SurvivalGuide 2016
SurvivalGuide 2016
San Diego
Department of Psychiatry
Survival Guide
2016-2017
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1
Introduction
Acknowledgments
(2012-13): Drs Allison Hadley, Louisa Steiger, Clara
Lee-Zimmerman, Shannon Robinson.
(2012-13): Drs. Robert Gorney, Louisa Steiger, Susan
Zink, Dave Larson, Nico Badre
(2011-12): Drs. Louisa Steiger, Allison Hadley, Emily
Gray
(2010-2011): Drs. Sheryllene Go, Robert Gorney, Anju
Hurria, Josh Kayman, Steve Koh,Clara Lee-
Zimmerman, Melissa Lorang, Jeanne Maglione,
Jennifer Nogde, I-Wei Shu
2
TABLE OF CONTENTS
Introduction 2
General 9
Mental Status Exam 10
MMSE 13
Neurological Exam 14
Legal 24
Confidentiality 25
Holds (5150, 5250) 26
Voluntary patient’s request to 29
leave
AMA discharge 29
Hearings (cert, writ of habeas 30
corpus, writ proceeding, riese)
Conservatorship 34
Behaviors indicating GD 34
LPS conservatorship hearing 35
Tarasoff 37
Reporting documentation 37
Psychopharmacology 39
First gen antipsychotics 42
Second gen antipsychotics 43
Treatment for EPS or neuroleptic 46
induced parkinsonism
Anxiolytics 47
Misc anxiolytics 48
Mood stabilizers 49
SSRI 51
Misc antidepressants 53
MAO-I 54
Heterocyclic antidepressants 55
3
Substance dependence 57
Cognitive enhancers 58
Sympathomimetics and related 59
Misc 60
Clinically relevant cytochrome 61
p450 interactions
Psychotropic meds & smoking 63
Nicotine replacement orders 63
Neurological SEs of antipsychotic 64
meds
Drug-drug interactions 65
Drug interactions with MAO-Is 66
Relative contraindications for 66
psych meds
Medications for pregnant patients 67
* Psychotherapy 71
* Alternative treatment modalities 72
General Medicine 95
AMS 96
Chest Pain 96
Constipation 97
Delirium 97
Diabetes 99
Diarrhea 103
Dyspnea 103
Electrolyte imbalances 104
Falls 105
Fever 105
Headache 105
HTN 106
Hypotension 108
Nausea/vomiting 108
Seizure 108
Stroke 108
Tachycardia 108
UCSD 117
Sign in 118
Rounds 118
H+P and Charting 118
Call and NF schedules 119
Transfers and Telephone Calls at 119
UCSD
Psych Consults from ED 120
Suicidal Patient in ED 122
5
Admission Order sets in EPIC 123
Progress Notes 126
Discharges in EPIC 127
Crisis House info 128
Outpatient follow up from UCSD 130
Senior Behavioral Health 130
Consults 133
Competency v Capacity 135
Medical floors and holds 135
Dialysis center 136
VA 137
2-South 138
Important contacts 139
MAOD 140
Teams 140
Meeting Times and Rounding 141
Admissions at VA 141
Admission orders 142
Suicide risk 143
Notes/Encounter information 145
ADTP consults 147
1-W virtual admissions 147
ED patient supervision policy 148
Hand-offs 154
Discharges 155
Day to day 157
Clinics/VA resources 158
Computer hints 162
On call 163
Codes 170
Holds 171
Tandem call checklist 172
Suicide/adverse event protocol 175
6
Misc 179
Pagers/Phones/Computers 180
IDs/Passwords/Door Codes 183
Important Addresses 186
Phone Directory 188
Most Useful Numbers and Codes 193
Notes 195
7
8
GENERAL
9
GENERAL
Mental Status Exam
Appearance/Behavior: Grooming, level of hygiene,
characteristics of clothing. Unusual physical
characteristics or movements. Refers to both
quantitative and qualitative aspects of patient’s motor
behavior.
Psychomotor activity: agitation or retardation.
Attitude: patient’s attitude in interaction with the
interviewer; also, can comment on level of rapport and
degree of relatedness
Degree of eye contact.
Speech: quantity, rate of production, quality, tone,
appropriateness, volume, amount, rate, rhythm,
pressured, poverty
Mood: internal emotional tone of the patient
Types of mood: Dysphoric, Euphoric, Angry, Euthymic,
Anxious
Affect: external range of expression, described in terms
of quality, range and appropriateness; also, comment
on whether or not affect is congruent to mood
Types of Affect:
- Flat: absence of all or most affect
- Blunted: Moderately reduced range of affect
- Constricted: mildly reduced range of affect (ex:
constricted to depressed range)
- Labile: multiple abrupt changes in affect
- Full or wide range of affect: generally appropriate
Thought Processes: normally, TP would be linear,
logical and goal oriented
Circumstantiality: unnecessary digression that
eventually reaches the point
Overly detailed: unnecessary amount of detail
Tangentiality: thoughts that wander from the
original point and don’t return
Flight of ideas: accelerated thoughts that jump
from idea to idea, typical of mania. Topics are
generally connected
10
Loosening of associations: relationship between
ideas disintegrates. Illogical shifting between
unrelated topics
Blocking: sudden cessation of speech, often in the
middle of a statement
Word Salad: little connection between words and
phrases
Poverty of content: minimal responses, such as
answering just, “yes or no.
Pressured speech: rapid speech, typical of
patients with mania
Echolalia: automatic repetition of someone else’s
speech
Perseveration: repetition of phrases or words, that
were the patient’s, in the flow of speech
Neologisms: invention of new words by the patient
Clanging: speech based on sound such as
rhyming rather than logical associations
Ideas of reference: interpreting unrelated events
as having direct reference to the patient (television
talking to the pt)
Thought Content:
Hallucinations: auditory, visual, tactile, gustatory,
olfactory.
Delusions:
- Persecutory
- Erotomanic: false belief that a person, usually of
higher status, is in love with the patient
- Grandiose
- Somatic
Illusions: misinterpretation of reality.
Derealization: feelings of unrealness involving the
outer environment
Depersonalization: as if one is outside of their body
Suicidal and homicidal ideation: must elaborate on
these (plan, intent, means.)
11
Sensorium / Cognition: Alertness, orientation,
memory, calculation, reading/writing capacity,
visuospatial ability, language / MMSE can be included
here / often derived from interview itself
Insight: the awareness of having an illness,
understanding factors contributing to illness,
recognizing signs and sx as part of a dz, recog impact
on others and need for treatment.
Judgment: cognitive awareness of dz (deciding that
you have a dz) and an action to care for dz.
12
Mini-Mental State Exam (MMSE)
ORIENTATION
Where are we: (state-1) (county-1) (city-1) (hospital
or clinic-1) (floor-1)? (5-points)
What is the (year-I) (season-1) (day of the week-1)
(date-1) (month-1)? (5 points)
REGISTRATION
Have patient repeat three words after you have
said them. Examiner says: apple, chair, Wisconsin
(1 second to say each). Give 1 point for each word
repeated correctly. (3-points)
ATTENTION & CALCULATION
Serial 7s (begin at 100 & subtract backwards by
7).Stop after 5 answers. One point for each correct
(5 points). Or: spell "WORLD" backwards. Score is
# of letters in correct order.
RECALL
Ask for the 3 words repeated above. One point for
each correct. (3-points)
LANGUAGE
Name a pen & watch. (2-points)
Repeat "no ifs, ands, or buts." (1-point)
Follow a 3-stage command: "Touch your left ear
with your right hand two times.'" (3-points)
Read & obey the following: "Close your eyes." (1-
point)
Write a sentence. (1-point) Copy design. (1- point)
13
Neurological Exam
MENTAL STATUS: Alert with normal attention. In good
spirits. The patient gives a clear history and has normal
language output.
Verbal memory (John Brown 42 Market St., Chicago)
Immediate = 5/5
5 min = 5/5
Orientation:
()Date ()Place
()Year loor
()Month ()City
()Day ()County
()Season ()State
Attention: normal
Presidents =
Repetition =
()"No if's, and's, or but's."
Naming =
()watch ()pen
()band ()clip
()crystal/face ()point
()knob/crown
()buckle
Similarities:
()apple/orange
()car/boat
()table/chair
()coat/suit
()poem/statue
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Calculations: $5.75 = 23 quarters
Naming
F-words =
Animals =
CRANIAL NERVES
II: visual fields intact, discs yellow, margins sharp
III, IV, VI: PERRL, EOMI, no nystagmus, normal smooth
pursuit and saccades.
V: Facial sensation intact
VII: Eye closure and smile are normal. No facial droop
or flattening of
the nasal labial fold.
VIII: Hearing is normal to finger rub bilat.
IX, X: palate elevates symmetrically. Speech is normal.
XI: The sternocleidomastoid and trapezius have normal
strength.
XII: The tongue protrudes in the midline.
MOTOR:
1) Strength
Delt/Bic/Tri/I.Rot/W.Ex/W.Fl/F.Ex/F.Flex/Uln/Med
R 5 5 5 5 5 5 5 5 5 5
L 5 5 5 5 5 5 5 5 5 5
HipF/HipEx/Quad/Ham/A.Dor/T.Dor/T.Plan
R 5 5 5 5 5 5 5
L 5 5 5 5 5 5 5
15
2) Bulk =
3) Tone =
4) Tremor =
5) Other movements:
6) Pronator Drift =
SENSATION:
Upper Extremities:
Lower Extremities:
COORDINATION:
Intact RAM/Fingertap/FTN bilaterally.
R biceps = L biceps =
R brachiorad = L brachiorad =
R triceps = L triceps =
R knee jerk = L knee jerk =
R ankle jerk = L ankle jerk =
Babinski:
R plantar response =
L plantar response =
(-) Glabellar/palmomental/snout/root
POSTURE/GAIT:
Romberg =
Retropulsion =
Gait = normal base/step/arm swing. Normal
heel/toe/tandem walk
16
LEGAL
24
LEGAL
Confidentiality
What a patient tells a physician is private. There are
some exceptions to this rule. If information must be
exchanged with other providers, consent must be
obtained. Providing information to insurance
companies also requires consent
25
HOLDS
* At UCSD only Psych and ED residents/attendings
can place holds. At Mercy, psychiatry residents
cannot place holds, only Psych Emergency Team or
Psych Attendings.
Only Psychiatry can DC holds.
27
The hold must be co-signed by a second clinician
(usually another MD on the treatment team, or
another clinical provider such as a nurse if a
second MD is unavailable).
Both signers must each document in a chart note
why they feel patient meets criteria for the hold.
Write an order updating the change in legal status
The hold may be d/c prior to their expiration if
appropriate. Call attending prior to discharge.
5270
Upon completion of a 5250 14-day period of
intensive treatment a patient may be certified
for an additional period of not greater than
28
thirty (30) days for grave disability. The form is
very similar to the 5250. Check the “grave
disability” box, and delineate the specific facts
which lead you to believe the patient is GD.
Hearings
Certification Hearing
1. State your name, spell your last name, and state
your relationship to the pt
2. Has the pt received medication today? If so what,
when, and please describe the effects of the
medication on this pt and any possible side effects
that may impair the pt’s ability to participate in the
hearing
3. On what basis is this pt certified? DTS? DTO? GD?
Impt to know date/time of hold beginning and end
4. What are the patient’s current diagnoses?
5. They will ask to see the original cert application -
must take chart
6. They will hear evidence from the hospital staff first
7. Describe the circumstances surrounding this
admission and specific facts, which lead you to
believe this person is DTS, DTO, and/or GD.
8. The pt will be represented by a pt advocate who
will ask you questions after your presentation
9. The superior court officer facilitates the hearing
10. The advocate presents the pt’s situation and the
court officer makes a decision.
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This is a proceeding wherein the MD/hospital must
prove justification to hold the patient against their will.
1. The officer will ask you the same questions as for a
cert hearing/proceeding.
2. Writs are held in the county court house in front of
a judge and both sides are represented by lawyers.
3. The patient can request a writ any time during a
hold except for during a 72hr hold.
4. If you “lose” a cert or a writ you must d/c pt AMA if
they are not willing to stay voluntarily.
- write AMA note in chart, documenting the
writ proceedings
Writ Proceeding
Counsel, will you stipulate that Dr. (psych resident) is
qualified to testify as an expert (psychiatrist). (if not,
qualify doctor by questions below under LPS
Hearing)
Have you had an opportunity to examine the patient?
Is he/she presently on a hold?
When did you examine him?
Did you form a diagnosis as to his mental condition?
What is that diagnosis?
In examining the pt what did you find that led you to
your diagnosis?
What else did you use in arriving at your diagnosis?
(medical records/ history/ comments from nurses or
family)
Under what circumstances did pt come to your facility?
Based upon your examination & diagnosis of pt, have
you formed an opinion as to whether the pt, as a
result of his/her mental disorder, is: (a) (unable to
provide his/her food, clothing or shelter; (b) a danger
to himself/herself; (c) a danger to others.
What is that opinion?
Why do you believe pt is (gravely disabled/ danger to
self/ danger to others)?
Does pt have any insight into their mental disorder?
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Has pt been advised of the need for treatment?
Is pt receiving medications of the need for treatment?
Is he/she showing improvement on the medications?
Is pt taking the medications voluntarily?
In your opinion, would pt continue to take the
medications if released?
Has pt been offered voluntary treatment? Accepted or
refused?
In your opinion, is pt able to accept voluntary
treatment?
Is your facility a County designated LPS facility?
Can your facility continue providing the needed
treatment for pt?
Riese Hearing
A hearing to “force” patient to take medications. Patient
must be on a hold to have this hearing.
Questions:
1) Doctor, on what basis is patient being detained?
2) What is the diagnosis?
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3) With what antipsychotic medication do you seek
to treat patient?
4) Have you attempted to discuss the proposed
treatment with patient, if so, on what dates and
times?
5) In discussing your desire to treat patient with
antipsychotic medications, did you inform patient
of the potential risks, benefits, and alternatives to
treatment? When - dates and times?
6) Did you use a written advisement? When?
7) In response to the information you gave, what
did patient say or do and what was your
response to patient?
8) When you discussed, or attempted to discuss,
use of antipsychotic medications, what occurred?
9) Did patient object to the use of medication
because of allergies or side effects from prior
treatment with such medications, and if so, did
you investigate these complaints further?
10) Does patient believe that he suffers from a
mental disorder?
11) Without regard to patient beliefs that he has, or
does not have a mental disorder, does patient
understand his situation (who he is, where he is,
who you are, etc.)?
12) Is patient able to understand the risks and the
benefits of medication or alternative treatments,
and upon what do you base this opinion?
Usually patient understands some risks but
because they don’t understand the benefits, they
are not able to make a rational decision. Point
this fact out at the hearing.
13) Is it your belief that patient is, or is not, able to
rationally understand and evaluate information
about the proposed medication treatment and
the alternatives to such treatment? Upon what
do you base this opinion?
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14) During admission, was patient treated with
antipsychotic medication over his objection? If
so, what dates, and why?
* Know the side effects of the medications (common &
potentially serious) and their benefits.
Conservatorships
Conservatorship is removal of someone’s civil rights
due to inability to make decisions in their own best
interest.
LPS Conservatorship:
Conservatorship is for grave disability due to mood or
psychotic disorder**
Probate Conservatorship:
Is used when someone is incompetent to make
decisions, due to impairment from non-psychiatric
illness (i.e. dementia, mental retardation, neurologic
illness, etc). Granted in court hearing and psychiatry is
generally not involved as it is not covered by LPS law.
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CLOTHING: Unable/unwilling to dress self, repeatedly
destroys his clothing, unable/unwilling to dress in
keeping with climatic conditions, clothing repeatedly
grossly torn or dirty, no realistic plan to obtain needed
clothing. Doesn’t bathe or wash hair.
36
Would he/she be a danger to others if he/she
possessed a firearm?
Do you have an opinion as to what the most appropriate
setting would be for the pt in which he/she would
receive adequate treatment for his/her mental
disorder?
Why is that the most appropriate?
Is that the least restrictive treatment setting available to
the Pt at this time?
Reporting Documentation
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PSYCHOPHARMACOLOGY
39
First Generation (“typical”) Antipsychotics
FGAs are generally not used first line due to greater risk for EPS and TD (SGAs are 5-10x less likely to cause TD). EPS risk is dose-dependent, so low doses of high potency
agents are used at times to augment very weak D2 blockers (e.g. quetiapine, clozapine) when pos Sx are not controlled. PET data show risk of EPS occurs at striatal D 2
occupancies greater than 78%, hyperprolactinemia at D2 occupancy > 72%. All FGAs can cause QTc elongation.
42
Second Generation (“atypical”) Antipsychotics (Serotonin-Dopamine antagonists)
Used commonly for many disorders. Effects seen within days, but continued improvement noted over 6 weeks. Common mechanism is potent 5HT2 antagonism (except
quetiapine) and relatively weaker D2 affinity than FGAs.
All SGAs have indication for acute mania, but studies have not yet been done for maintenance. Olanz, geodon & aripip have indication for maintenance in bipolar, but major
metabolic SEs and related deaths have significantly decreased use of olanz. Beware of added wt gain when combining mood stabilizers and SGAs.
Other uses with compelling data include augmentation to SSRI for major depression, PTSD (used at low doses to maximize 5HT2 effects with little D2) and bulimia.
FDA has issued warning in general about new onset DM or DKA with SGAs, but biggest offenders are clozapine & olanzapine and possibly risperidone and quetiapine. All schiz
pts should have baseline fasting gluc, lipids, BMI, waist circumference, then quarterly monitoring, with highest frequency for patients on olanz or cloz, esp if other DM risk factors
(e.g. ethnicity).
There is also an FDA warning about CVAs with SGAs and increased mortality with atypical antipsychotics when used in elderly dementia patients (.7-.9%, mech unknown).
Risperidone has most safety and efficacy data in children (tics, behavior control) and dementia (but not FDA approved for these uses).
