 48-72 2. Removing hair appropriately
Hours Post-Operatively. - Done before the surgery
- If necessary, remove with electric clippers
Diets - Carried by surgeon’s order
Clear Liquid Diet - Against the direction of hair growth when using
- Broth surgical clippers; razor is with the hair growth
- Clear Juice
- Gelatin 3. Keep blood glucose control
- Tea and Coffee(w/o milk) - Patient will be under stress - then there will be
- Sodas (Sprite) increase metabolism in the body - SNS will be
- Beverages w/o milk stimulated to stimulate adrenal cortex to release
- Adequate fluid and water cortisol - then cortisol will go to the liver and
- Recommended 3-5 Days undergo gluconeogenesis wherein fats and protein are
being converted to glucose causing hyperglycemia
Full Liquid Diet - Blood will be viscous – blood full of sugar – will
- With milk promote growth of bacteria
- Provide water, vitamins, calories, and minerals
- Control starting first 48 hours
- Dairy products
- Blood glucose should be below 200mg/dl before
- Considered to be low in residue
surgery (Normal 80-120mg/dl of blood)
- For clients with difficulty in chewing and swallowing.
- Hyperglycemia hinders surgical recovery and
Soft Diet wound healing by:
- Oatmeal - Impairing immunity
- Bananas - Inhibiting inflammatory response
- Boiled Eggs - Interfering with collagen synthesis (for
- Milkshakes wound healing and tissue repair).
- Ice Cream - Good medium for growth of bacteria
- Cream soup
- Pudding 4. Keep patient warm post operatively
- Yogurt - Provide warm IVF
- Have patient wear cap, booties and socks
- Check temp pre op
- Drink warm liquid
- Forced warm air blanket
Maintaining elimination
Urinary Output 5. Shower or bath using antiseptic soap to decrease skin
- 1000-1500mL for 24 hours NORMAL microbial colony counts
- 30-50cc for an hour
- Decrease urinary output – d/t loss of blood during surgery > 6. Aseptic technique should be followed, cleaning and
hypothalamus can feel that > Posterior Pituitary Gland will disinfecting the instrument
release ADH – orders kidney to reabsorb fluids – Aldosterone
is secondary to retain sodium = PHYSIOLOGIC OLIGURIA. 7. Cover incision site with sterile dressing 24-48 hours
- 4th Post-Operative will give a Normal I&O
- 2-3 days of Post-Operative will give you normal bowel 8. Meticolous Hand Hygiene
sounds - Before and after dressing change
- Dull if you percuss an organ and fluid - Sterile to sterile
- 6 to 8 hours is the expected for the patient to void after
removal of Foley Catheter. * Dehiscence - separation of the wound with protrusion organ
- To prevent constipation * Evisceration - total separation of wound layer and protrusion
- Early Ambulation of inter organ (cover with sterile dressing and always splint)
- Increase Fluid Intake * 5- 10 – days to expect dehiscence and evisceration to occur
- Fibers in Diet Causes of this two:
1. Obese o Give antiemetics when client verbalizes
2. Malnutrition (Insufficient protein and Vit. C) being nauseated.
3. Defective suturing (Incompetent suture) - Orthostatic hypotension
4. Not splinting o If client is more than 3 days in bed, do not
5.Unusual strain of the incision
let the patient to stand up immediately.
o Gradually move the client
Signs and Symptoms:
- Something gave away stated by the patient o Semi-fowler’s, fowler’s, let the feet dangle
- Clear pinkish drainage may appear on the edge of the bed feet flat on the
- Wound edges are partially/entirely separated ground, assist the patient to stand first, then
walk.
Nursing Intervention: o Do not leave the patient alone! At risk for
- Place patient in a position that puts least strain falls due to dizziness because blood pressure
- Bend the knees and avoid coughing will be dropping. 20 mmHg for the systole
- Notify the physician immediately and 10 mmHg for the diastole.
- Patient will stay in recovery until fully recovered o Older clients are more at risk for this.
- Patient can be transferred to private room if: Because the tunica intima of the arteries
- Has patent airway have inadequate production of NO (nitric
- Conscious oxide) which causes dilation of the arteries.
- BP normal o >60 years old decreased production of NO
- Early ambulation – Most significant general nursing When to give food?
measure to Post-Operative patients
- Before giving the patient food, aside for waiting for
-Increases vital capacity and maintains the doctor’s orders, assess!
normal RR functions - Assess if protective reflexes are back: swallowing
-Stimulates circulation and gagging reflex
- Auscultate for bowel sounds (5-25 bowel sounds/
-Increases muscle tone min- normoactive)
- If there is no bowel sound in one quadrant auscultate
-Improves GIT and Gut Function
the other quadrants for a full minute.