Dosing / equivalence
Receptor / t1/2
Name Indication to 100mg Side-effects (relative) Notes
Potency (hrs)
chlorpromazine
Risperidone
(Risperdal) - not much benefit in increasing dose beyond 6mg/day
- start 1mg bid to max Low EPS w/ dose
Consta - decanoate and rapidly dissolving form available
16mg/day below 6mg, orthostatic
(depot), * paliperidone (Invega) is metabolized form of risperdal, has half-
- depot – 25-50mg IM hypotension, reflex
M-Tab Psychosis, mania, life of 23hr, reportedly has safer SE profile than risperdal, can be
3-20 q2wk tachycardia, insomnia,
(rapid mood disorders used for patients with extensive liver damage, shares most of the
- metabolized by 2D6 agitation, inc prolactin,
dissolving) characteristics as risperdal; start 3mg qday and titrate up by
- level inc by fluoxetine weight gain (+), lipids
See 3mg/day q6days to max of 12mg/day; like risperdal, it may not
and paroxetine (+/-), glc (+/-)
*paliperidone receptor be very effective after 6mg/day dose
(Invega) affinity
table Psychosis, mania, - start 50-100mg qday
Orthostatic
mood disorders, and inc by 50mg/3day - Very weak affinity for all receptors, profile similar to
hypotension,
GAD; many off label until max dose antihistamine at doses < 200 mg/d
Quetiapine somnolence, weight
uses including 800mg/day (seroquel - doses at 300mg/day has indication for bipolar depression
(Seroquel, 6 gain, dyspepsia, abd
agitation w/ XR can be dosed - Very weak D2 antagonist with low EPS. Slightly fewer metabolic
Seroquel XR) pain, dry mouth,
dementia, insom, starting at 300mg/day SEs than olanzapine.
weight gain (+), lipids
borderline to max 800mg/day) - XR can be used for bipolar depression
(+), glc (+/-)
personality - metabolized by 3A4
(cont)
43
SGAs, cont
t1/2
Name Receptor Indication Dosing / metabolism Side-effects Notes
(hrs)
- Twice as costly as other atypicals. Major metabolic SEs, avg >
Drowsiness, dry st
20 lb wt gain in 1 yr, DM and DKA (with deaths), sedation, ↑
Psychosis, - start 10mg/day to max 40mg/day mouth, akathisia,
Olanzapine lipids (get initial and frequent lipid panels)
mania, - metabolized by 1A2 insomnia, weight
(Zyprexa, 21-54 - least noncompliance per CATIE trial
mood - level dec by tobacco (x5) and gain (++++),
Zydis) - avoid IM use in elderly
disorders carbamazepine, inc by fluvoxamine lipids (+++), glc
- available as rapid acting IM and dissolving form, also as
(+++)
combination with fluoxetine for bipolar depression (rarely used)
Dizziness,
- start 20mg bid, up to 60 bid in 2
nausea, postural
days, to max 80mg bid
Psychosis, hypotension, - Minor QTc prolongation but no cases of Torsades ever
- must give w/ food (needs bulk to
Ziprasidone mania, prolactin reported, no mandatory EKG
7.5 slow down gastric emptying to
(Geodon) See mood elevation, - w/o food will decr absorp by 50%. Wk SNRI property. Not
allow for absorption; 300 calories is
receptor disorders sedation, weight effective at low dose. Metabolic neutral.
the general guideline
affinity gain (+/-), lipids
- metabolized by 3A4
table (-), glc (-)
Psychosis, - Agranulocytosis, salivation, orthostasis, seizure at high
- start 25mg bid then inc by 25- Orthostatic st
mania, dosages, avg > 10 lbs/ weight gain in 1 year, DM and DKA
50mg/2-3day to max 900mg/day hypotension,
mood (with deaths), ↑ lipids (get initial and frequent lipid panels), ↑
- refer to clozapine dosing sedation,
disorders, saliva production.
guideline for monitoring issues anticholinergic,
refractory - Weekly CBC for 6 mos, then biweekly after, shouldn't be used
Clozapine - metabolized by 1A2 tachycardia,
12 psychosis, with other bone marrow suppressants (Sulfonamides, Captopril,
(Clozaril) - level inc w/ cimetidine (use constipation,
some Propylthiouracil, Tegretol)
ranitidine), risperdal, fluvoxamine hypersalivation,
evidence - Quarterly monitoring of gluc, lipids
(up to x5-10), TCA can inc SEs weight gain
of - ONLY agent effective in refractory schiz (60% response rate,
(esp seizure), level dec w/ smoking (++++), lipids
reversing aim for serum level > 450 ng/ml)
(50%), carbamazepine dec by 50% (+++), glc (+++)
TD - Needs to be registered in the Clozaril national database
44
SGAs, cont
t1/2
Name Receptor Indication Dosing / metabolism Side-effects Notes
(hrs)
- Weak D2 partial agonist, may get stimulation at high doses.
Headache, n/v, Half-life 75 hrs-don’t stop primary drug too soon. Metabolic
- start 10-15mg qday to max sedation w/ high neutral.
See Psychosis, 30mg/day doses, anxiety, - poor metabolizers have 80% level inc
Aripiprazole receptor 75; 94 mania, - metabolized by 2D6 and 3A4 insomnia, - no QTc elongation or inc prolactin have been reported
(Abilify) affinity (metab) mood - level inc w/ quinidine, prozac, orthostatic - To switch, add at 10-15 mg hs for two wks before decreasing
table disorders paxil, ketoconazole; level dec w/ hypotension, primary agent
Tegretol weight gain (+/-), - Available as nonrefrigerated liquid, rapidly dissolving tab,
lipids (-), glc (-) rapidly-acting injectable
- 2D6 and 3A4 convert to active metabolite
18
(2D6 - titrate 1mg bid day 1, inc to 2,
D2, 5HT2
fast 4, 6, 8, 10, 12mg bid on
(high), orthostasis risk, - just approved in May 2009
Iloperidone metab) schizophr subsequent days as needed;
NE weight gain (+), - impact of 3A4 inducers not documented
(Fanapt) ; 33 enia max 16mg bid
(mod), H lipid (+/-), glc (+/-)
(2D6 - fluoxetine inc level x2-3,
(low)
slow paroxetine inc level x1.6
metab)
45
Receptor Affinities of 2nd Gen Antipsychotics
RISP QUET ZIPR OLAN CLOZ ARIP
D2 ++++ + ++++ ++ + ++++ (prt ag)
5-HT2A +++++ + +++++ ++++ ++++ ++++
5-HT2C ++++ - +++++ ++++ ++ ++
5-HT1A + + ++++ - + ++++
5-HT1D + - ++++ + - N/A
α1-adrenergic ++++ ++ ++ ++ ++++ ++
M1-muscarinic - ++ - ++++ ++++ -
H1-histaminergic ++ ++++ ++ ++++ ++++ ++
5-HT reuptake - - ++ - - +
NE reuptake - + ++ - + N/A
For more detailed and updated table please go to http://cdn.neiglobal.com/content/practiceres/posters/50188_nei_009_bindings.pdf
46
Anxiolytics (Benzodiazepines)
Act on specific sites of (GABA) type A receptors. GABAA is the major type of brain GABA receptor, and is an integral membrane chloride channel comprised of 5 subunits.
[GABAB receptors are coupled to G-proteins, and are not acted upon by benzodiazepines.]
Unlike barbiturates, benzodiazepines do not directly open the GABAA receptors, but bind to a distinct site on the GABA receptor (the BZ site = omega site) and allosterically
modify GABA binding, potentiating the action of GABA. BZ 1 agonism is associated more with sleep, while BZ2 binding is associated with effects on cognition, memory and
motor control.
Benzodiazepines are effective agents but there is a concern for dependence with long-term use. USE SPARINGLY on pts with history of addiction to other substances.
Short-acting agents cause most abrupt withdrawal. Use of as little as two weeks may cause rebound insomnia upon d/c.
Receptor / side t1/2 Indication / onset of
Name Dosing / equivalence Side-effects Notes
chain group (hrs) action
- no active metabolite
Anxiety, agitation,
- not metabolized by 3A4 isoenz and so okay to
Lorazepam anticonvulsant, 1-4mg per dose as
3-OH 15 use w/ liver damaged pts
(Ativan) alcohol withdrawal / needed as tolerated / 1
- drug of choice for alcohol detox if liver
medium onset
damaged
- no active metabolite
Oxazepam Anxiety, agitation / 30-120mg/day in bid to - not metabolized by 3A4 isoenz and so okay to
3-OH 8
(Serax) slow onset qid dosing / 15 use w/ liver damaged pts
- no active metabolite
Temazepam Anxiety, agitation /
3-OH 11 7.5-30mg/day qhs / 5 - not metabolized by 3A4 isoenz and so okay to
(Restoril) medium onset
use w/ liver damaged pts
Sedation, dependence,
10-200mg per day
Chlor- Anxiety, agitation, withdrawal, confusion, ataxia,
safely as outpt; pt - drug of choice for outpt alcohol detox
diazepoxide 2-Keto 100 alcohol withdrawal / paradoxical disinhibition
needing higher doses - avoid use if severe liver damage
(Librium) medium onset
should be admitted
Diazepam Anxiety, agitation / 4-40mg/day bid to qid - long half-life makes it okay to do once a day
2-Keto 100
(Valium) rapid onset dosing / 5 dosing
Anxiety, agitation,
Clonazepam - 2:1 ratio dose equivalence and long half-life
Nitro 34 alcohol withdrawal / 1-6mg/day bid / 0.5
(Klonopin) make it ideal for conversion from lorazepam
medium onset
- fast onset of action makes it highly dependence
Alprazolam Anxiety, agitation / 0.5-10mg/day bid to
Triazolo 12 prone
(Xanax) medium onset qid dosing / 0.25
- withdrawal sx can be acute and severe
Triazolam Anxiety, agitation / 0.125-0.250mg qhs / - not commonly used because of short half-life
Triazolo 2
(Halcion) medium onset 0.1-0.03 - careful use in elderly population
47
Misc Anxiolytics
Name Receptor t1/2 (hrs) Indication Dosing Side-effects notes
Sedation, hypotension,
Hydroxyzine - start 50-100mg q6hr
antihistimine 20-25 anxiolytic dizziness, paradoxical - alternative for benzos as short acting anxiolytic
(Vistaril) prn to max 600mg/24hr
excitement and agitation
Partial agonist
Buspirone - start 5mg bid or tid to - takes about 2wk to get optimal therapeutic effect
serotonin 5-HT1A, 2-11 anxiolytic Restlessness, nervousness
(BuSpar) max 60mg/24hr - avoid w/ MAO-I
5-HT2, D2
- start 5-10mg qhs; for - rapid onset
Zolpidem
Binds to GABA CR start at 6.25 or Dizziness, GI upset, n/v, - avoid w/ other bezo or alcohol
(Ambien, 2-3 Insomnia
type 1 12.5mg qhs anterograde amnesia - can be habit forming
Ambien CR)
- do not crush/cut/chew CR formulation
- rapid onset
Zaleplon Binds to GABA Dizziness, dyspepsia,
1 Insomnia - start 5-10mg qhs - avoid w/ other bezo or alcohol
(Sonata) type 1 diarrhea
- can be habit forming
- start and maintain at - rapid onset
Eszopiclone Binds to GABA Headache, somnolence,
6 Insomnia 2-3mg qhs (1mg qhs if - avoid w/ other bezo or alcohol
(Lunesta) receptor complex dizziness, n/v
pt has liver damage - can be habit forming
* Notes on insomnia medications
Often new abstinence from CNS depressants result in insomnia; best tx is to continue abstinence, practice good sleep hygiene.
For insomnia with acute mania or psychosis, aggressive medication is indicated, including liberal use of benzodiazepines.
For a depressed inpatient, the insomnia should be documented before treating it. Maximize the sedative potential of other meds (antidepressants, neuroleptics, and mood
stabilizers).
trazodone and diphenhydramine (Benadryl) may sometimes be used and do not lead to dependence, but do disrupt the normal sleep cycle.
zolpidem (Ambien), zaleplon (Sonata), and eszopiclone (Lunesta) are newer agents with reportedly less abuse potential, although this is debated. They appear to be very effective
and safe (does not disrupt the normal sleep cycle) but are expensive and hard to get at the VA.
Sometimes clonidine 0.1-0.3 mg QHS is very helpful, although watch for hypotension.
Ramelton is a melatonin type 1 and 2 receptor agonist approved by the FDA for insomnia; not available at the VA.
48
Mood Stabilizers
Name Receptor t1/2 (hrs) Indication Dosing Side-effects Notes
- start 300mg bid and - preLi workup – chem10, cbc, TFT, EKG (if
GI distress, weight gain,
Bipolar titrate up till level of 0.6- older or w/ cardiac condition)
tremor, cognitive
disorder (not 1.2mEq/L (up to 1.5 for - use lower dose in elderly because of lower
impairment, diabetes
as good for acute mania) Cr clearance
insipidus can occur,
May act by bipolar - monitor level after - rare cases of Ebstein’s anomaly from use in
Lithium thyroidtoxic, T-wave
inhibiting depression), 5days (12 h trough), first trimester of pregnancy)
(Lithobid, 20 flattening, leukocytosis
inositol-1- unipolar mood qwkly for 1-2mo then - medications that inc or dec renal clearance
Eskalith) - toxicity (n/v, diarrhea,
phosphatase disorder, biweekly for 2mo then influence Li level
tremor, inc DTR, ataxia,
impulse q3-4mo - Lithobid and Eskalith CR are both slow
confusion, arrhythmia)
control - QHS dosing is release and are rarely used due to increased
severe >2.5 and mild/mod
disorders preferred to minimize risk of long-term renal SEs. May have fewer
1.5-2.0
polyuria. GI SEs.
Bipolar - loading – 20mg/kg st
- 1 line agent for acute mania
disorder (good divided tid or 30mg/kg
- depakote is coated and better tolerated
Valproic acid for acute for ER (dosed qday);
Acts on protein n/v, sedation, tremor, low - follow cbc and LFTs
(VPA; mania, rapid max 60mg/kg/day
kinase C and plts, pancreatic and hepatic - depakote ER's level should be checked at
Depakote, 8-10 cycling and - alternatively, start
GABA, Na toxic, hair loss, hyper- 24hr trough (usually 1800 or prior to next
Depakote ER, mixed), mood 500mg bid and titrate up
channel blocker ammonemia dose)
Depakene) lability, as needed
- high risk of causing many different birth
impulsive - level (50-125µg/mL)
defects if taken during pregnancy
behavior check after 3days
- start 25mg/day for 2wk,
Effects Na
Bipolar 50mg/day 2wk,
channels that
depression, 100mg/day 2wk then - Multiple drug interactions- including oral
modulate
not very good 200mg/day Dizziness, sedation, contraceptives decreasing Lamictal by 50%.
glutamate and
Lamotrigine for acute - no need to check headache, diplopia, ataxia, - If on VPA start at 25 qod for 1 week, 25mg
aspartate 25
(Lamictal) mania or rapid serum levels dec coordination, rash (SJS qhs for 1wk and increase by 25mg q wk to
release, weak
cycling - carbamazepine will can occur) 100-150 mg qd with no one dose greater than
inhibitor 5-HT3,
enhance Lamictal 75 mg. VPA increases levels several fold.
reduce GABA-A
metabolism
transmission
(cont)
49
Mood Stabilizers, cont
Name Receptor t1/2 (hrs) Indication Dosing Side-effects Notes
Prolong - pre workup – chem20,
- Less efficacy data than Li or VPA for acute
inactivation of cbc, EKG in older pts
Bipolar mania or maintenance
voltage- - start 200mg bid to level GI complaints,
Initially 25- disorder (good - use lower dose in elderly
dependent Na 8-12µg/ml after 5day use sedation, dizziness,
65 then w/i for rapid- - do not use in pregnancy (inc risk of spina
channels, - monitor level qwkly for ataxia, confusion, rash
Carbamazepine one mo, cycling and bifida)
reduce current 1-2mo then biweekly for (can cause SJS),
(Tegretol)* 12-17 mixed), - can cause fatal thrombocytopenia,
of NMDA 2mo then q3-4mo toxicity (confusion,
(auto- cyclothymia, agranulocytosis, aplastic anemia
channel, - metabolized by 3A4; stupor, trmor, dilated
induction) impulse control - contraindicated for bundle branch block
antagonize induces its own pupils, n/v)
disorders - there is now XR version that is dosed
adenosine A1 metabolism (need higher
st similarly to max 1600mg/24hr
receptors doses after the 1 month)
Oxcarbazepine
For sz do starting dose is Less sedating than
(Trileptal; No double-blind studies, only open-label or
300bid and increase by carbamazepine, but
active metabolite retrospective data. Efficacy and optimal dosing
300 every 3 d to sz may cause
of unknown
control or 1200mg bid. hyponatremia.
carbamazepine)
acute mania
Equetro
and mixed
(extended
states for
release Tegretol)
bipolar pts
Topiramate (Topamax)
Ineffective in double-blind studies as adjunctive agent for mania.
SE - fatigue and psychomotor slowing
Dizziness, ataxia, nausea, wt. Loss, speech disorders, blurry vision.
Precaution kidney stones, acute angle glaucoma, 25% develop metabolic acidosis.
50
SSRI Antidepressants
Chosen mostly on basis of half-life and potential for drug-drug interactions. No difference in efficacy, but occasionally difference in tolerability.
Commonly higher doses are often used for anxiety disorders (occasionally above FDA max rec dose- impt to document consent)
Most SSRIs have the potential of causing withdrawal if d/c too quickly; use w/ MAO-Is can cause serotonin syndrome (in order of appearance: diarrhea, restlessness,
agitation, hyperreflexia, autonomic instability, seizure, myoclonus, hyperthermia, coma, delirium, death)
The FDA has a warning on all antidepressants that they can cause suicidality in children and adolescents. There is also a warning for Paxil in adults about suicidality.
Any young person (<25 years) should be monitored weekly for the first month after starting an SSRI
Dosing / p450
Name Receptor t1/2 (hrs) Indication Side-effects Notes
inhibition
- few p450 interactions
Citalopram Block presynaptic - start 20mg qday to - SSRI of choice to minimize
Depressive disorder,
(Celexa) serotonin 33 max 40mg/day interaction w/ other meds
anxiety disorders
avail as generic reuptake - 2D6, 2C19 (weak) - FDA warning, dose
dependent increase in QTc
Block presynaptic - start 10mg qday to - expensive ‘S’ isomer of
Escitalopram Depressive disorder,
serotonin 30 max 30mg/day GI effects, insomnia, citalopram, somewhat fewer
(Lexapro) anxiety disorders
reuptake - 2D6, 2C19 (weak) sedation, sexual side effects than citalopram
- start 20mg qday to dysfunction, headache. - can be activating
Fluoxetine Block presynaptic Depressive disorder, max 80mg/day - metabolites are active and
(Prozac) serotonin 15days anxiety disorders, - 2C9, 2C19, 2D6, 3A4 Can cause mania, so self tapers; overdose is
avail as generic reuptake anorexia nervosa, bulimia (mod) (increases TCA, restlessness, increased relatively safe
SGA levels) anxiety.
- start 50mg/day to
Block presynaptic Has significant
Fluvoxamine Depressive disorder, max 300mg/day (usu - most interactions w/ other
serotonin 22 antiplatelet effect
(Luvox) anxiety disorders in bid dosing) meds through p450
reuptake (bleeding risk).