Additional notes from the lecture: - Ask if the patient has passed flatus. This indicates
peristalsis.
Post-operative Management o Peristalsis comes back 3-5 post op days
- Do not conclude patient has constipation, client has
- Number 1 post-operative complication is respiratory
been on NPO for more than 3 days. Wait till patient
complications
has eaten.
o Due to immobility, anesthesia side effects,
and pain (shallow breathing may occur Why is there physiologic oliguria during the postop?
because of this)
o Alveoli are not expanding enough - Physilogic oliguria is normal especially for patients
who underwent surgery and has lost a lot of blood.
Complications - There will be decreased blood circulating the body
and also because of lost of fluids through respiration
- Deep vein thrombosis due to immobility
> the body will always compensate for its needs > the
o If patient is in bed for more than 3 days at
CNS will be activated, hypothalamus will stimulate
risk for DVT the posterior pituitary gland to produce ADH > it will
- Constipation- due to effect of anesthesia to the bowel go to the blood and to the renal tubules > order
muscles tubules to reabsorb water due to compensation
o Decreased peristalsis (negative feedback system) > decreased urine output
- Nausea and vomiting > at the same time the zona fasciculate of the adrenal
o Do not wait for the patient to vomit glands are stimulated releasing aldosterone >
o This will cause the stimulation of the aldosterone will be going to the blood and to the renal
vasalva maneuver, causing tha patient to tubules and reabsorb sodium > where sodium goes
hold breathe. water follows > decreased urine output.
o This will increase ICP - The client will be able to have an equal intake and
o Very dangerous for patients who just had output at the 3rd- 4th post-operative day.
brain and eye surgeries - If it is already more than 3-4 days and patient still
does have scanty urine output the doctor will order
for blood-urea nitrogen, creatinine clearance both - Lungs and the buffer systems compensate very
these tests determine the functioning of the kidneys quickly within minutes, but cannot bring blood pH
- It is important to provide IV fluids to restore lost back to normal.
fluids - The kidneys, on the other hand, compensates slowly
- Always check for VS especially the BP, the patient (24-49 hours) but it is the only system that can bring
may not present signs of bleeding but there may be the pH back to normal.
internal bleeding - Extracellular- outside the cell (intravascular and
- Decreased BP, decreased blood supply will be going interstitial spaces)
to the brain. - For mixed acid-base problems can be seen in chronic
kidney disease
Infection o Interventions are through medicines
- Patients are prone to urinary tract infections due to - If the body cannot compensate any more, the kidneys
catheter inserted to them will work.
o Do perineal care to prevent this o Produce H+ and secrete HCO3 for alkalosis
- Usually the surgeon will ask the catheter to be pulled o Secrete H+ and reabsorb HCO3 for acidosis
out 2nd postop day o Damaged kidneys cannot produce HCO3
- If it is removed expect the client to void and H+
independently after 6-8 hours. - There is hypovolemia because:
- If client has still not voided, stimulate them by letting o 98% of potassium is the main cation inside
them hear drips of water, placing hands on basin with the cell, while sodium is the main cation
warm water, and assist the client to go to the outside the cell.
bathroom. If client cannot stand and go to the o Increased K in the blood (3.5-5.5) <5.5 is
bathroom provide a bedside commode for females hyperkalemia
and urinal for males, make sure to provide privacy. o This causes cardiac dysrhythmia if not
- Clitoral stimulation is another way to let the patient treated, may lead to cardiac arrest in hours.
void, drop warm water on the clitoris - pH acidity and alkalinity is measured by the H+
- Any tubes that are inserted to the patients are good concentration in the blood
medium for bacterial growth o H+ enters the cells > K will go out > this
will cause hyperkalemia > Remove it by (1)
Wound infection
diuretics: furosemide (Lasix) this will
- This is not seen immediately postop. Seen in the third increase urine output, (2) give base via IV
day or later. like sodium chloride, (3) dialysis (late
- Characterized by temperature above 38 degrees management) (4) insulin, because insulin
Celsius. does not only deliver glucose into the cell
- Temperature is assessed q4 starting 1st post-op day. but also potassium.
Other VS are assessed q15, q30, and q1 o If treatment is diuretic, it will remove both
extracellular and intracellular K.
o Insulin- 2% of the K is only seen in the
blood is carries inside the cell
Acid-base balances
o This causes hypokalemia > dysrhythmia >
Respiratory alkalosis arrest
- Anaerobic metabolism means activity of the cells,
- Doctors will not immediately give diuretics metabolism but there is less oxygen.