- 1A2, 2C19, 3A4
- start 10-20mg qhs to - can be sedating
Paroxetine max 80mg/day; need Rare hyponatremia in - shortest half-life, to avoid
Block presynaptic
(Paxil) Depressive disorder, slightly higher doses elderly (especially withdrawal, take time to taper
serotonin 21
avail as generic anxiety disorders for CR formulation women). off
reuptake
avail as CR - 2D6 (increases - preferred agent if
digoxin levels) breastfeeding
- moderately activating and
Block presynaptic - start 50mg qday to
Sertraline (Zoloft) Depressive disorder, sedating
serotonin 26 max 200mg/day
avail as generic anxiety disorders - preferred agent if
reuptake - 2D6 (mod)
breastfeeding
51
Affinity Of Antidepressants For Neurotransmitter Receptors
52
Miscellaneous Antidepressants
Name Receptor t1/2 Indication Dosing Side-effects / interactions Notes
- start 100mg bid then - increased seizure risk if dose
Inhibit norepinephrine titrate 100mg/day every Insomnia, CNS stimulation, >450mg/day and w/ electrolyte
Bupropion MDD, ADHD, as
reuptake and 3d to max 450mg/day headache, constipation, dry disturbance
(Wellbutrin adjunct w/ SSRI,
dopaminergic - SR form: 150mg qday mouth, n/v, tremor - no sexual, weight gain, sedation side-
IR, SR, less risk of inducing
neurotransmission, 4-24 then titrate to 150mg bid effects
XL, Zyban) mania in bipolar
noncompetitive until max 200mg bid inhibits 2D6, carbamazepine, - second line agent for ADHD
avail as depression,
inhibitor nicotinic - for smoking cessation, Phenobarbital, phenytoin can - do not use in patients w/ eating disorder
generic smoking cessation
acetylcholine start 2wk prior to q then dec level - do not use w/ MAOIs as it can lead to
cont for 7-12wks serotonergic syndrome
Venlafaxine Blocks 5HT and NE MDD, GAD, social - can see discontinuation syndrome w/
- start 37.5mg bid then Dose dependent HTN,
(Effexor, reuptake (120:1 anxiety, panic abrupt cessation
5-10 inc to max 375mg/day insomnia, n/v, anxiety, dizzines
Effexor ratio), very little disorder, dysthymia - avoid w/ MAOIs
- XR – qday dosing Metabolized by 2D6, inhib 2D6
XR) anticholinergic or H1
n/v, dec appetite, dry mouth,
MDD, somatization
dizziness, constipation, - can see discontinuation syndrome w/
Blocks serotonin and disorders, pain
Duloxetine - start 20mg bid then fatigue, insomnia, sexual SEs / abrupt cessation
norepinephrine 12 syndromes,
(Cymbalta) titrate to max 60mg bid metbz by 2D6 (inc level of - there are reports of liver toxicity
reuptake (9.4:1 ratio) peripheral
TCA, SGA) and 1A2 (will inc
neuropathy
level by 2.5x and 1/2-life 3x)
5-HT2, 5-HT3, α2 MDD, dysthymia, - low sexual SE
- little effect on p450
Mirtazapine adrenergic 20- anxiety disorder, - start 15mg qhs to max - inc appetite, dry mouth,
- good choice for elderly w/ depression
(Remeron) antagonist, some H1 40 bulimia, chronic 60mg qhs constipation, fatigue,
- some risk for agranulocytosis
receptor antagonism pain dizziness, orthost hypotension
Inhibits presynaptic n/v, dry mouth, dizziness, - few sexual side effects; no priapism
Nefazodone MDD, dysthymia,
serotonin reuptake - start 50-100mg bid sedation, agitation, - black box for rare fatal hepatotoxicity
(Serzone) premenstrual
and postsynaptic 2-18 then titrate every few constipation, headache / - analogue of trazodone
avail as dysphoric disorder,
5HT-2A, some α1 days to max 600mg/day inhibits 3A4 (inc levels of- do not use w/ MAOIs
generic PTSD
antagonism triazolam and alprazolam) - does not suppress REM
Inhibits presynaptic
Trazodone - start 50-100mg qhs - metabolizes to nefazodone
5HT reuptake, Depressive Sedation, orthostatic
(Desyrel) then increase by - commonly used for insomnia; too
postsynaptic 5HT2, 6-11 disorders, anxiety, hypotension, priapism (doses
avail as 50mg/day as tolerated sedating to use as primary antidepressant
antagonizes α agitation, insomnia >150mg)
generic to max 600mg/day - avoid using w/ MAOIs and w/ ECT
adrenergic and H1
* Symbyax is combination of fluoxetine and olanzapine – approved for bipolar depression (usefulness of 5HT2 antagonism and SSRI) SE profile makse it difficult to use
53
Monoamine Oxidase Inhibitors
An MAO-I irreversibly inhibits the MAO enzyme; type A (CNS, sympathetic terminals, liver, GI, skin), type B (CNS, liver, plts); tyramine accumulates when type A is blocked which
accounts for the major SEs of MAO-Is; patients on MAO-Is must adhere to low tyramine diet to avoid hypertensive crisis
It takes 2wks after d/c medication to replenish body of MAO, so avoid TCA, SSRI until after 2wk washout period (otherwise might get Serotonin Syndrome)
As a general rule, avoid the following: antiashmatics, antihypertensives, buspar, levodopa, opioids, sympathomimetics, SSRI, SNRI, TCA
Name Receptor t1/2 (hrs) Indication Dosing Side-effects* Notes
Depressive disorders (esp - start 15mg bid and titrate up Higher incidence of
Phenelzine useful w/ atypical features), by 15mg/wk until max weight gain, drowsiness,
MAO 11.6
(Nardil) anxiety, panic disorder, 90mg/day dry mouth, sexual
social phobia, OCD dysfunction
Depressive disorders (esp
Tranylcypromine useful w/ atypical features), - start 10mg bid and titrate up More likely to cause
MAO 2.5
(Parnate) anxiety, panic disorder, by 10mg/wk to max 60mg/day insomnia than phenelzine
social phobia, OCD
- start 10mg bid and titrate up
Isocarboxazid Similar SE profile as
MAO ? Depressive disorders 10mg/day q2-4d x1wk; max
(Marplan) above
60mg/day
Depressive disorders (esp - start 6mg/24hr patch then Transdermal patch will avoid GI; lower
Selegiline
MAO-B 18-25 useful w/ atypical features), inc by 3mg/24hr q2wk to max dietary restrictions (only for 9, 12mg dose,
(EmSam)
anxiety 12mg/24hr; do not cut patch none for 6mg)
MAO-A selective reversible inhibitors (RIMAs) are not available in US; they require less dietary restrictions; moclobemide and befloxatone
MAOI Food Interactions: (pts on MAOIs should avoid these foods) Pt education is important regarding diet and other medications because of risk of acute hypertensive crisis.
Aged cheeses
o English stilton, blue cheese, old cheddar, Danish blue, parmesan, gruyere, brie, Swiss, camembert, etc.
o Because 80% of all hypertensive crises are secondary to aged cheeses, they are called “cheese reactions.” Even some of the more moderate tyramine cheeses (e.g., brie, emmantaler,
and gruyere) should be avoided; Some cheeses are allowed: cottage, processed cheese slices, mozzarella (currently a debated issue), ricotta, and cream cheeses are safe.
Chianti wine and tap beer should probably still be avoided, despite questionable findings; Fava (Italian, broad) beans (because of DOPA content)
Avoid concentrated yeast extracts, especially Marmite; Brewer’s yeast is safe; avoid pickled herring, brine and other processed packaged fish, like anchovies; Fresh fish is safe.
Avoid sauerkraut, eggplant, dried fruits and overripe fruits; Avoid sausage: salami, mortadella, air-dried sausage, bologna, pepperoni, summer sausage, chicken liver, corned beef,
liverwurst, and pastrami should be avoided.
Avoid Chinese foods, oriental soup stocks (e.g., miso) should be avoided until more evidence becomes available.
Avoid Tofu and all soy products, including soy sauce (there is some dispute that soy milk and tofu are ok).
Avoid Aspartame, the artificial sweetener, may cause a hypertensive reaction; Consume less than 1 gram of aspartame in beverages per day.
Foods thought to be no longer at risk (still recommend caution)
Tea, coffee, cola, and other caffeine-containing beverages (some experts limit these to 3 cups/glasses a day). Chocolate should also be limited.
White and red wine, other spirits (wine should be under 3 oz/day).
Yogurt, caviar, snails, tinned fish (that isn’t pickled or brined), canned and packaged soup
54
Heterocyclic Antidepressants
Avoid use with MAO-I
TCAs and Therapeutic Blood Levels
Largely irrelevant, except for nortriptyline, which has a maximally effective dose (larger than 150 is less effective). If in doubt about whether pt is toxic, get an EKG and check for QT
prolongation.
t1/2 Dosing / therapeutic level Side-effects** /
Name Structure Indication Notes
(hrs) (includes metabolites) metabolism
MDD, dysthymia, anxiety - start 25mg qhs then inc q1-4wk - widely used for pain, sometimes for
Amitriptyline 1A2, 2C19, 2D6
3º amine 10-50 disorder, bulimia, chronic to max 300mg/day insomnia
(Elavil, Endep) (less 2C9, 3A4)
pain, insomnia - 100-250 - used for migraine prophylaxis
- higher doses and longer treatment for
MDD, dysthymia, anxiety - start 25mg qhs then inc q1-4wk
Clomipramine - higher risk of OCD
3º amine 20-50 disorder, bulimia, chronic to max 250mg/day
(Anafranil) seizures - maybe useful for depression w/
pain, OCD - 100-450
obsessional traits
Doxepin MDD, dysthymia, anxiety - start 25mg qhs then inc q1-4wk
- antihistamine effect make it good
(Adapin, 3º amine 8-24 disorder, bulimia, chronic to max 300mg/day - very sedating
antipruritic agent
Sinequan) pain, insomnia, pruritus - 120-250
MDD, dysthymia, anxiety
- start 25mg qhs then inc q1-4wk
Imipramine disorder, panic disorder, - good for panic disorder and enuresis
3º amine 5-25 to max 300mg/day 1A2, 2C19, 2D6
(Tofranil) bulimia, chronic pain, in children
- 150-300
enuresis in children
MDD, dysthymia, anxiety - start 25mg qhs then inc q1-4wk - mildly CNS
Desipramine - least sedating and anticholinergic
2º amine 12-24 disorder, bulimia, chronic to max 300mg/day activating / 2D6 (less
(Norpramin) - first line TCA for elderly
pain - 50-400 3A4)
- least likely to cause
Nortriptyline MDD, dysthymia, anxiety - start 25mg qhs then inc q1-4wk - antidepressant effects is related to
orthostatic
(Pamelor, 2º amine 18-44 disorder, bulimia, chronic to max 150mg/day serum level
hypotension / 2D6
Aventyl) pain - 50-150 - widely used for pain
(less 3A4)
MDD, dysthymia, anxiety - start 75mg qhs for 2wk then inc - higher rate of
Maprotiline - avoid in patients w/ seizure d/o, avoid
tetracyclic 21-25 disorder, bulimia, chronic by 25mg to max 200mg/day seizure, arrhythmia,
(Ludiomil) meds that lower seizure threshold
pain - 50-500 fatality w/ overdose
MDD (esp w/ psychotic
- start 25-50mg qhs then inc q1- - higher rate of
Amoxapine features), dysthymia, - metabolite is the antipsychotic
tetracyclic 8 4wk to max 300mg/day seizure, arrhythmia,
(Asendin) anxiety disorder, bulimia, loxapine and can have related SEs
- 200-400 fatality w/ overdose
chron pain
Receptor profile: see below SE profile: see below
55
Tertiary amines are more sedating/anticholinergic than secondary amines
Tertiary amines have more SRI activity than NRI activity
Secondary amines have more NRI activity than SRI activity
Tetracyclics have primarily NRI activity
56
Substance dependence
Name Receptor t1/2 (hrs) Indication Dosing Side-effects Notes
- start after atleast 12- Can cause CV
24hr after last drink; collapse w/ large - causes n/v, headache, hypotension,
Aldehyde
Disulfiram Adversive conditioning for start 500mg qday for alcohol intake; w/o flushing, blurred vision, pain,
dehydrogenase 60-120
(Antabuse) alcohol dependence 1-2wk then alcohol, it can cause tachycardia, dyspnea after alcohol
inhibitor
maintenance dose of fatigue, dermatitis, ingestion and can last upto 30min
125-250mg qday AMS
Lightheadedness, - half-life depends on pt’s tolerance to
- start 15-20mg qday
Detoxification and dizziness, sedation, opioids
Methadone Opioid receptor and titrate up as
8-59 maintenance of opioid constipation, - for maintenance, need special
(Dolophine) agonist needed; max
dependence tolerance, enrollment in methadone
120mg/24hr
dependence maintenance program
Can cause opioid w/d
- start 5-10mg while sx if not abstinent;
- has active metabolite 6-β-naltrexol
assessing for w/d sx independently,
Opioid receptor - often used w/ clonidine and benzos
Naltrexone 4, 13 for Opioid dependence, and then titrate up to naltrexone can cause
antagonist - ensure there is no signs of w/d; can
(ReVia) metabolite alcohol dependence 50mg/day and/or cramps, n/v, elevate
(potent µ) do narcan challenge to ensure
100mg every other transaminases, can
abstinence
day cause hepatotoxicity
w/ high doses
Interact w/
Acamprosate glutamate and - 666mg tid; 333mg tid Diarrhea, n/v, - exact mechanism unknown
20-33 Alcohol dependence
(Campral) GABA if renal impairment insomnia, anxiety - continue even if relapse
neurotransmission
- induction – subutex
- suboxone is combination of
8mg on day 1 then Respiratory and CNS
Partial agonist at buprenorphine and naloxone
Buprenorphine 16mg thereafter depression can occur,
µ and antagonist - induction w/ subutex should occur
(Subutex, 37 Opioid dependence - maintenance – withdrawal and
at κ opioid only under MD supervision
Suboxone) suboxone w/ 2-4mg dependence, possible
receptor - suboxone is sometimes preferred
inc per day w/ target hepatocellular injury
because it contains naloxone
16mg/24hr
57
Cognitive enhancers
In 1996 the International Psycho geriatric Association introduced the term Behavioral and Psychological Signs and Symptoms of Dementia (BPSD). This term is used to label the
wide spectrum of possible behavioral complications that accompany dementia (e.g. depression, psychosis, wandering, ADL refusal, agitation, sexual disinheriting, etc.). It is
absolutely essential to rule out previously unrecognized and untreated medical illness whenever patient who has dementia develops a behavioral problem.
If medical illness is ruled out, then the current strategy to decide which class of psychotropic medication to use for BPSD involves the concept “psycho behavioral metaphor”. The
idea is conduct an evaluation that helps place the problem behavior or behaviors in the context of a recognized psychiatric syndrome e.g. Is the patient’s irritability part of an
episode of a previously unrecognized and untreated depression episode? Is the patient’s irritability secondary to a delusion that family members are stealing from him or her? If
you can “build a case” for depression, then a trial of treatment with an anti-depressant is the best first pharmacological intervention. Keep in mind that both age and dementia will
change the way a person’s depression appears. For example, a dementia patient who has severe language impairment may not be able to say “I have low self-esteem”. If your
evaluation reveals that the irritability is triggered by delusions, then a trial of treatment with an atypical antipsychotic is the best first step. You will learn more about all of this during
your Senior Behavioral Health Inpatient Unit Rotation during your second year.
58
Sympathomimetics and related
Mechanism: methylphenidate block DA reuptake, while amphetamines block DA reuptake and stimulate presynaptic monoamine release.