- Due to hyperventilation more CO2 are eliminated o Pyruvic acid will be an end product of the
causing alkalosis mitochondria > lactic acid > metabolic acid
- Hyperventilation- fast RR, rapid, deep breathing
o Anxiety, severe pain, COPD, high-grade Why do we give H2 receptor blockers for metabolic
fever) alkalosis?
- Tachypnea- Increased RR but depth can be shallow.
- Action of H2 receptor blocker is to decrease gastric
- Not immediately give diuretics, if increased RR, give
juice (by inhibiting conversion of pepsinogen to
brown bag to recycle that CO2
pepsin created by the chief cells) and increasing the
o For pain- give Demerol or fentanyl
gastric pH (normal pH of stomach is 1.2-2.4) to 3.5-4
o High-grade fever- acetaminophen, cool the
> therefore, only HCl exists (made by the parietal
room, tepid sponge bath, and dressing
cells)
patient lightly.
Interpretation of arterial blood gases
Compensatory mechanisms
- pH is ↓7.35, PaCO2 ↑45 > respiratory acidosis Bronchodilators
- pH is ↓7.35, HCO3 ↓22 > metabolic acidosis
- pH ↑7.45, PaCO2 ↓35 > respiratory alkalosis - Beta-adrenergic drugs
- pH ↑7.45, HCO3 ↑26 > metabolic alkalosis - Albuterol (ventolin)
- sequence: compensation, respiratory or metabolic, - Metaproterenol (alupent)
acidosis or alkalosis. - Bronchodilators with long duration of action
- Frequently administered by MDI
Asthma
Metaproterenol
- diminished breath sounds are an indication of severe
obstruction and impending respiratory failure - Metaproterenol (alupent) is a sympathomimetic
- a hereditary inflammatory disorder bronchodilator
- Irritation of the goblet cells will cause secretion of - The client should take the last does few hours before
mucus bedtime so that the medication does not produce
insomnia
Three reasons for difficulty of breathing (DOB)
Albuterol
- Increased mucus in the lumen of the bronchi
- Decreased O2 in the lungs - Proventil
- Edema - Is a bronchodilator
- Patient should avoid drinking large amounts of
Consequences of asthma caffeine-containing drinks such as tea, cocoa, and
cola drinks
- Atelectasis- there will be a V/Q mismatch - Sprite and 7-Up do not contain caffeine
(ventilation/perfusion mismatch), where in - Should be given 2-3 hours before sleeping, because
ventilation is not good but perfusion is adequate > not this will keep the patient awake
all the blood is oxygenated due to atelectasis
(collapse of the alveoli) > unoxygenated blood will Anticholinergics
go to the left side of the heart and will be pumped to
the systemic circulation > hypoxemia - Acts on the parasympathetic nervous system by
- Hyperinflation of the lungs > accumulation of Co2 > inhibiting its stimulation
the lungs will compensate by increasing the RR to - Ipratropium bromide (Atrovent, duavent)
remove that Co2 > but this further results to more - Used to treat asthmatic conditions by dilating the
accumulation of Co2 due to the obstruction in the bronchioles
bronchi > respiratory acidosis - Administered by aerosol
- If you auscultate a patient with asthma and there is no Ipratropium
lung sounds that is dangerous
- Side effects
Manifestations of hypoxemia - Atrovent
- Restlessness – braincells will be immediately o Dryness of mouth and cough
affected, it will not function well o Most commonly given due to lesser side
- Within 4 minutes brain cells will die without O2 effects than duavent
- Duavent
risk factors o Dyspnea, cough, hypertension, tremors and
nervousness, and insomnia
- dust
- weather Combivent
- smoking
- food choices - The combination of ipratropium bromide with
o eggs albuterol
- detergents - Used to treat chronic bronchitis
- For patients who require more than a single
Drugs used to treat asthma bronchodilator
Short-acting bronchodilators MDI teaching points
- short-acting beta 2- agonists - Wait 30 seconds between inhalation of same
- salbutamol (Ventolin/asmalin) medication
- terbutaline sulfate (bricanyl) - Wait 5-10 minutes between inhalations of different
- Usually given through MDI- metered-dose inhaler medications
- Inform the patient to start to breathe in slowly for 3-5 this is where the peripheral chemoreceptors in the
seconds to draw in the medicine carotid artery will start to work > it will stimulate
- Instruct the patient to hold his breathe for 10 seconds breathing when there is less oxygen or hypoxia, thus,
to allow the medicine to go deeply into his lungs the hypoxic drive.