Name Receptor t1/2 (hrs) Indication Dosing Side-effects Notes
- start 5-10mg bid or tid and
- Ritalin is immediate release w/ SR
titrate to max 20mg qid
version and Concerta is extended
- for SR, start 20mg qday and
release
2-3 (IR), titrate to max 60mg/24hr
Methylphenidate - also weakly inhibit catecholamine
4-6 (SR), - for ER, start 18mg qday and
(Ritalin, Concerta) reuptake and monoamine oxidase
6-8 (ER) titrate up to max 72mg/24hr
- dec metabolism of coumadin,
- narcolepsy – usually
phenytoin
between 20-30mg/ 24hr in
- avoid MAO-I
divided doses of IR
ADHD, narcolepsy, - ADHD – start 2.5mg qday Anxiety, irritability, - narcolepsy dose not established
Indirectly acting
Dexmethylphenidate depressive and titrate to max 60mg/24hr insomnia, - dec metabolism of coumadin,
(α and β 7
(Focalin) disorders in divided doses tachycardia, phenytoin
adrenergic
(specifically in arrhythmias, - avoid MAO-I
agonists) to inc
palliative care or dysphoria, anorexia, - also weakly inhibit catecholamine
dopamine and
treatment - ADHD – start 5-10mg qday dizziness, reuptake and monoamine oxidase
norepinephrine
resistant) then titrate to max 40- dependence - about twice as potent as
Dextroamphetamine
6 60mg/24hr in divided doses methylphenidate
(Dexedrine)
- narcolepsy – usu 5- - dec metabolism of coumadin,
60mg/24hr in divided doses phenytoin
- avoid MAO-I
- ADHD – start 5-10mg qday - also weakly inhibit catecholamine
Amphetamine + to max 40-60mg/24hr in reuptake and monoamine oxidase
3 (IR),
Dextroamphetamine divided doses - dec metabolism of coumadin,
7 (ER)
(Adderall) - narcolepsy – usu 5- phenytoin
60mg/24hr in divided doses - avoid MAO-I
weak inhibitor of Narcolepsy, shift
- start 200mg qday to max Abuse potential, - metabolized by CYP 2C9 and
Modafinil (Provigil) dopamine 15 work sleep d/o,
400mg/24hr headaches, nausea induces 3A4
reuptake daytime sedation
only nonstimulant - start 40 mg qd for 3d, then
Atomoxetine SNRI > 5HT - metab by 2D6, so beware of
5 approved for up to 80mg qd, can divide bid Least abuse potential
(Strattera) (80:1) interaction with 2D6 inhibitors
ADHD - requires 4 wks for effect
59
Miscellaneous
Name Receptor t1/2 (hrs) Indication Dosing Side-effects Notes
- (adult) start 0.1-
reduce sx of opioid, - withdrawal – anxiety, restlessness,
0.2mg bid to qid
alcohol, benzo palpitation, tremor w/i 20hr
Clonidine α2-adrenergic (1.2mg/24hr max)
6-20 withdrawal; treat Sedation, hypotension - overdose – coma, constricted pupil, similar
(Catapres) agonist - (child) start 0.05mg
Tourette’s disorder; to opioid overdose
qday to max 0.3mg in
ADHD - avoid in pts w/ arrhythmias
divided doses
reduce sx of opioid, - withdrawal – anxiety, restlessness,
alcohol, benzo palpitation, tremor w/i 20hr
Guanfacine α2-adrenergic - start 1mg qhs to max Sedation, hypotension
10-30 withdrawal; treat - overdose – coma, constricted pupil, similar
(Tenex) agonist 3mg/24hr (less than clonidine)
Tourette’s disorder; to opioid overdose
ADHD - avoid in pts w/ arrhythmias
anxiety disorders, - start 10-20mg bid or
Propranolol β-adrenergic Hypotension, - contra indicated for asthma, IDDM, AV
3-6 akathisia, postural tid to max 30-140mg
(Inderal) antagonist bradycardia conduction defects, hyperthyroidism
tremor bid
Direct muscle - can cause hepatitis, seizure, pleural
relaxant Treatment for NMS, - usu 1mg/kg po qid or Muscle weakness, n/v, effusion w/ pericarditis w/ long-term use
Dantrolene
beyond 9 catatonia, serotonin 1-5mg/kg IV; up to diarrhea, drowsiness, - do not initiate use until supportive care for
(Dantrium)
myoneural syndrome 10mg/kg/day dizziness pt is started and neuroleptic is removed
junction - do not give w/ CCB
- do ABCs first; should be administered w/
Antagonist at - 0.2-0.5mg IV over
Flumazenil Treatment for benzo Seizure, arrhythmia, rapid response team present
benzodiazepine 54min 30sec until max 3mg
(Romazicon) overdose resedation - there is no added benefit after 3mg
receptors cumulative dose
cumulative dose
Neuropathic pain, pain - start 300mg tid and
syndromes, no evidence titrate up to max Somnolence, fatigue, - not indicated for mood stabilization (many
Gabapentin Related to
5-7 of effectiveness as 3600mg/day ataxia, n/v, dizziness, mistakenly use it in community)
(Neurontin) GABA
single agent or adjunct - no need to check can cause rash - very good agent for treatment of pain
for mania serum levels
- start 25-50mg qhs Fatigue, somnolence,
Migraine headaches,
then inc by 25- dizziness, n/v, anorexia, nd
Inhibits Na bulimia, weight loss, no - not first or 2 line agent; no evidence as
50mg/wk to max rash, psychomotor
Topiramate channels and evidence of single agent use for bipolar d/o
21 400mg/day in divided slowing, can develop
(Topamax) potentiates effectiveness as single - no need to check serum levels
doses metabolic acidosis,
GABA-A agent or adjunct for - if renal impaired, use half doses
- Tegretol and VPA will acute angle glaucoma,
mania
lower level kidney stones
60
Clinically Relevant Cytochrome p450 Interactions
Substrates
1A2 2B6 2C8 2C19 2C9 2D6 2E1 3A4,5,7
amitriptyline bupropion paclitaxel Proton Pump NSAIDs: Beta Blockers: Anesthetics: Macrolide
caffeine cyclophosphamid torsemide Inhibitors: diclofenac carvedilol enflurane antibiotics:
clomipramine e amodiaquine lansoprazole ibuprofen S-metoprolol halothane clarithromycin
clozapine efavirenz cerivastatin omeprazole meloxicam propafenone isoflurane erythromycin (not
cyclobenzaprine ifosfamide repaglinide pantoprazole S-naproxen=>Nor timolol methoxyflurane 3A5)
estradiol methadone E-3810 piroxicam sevoflurane NOT azithromycin
fluvoxamine suprofen Antidepressants:
haloperidol Anti-epileptics: amitriptyline acetaminophen Anti-arrhythmics:
imipramine N-DeMe diazepam=>Nor Oral Hypoglycemic clomipramine =>NAPQI quinidine=>3-OH
mexiletine phenytoin(O) Agents: desipramine aniline (not 3A5)
naproxen S-mephenytoin tolbutamide imipramine benzene
olanzapine phenobarbitone glipizide paroxetine chlorzoxazone Benzodiazepines
ondansetron ethanol :
phenacetin=> amitriptyline Angiotensin II Antipsychotics: N,N-dimethyl alprazolam
acetaminophen=>NAP carisoprodol Blockers: haloperidol formamide diazepam=>3OH
QI citalopram losartan perphenazine theophylline midazolam
propranolol clomipramine irbesartan risperidone=>9OH =>8-OH triazolam
riluzole cyclophosphamide thioridazine
ropivacaine hexobarbital Sulfonylureas: Immune
tacrine imipramine N-DeME glyburide/ alprenolol Modulators:
theophylline indomethacin glibenclamide amphetamine cyclosporine
verapamil R-mephobarbital glipizide atomoxetine tacrolimus
(R)warfarin moclobemide glimepiride bufuralol (FK506)
zileuton nelfinavir tolbutamide chlorpheniramine
zolmitriptan nilutamide chlorpromazine HIV Antivirals:
primidone amitriptyline codeine (=>O-desMe) indinavir
progesterone celecoxib debrisoquine nelfinavir
proguanil fluoxetine dexfenfluramine ritonavir
propranolol fluvastatin glyburide dextromethorphan saquinavir
teniposide nateglinide encainide
R-warfarin=>8-OH phenytoin=>4-OH flecainide Prokinetic:
rosiglitazone fluoxetine cisapride
tamoxifen fluvoxamine More 3A4,5,7
torsemide lidocaine Miscellaneous: Antihistamines:
S-warfarin metoclopramide alfentanyl astemizole
methoxyamphetamine buspirone chlorpheniramine
mexiletine cafergot terfenidine
nortriptyline caffeine=>TMU
minaprine cocaine Calcium Channel
ondansetron dapsone Blockers:
perhexiline codeine- N- amlodipine
phenacetin demethylation diltiazem
phenformin dextromethorphan felodipine
propranolol eplerenone lercanidipine
quanoxan fentanyl finasteride nifedipine
sparteine gleevec nisoldipine
tamoxifen haloperidol nitrendipine
tramadol irinotecan verapamil
venlafaxine LAAM
lidocaine HMG CoA
methadone Reductase
nateglinide Inhibitors:
odanestron atorvastatin
pimozide cerivastatin
propranolol lovastatin
quinine NOT pravastatin
salmeterol simvastatin
sildenafil Steroid 6beta-
sirolimus OH:
tamoxifen estradiolhydrocorti
taxol sone
terfenadine progesterone
trazodone testosterone
vincristine
zaleplon
zolpidem
61
Inhibitors
1A2 2B6 2C8 2C19 2C9 2D6 2E1 3A4,5,7
amiodarone thiotepa trimethoprim chloramphenicol amiodarone amiodarone diethyl- HIV Antivirals:
cimetidine ticlopidine quercetin cimetidine fluconazole bupropion dithiocarbamate delaviridine
fluoroquinolones glitazones felbamate fluvastatin celecoxib disulfiram indinavir
fluvoxamine gemfibrozil fluoxetine fluvoxamine chlorpromazine nelfinavir
furafylline fluvoxamine isoniazid chlorpheniramine ritonavir
interferon? indomethacin lovastatin cimetidine saquinavir
methoxsalen ketoconazole paroxetine clomipramine
mibefradil lansoprazole phenylbutazone cocaine amiodarone
ticlopidine modafinil omeprazole probenicid doxorubicin NOT azithromycin
paroxetine sertraline fluoxetine chloramphenicol
probenicid sulfamethoxazole halofantrine cimetidine
ticlopidine sulfaphenazole red-haloperidol ciprofloxacin
topiramate teniposide levomepromazine clarithromycin
trimethoprim metoclopramide diethyl-
zafirlukast methadone dithiocarbamate
mibefradil diltiazem
moclobemide erythromycin
paroxetine fluconazole
quinidine fluvoxamine
ranitidine gestodene
ritonavir grapefruit juice
sertraline itraconazole
terbinafine ketoconazole
mifepristone
histamine H1 receptor nefazodone
antagonists norfloxacin
diphenhydramine norfluoxetine
chlorpheniramine mibefradil
clemastine verapamil
perphenazine
hydroxyzine
tripelennamine
Inducers
In
1A2 2B6 2C8 2C19 2C9 2D6 2E1 3A,4,5,7
broccoli phenobarbital rifampin carbamazepine rifampin dexamethasone ethanol HIV Antivirals:
brussel sprouts rifampin norethindrone secobarbital rifampin isoniazid efavirenz
char-grilled meat NOT pentobarbital nevirapine
insulin prednisone
methyl cholanthrene rifampin barbiturates
modafinil carbamazepine
nafcillin glucocorticoids
beta- naphthoflavone modafinil
omeprazole phenobarbital
tobacco phenytoin
rifampin
St. John's wort
troglitazone
pioglitazone
rifabutin
Genetics
1A2 2B6 2C8 2C19 2C9 2D6 2E1 3A4,5,7
3-5% Caucasian
3-4% Caucasians 1-3% Caucasian
N/A PMs , 15-20% 5-10% Caucasian PMs N/A N/A
PMs PMs
Asian PMs
For more up to date info go to www.drug-interactions.com
62
Psychotropic medications & smoking
Metabolism of many drugs is affected by tobacco
smoke. In most cases it is the tobacco smoke itself
(not the nicotine) that causes these drug interactions.
Substances in tobacco smoke induce the cytochrome
P450 system, primarily CYP 1A2. These drug
interactions most commonly become an issue on our
unit because NBMU is smoke-free, so patients stop
smoking when they come into the hospital and this
may need to be accounted for when adjusting their
medication dosages.
63
Neurological SEs of antipsychotic medications
- Acute dystonia - spasm of musc of tongue, face,
neck, back
o time to develop – 1-5d; young and neuroleptic
naïve at risk
o mechanism – acute dopamine antagonism
o txt – antiparkinsonian agents
- Akathisia - Sub/obj restlessness
o time to develop – 5-60d
o mechanism – unknown
o txt – reduce dose or change med; clonazepam
and propranolol > antiparkinsonian agents
- Parkinsonism - Bradykinesia, rigidity, variable
tremor, mask facies, shuffling gait
o time to develop – 5-30d; elderly at risk
o mechanism – dopamine antagonism
o txt – reduce dose or change med;
antiparkinsonian agents
- NMS - Extreme rigidity, fever, unstable VS,
myoglobinemia, can be fatal
o time to develop – wks-months; can persist for
days even after d/c med
o mechanism – dopamine antagonism
o txt – stop antipsychotic agent; supportive care;
dantrolene and bromocriptine
- Perioral tremor - Perioral tremor (maybe late variant
of parkinsonism)
o time to develop – after months or years of txt
o mechanism – unknown
o txt – antiparkinsonian agents
- Tardive dyskinesia - Orofacial dyskinesia; rarely
widespread choreoathetosis or dystonia
o time to develop – after months or years of txt;
elderly at x5 risk; risk proportional to D2
blockade potency
o mechanism – postsynaptic D receptor
supersensitivity, upregulation
o txt – prevention crucial; txt unsatisfactory;
maybe reversible w/ early recognition and drug
discontinuation
64
Drug-drug interactions
Mood stabilizers
Li level decreased by: Hypernatremia,
Theophylline, Psyllium, Acetazolamide.
Li level increased by: iodine, thiazide diuretics,
ACE inhibitors and Ca channel blockers,
and 50% increase with NSAIDS
Tegretol induces 3A4 and decreases drug levels
of many agents
(can produce oral contraceptive failures and
failure of protease inhibitors in HIV pts)
Tegretol levels increased by erythromycin, Ca
channel blockers, Isoniazid, grapefruit juice.
VPA increases level of 10,11 epoxide metabolite
of Tegretol
Don't give Tegretol with other bone marrow
suppressants
VPA increases coumadin and aspirin effects
VPA increased lamotrigine (therefore, only
requires ½ dose of lamotrigine)
65
Drug interactions with MAOIs
Amphetamines, appetite suppressants, stimulants
Decongestants, Epinephrine/ ephedrine
Asthma drugs esp bronchodilator inhalers
Ginseng, tryptophans, tyramine
Anesthetics (general & local), Opioids (meperidine)
Serotonergic agents including tryptophan, SSRIs,
TCAs, SGAs, and Triptans (5HT1D agonists)
Tegretol, Buspirone, Dopa & dopamine
Antihypertensives,
Flexeril, Antabuse
Insulin, Sulfonylureas
Isoniazid and linezolid are each an MAOI and
therefore should also be watched for potential HTN
crisis and serotonergic syndrome
66
Medications for Pregnant Patients
Some basic points:
1. Pregnancy is NOT protective against mental
illness: women with preexisting mental illness
have high relapse rates if off meds during
pregnancy, and pregnancy and the postpartum
period are vulnerable times for new onset of
illness, especially MDD and bipolar disorder.
2. The goal of treatment of maternal mental illness
is to minimize fetal/infant exposure to BOTH
medications and maternal illness—both have the
potential to harm a fetus/infant.
3. Pregnancy is not the time for experimentation: if
a woman has a complex history of mental illness,
with few exceptions she should be maintained on
her current medication regimen, unless there is
an overwhelming need/reason to change
medications or doses.
4. The exposure of infant to medication in breast
milk is orders of magnitude lower than in utero,
so (except for lithium), do not change medication
from pregnancy to postpartum to avoid breast
milk exposure
Depression:
68% of women with MDD who stop their meds will
relapse during pregnancy.
67
(Depression cont.)
SSRI’s and TCA’s: no pattern of congenital
malformations or neurobehavioral toxicity found in
multiple studies
- possible incr risk of persistent pulmonary
hypertension of the newborn (risk increases from
1/1000 to 6/1000 with third trimester use). Still
controversial.
- Paroxetine: FDA class D, but prospective studies
negative for ASD/VSD incr risk, so if a woman is
stable on it, safest thing is to continue.
- Clearance of SSRI’s incr with later pregnancy,
one study with 2/3 women needing incr dose (avg
at 27wks) to maintain euthymia.
Venlafaxine, bupropion: no major malformations with
limited data
Duloxetine: no malformations in animals, but no
human data
Anxiety/Insomnia:
Benzodiazepines: no major risk congenital
malformations, include cleft lip/palate
- consistent use at high doses to time of birth can
lead to neonatal resp depression and “floppy
baby” but resolves with metabolism
- Good option for insomnia in pregnancy: 0.5-1mg
(or more) lorazepam qhs
- be careful with breastfeeding: small amts get into
breast milk and can cause neonatal sedation and
resp depression
- preferred lorazepam or clonazepam over
diazepam (very long t1/2) and alprazolam (rapid
onset/offset action)
Benadryl: class B, effective for many women with
insomnia who are psychotropic-naïve, can cause mild
neonatal sedation with breastfeeding
68
Bipolar disorder:
Rapid tapering of mood stabilizers (<2 weeks) leads
to higher rate relapse. If women are off mood
stabilizers and do not relapse during pregnancy,
nearly 100% will relapse in the first few mos
postpartum. If pt stable off meds during pregnancy,
consider restarting immediately PP to decr risk of
relapse.
VPA: 5-9% risk neural tube defects, 8.9% risk major
anomalies, also with learning disabilities,
developmental delays/retardation, neonatal
hepatotoxicity. This is the only medication that
absolutely SHOULD NOT be used in pregnancy.
Lithium: risk Ebstein’s anomaly 1/1000, much lower
than prev thought (downward displacement of
tricuspid valve), can cause maternal hypothyroid, rare
DI, rare fetal goiter. Lithium should be dosed bid-tid
to avoid high peak levels, and will need incr dose
nd rd
during late 2 and 3 trimesters 2/2 incr GFR.
Neonatal toxicity common, with “floppy baby” and
resp depression lasting until lithium metabolized by
neonate. This can be avoided by holding lithium at
onset of active labor or 24hrs prior to scheduled
induction or C/S. Mother needs IVF to prevent
dehydration and toxicity during labor. Needs to be
restarted immediately PP. Relatively high passage
into breastmilk, with possible infant toxicity, so not
recommended for breastfeeding.
CBZ: 1% neural tube defects, 3x increase in
cardiac/craniofacial anomalies (3%), 20%
developmental delay. Mother needs vitamin K 10-
20mg PO qd for 4-6 weeks before delivery 2/2 poss
neonatal coagulopathy or thrombocytopenia from liver
toxicity.
Lamotrigine: no incr major congenital malformations,
except for possible incr cleft palate (0.37/1000 incr to
nd
8.9/1000 in one study). Will need incr dose in late 2
69
rd
and 3 trimesters 2/2 incr GFR. Restart lower dose
immediately post partum
Breast feeding:
- VPA and CBZ safest in breastfeeding,
increasingly favorable data on lamotrigine, not
recommended with lithium.
- Antidepressants: Sertraline and Paroxetine have
the lowest penetrance into breastmilk, and should
be started preferentially in treatment-naive
patients requiring an antidepressant. However, if
a patient has failed these medications, please
consult the lactmed database for information on
all other meds: http://toxnet.nlm.nih.gov/cgi-
bin/sis/htmlgen?LACT (or google Lactmed)
- Antipsychotics: Haloperidol generally considered
lowest risk, but all antipsychotics penetrate
breastmilk (except for quetiapine<100mg). See
LactMed database for data on individual meds.
Psychosis:
Postpartum psychosis 0.1% of women (rare), mostly
in women with undiagnosed bipolar disorder. Often
responds well to low-dose antipsychotics; consider
mood stabilizer based on history.
Schizophrenia: high fertility rate with incr risk LBW,
poor neonatal outcome and SIDS regardless of
medication.
FG antipsychotics: higher-potency are safest, limited
data but no long-term sequelae found, haldol most
frequently used.
SG antipsychotics: Quetiapine with lowest placental
passage, limited data on all of them with no human
data on ziprasidone or aripiprazole.
Few cases of BF with atypicals; quetiapine with no
penetrance into breast milk <100mg/dose
70
Few cases of BF with atypicals; QUETIAPINE WITH
NO PENETRANCE INTO BREASTMILK
<100MG/DOSE.
Psychotherapy
71
structure is analyzed as it unfolds in relation with the
therapist as perceived by the patient.
Dialectical-behavior therapy – directly targets suicidal
and other self injurious or destabilizing behaviors;
increases behavioral capabilities as problems come
up in day-to-day life; focuses on functional behavior
72
PATIENT
MANAGEMENT
ISSUES
73
PATIENT MANAGEMENT ISSUES
ER Patients
First Look: Safety!
1) Always make sure the patient is gowned and
has been searched for weapons.
2) Always make sure an exit is readily
available. Keep the door open if the patient
is agitated.
3) Never try to be the hero – when in ANY
doubt, request help.
Leave the room calmly:
- if you feel uncomfortable
- if the pt makes any threat (verbal or
physical)
- if the pt does not do as told, e.g. “please
sit down”
Call for back-up – UCSD security or VA
police (even if you just want them to stand
there while you interview the pt.).
Second Look: Dx & Dispo! Agitated pts are
often one of these:
- Psychotic
- Intoxicated
- Delirious
- Manic
- Suicidal
If you are seeing an agitated patient and
medicating him/her, he/she will likely need
admission.
Intoxicated pts
Request an alcohol level (breathalyzer or blood is
used at the VA or breathalyzer at the U) and urine
tox (blood and breath concentrations of EtOH
correlate more closely than urine concentrations
with CNS impairment).
74
See the pt as soon as possible, within 15-20 minutes,
but realize you can’t really assess someone until
the breathalyzer is <0.08 (80) (the legal limit in CA)
or half of what it was when the patient came into
the ER, whichever happens first.
Intoxication in and of itself is not an appropriate
reason for admission but it will often be the safest
option to admit the pt when they complain of
depression + SI. Remember: an intoxicated male
with no social contacts is at high risk for
completed suicide.
If the UCC/ER is pressuring you to dispo the pt, ask
the ER doc to start a “banana bag” (1 liter NS
mixed with MVI 10mL, thiamine 100mg, folic acid
1mg, IV, over 2 hours) which will buy the pt time to
sober up and you time to get a better evaluation.
This option also should be considered if waiting for
labs to come back and if there is question of
disposition.
Alcohol Withdrawal/Detox
We frequently must detox patients who are
withdrawing from ETOH. A patient can die if this is
not done properly.
a. Acute Alcohol Withdrawal: a syndrome occurring
in alcohol dependent patients following the
cessation or reduction of regular, high dose
alcohol ingestion. This syndrome starts usually
within 6-24 hours after cessation or reduction in
alcohol consumption.
b. Withdrawal Symptoms such as, tremors, nausea
and vomiting, anxiety, mild agitation, tachycardia,
hypertension, insomnia, and diaphoresis may
occur. These symptoms usually peak between
24-36 hours and resolve within a few days. Milder
more protracted withdrawal symptoms can last
75
days to weeks. Hallucinations occur in 3-10% of
patients.
c. Convulsions, usually 1 or 2 grand mal seizures,
occur in less than 5% of patients in acute
withdrawal and typically occur within 24-48 hours.
The risk of withdrawal complications e.g.
seizures, increases with the duration of alcohol
dependence and the number of previous
withdrawal episodes. Patients with a history of
withdrawal seizures are at greatest risk.
Concurrent medical conditions can complicate the
withdrawal process and medications can mask
withdrawal signs. The onset of withdrawal can be
postponed by the actions of various anesthetics,
narcotics and benzodiazepines used in medical
and operative procedures.
d. Delirium Tremens: a syndrome characterized by
disorientation, confusion, and autonomic
hyperactivity that occur in less than 5% of patients
undergoing alcohol withdrawal. The onset is
usually within 2-5 days after cessation of alcohol
and can last several days. The overall death rate
is as high as 10% from cardiovascular, metabolic
or infectious complications in untreated patients.
76
and the patient’s response to medication. An
assessment tool such as the MINDS can help guide
therapy. This method reduces the risk of over and
under-medication, and for most patients enables
individualized treatment. Studies have shown that this
form of treatment requires less treatment and has a
decreased length of stay.
Outpatient detox
For patients who can be detoxed as outpatients, give
a 24h supply of the benzo taper, and have them come
back daily for the next day’s doses. Keep this up until
the taper is complete, doing a breathalyzer each day.
Patients will be instructed to come on the weekends
for daily detox appointments. PATIENTS MUST BE
SEEN FACE TO FACE by the weekend resident
before meds are ordered.
77
For Ativan: select this if they have cirrhosis or severe
liver inflammation, or are older than 60.
(Because Ativan half life is not as long as Valium,
Dosing should not be more than Q8H)
ATIVAN SAMPLE DOSING:
Day 1: 2 mg PO Q6H x 4 doses
Day 2: 2 mg PO Q8H x 3 doses
Day 3: 1 mg PO Q6H x 4 doses
Day 4: 1 mg PO Q8H x 3 doses
Day 5: 0.5 mg PO Q6H x 4 doses
Day 6: 0.5 mg PO Q8H x 3 doses
Pulse
0 <90
1 90-110
2 >110
BP (Diastolic)
0 < 90
1 90-110
2 >110
Sweating
0 No sweat visible
2 Barely perceptible, moist palms
4 Beads of sweat visible
6 Drenching sweats
Agitation
0 Normal activity
2 Somewhat more than normal activity
4 Moderately fidgety and restless
6 Pacing, or thrashing about continuously
79
Delusions
0 Absent
4 Present
Tremor
0 None
2 Not visible, can be felt fingertip to fingertip
4 Moderate w/arms extended
6 Sever even w/arm not extended
Seizures
0 None since last rating
6 Have occurred since last rating or at all if first rating
Orientation
0 Oriented to time, place, person
2 Oriented only to place and person
4 Totally disoriented
Opiate Detox
Symptoms: chills, diarrhea, piloerection, big pupils
when withdrawing, bone pain, runny nose, pain.
“Everything runs.”
Record vitals.
Meds:
Imodium 4mg 1-2 tabs q1 hr prn diarrhea, NTE
16 mg/day
Bentyl 10 mg qid prn abdominal cramping. Used
infrequently.
Motrin 600 mg q6hr prn bone pain
Compazine (prochlorperazine) 10mg qid prn n/v.
Give by any route available. May use Phenergan
(promethazine) also 25 mg q8h.
Benadryl 25-50 mg q6hr prn nasal congestion,
insomnia, or anxiety.
Clonidine: start at 0.1 mg bid for bone pain and
autonomic arousal, may increase but watch for
hypotension. Often used as 0.1 bid to 0.3 bid
must be observing pt daily and check vitals.
80
Valium: for muscle spasms and insomnia, one
night at a time; use your discretion (is pt drug-
seeking?), usually 10-15 mg hs.
Suicide Assessment
82
Risk Factors are objective patient characteristics that
have been shown in published studies to be
associated with a risk of suicide in long-term follow-
up. Though they are objective, they are less helpful in
predicting imminent risk. Non-modifiable risk factors
might raise or lower concern, but do not, alone,
suggest that a patient needs hospitalization. Non-
modifiable risk factors include a history of previous
suicide attempts/self harm, previous psychiatric
hospitalizations (especially with recent discharge),
family history, history of trauma, or recent divorce.
The presence of modifiable risk factors suggests
avenues for treatment. Examples of modifiable risk
factors include the Axis I disorders (e.g. treat the
depression and suicide risk goes down), poor social
support, easy access to lethal means (e.g. owning a
gun), and intoxication.
Suicide Prevention
Limit access to lethal means. Does the patient have a
gun at home? What medications (fatal in overdose)
are in their possession? Ask that they be removed.
Increase clinical/social resources. Treat Axis I
disorders, attempt to house patients, etc.
Create a safety plan with the patient. Safety contracts
have no evidence that they are effective. Instead,
create a written, easily accessible plan for any crisis.
–Note when the plan should be used: “What
warning signs do you have that you are in crisis?”
(e.g. using substances, feeling trapped, withdrawing
from others)
–Ask the patient to name activities they use
to manage their suffering, and specifically note these
soothing activities, such as exercise, watching TV, or
prayer.
–Sometimes activities aren’t enough. List
names & numbers of supportive people.
–For the situation when none of the above
strategies work, list a suicide hotline, the appropriate
85
health provider’s phone number, specific emergency
dept., and 911.
–Rehearse the plan. “Where are you going
to keep this plan?” “How likely are you to use this plan
in crisis? Why?”
Educate friends or family members, giving concrete
examples of warning signs and familiarizing them with
the Safety Plan and how to respond during a crisis.
Example Documentation
“Assessment: 54 y.o. homeless man with alcohol
dependence and depression NOS. The patient has a low-
moderate level of risk of suicide. His risk factors include
homelessness, a history of suicide attempts of low to
moderate severity, and alcohol dependence, and his warning
sign is that he is thinking about suicide. However, he does
not have a clear plan or access to a gun. With his written
permission, I called his sister, and she says that he has
expressed suicidality in the past many times without making
a suicide attempt. He shows signs of hope about getting a
place to live, has plans to get SSI, and demonstrates an
ability to access care by bringing himself to the Emergency
Department today. He was smiling and joking with me during
the interview. I will try to get him a bed at a crisis house, and
if that does not happen, provide information about shelters in
the area. I have also provided him with resources on getting
sober and given him the San Diego crisis line so that he can
obtain follow up services. Finally, we made a safety plan
together.” Include a copy of the safety plan in the chart.
86
•Nock MK, Borges G, Bromet EJ, Cha CB, Kessler RC, Lee
S. Suicide and suicidal behavior. Epidemiol Rev.
2008;30:133-54.
•American Association of Suicidology: www.suicidology.org
•Suicide Prevention Resource Center: www.sprc.org
Treating EPS:
- Dystonias, tongue swelling, jaw locking, oculogyric
crisis etc. Risk increases with young age male
gender and high potency neuroleptics. This is an
emergency: use Cogentin 2mg or Benadryl 50mg IM.
Meds must be IM or IV. PO takes too long to be
effective & this is an emergency.
- Akathisia (severe restlessness): propranolol 20mg
PO tid unless they also have Parkinsonism. Then
use Cogentin 2-6 mg/d first and add propranolol 10-
30mg PO tid if Cogentin alone ineffective. May
require high potency benzos.
- Parkinsonism (shuffling gait, cogwheeling,
bradykinesia, masked facies): decrease dose of
neuroleptic or Cogentin 1-2mg PO. Must be bid if
really for EPS because drug is very short acting.
May also use Benadryl 25-50mg.
- EPS gets worse with increased dose of neuroleptic.
- TD (late onset stereotyped movements, usually
mouth or face such as lip-smacking):
o 15-20% of patients get TD
o Risk factors: female, smokers, African
American (non-Caucasian), age > 50
y.o., mood d.o., increased dose,
increased duration, brain injury.
o DC meds: 1/3 get better, 1/3 no
change, 1/3 get worse.
o TD worsens with anticholinergics or
removal of antipsychotic.
o TD improves with increased dose of
neuroleptic, at first. Need to switch to
new class of antipsychotics.
o Vit E as tx for TD was used by some.
o There is no reliable tx.
88
Neuroleptic Malignant Syndrome
Can be fatal (causes rhabdomyolisis, which may lead
to renal failure)
Sx: delirious, increased vitals (temp, HR),
rigid/tremor, increased CPK
- Tx: IVF, cooling blanket, Dantrolene.
Always on a medicine service, not psych.
- Difficult to treat.
Serotonin syndrome
Risk with MAOIs, TCAs, SSRIs, & other serotonin
antidepressants.
Mental status change, confusion, hypomania,
restlessness, myoclonus, hyperreflexia,
diaphoresis, shivering, tremor, diarrhea,
incoordination.
Potentially fatal but much less often than HTN crisis,
although serotonin syndrome more common than
HTN crisis.
Medicine service will treat symptomatically.
HTN crises
Risk with MAOIs and symphathomimetics or other drugs or
food contraindicated with MAOIs. See HTN section.
Because this is life threatening, call a Medicine consult.
Potentially fatal from intracranial hemorrhage, cardiac
arrhythmia, or cardiac arrest.
Sxs: Increased BP, palpitations, headache.
Medicine service will treat this condition aggressively.
89
Sleep: 7-9 hours, no naps, wake up at the same time every
day. See instructions for insomnia for more info.
Eat: small amounts of good food often, more fruits &
vegetables, less fat.
Exercise: Stretching and warming up and cooling down are
important. Current recommendations include 30 minutes per
day, four times per week, at 60-80% of your maximum heart
rate (cardiovascular/aerobic exercise). Exercise has been
shown to help depression in clinical studies.
Strength can be worked on in several ways including free
weights or exercise machines and therapeutic rubber bands.
Light: Exposure to light has been studied in people & the
benefits are remarkable. Living in a sunny climate alone is
not enough. To benefit from natural light you must actively
expose yourself to it. For depression, morning light, as soon
as possible after awakening is best. From 10 am to 3 pm the
sun is at its most intense, increasing risk of sunburn. To
avoid sunburn & increased risk of skin diseases, try early
exposure & always use the appropriate sunscreen. Light
boxes are available for about $300.
Relaxation Techniques
These are very important for anxious people. These
techniques can be helpful to teach patients even in an ER
setting. Different types of described in brief below.
Progressive Relaxation
Toe Tensing
Relaxed Breathing
Guided Imagery
Insomnia
Insomnia is common (about 11% of adults). Usually is
related to some other problem; often bad sleep habits or
psychiatric problem.
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Insomnia is usually a co-morbid condition of something else
that needs to be treated (i.e. depression, mania, and
psychosis).
Insomnia is assessed as
INITIAL (can't GET to sleep)
MIDDLE (can't STAY asleep)
TERMINAL (wakes up too early & can't get back to
sleep, aka “Early morning awakening”
(Shorthand: “+/-/-“ means: trouble getting to sleep, no trouble
staying asleep, no early morning awakening).
* See psychopharm section for meds for insomnia
Dementia
Admit them to inpatient psychiatry if they are exhibiting
psychotic symptoms, severe depression, suicidality, etc. Try
to avoid admitting someone just for memory trouble without
Grave Disability 2/2 depression or psychosis (at NBMU
consider calling Dr. Feifel/Perry before admitting one of
these pts). Those at UCSD who are semi-voluntary (not
92
fighting too hard to leave) can be evaluated for admission to
Senior Behavioral Health (a nonlocked med-psych ward).
Voluntary demented patients without behavioral problems
are usually admitted to medicine for whatever acute medical
issue with which they present.
93
Be aware that the use of trazodone in dementia for either
agitation or insomnia is common but controversial.
94
GENERAL
MEDICINE
95
GENERAL MEDICINE
Medical issues you frequently get called about
either on call or that may occur on your
inpatients:
96
- Serial cardiac markers (CPK, CKMB, Trop I
q6hrs x 3), chem10, cbc, BNP (if suspected
heart failure), coags, CXR
- If SBP >90, give trial of nitroglycerin 0.4mg SL
(this does not r/o GI etiology of CP)
- If most likely GI, give Maalox 30cc and assess
- If suspected cardiac give ASA 325mg to chew,
O2 and call medicine consult or rapid
response, and prepare to transport patient
Constipation
- R/o obstruction and acute abdomen with exam
and acute abdominal series
- Stool softener – colace 250mg bid
- Motility agent – senna 8.6-13.2mg, dulcolax 10mg
PR, enemas, MoM 30ml qid, miralax qd to bid,
Mag citrate.
- Miralax (polyethylene glycol) is Dr. Sewell’s choice
for elderly patients.
Delirium
20-25% mortality – fluctuating level of consciousness,
can be hypoactive (quietly delirious patient who is
disoriented) or hyperactive (agitated patient)
Delirium is often a consult from medical or surgical
services. Remember it is a medical disorder with
psychiatric manifestations, including psychosis.
The underlying medical disturbance may not yet be
known but it will probably declare itself if proper
work up is undertaken.
Post-op: think 50% of ICU pts. 25% of med/surg
ward pts may be delirious.
ER: think drugs – intox or withdrawal
Patient may need restraints.
Patients benefit from sensory stimuli like clock,
calendar and being near window; also need
frequent orientation.
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Delirium Etiology/ Differential diagnosis
“I WATCH DEATH”:
Infections (including pneumonia & sepsis)
Withdrawal
Acute metabolic (CO2; uremia, dialysis; hepatic
failure; pancreatitis; alk/acidosis; electrolyte
problem: Na, Ca, Mg, Glucose!)
Trauma
CNS pathology (O2 tumor, BP bleeds, trauma, post
ictal, CVA, emboli infection)
Heavy metals
Deficiencies (Anemia, porphyria, B12, folate,
thiamine, etc.)
Endocrinopathies
Acute vascular accident (stroke or hypotension)
Toxins (drugs or meds: anticholinergics, sedatives,
steroids)
Hypoxia or hypercarbia: PE, BP, CHF
Delirium Workup
- Risks with age, >65, <10, malnutrition,
dementia, above causes, etc.
- History from significant others, physical &
neurological examination.
- Labs: start with Tox screen, CBC, chem10, NH4
(if hepatic encephalopathy possible), UA; can
also get B12, folate, ABG, EKG, chest x-ray, drug
levels, head CT, consider blood culture
- TX: risperidone 0.5 to 4 mg po bid or Haldol 1-
5mg (po or IV) for psychosis. AVOID BENZOS.
Start with low dose in elderly patients.
- If significant agitation can give Haldol 5mg IV q
10-15mins until calmed down. Most medical
floors require telemetry if IV Haldol given.
- Consider Naloxone IV, flumazenil if suspected
narcotic or benzo toxicity.
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Diabetes Mellitus (DM)
Hypoglycemia:
- Almost always iatrogenic
- Give orange juice, food and then recheck; if
severe (<40), consider giving D50 but this may
require pt to be on medicine floor
Hyperglycemia:
In gereral, if a patient is symptomatic from
diabetes, you should call medicine to help with
management.
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If pt type I diabetic, needs to be on scheduled insulin:
total daily dose 0.2-0.4units/kg/day, give half as
long-acting (lantus) once daily, and divide rest as
tid regular or lispro.
FBS Action
<50 30gm oral liquid glucose call HO
51-80 give juice, repeat in 30min
81-150 no coverage
151-200 2 Units insulin SQ
201-250 4 Units insulin SQ
251-300 6 Units insulin SQ
301-350 8 Units insulin SQ
351-400 10 Units insulin SQ
>400 12 Units insulin SQ, call HO
Treatment of DM2:
If patient is admitted to 2S and already on oral
hypoglycemic agents, does not need fsg qac and
hs, or insulin correction scale.
Check A1C to assess level of control, if not done
already in last 3 months.
Order of starting oral medications for DM2 is:
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1. metformin 500mg bid, increase to 1000mg
bid after 1 week
2. glyburide 5mg qday, can increase as needed
up to 20mg bid; do not use if renal insuff
(use shorter-acting glipizide 5-10mig bid)
3. actos 15mg qday, can increase to 30mg
qday (do not use avandia 2/2 incr cardiac
risk)
4. If still with poor control, add lantus 10u qhs
and stop sulfonylurea.
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Start Max Contraindicated Advantages Disadvantages
Med (class)
dose dose in of of
Cr>1.4
No
500 CHF GI SE’s
metformin 1000 hypoglycemia
mg Liver dsfxn (diarrhea)
(biguanide) mg BID Wt loss
BID Iodine contrast Lactic acidosis
cheap
Met acidosis
2.5-5
glyburide, glipizide 10 mg DKA Hypoglycemia
mg cheap
(sulfonylurea) bid CrCl<50 Wt gain
qam
CHF Expensive
thiazolidinediones No
DKA Wt gain
(TZD): hypoglycemia
Liver dsfxn Follow LFTs
15-30 45 mg
Actos (pioglitizone)
mg qd qd
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Diarrhea
- Is the patient having “loose stool” or “watery stool”?
Loose stool is not diarrhea, watery stool is diarrhea.