- Use bronchodilators before corticosteroids - We only give 1-2L of O2 to a COPD patient because
o Bronchodilators should be given first so that if too much O2 is given this hypoxic drive will be
steroids will be easily absorbed because knocked off resulting to respiratory distress.
bronchi are not constricted
Main causes
o Not all COPD patients are given steroids due
to multiple adverse effects - Smoking
- Avoids repeating inhalations before the next - Chronic bronchitis (blue bloaters)
scheduled dose o Obstructed airways resulting to cyanosis due
to hypoxia
Immediate adverse effects of steroids
- Emphysema (pink puffers)
- Patients become voracious eaters due to increased o Can compensate even in the last stage of
appetite. Results in gaining weight. COPD
o Educate patient to decrease sodium intake, o Because we have 300 million alveoli and not
because another effect of steroids is sodium all will be destroyed only a part
retention and this will attract water o Barrel chest due to accumulation of Co2 in
o 3-4 teaspoons are the normal intake of the lungs
sodium - Dyspnea and productive cough
- Prone to infection is steroids are taken for more than
two 233ks it will decrease the immune system and Cor pulmonale
the action of the WBCs - It is only called cor pulmonale when there is right
o > 3 months use it softens the bones > ventricular failure due to increased pressure in the
osteoporosis (this is a late adverse effect) pulmonary arteries and not for any other disease.
o Asepsis is a must! - First cause of cor pulmonale- due to hypoxia arteries
o Check all the tubes inserted because this is in the lungs will compensate by constricting in order
good medium for bacterial growth to shunt that blood to healthier alveoli > but with
o Given via MDI prone to infection of the vasoconstriction there will be increased pressure on
mouth the pulmonary arteries > this will increase the
o If given orally make sure patient will gurgle, workload of the right ventricle because it needs to
mouthwash can be used, or a spacer (use of push harder to overcome that high pressure in the
tube to prevent direct administration in the lungs > this will cause the ventricular muscles to
mouth) hypertrophy and fail > this will decrease cardiac
output of the heart
Glucocorticoids - Second cause- due to hypoxia the vessels will
- Beclomethasone (foster)- MDI constrict in order to supply oxygenated blood to the
primary organs of the body (brain, heart, and lungs) >
Chronic obstructive pulmonary disease (COPD) this decrease in blood will be detected by the kidneys
> and as result is will compensate by releasing
- Rebamipide is used as a cytoprotective drug because erythropoietin > this will go to the bone marrow >
majority of the drugs taken by a COPD patient are create more RBCs > at the same time renin will also
gastric irritants be release due to decrease in blood volume > it will
o Steroids are given as well this can cause go to the liver and combine with angiotensinogen and
gastric ulcers convert it to angiotensin I (a mild vasoconstrictor) >
Hypoxic drive will travel to the lungs and it will combine to the
angiotensin- converting enzyme > angiotensin II will
- The medulla oblongata and the pons of the brain stem be produced (a potent vasoconstrictor) > with the
are the breathing centers of the body > this will increase in RBCs and vasoconstriction > this will
immediately respond to the presence of Co2 in the cause the blood flow to be sluggish > increase
body (thus the body will initiate breathing whether workload of the right ventricle > high pressure in the
you like it or not) > in COPD the alveoli are already lungs due to vasconstriction > prolonged increase in
destroyed and the bronchi are constricted > there will pressure and workload > cor pulmonale
be accumulation of Co2 > this will narcotize the
medulla and pons where the central chemoreceptors Alpha I- antitrypsin
are located it will not be sensitive anymore to Co2 >
- It is a disorder wherein the protein alpha-1 antitrypsin - Preload- the amount of blood filling the chambers of
is defective or absent. This protein is a protease the heart during diastole, Mitral and tricuspid valves
which inactivate elastase that breaks down elastin. are open, atria contract > fill ventricles with blood
But since there is a deficiency, the elastase cannot be - Afterload- the amount of resistance of pressure the
prevented from breaking down too much elastin. This ventricles must overcome to circulate blood to the
primarily affects the lungs. If there are bacteria or different organs of the body
foreign matter that has entered particularly in the - Place patient in a semi-fowler’s position to decrease
alveoli, the Neutrophils usually arrive to release workload of the heart by decreasing the preload
Neutrophil Elastase. This elastase is going to break - With hypertension when systolic BP is 160 and
down the proteins of the bacteria and as well as the diastolic is 120, the ventricles need to generate more
elastin - which gives the lung tissues elasticity and pressure to exceed that 160 mmHg to push that blood
strength. But before this elastase could break down > increased workload of the left ventricle >
the elastin in our lung tissue surface, the liver will ventricular hypertrophy
release the alpha-1 antitrypsin to inhibit the elastase.