- General rule is to treat the underlying cause: consider
new medications as cause or infectious
o stool culture, WBC, ova and parasite
exam and C Dif toxin
- Acute diarrhea – loperamide 4mg x1 then 2mg after
each loose stool (NTE 16mg/day); do not give if pt
febrile or with bloody diarrhea
Dyspnea
- What is the patient’s baseline O2 sat and pulmonary
status (do they have asthma or COPD, etc?)
- Do a full set of vitals, including O2 sat.
- Do focused PE.
- Check O2 sat, make sure getting good reading, must
be picking up consistent pulse on machine when you
read O2 sat (try to see the reading yourself to
confirm). Make sure pt isn’t wearing finger nail polish.
If pt wearing nail polish or has peripheral vascular
disease, then use ear lobe to check sat.
- If O2 sat normal, this is reassuring and you have
more time to dx, think 1.Asthma attack 2.COPD
3.Pneumonia 4.Pneumothorax 5.Pulmonary
Embolus 6.Pulmonary Edema 7.MI 8.Panic attack
9.Aspiration
- If O2 sat abnormal (<94%)
- What is pt’s baseline O2 sat? If has COPD may
have chronic hypoxia. If this is case O2 sat <93%
may be normal for pt.
- If pt has tachypnea with new desaturation: consider
calling rapid response team. If not yet warranted,
act quickly to try and figure out cause, get stat
portable CXR and ABG. If O2 sat consistently low
with good reading, then place pt on oxygen
(maintaining O2 sat above 93%) and call medicine
consult for possible transfer.
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Electrolyte imbalances
Almost all significant electrolyte imbalances should warrant
a Medicine consult. Also, before you treat an electrolyte
disturbance or call Medicine to do so, it’s probably a good
idea to re-check electrolytes if you notice a disturbance.
Calcium
Hyper - >10.5mg/dl, give fluids as most pts are
hypovolemic; consider medicine consult
Hypo - <8.5mg/dl, check albumin to make sure this is
true hypocalcemia
Magnesium
Hypo - <1.8mg/dl, can make repletion of Ca and K
difficult, for every 0.2mg/dl below normal, give 1g
MgSO4 IV (most likely on medicine service)
Phosphate
Hyper - >4.5mg/dl, can give calcium carbonate,
calcium acetate, sevelamer (usually pt with CRI)
Hypo - <2.6mg/dl, oral preparations (K-phos-neutral,
neutral-phos-K, neutra-phos) can give BID to QID;
consult medicine if IV repletion is needed
Sodium
Check volume status of patient, mucous
membranes, urine output, edema, skin turgor,
etc.
Hyper - >145meq/L, correct w/ vol repletion; correct
slowly (never more than 12meq/day)
Hypo - <135meq/L, place on free water restriction,
most likely will need IVFs and so consult medicine
Potassium
Hyper - 5.1-6meq/L, make sure that this is not 2/2
lysed blood sample; if not then check EKG and give
kayexalate (takes 2-3hr to work; 30g will lower by 1);
>6.0meq/L, same as above and give 1amp calcium
gluconate, 10U insulin and 1amp D50 (lowers by 0.5
to 1.5 transiently), 1amp sodium bicarbonate, and
consult medicine
Hypo - <3.5meq/L, check EKG, for every 0.1meq
below, replace w/ 10meq KCl
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Falls
- If trauma or LOC involved, get head CT w/o contrast;
consider cardiac causes for LOC
- If elderly or alcoholic, there is increased risk of subdural
- If osteoporotic, there is increased risk of fracture
- Assess for possible seizure
- Examine any injured limb, check for range of motion
(passive/active), point tenderness. If knee or ankle injury,
walked immediately after, and no point tenderness to
joint, likely does not need X-Ray. If any question, get
plain films of joint or bone at least 2 views (if unsure what
to order can call radiologist).
- If hit head, do neuro exam. If any abnormalities, get
non-contrast head CT.
- Decide whether you should initiate fall precautions,
seizure precautions, or regular neuro checks.
Fever
Need to get history and full PE to look for etiology of
fever.
Everyone has different cut off for fever, conservative cut
off is T>100.4.
If T>101.5 would suggest full w/u: UA, urine culture, blood
culture x2, CXR, CBC with diff. If sx’s of meningitis, then
pt needs LP with studies (call medicine).
Tx fever with Tylenol (650 mg) and repeat 650 mg in 2
hours if temp still elevated. NTE 4 g daily or less in liver
pts.
Consider: EtOH withdrawal, pyelonephritis, pneumonia,
cellulitis, bacteremia, endocarditis (esp if IVDU, artificial
valve), appendicitis, diverticulitis, viral syndrome, pelvic
inflammatory disease.
Headache
Things to r/o acutely (consult medicine urgently):
105
- Meningitis- red flags: fever, photophobia, N/V,
nuchal rigidity, any neurologic sx’s, or abnormality
on neuro exam (esp. cranial nerves)
- Subarachnoid hemorrhage- red flag: worst
headache of life
- Hypertensive emergency (see HTN section)
- Temporal arteritis – palpate temporal region (get
ESR)
Treatment based on acuity and suspected etiology:
- HTN related headaches should be managed by
lowering BP
- Fever should be managed with Tylenol or
ibuprofen
- For migraine headaches try Imitrex 25-50mg PO x
1 or 6mg SC x1 (if nl BP). Caution repeated use in
patients on SSRIs/seroternergic agents.
- Cluster headaches (asymmetrical, rhinorrhea,
lacrimation) - try oxygen.
Hypertension (HTN)
- Make sure patient is not having hypertensive
emergency (si/sx of end-organ damage)
- Get full vital signs including temp, O2 sat if indicated
- Compare with baseline BP
- If pt symptomatic (headache, chest pain, blurred vision),
examine pt, do neuro exam, look in eyes (for
papilledema). If suspect HTN emergency (elevated BP,
usually >200/120, with end organ (brain, eye, heart,
kidney) damage), call medicine consult immediately for
evaluation.
- If BP is 220/110 and asymptomatic then give clonidine
0.2 mg and check BP in 2-3 hours. Repeat once if BP
still >180/100. If BP does not come down, then
consider calling medicine.
- If pt asymptomatic and BP is less than 220/110, pass on
to primary team in AM.
If this is one of your inpt’s and BP sig elevated from
baseline but asymptomatic, make sure pt has received
any scheduled HTN meds. If BP continues to be
>180/100, could consider starting HTN med.
106
Anti-HTN Starting Max Avoid if Good Notes
(class) Dose Dose Choice
for
Metoprolol 25-50mg 100mg Asthma BB not good first-line choice 2/2 incr
(-blocker) bid bid Bradycardia risk glucose intolerance, CAD and CVA
AV block in recent studies
HCTZ 12.5mg 50mg Electrolyte edema Previously first-line, now 2nd or 3rd
(Thiazide qd qd imbalance choice
diuretic) Sulfa allergy
gout
Lisinopril 10mg qd 60mg Pregnant Diabetic Make sure baseline Cr, and recheck
(ACE-inhibitor) qd Hx angioedema CAD one week after starting; not much
Hyperkalemia CHF benefit above 40mg
Renal Failure
Norvasc 5mg qd 10mg Edema BLE edema most common side effect.
(Ca Channel qd
Blocker)
First line for otherwise healthy person is more controversial in last year, now likely ACEI if no contraindications.
Diabetics/CHF with stable renal function should be on an ACE inhibitor.
Calcium channel blockers generally added on for HTN not controlled with Beta blocker, ACE and HCTZ.
Check EKG before and after adding to BB to screen for AV block.
Combining low dose anti-HTNs more effective than maxing out dose on one med, but must consider SE
107
Hypotension
Make sure the reading is accurate; don’t forget your eyes
are more reliable than any report
- Compare with baseline BP and check med list
- Workup labs: CBC, chem10, EKG (r/o Afib, SVT,
Vtach), cardiac markers (consider lactate, ABG,
BCx)
- Major differentials: septic/hypovolemia/cardiogenic
- Perfusion defects (shock): AMS (brain), CP (heart),
decreased urine output (GI), LFT/lipase leak (lactate
level indicate hypoperfusion)
- Depending on cause, you can fluid bolus or if IVF
and supportive care is indicated, consult medicine
Nausea/Vomiting
- r/o acute abdomen, MI, DKA, AAA
- workup: cbc, chem10, lipase, LFTs, UA, consider
radiological study, U/S
- treat w/ ondansetron 4-8mg PO or IM q4hrs (5HT3
blocker), prochlorperazine 10mg q6hr (D2 blocker),
promethazine 12.5-25mg q4-6hr (H blocker),
metoclopramide 10mg q4-6hr (dopamine blocker)
Seizure
- Call rapid response and prepare to transfer pt
- Assess ABCs, evaluate meds, vitals, chem20, FSG, cbc
- Initial acute treatment is to use ativan IM to control
Stroke
- Call stroke code
- Assess ABCs, evaluate meds, vitals, chem20, FSG, cbc
- Prepare to transport pt. Time is of the essence.
Tachycardia
Compare with baseline pulse; check med list
- If pulse >120, get EKG to r/o AFib/SVT/Vtach
- If sinus tachycardia, think of possible causes and
correct if possible
108
Differential: 1.EtOH withdrawal 2.Anxiety 3.Pain
4.Fever 5.Dehydration 6.Med effect (esp antipsychotics)
- consider medicine consult
109
WARD ISSUES
110
WARD ISSUES
Seclusion and Restraint
Seclusion involves locking patient in a room
Restraint is the application of straps to
immobilize limbs
One OR the other may be used, never both
Rationales for restraint include
o Medical: To promote medical healing.
Restraints are used to limit mobility,
temporarily immobilize a patient, or
prevent patient from walking before
medically appropriate.
o Behavioral: The patient’s behavior
presents an immediate and serious
danger to the safety of the patient or
others
Restraint note
o Date/Psychiatrist on call/time
o “Patient placed in restraint (or
seclusion) at __p.m. Restraints were
needed because ___. Alternatives to
restraints were tried including
redirection, 1 to 1 interaction, time out,
PO medications, and seclusion.
Patient will be evaluated at ___
intervals and released when no longer
exhibiting behaviors for which seclusion
and restraints were initiated.”
o Signature and provider number
Orders
o Medical: Every 24 hours there must be
a face-to-face MD encounter,
documentation, and renewal of restraint
orders
o Behavioral: Guidelines for seclusion or
restraint due to a behavioral issues are
more stringent as follows below
111
Seclusion or Restraint for Behavioral Rationale:
Physician Responsibilities
Initial order (obtain within 1 hour): Use pre-
printed form at UCSD or computer template at VA.
Duration limits for initial order vary by age.
o ≥ 18 yo: 4 hour limit for each order
o 9-17 yo: 2 hour limit for each order
o 1-9 yo: 1 hour limit for each order
Initial face-to-face MD assessment (obtain within
1 hour): Document in chart with note
Face-to-face MD reassessment: Frequency varies
with age. Document in chart with note
o ≥ 18 yo: Every 8 hours
o < 18 yo: Every 4 hours
Misc Documentation
On Call Note: Write observations, patient exam and any
changes to treatment plan on the incident form. Put note
in progress notes. If patient dies, write Death Note,
contact the attending and unit director.
112
Electroconvulsive Therapy
113
Remember
o No metal or jewelry on body
o Bite block face up
o Apply gel
Attendings will give you guidance on parameters
for ECT (i.e. settings to be used)
ECT at VA
24 hours before ECT, (1) verify with PACU that
ECT is on their schedule for tomorrow (generally
AM; you can generally book sessions in
advance, say, MON, WED, FRI mornings for 2
weeks) and (2) verify that the following forms are
complete (ask RN where to find these):
o ECT informed consent form
o ECT procedural checklist
The machine is on its own cart, located in the
exam room off B pod
There are instructions taped to the machine
regarding placement of electrodes and changing
the percent energy (again, can discuss with
attending)
The supplies (electrodes, BP cuff, etc.) are
located in drawers in the cart
When ready, with another staff member, say,
nurse or assistant, wheel the cart up with the
patient to the PACU, which is located on 5 West.
ECT at UCSD
The ECT machine belongs to Senior Behavioral
Health (SBH).
Nurse manager at NBMU will help with
scheduling ECT.
If on NBMU, nursing or an assistant will usually
bring ECT machine from SBH to NBMU,
although, depending on staffing issues, you may
need to do it.
114
The supplies (electrodes, BP cuff, etc. ) are
usually in the cart -- there are extra supplies in
the storage room on Senior Behavioral Health
When ready, with another staff member, say,
nurse or assistant, wheel the cart and the patient
nd
to the PACU, which is located on the 2 floor of
main hospital
115
Somewhere in the procedure note include Beck
and Hamilton Score done on admit and prior to
each ECT.
116
UCSD
117
UCSD
SIGN IN
8 am. Attended by the on-call intern/resident, NBMU
interns, NBMU chief, C/L residents, C/L attendings and
medical students.
The on-call person who is signing out reports the
following:
Emergency Department: presents patients still in
the ED. Presents any administrative problems.
Consults: presents new consults on hospitalized
patients seen overnight.
NBMU: presents issues arising on the psychiatric
unit. Include medical and administrative issues.
Telephone calls: presents any calls from outside
patients to the on-call pager.
Admissions: are NOTpresented until rounds unless
there is something that requires emergent attention
like a serious medical issue or a hold.
ROUNDS
Schedule varies based on attending coverage, but
typically formal rounds are Monday/Wednesday/Friday at
9:30. Informal card-flip on Tuesdays. No rounds on
Thursdays. Attended by interns, medical students, chief,
ward attending, social work, nurses, pharmacist and
pharmacy residents.
CHARTING
Nearly all charting is done in the EPIC system.
Within epic, there are pre-made “SmartText” templates
for all notes, just type “psych” into the SmartText
search box. You MUST use these templates for your
notes, do NOT make your own!
If something that you are writing has obvious legal
118
implications (e.g. domestic violence, assault ,etc) be
sure to qualify your statements of accusation with
the source - e.g. <Patient states that he sometimes
'comes home drunk & beats his wife'> or <the pt's
wife says that he 'always comes home & beats her
up'> not <He often beats his wife>.
Avoid incriminating or inflammatory statements.
Remember that the medical record is a document
frequently used in court.
It is unprofessional to squabble and bicker between
services in writing. If you have questions about
another provider regarding decisions, ask in person,
gently. If you disagree even after you've talked it
over, keep it to yourself until supervision.
CALL/NIGHTFLOAT SCHEDULE
Nightfloat covers Sunday-Friday. Night float begins
at 6 PM on all nights except Sunday night when it
begins at 8 PM. Saturday and Sunday shifts are 12
hours beginning at 8 AM and 8 PM.
119
advice other than come to ED or call crisis line. This is
for emergencies only. Keep the calls very brief!
1) Get the name, telephone number and address of the
patient BEFORE you engage in further conversation.
This is so you can send emergency services out if
there is any indication that the person is
DTO/DTS/GD. If patient will not give you this info,
end the conversation.
2) Get a brief description of the reason the person is
calling.
3) Triage the call: a) If the patient is acutely homicidal or
suicidal have one of the nurses call 911 or hang up
and call 911. b) If the patient is appropriate for further
evaluation and cooperative have them go to their
nearest ED; c) If they are non-acute, give county
crisis line 1-800-479-3339).
4) Log the call on the phone call list in ishare.
5) If the call was from a Gifford patient, please leave the
Giffod MD a voicemail letting them know about the
call.
NBMU ADMISSIONS
Call the NBMU charge RN for a “bed hold” – will be
asked patient’s name, DOB, SSN, psych dxs,
medical conditions, whether independent with ADLs,
mobile, etc.
Inform ED resident and RN of plan
ED nurses will give NBMU nurses their report (if
NBMU gets “report” before getting a bedhold,
confusion and agitation ensue).
Security will take patient to unit.
If the patient is admitted voluntarily, make sure they
sign the voluntary form while in the ED.
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RISK LEVEL ASSESSMENT
0 = NONE I = LOW II = MODERATE III = HIGH
No current No current Currently/recently ***Is now actively
suicidal suicidal expressed SI suicidal.
thoughts, thoughts, AND may be May be using self-
Gestures gestures or using non- injurious behavior
or plans plans injurious gestures AND
SUICIDE
Admission labs
HIV screen on all patients. Only verbal consent is
needed. Order this as default on all admissions.
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CBC with diff, checking for infection or anemia which
can look like many psychiatric disorders.
CMP includes LFTs, Mg, Phos. Order ammonia if
suspect delirium – VPA can elevate ammonia without
affecting LFTs.
TSH – if abnormal can mimic any psych DO & can be
interfered with by Lithium.
Fasting lipid panel – Required for anyone admitted to
NBMU. Especially important for anyone on a
neuroleptic or mood stabilizer considering the SEs of
those meds.
Hemoglobin A1C for all new admissions to screen for
diabetes.
Urine pregnancy test (UPT) – for any female with
child-bearing potential.
UA – Very helpful in elderly and anyone who is GD
UTox – always
Baseline EKG
Consider Viral Hep panel, RPR, B12, folate
Drug levels for lithium, Depakote, some TCAs.
Please check at the appropriate time, but before
administration of the med!
Consider prealbumin if suspicion for malnutrition
exists (can help build in the case for GD during
hearings).
Paperwork for chart
- Have pt sign med consent for psychotropic
medications. Need to use specific medication names.
- Voluntary patients – Voluntary Form
- 5150 - original and copy of advisement
- If patient is on a permanent conservatorship, copies of
the conservatorship paperwork must be placed in the
chart before legal status can reflect this. Until then,
patient must officially be put on a 5150. Conservator
must sign the med consent form, sign special permission
form for admission. Conservatorized patients cannot be
voluntary (a legal status) even if they are amenable to
hospitalization.
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Medication administration times:
BID is given at 6:30AM and 9PM.
QHS is given at 9 PM.
Q12h is spaced literally 12h apart (important for
some antibiotic dosing); usually 9 am and 9 pm. If
you order a medication Q12h at 4AM, the computer
will instruct staff to administer at 4 AM and 4 PM,
which is not good for the patient or staff.
PRNs always require an Indication and a “Not to
Exceed” specification. Please make sure there are
no duplicate medications, such as more than one
PRN for anxiety.
Progress Notes
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"Progress Note." In the smart text box type "psych" for a
progress note template.
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B. Page 2: REQUIRED ORDER SET: "IP Gen
Discharge Patient." Patients absolutely
CANNOT BE DISCHARGED without completing
this order set.
B. page 3: Prescribe any new medications that
patient did not receive as an inpatient or place
consults for outpatient medical follow up.
C. Page 4: "Review and Sign" all orders area.
You MUST SELECT A PHARMACY (UCSD
discharge pharmacy or otherwise) before your
orders will be accepted.
6. Select "Discharge Instructions" in left list of buttons. In
the smart text box type "psych" and select "Psychiatry
Discharge Instructions." Fill in all required fields. You can
use the yellow arrows, which will guide you through the
required smart text fields.
7. Discharge summary: Start a new note, add “Discharge
Summaries” in Note Type field and select the Psychiatry
template from the yellow list.