Without this alpha-1 antitrypsin protein, the Positions of auscultation
neutrophil elastase goes unchecked causing further
breakdown of the elastin in the alveolar walls
therefore also resulting in the alveoli to lose its
structural integrity and elasticity. If this happens,
there would be loss of elastic recoil resulting in
decrease in ventilation and destruction of the alveolar
wall and capillary bed would result in decreased
perfusion.
Chest physiotherapy
Auscultation
The heart
Nitric oxide
Etiology
- Obesity
- Injure of the intimal layer
- This is a progressive disease that takes years to show
symptoms > easy fatigability, shortness of breath
- Avoid eating too much red meat because there are too
much fats there
- Limit food intake > exercise so that fats will go to the
muscles
- growth of new blood vessels when there is o No buildup of fatty deposits in the artery
obstruction the body will compensate. walls
- Can easily rupture because it is new and can cause o Experienced at night, which can be
bleeding disruptive to sleep
o A medical condition in which there is
Risk factors of CAD
temporary spasm of the coronary arteries
- Divided into two factors: nonmodifiable and causing pain and discomfort
modifiable o Unlike typical angina which is often
- Nonmodifiable- cannot be changed triggered by exertion or emotional stress
- Modifiable- can be changed o Prinzmetal’s angina almost always occurs
when a person is at rest usually between
Nonmodifiable factors midnight and early morning
- Age o These attacks can be very painful
- Gender - Unstable angina and NSTEMI result from paritally or
o Has higher risk of developing CAD intermittently occluded coronary artery
o Smoke or drink when stressed - STEMI results from a fully occluded coronary artery
o Nicotine- constricts blood vessels ECG durations
o Alcohol decrease contractility of the heart
- Ethnicity -
o African-Americans due to the nature of their
jobs
o Koreans and filipinos have high sodium
intakes > hypertension
- Family history - P wave- 0.08-0.10 s
- Genetic predisposition o < 0.11 second
- PR interval- 0.12-0.20 s
Modifiable factor - QRS complex- 0.06-0.10
- T wave- 0.16 second
- Elevated serum lipids
o Exercise, walking is the best, and lower food
intake
- Hypertension
o Smoking cessation and exercise to decrease
obesity
- Diabetes
o May be due to over eating > pancreas will
secrete insulin > it will eventually get tires >
diabetes
o Steroids may cause this
o It may not only be due to hereditary history
but also the use of alcohol, drugs, and
overeating
Angina pectoris
- Chest pain
o Heaviness, pressure, and squeezing
- Coronary artery is blocked by lipids or cholesterol > Electroacardiography
decreased blood supply due to blockage > will cause
anaerobic metabolism > lactic acid will be produced - Zone of ischemia- Myocardial ischemia causes ST
< this will irritate the nerve endings in the heart > segment depression with or without T wave inversion
chest pain as result of altered repolarization
- Zone of injury- myocardial injury causes ST segment
Classes of angina elevation with or without loss of R wave
- Zone of infarction- Myocardial infraction causes deep
- Prinzmetal
Q waves as result of absence of depolarization
o Vasospasm occurs
current from dead tissue and receding currents from
o Narrowing of the coronaries opposite side of the heart
Revascularzation procedure ECG changes in pericarditis
- Coronary angioplasty - T wave initially upright and elevated but then during
recovery phase it inverts
Pericardium - ST segment elevated and usually flat or concave
- Provides lubrication to decrease friction during
systolic and diastolic heart movements
- Normally it contains 10-15 mL of serous fluid
- Assist in preventing in excessive dilation of heart
during diastole
- Cardiac tamponade
o If accumulation is rapid, as little as 100-150
mL (100- 2L of fluid) of blood in the
pericardial sac can adversely affect the
cardiac output
Pathophysiology of pericarditis
o Signs and symptoms:
o Confused, anxious, and restless
o Tachypnea and tachycardia
o Distended neck veins
o Muffled heart sounds
o Although muffled heart sounds indicate
accumulation of fluid around the heart,
narrowing pulse pressure signals cardiac
tamponade
Diagnostic studies
Medical management
- Aspirin, ibuprofen
- Colchicine or prednisone for severe pericarditis
- Pericardiocentesis- performed only for:
o Pericardial effusion wit cardiac tamponade
o Purulent pericarditis
o neoplasm