UNPLANNED DISCHARGES
Crisis houses
Crisis houses are a good option for the patient who may
not need to be in a locked psych hospital, but is at a
certain level of distress where going back home or
waiting for an outpatient appointment is not a good idea.
Crisis houses have nursing staff to provide meds and
counselors to provide counseling and groups. A
psychiatrist (often UCSD/VA faculty/fellows) visits a few
times per week. The facilities are not locked, are not just
for shelter, but are essentially non-locked hospitals in the
community. The patient can stay for up to 2 weeks at a
crisis house. Typically, the patients are required to stay in
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the house for the first few days. After that time period
they can leave.
Should the pt go to a crisis house?
They must be able to contract for safety to go to a
crisis house.
Alert the ED MD and RN
Fill out Transfer form from ishare and give to the ED
HUSC.
Medi-Cal patients have additional beds held in
reserve for them, only available through Optum
Health. You or the HUSC need to call Optum to
reserve a bed.
If you don’t think the pt really needs a crisis house
bed immediately, then you can give them the list and
tell them to call the crisis houses on their own.
Sometimes all a patient needs is the prospect of
resources being available to them in the near future
to tide them over until they get actual help.
Do they just need a place to stay? Give them a list
of shelters.
Should the pt go to detox? Only if they are not
actively suicidal/homicidal or GD. Send to VOA.
Does the pt need a Librium taper? See EtOH w/d
section. The ER MD can give a Librium taper Rx, but
the bag must be sealed or the pt will not be accepted
at detox.
If you are sending a pt home, then make sure they
know where to go for follow-up or future
emergencies- i.e. CMH if they don’t have insurance.
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Outpatient follow-up from UCSD
If the pt has private insurance refer them to UCSD
Outpatient Psychiatric Services in am, referral line (619)
543-7946. If the pt has Medi-Cal or is unfunded, give the
list of providers in their zip code from iShare. Patients
can present to the walk-in clinics designated for their zip
code. Homeless patients go to the Jane Westin clinic
downtown.
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7) Examples of psychiatric conditions sufficiently acute
for SBH:
a. active expression or preoccupation with suicidal
thoughts
b. feelings, thinking or behaving in such a way as to
endanger the person, his reputation or resources
(e.g. psychosis preventing eating or good
hygiene; financial abuse; upsetting hallucinations
or delusions)
c. combative, aggressive or self-destructive
behavior, presumably due to a mental illness
(including dementia)
d. persistent incapacitating psychiatric
symptomatology of such severity as to interfere
with patient’s normal and usual activities and/or
not responsive to outpatient, partial
hospitalization or other less intensive and less
costly therapeutic interventions (constant crying,
excessive anxiety in the context of pain and/or
prescription drug misuse; dementia related
psychosis)
e. symptoms or behavior of such severity that
temporary removal from the living situation
appears advisable for the patient’s welfare, (i.e.
inability to maintain nutrition; driving while
demented; dangerous wandering – out into traffic,
not redirectable; not sleeping)
Administrative Criteria:
1) The patient must have insurance that will pay for his
or her care at UCSD or must be willing to pay out-of-
pocket for care. A number of seniors in San Diego
County have signed over their Medicare benefits to an
HMO. In these instances, the patients must receive
inpatient psychiatric care according to the
requirements of the HMO insurance contract which
the patient signed. For example, patients who have
insurance with Kaiser Permanente must receive
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inpatient care at Sharp Mesa Vista Psychiatric
Hospital.
2) The SBH inpatient unit is required by state law to
maintain a certain nurse to patient ratio. If SBH does
not have enough nurses on-duty, then SBH can not
admit patients.
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d. If the night float resident is not certain what
disposition may be best for a patient, then the
resident should contact the SBH attending to obtain
assistance with making this determination.
3) When accepted, the patient is DISCHARGED from the
medicine service and admitted to SBH with nursing
report, etc.
Contact Information:
Dr. Daniel Sewell, Medical Director 619-543-3779
Debbie Crutchfield, Nurse Manager 619-471-0600,
pgr 9655
Sarah Beiber, Social Worker 619-543-3253
7E Unit 619-543-7505
CONSULTS
Data sources to review before seeing the patient:
- Requesting physician (summary of case and question
being asked)
- Nurses and other staff
- Chart
- Old records
- Miscellaneous: family, friends (only after consent
obtained from patient)
Clarify the question asked
Form hypotheses about reason for referral
Note interaction between patient and staff
Note patient’s problems dealing with the illness
Consult Note
Follow template in Epic
Recommendations
- Medical: Medications or further medical tests or
treatments recommended.
- Psychological: pharmacotherapy +/-
psychotherapy
- Behavioral: Specific behavioral treatments, or
recommendations to staff to use specific
behaviors.
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- Social: Day care, home nursing, decreased
visiting hours. Pictures from home, increased
sunlight, bring hobbies to hospital.
- Address whether a patient needs to be on a hold
- Address whether the patient need a sitter or
camera.
- Record risk level for suicide (“A comprehensive
suicide risk assessment was performed and the
patient is deemed…”), AWOL/ wander and
assault.
FU plan- will the pt be seen the next day and do you
have any outpatient recommendations?
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-Patients on a 5150 must be seen and have a note
written every day, including the weekends. This needs to
be passed along to the residents on call over the
weekend. If a 5150 is expiring, the resident must see the
patient and decide if a 5250 is needed. The paperwork
must be given to the social worker for that floor of the
hospital to be faxed to the court.
Competency
At times we are consulted to determine a patient’s
“competency”. “Competency” can only be decided by a
judge. We can merely give an opinion as to whether the
person is informed of procedure, risks, benefits, &
alternative and what we think about their decision making
capacity:
Are they making a rational decision (not just the one you
think they should make)? Do they understand (and can
explain) procedure, risk, benefits, and alternatives and is
their decision impaired by mental illness including
psychosis, affective states, have decisional capacity.
Any MD can determine decision-making capacity, not just
psychiatry. In today’s litigious society, however, it might
reassure the other service (who is requesting the consult)
to have a second opinion and documentation in the chart.
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considered medical restraints not behavioral/ psychiatric
restraints.
DIALYSIS CENTER
Occassionally you will receive pages to the 5050 pager
requesting that you come to see a patient in the Dialysis
Center, which is located inside the UCSD Hillcrest
Hospital, but technically is part of outpatient services. If
the patient is an OUTPATIENT and his treating physician
feels he/she needs emergency psychiatric care, please
tell them to send the patient to the emergency room for
evaluation. Explain that our C&L service is not
allowed/does not see outpatients.
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VA
137
2 SOUTH
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Important Contacts
VA Main Number: 858-552-8585 (you can dial your
extention at any time)
Nursing Station: 3005
VA Resident On Call: The VA On call phone is 858-642-
6353 or x6353 from any VA phone. The pass code to
check voice mail is 1111.
VA Police
Dial x3333 for an emergency (or to call a code) or 858-
552-7596 for non-emergencies. These are federal police
officers with guns. They are very helpful in Codes, in
helping you get unruly patients to cooperate, and, when
needed, to escort patients out of the UCC. If you get a
feeling that a patient may be dangerous, only interview
them once the police are present, or AT LEAST other 2S
staff. They can attend hearings on the ward, accompany
you when you give a patient hold paperwork, etc.
San Diego Police: non-emergency number (used for
welfare checks): 619-531-2000. You cannot dial 911
from the VA. That is the CODE LINE.
Main station
Ward clerk and legal expert: Jim is usually the daytime
ward clerk and Judy Tellez is the day time legal expert
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MAOD: ext: 4344. This person is great. He or she helps
you place patients when they don’t need admission, need
transportation somewhere, if you need info from other
hospitals, etc. They sit in an office across from the UCC.
Printer Names:
2-South Main Station: “2S-C”
2-South Main Nursing Station: “Happy”
2-North: Freud and Jung
2-West: Main2W
ED Doc box: UCARE
Teams:
There are 3 teams with 3 different attendings. Team I is
headed by Dr. Lehman, Team II is headed by Dr. Rao,
and Team III is headed by Dr. Printz. Each team has its
own occupational/recreational therapist, its own
pharmacist, its own senior resident, its own junior
residents (typically 2), and its own medical students
(typically 2). There are currently 2 social workers on 2S
(John Borges and Jenny Martinez), split among the 3
teams.
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Meeting Times and Rounding:
Mon Tues Wed Thu Friday
Admissions at the VA
First make sure we have beds/staff can handle the acuity,
etc., by calling the charge nurse at 858-864-2684.
Admission Orders
Nurses appreciate admission orders before the patient
comes to 2-South. This is frequently impossible, do your
best.
Given the above request, you need to know about writing
“delayed orders.” Such orders do not become effective
until the ward clerk enters the patient into the computer. If
you don’t write them as, “delayed”, they get erased when
the ward clerk enters the pt into the computer.
Hit the “Write Delayed Orders” button at the upper left of
the screen. It asks when you would like them to become
active. Highlight, “admit to ward.” That way, when the pt
is actually admitted to the ward by the clerk, they begin
being valid and don’t get erased.
Now you can write the rest of the admission order set.
There is a special pre-formatted order set for Psychiatry
(2-South) and another pre-formatted set for ADTP.
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at level 3, preferably C pod, to be eligible for hospital
group meetings, such as ADTP.
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ensure they get adequate recognition in the
chart and appropriate follow up.
3. Suicide Behavior Report: Patients who have
made ANY suicidal gestures (this can be as
benign as walking over to a bridge where they
have thought of jumping, or buying a rope, etc)
need a suicide behavior report note in CPRS.
4. Safety Plan: For suicidal patients, a Safety Plan
must be created prior to discharge; this is
usually done by nursing staff prior to discharge.
5. Follow-up Appointments: A patient who is
flagged as High Risk for suicide will need 4
appointments within 30 days post discharge.
An face-to-face appointment needs to be within
2 weeks. A phone call or “Aftercare
Appointments” can serve as other
appointments. Patients who are not at high risk
for suicide need a face-to-face follow-up
appointment within 7 days of discharge or 2
weeks with a phone call within the first 7 days.
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receiving a patient from the on-call resident), renew the
medications for each of your patients so that the meds
are reviewed by you and then are officially under your
name.
Encounter Info:
BEFORE WRITING NOTE:
1. Click on location (box at top of CPRS to the right
of patient name)
2. Click “New Visit”
3. Type:
a. LJ 2S PSYCH INPATIENT-X for notes
on 2S patients
b. LJ 2N PSY EMERG CONSULT
CLINIC for ED consults
c. LJ PSYCH CONSULT SERVICE-X for
floor consults
d. LJ 2W SARRTP PSYCH IND for 2W
notes
4. Click “Ok”
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6. Under “Visit Type” tab – Make sure boxes are
checked YES OR NO if SC or MST
7. Under “Diagnoses” tab – Make sure diagnosis
is selected
8. Under “Procedures” tab – Type relevant CPT
code (see below)
9. A menu will pop up on the right – scroll down
and select “service by VA resident”
10. Click Ok
11. Enter signature code
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ADTP consults: For patients who needs ADTP consults,
place a formal consult. Order CXR (if not done within the
past 3 months), PPD, and make sure screening labs are
done which include Chemistries, CBC, LFTs, TSH, RPR,
and Hepatitis Panel. You will need to write 2 text orders:
"Patient can leave unit with escort for CXR" and "Patient
can leave unit with escort for ADTP groups."
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7) During work hours (8-5 pm, Monday through Friday),
the attending on record is the PEC Attending.
Overnight, the attending of record is the on-call
attending. Thusly the patient MUST be staffed with
the backup attending if you are admitting to 1W
8) In the morning after the patient is seen in the ED,
and there is still no available bed, the ED SW will
reassess the patient and coordinate with the PEC
attending regarding the patient's most recent
assessment and determine whether the patient still
requires admission.
9) Until the patient's transfer has been decided, the
patient will be under the care of the Psychiatry
Service in 1W and any medical issues will have to be
referred to the Medicine consult service.
2. DEFINITIONS:
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c. Gravely Disabled - a patient is considered to be
gravely disabled when he/she lacks the physical
and/or mental capability to provide basic survival
needs for himself/herself. These basic survival
needs include, but are not limited to, the ability
to:
3. RESPONSIBILITIES:
a. The ED triage nurse will perform the initial
suicide/homicide or gravely disabled screening
for all patients who present to the Emergency
Department.
b. The ED Social Worker (present 8AM-11PM, 7
days/week) will be responsible for the initial
evaluation of the patient within 20 minutes of
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presentation to the ED. The Social Worker is
responsible for completing a Comprehensive
Suicide Risk Assessment as part of this initial
evaluation.
c. The ED physician will medically evaluate all the
patients and provide a medical clearance for the
patient. The ED physician will make the final
decision on the need to consult the on call
psychiatrist.
d. Any provider who is a certified 5150 designee
may place a patient on a 5150 hold for Danger
to Self, Danger to Others, or Grave Disability.
(The ED social worker usually has the ability to
place holds in the ED).
e. The on-call psychiatrist is responsible for
performing a psychiatric evaluation of patients
when consulted by the ED attending.
f. The ED charge nurse will be responsible for
notifying the Clinical Services Director (CSD) or
designee (or the Nursing Supervisor during non-
business hours) when additional staffing
resources are needed to provide 1:1
supervision.
g. An ED RN will be appointed to serve as the
primary RN for the patient and as a resource to
the sitter for care issues and guidance.
h. The sitter is responsible for monitoring the
patient's safety and immediately summoning
assistance from the ED care team if the patient
exhibits any behaviors that compromise or have
the potential for compromising the patient's or
other individual's safety. These behaviors can
include, but are not limited to: unauthorized
attempts by the patient to leave, verbal threats
of violence by the patient directed toward others
or himself/herself, and/or actual attempts by the
patient to harm himself/herself or others. The
sitter can summon immediate assistance from
VA Police by pressing one of the multiple "panic
buttons” just inside the ED or asking for
150
assistance in calling a Code Green or Code
Yellow.
4. PROCEDURES:
a. All patients who present to the ED will be
screened by the triage RN for homicidal or
suicidal ideation or gravely disabled. The
patients' answers will be recorded in the
electronic ED triage note.
b. Any patient who presents to the ED with a
primary diagnosis or complaint of an emotional
or behavioral disorder and is found to be gravely
disabled, a threat to others, and/or a threat to
themselves or who answers positively to the
suicide screen:
(1) Will have immediate safety needs
addressed.
(2) The ED triage nurse will notify the ED
charge nurse of resource needs for special
1:1 supervision and the patient will be
placed in a room as soon as possible.
(3) The Triage nurse will have face-to-face
hand off communication with the primary
ED nurse assigned to the patient.
(4) If necessary, the triage nurse will ask a
5150 designee to place the patient on a
5150 hold and obtain from a physician an
electronic order for 1:1 supervision..
(5) The triage nurse will notify VASDHS police
x3333 to request assistance as needed.
(6) The triage nurse will initiate an ESI Level 2
(high priority patient) and notify the ED
Social Worker between 0800-2300 and the
ED Attending.
(7) The triage nurse will initiate mental health
protocols for medical screening
(8) The ED social worker or psychiatrist on call
will administer a Comprehensive Suicide
Risk Assessment.
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c. If a patient from a VASDHS Medical Center
ambulatory care area (including the Psychiatric
Emergency Clinic) is suspected to be (1) gravely
disabled; (2) a threat to others, and/or (3) a
threat to himself/herself, the patient will be
transferred to the ED for further evaluation. The
ambulatory care area provider must contact the
ED physician and nursing staff regarding the
imminent transfer of the patient. The patient will
be escorted to the ED by staff, and the staff will
utilize Situation, Background, Assessment, and
Response or Recommendation (SBAR) hand-off
communication. The ED nursing staff will triage
the patient as an ESI Category 2 with high
priority assigning the patient to an Emergency
Department room. The staff that escorts the
patient to the ED from clinic will need to stay
with the patient until the patient is placed in an
ED treatment room with a sitter. The patient will
then be evaluated as described above.
d. A patient who either verbally expresses intent or
physically exhibits behaviors harmful to
himself/herself or others will be asked by the ED
RN if he/she has any items that can be used as
weapons. If any such items are surrendered,
the VA police will be immediately called to take
custody of the items.
e. All patients on 1:1 supervision will be placed in a
gown in the treatment room and separated from
their belongings, including medications. If the
patient refuses to put on a gown for
examination, the VA police and the on duty
psychiatrist will be notified for further action
appropriate to the situation. The treatment room
will not be in an isolated area. It will be free of
equipment that could be used as a weapon.
f. The ED attending will elicit a medical history and
examine the patient, and review lab data
obtained from the mental health protocol for
medical screening. The ED attending will
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provide any necessary medical care to the
patient.
g. The on-call psychiatrist is responsible for
performing a psychiatric evaluation of these
patients. The on call psychiatrist will develop an
initial treatment plan and document the plan in
the CPRS progress notes. The psychiatrist will
communicate and coordinate this plan with the
ED charge nurse and ED attending physician.
The plan will include detailed interventions to
maintain the safety of the patient. If this
includes continued supervision/observation by a
sitter, the psychiatrist will write an electronic
order for supervision/observation. The plan will
include interventions should the patient become
agitated.
h. In order for a patient to be placed on 1:1
supervision, the patient must meet at least one
of the following criteria: gravely disabled, threat
to others, and/or threat to himself/herself. 1:1
supervision is appropriate for both patients who
seek voluntary treatment or those on a 5150
hold.
i. Patients who exhibit high or imminent risk
despite treatment interventions will be offered
voluntary admission to the psychiatric inpatient
unit or will be detained involuntarily on a 5150
hold. If there are no available beds within the
VASDHS Medical Center, the patient will be
expeditiously transferred to an appropriate
qualified VA or community hospital.
j. Patients who present with suicidal ideation,
which resolves, will develop a safety plan with
the ED Social Worker or the on call Psychiatrist.
The Safety Plan will be given to the patient and
will include information about the National
Suicide Hotline. When appropriate, any
physician can discontinue the observation
status.
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k. If at any time the patient displays increasing
anxiety or agitation, the RN should refer to the
individual distress treatment protocol designed
for the patient. This may include use of
medications, manipulation of the physical
environment to provide a calming effect for the
patient, and/or requesting a police presence to
de-escalate the patient. If necessary, restraints
may be used with a physician's order.
l. If a voluntary patient who is under 1:1
supervision attempts to leave, the ED RN or
physician should call a Code Green or Code
Yellow.
m. If an involuntary patient (on a 5150 hold) who is
under 1:1 supervision attempts to leave, the ED
RN or physician should call a Code Yellow.
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out. It is not OK to interrupt them if they are in
with a patient so that you may sign out.
4. You must sign out anything that the resident
must follow up on that evening, and any
concerns or other issues that the overnight
person should be made aware of (ie what to use
as prn in case of agitation or pain, allergies or
adverse reactions to medications)
5. In the morning, the resident designated to come
in at 8 am will need to get signout from the
overnight resident. It is expected that when 2S
and ADTP residents come in in the morning, that
they find the 8 am resident and pick up their
signout to see if anything has happened
overnight.
6. The overnight resident is tasked with both
leaving a note in CPRS and making a notation
on the signout if there is an issue with a patient.
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discontinue old outpatient medications the patient is
no longer using.
Make follow-up appointments for the patient to be
seen within 1 week of d/c. There are several options
to ensure patients are seen within 1 week. Under the
orders tab in CPRS, click on “discharge time (for
planning)”. You will then enter the anticipated
discharge date and time. You can enter your
preferred discharge plans in the next screen.
The clerk will ensure the patient will need to be seen
in after care clinic or group for a follow up appt within
7 days of discharge. If a patient is flagged in CPRS
as “high suicide risk” they will need to have 4
appointments scheduled within the month after their
discharge. The ward clerk will schedule these
appointments once you place the order but double-
check as some ward clerks are more responsive
than others.
Also make sure to place “Discharge Instructions”
which the nurses will go over with patient
Let your patient know that standard discharge time is
10 AM, not 5 AM or 5 PM. This is helpful for the
nurses as any earlier discharge time will be the
responsibility of the P.M. shift. Special arrangements
can be made if you communicate with nursing staff
first.
Social Workers should be kept up to date on
discharge planning. When you know the planned
discharge date (ie patient is likely to d/c on Friday for
instance, not necessarily the anticipated discharge
date initially enterned in CPRS), you can alert the
SWs by putting them as a cosigner on the note. If
placement is going to be difficult (ex. aggressive
patient with dementia) get social work involved very
early.
Transfers to SARRTP must be done as a
DISCHARGE from 2S (including your discharge
summary); they will be readmitted to SARRTP by the
2W resident. Discharge patients from 2S at 7:30am if
they are going to be transferred to SARRTP. This will
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give the patient time to check into ADTP at the ED
window. If a patient is “transferred” from ADTP to 2S,
they will need admission orders to 2S and an H&P.
Discharge summaries should be completed within 24
hours of discharge and must be completed prior to
leaving the service. If you discharge a patient over
the weekend, you must either complete the
discharge summary yourself, or identify the person
who should be responsible for the discharge
summary and alert them.
Day to Day:
Progress Notes: Patient's need daily notes for
the first 5 days of admission, or if they are on a
hold. If a patient has been in the hospital >5
days, and is not on a hold, notes need to be
written every other day.
All notes need Encounter Information as
described in the admissions process above.
Discharge planning orders should be made as
soon as possible and updated at each treatment
team meeting.
Presentations: Ideally the average patient
presentation should take no more than 5
minutes, pithy, concise and not overly inclusive.
Reading the H+P to the attending is the least
useful way of presenting, both from the
perspective of efficiency as well as learning
good presentation skills and modeling them for
medical students. Presentations do not need to
be overly inclusive. Occasionally a utilization
review manager will be in rounds to discuss
whether the patient meets acuity definitions for
admission. DO NOT TAKE HER QUESTIONS
PERSONALLY. Just give an honest opinion
about how acute the patient is.
Working with Medical Students: Spend time
observing their skills interviewing patients and
review their notes. Also, help prepare them for
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rounds by prepping them on questions attending
may ask.
Staying Safe:
o When doing physical exams, you must
have a staff member present to
observe.
o Residents are most likely to get
attacked when placing a hold. Error on
the side of having police present when
you are placing a hold.
o During a Code Green situation, stay out
of the way of the code green team.
Although you may want to try to calm
the patient yourself, once the code is
called, you must let the team leader
lead the process.
o
Clinics/VA Resources:
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Further information specific to the ADTP rotation is
given to residents by the ADTP chief at the start of
rotation.
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medicine: in this case the medicine admitting pager
(7173) can be contacted.
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and nurse practitioner, Christine Geniza, and residents
see the detox patients. Detox patients are frequently
asked to come to UCC over the weekend for one day
supply of benzodiazepines, to check their vitals, and to
ensure that they are not still using & are engaging in
recovery. Residents see the patients on the weekends,
you will be flagged to the Friday Detox note, so as to
know who to expect.
SAMI: Substance Abusing Mentally Ill: Located on 2-
North. Many of the VA patients can benefit from this
clinic. This is for patients with dual diagnoses. SAMI
provides additional CBT therapy as well as substance
treatment.
MOOD: 2-North, ext 3391. Many different mental health
providers see patients through the MOOD clinic. Patients
with mood disorders should be directed here.
Mental Health Clinic (MHC): Mission Valley generic
psychiatry outpatient clinic.
Mental Health Intensive Case Management (MHICM):
Intensive Case management, 2S D pod. Reserved for
patients with high recidivism rates.
Cognitive Disorders Clinic: 2-North, ext 3391 Patients
with illnesses in the psychotic spectrum (schizophrenia)
see providers in this clinic.
STEP (“Special Treatment and Evaluation Program”):
This is primarily a research clinic for Bipolar Disorder, but
they also serve as a normal treatment clinic. Patients
with bipolar disorder and unipolar depression can go
here. Pts get SCID dx and some group CBT exposure.
Located on 2-West.
PCT: PTSD clinic. This is only for combat-related PTSD.
They have groups and individual providers.
Other kinds of PTSD do not have a special clinic, and are
treated along with the patient’s other mental health
needs.
OEF/OIF: Operation Enduring Freedom (Afghan)/
Operation Iraqi Freedom. Groups, individual therapy and
meds.
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CBT: Cognitive Behavioral Therapy: Mainly groups and a
few individual providers (long wait list).
DBT: Dialectical Behavioral Therapy. Group and
individual.
WAVE: vocational rehabilitation. Very important, get the
vets back to work! They also have “healthy living”
educational and exercise classes that can be helpful.
Anxiety Disorder Clinic: Med mgt at MV (Murray Stein)
but La Jolla has meds and therapy (Emmanuel Espejo).
MST (Military Sexual Trauma): Run by Carrie Rodgers at
MV- individual and group therapy. Pts can get meds in
other clinics.
Behavioral Medicine Clinic: CBT for medical conditions
(diabetes, pain, htn, etc.) and CBT for anxiety disorders.
Smoking Cessation Clinic: bupropion, nicotine
replacement and therapy. All nicotine patch prescriptions
must be coordinated through this clinic, since vets are not
supposed to get them without going through the
educational component.
Computer Hints
Tracking Medications: There are 2 different ways to
check it on CPRS. You can right click on individual
medications under the “meds” tab and see the
"administration history" or when the specific med is
given. Or you can look under the “Reports” tab, then
under, “BCMA Med Admin Log”.
Scheduled meds are viewed at the top, PRN meds are
next. Next to each administration time for a single letter
indicating: G: given R: refused H: held
If you want the reasons for medication refusal
documented in CPRS by nurses you can write a text
order requesting the nursing staff to document reason for
refusal. Do this if you are planning on RIESEing the pt.
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they expired, just highlight the expired meds, right click,
and click, “copy to new order.”
VA-on-call
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PEC residents are responsible for all patients signed into
PEC during PEC operational hours. The agreement is
that the on-call resident will only handle after-hours
patients that are signed into the ED.
Schedule:
Night float (PGY2s) Sunday- Friday, 6PM-8AM. Except
Sunday start at 8PM.
Weekend days (PGY2s) 8AM-8PM Saturday/Sunday.
Saturday nights: PGY-4s cover 8PM until 8AM.
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st
in their 1 five days of admission, pts on 5150’s, and pts
on 5250’s. The back-up attending will write notes on the
remaining pts.
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Double check that the patient is actually a psychiatric
patient and not acting crazy because they are delirious or
have some other medical problem! Make sure they are
medically cleared by you, as well as by the ER doctor.
This happens, so be careful!
Completing a Consult:
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o An ED attending will need to submit a CPRS consult
to psychiatry prior to a psychiatrist evaluating a
patient in the ED. The consult is titled "Psychiatry -
Emergency Department." The ED attending must
document that the patient has been medically
evaluated and the ED attending should comment on
any medical condition that could be influencing the
patient's presentation to the ED. In the event of an
actual psychiatric emergency the patient must be
gowned and have all personal belongings removed
from their person.
o The psychiatrist completing the consult will need to
click Encounter->New Visit->. LJ 2N PSY
Emergency Clinic. Kassab’s name will show up
on top panel where 2South usually is
o Click “New note”->The progress note title will be
PSYCH<CONSULT/PSYCH/GEN>. Then highlight
psych consult listed below co-signers name
which will link your note to the consult (if nothing
is there, tell ED attending to place consult
because you cannot attach a note to the consult
without a consult order by the ED attending)
o After writing the note the psychiatrist will go to File,
then Review/Sign Changes.
o The Encounter Form will be completed. Skip Visit
Type… no need to put anything under Visit Type.
Under Diagnosis either click appropriate diagnosis
or enter another one using menu at left or "Other
Diagnosis." Then go to Procedures at the top and
click one of the following initial ED consult Encounter
Codes: 99243 (simple patient), 99244 (medium
patient), or 99245 (complex patient).
o Sign the note. Your backup attending is the cosigner.
o If you follow up the same patient during the same ED
visit, coding is as follows: 99213: 15 min visit; 99214:
25 min visit; 99215 40 min visit.
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Where the patients come from: Patients usually self-
present via the public transit system. Thus, if you are not
going to admit them try to get them out before the bus
stops running at midnight. Patients also frequently come
from CMH or other outside hospitals by ambulance.
Generally, only VA attendings do direct admissions.
Often, the MAOD will call you first, letting you know that a
hospital needs to transfer a vet to us. If the unit is full you
can deny the transfer. In fact, you can deny any transfer
that you feel is not warranted (not medically stable, not
fully assessed, not warranting psychiatric admission, etc).
If you accept a transfer, you could have them go through
ER before getting admitted to 2-South if you feel that their
medical issues could be concerning. This is smart
because you can medically clear them and make sure
they actually need to be hospitalized.
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four digits of the social security number, the diagnosis,
if they are on a hold, and if they need help with ADLs.
Escort: 2 people must escort the patient. The doctor and
a nurse who is PART-trained (able to handle an
assaultive patient in the elevator) will take the patient
upstairs in a wheelchair. If you think the patient is
potentially dangerous, have the police come too. If you
are very busy in the UCC you may ask a nurse and a
police officer to escort the patient.
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Codes
To call a code Green or Yellow Dial 3333.
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important to have the floor nurse available and aware that
they need to act quickly.
Meds: Given the acuity of the situation it is helpful to only
request meds that can be obtained quickly. On other
floors and in the ER this generally means you are
restricted to haloperidol, lorazepam, and
diphenhydramine. But, the patient may be on other
antipsychotic meds or benzos that will be available for
your use in the floor’s PYXIS.
Holds:
Psych holds: Generally before a patient can be
restrained, they need to be placed on a hold for either
DTS, DTO, or GD. If you place someone on a hold on a
medical floor or anywhere else in the hospital you must
notify the Psych 2S legal coordinator: Lewana Betts. On
the weekend leave her a phone message. You must fill
out the paper work, do the advisement, and place an
order in CPRS. The originals go to the 2S main office,
and copies go in the chart on the floor. (Except original
5150 advisement goes to patient!, copy goes to 2S, and
copy goes in floor chart.)
If the patient is on a hold in the ED, they must have a
one-to-one sitter.
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Tandem Call Checklist
172
The following list summarizes the oncall experience to be done
together during PGY1 year call with a senior resident. It is
provided here so to be reviewed and referred to. Actual
checklist should be done while on call with the senior resident.
Sign out
o Receive 5050 pager and get floor/ED signout
o Review following components of signout: seen,
staffed, not staffed
o Learn to access and edit patient lists in EPIC
o Learn to udate Handoff in EPIC.
o Review relevant f/u issues during overnight call
On-call contact information
o Attending, senior resident, MS3
Hospital locations
o NBMU – 2 doors to NBMU, nurses’ station, utility
room, call room
o Main hospital – how to get to NBMU, hosp floor
codes, ED, cafeteria
Phone numbers – see this guide
ED consults
o Response to page – get relevant info for consult
o Gather information from Epic, WebCharts
o Interview patient
o Develop disposition – refer to algorithm in ishare
o Presention to attending over phone
o Determine appropriate status level of patient
o Reassess “old” patients in ED
o Dealing with 24hr unfunded ED pt requiring
admission
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Hospital consults
o Respond to page from floor, doing consult on
floor, determine appropriate/inappropriate
consults, locate paper charts on floors
o Perform consult, writing consult note,
communicate w/ primary team
Disposition algorithm
o Review different possible dispositions and know
how to execute each one
Forms
o Learn to find (nurses’ station and/or ishare) and
to do the following: hold paperwork (5150, 5250,
vol), med consent, templates (H&P, consult),
disposition (CMH, crisis house, outside psych
hosp)
NBMU admissions
o Insurance status, alerting appropriate staff,
admit orders, forms completion, additions to
signouts
Conclusion of overnight call
o f/u of pending studies/orders, edit sign out
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Suicide/ Adverse Event
Protocol
175
Suicide/Adverse Event Protocol:
This protocol was created to ensure that residents get
proper support in situations where their patient has had a
completed suicide, attempted suicide or serious adverse
event. As a junior resident, please follow the following
checklists. These are divided based on the site you are
at. If you are at the hospital, like WW or VA, you would
use the hospital checklist. If you are at Gifford clinic or an
outpatient clinic, you would use the outpatient checklist.
The checklist and protocol can be found on I-share.
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MISC
179
PAGERS/PHONES/COMPUTERS
Pagers
Only 619-290-xxxx and a few of the VA pagers (i.e. the
call pager) take text pages. The 858-347-xxxx VA pagers
usually do not.
Phones
Hillcrest:
to dial local numbers (619 or 858):
o dial 8 then phone number
o if you need to use the keypad at all during
your call you need to activate it by pressing
9
after you’ve dialed the phone number &
before you enter an extension or page
someone to the number you are at.
to dial long distance:
o dial 0 tell operator this is “Dr. ------ from
(input service you are on at the time)” and
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I would like to dial out.
o you’ll get a dial tone, no need to dial 8
o still need to press 9 to activate keypad as
stated above
o The first three digits to a UCSD Hillcrest
number is 543-xxxx
VA in La Jolla:
dial 9 to dial out can proceed to dial locally or long
distance
U Computers
Beeper Etiquette
Turn mode to vibrate when you are in meetings.
Use the * button to separate parts of your call-back
number. When you do this, the number appears
with dashes where ever you placed a *. So if you
are putting an area code before the number, use
the star 858*552*8585 (appears as 858-552-8585).
Put the extension where you are followed by * and
your pager number, in case the person you are
paging can’t answer you right now. They will have
your pager number and page you as soon as they
can.
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Don't page to a page number, unless you don't
mind implying to whomever you are paging that
your time is more valuable than theirs.
When using voice pagers always remember that
others around the pager can hear the message.
Never use the name of the pt or discuss a problem
on a voice pager. Your name, extension & level of
urgency is all that is needed. For example 'Leslie
paging Dr. Smith, please call extension X, when you
get a chance' (or 'as soon as possible', or 'now' for
reasonably urgent matters).
If you are paging on an emergency issue, it is
acceptable to put *911 after your extension to
indicate importance.
182
IDS/PASSWORDS/DOOR CODES
Provider # (PID):
License #:
National Provider ID (NPI):
DEA #:
Computers:
UCSD
EPIC:
User ID:
Password:
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Computers, cont’d:
VA
Network login: vhasdc_________
st
usually 1 five letters of last name
st
and 1 letter of first name
Password (changes often):
CPRS:
Access:
Verify (changes often):
ESC:
Password:
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Door Codes
UCSD
ER: 035* ER supply rm 25#
NBMU: 6 digit employee ID # + UCSD ID
SBH: 8631
th th
CCU (10 fl): 619* MICU (9 fl): 1234
nd th
SICU (2 fl): 642 BURN ICU (5 fl): 543
nd nd
PACU (2 fl): 7788 L&D (2 fl): 8710*
nd
Main OR (2 fl): pick up phone
House-staff lounge/gym (WW): 4512
House-staff lounge(next to cafeteria) 142 enter
Urgent Care 413*
VA
Mercy
ER: 019
Endoscopy 760
Chest Pain Center: 19
IntermediateCU: 323
SICU: 0234
MICU: 234
th
5 fl copier room: 235
th
8 fl supply room: 521
nd
Intern call room (2 fl): needs a key from MedEd
185
Important Addresses:
VA Medical Center
3350 La Jolla Village Drive
Dept. of Psychiatry – 116A
San Diego, CA 92161
858-552-8585
858-534-4040 (RTO)
186
CAPS
6535 Alvarado Road
San Diego, CA 92120
(619) 229-3700
Children’s Hospital
3020 Children’s Way
San Diego, CA 92123
(858) 576-1700
187
PHONE DIRECTORY
Residency Training Office at the VAMC
(858) 534-4040 fax: (858) 822-0231
UCSD
Many extensions can be dialed from an outside line:
(619) 54X-XXXX (with Xs representing extension #s)
UCSD Labs
(619) 543-9600
chem 3-6020
heme 3-5950
tox 3-5780
EKG 3-6399
EEG 3-5760
radiology file room 3-6586
Thornton 858-657-7000
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VA
Main number (858) - 552- 8585
(automated menu)
To reach an extension, press 4, 4-digit ext., “#”
To reach operator, press 0
To call an extension directly from o/s hosp:
(858) 642-xxxx
VA pagers all start with (858) 347-
Online phone directory: start…7 with lightning bolt
On call phone 858-642-6353
2S Charge RN 858-864- 2684
Psych consult 858-230-2080
2S pharmacist 3490
Pager-days 347-1414
Pager-nights 347-1408
Pager-outpatient 347-2060
Susan Leckband 5537 Pgr 347-1917
190
Dr. Lehman 3674 Pgr (619) 290-4706
Dr. Rao 1270 Pgr 347-1218
Dr. Printz 3045
Dr. Robinson 3409 Pgr 347-1559
Dr. Groban Pgr 347-0117
home (858) 755-0099
cell (858) 245-2323
Dr. Banta 3418 cell (619) 296-8419
Dr. Flood 3844 Pgr 347-1968
cell (415) 794-9070
2N OP clinics 3391/3665
PEC, Mood, Cognitive, ADTP
SAMI 7300
Frank Garcia 3771
2W STEP 3724
Gerri Smith 1196
2E Geropsych 3046
Psych /PC Clinic 3983
Kathy Lyttle pgr 347-1782
Maureen Grone 3800 pgr 347-1661
Main Psych Office 3576
191
Notary Public 3474
Labs
Phlebotomy 2380
Lab Processing 7707
Add on labs 3426 or 7707
Chemistry 7751
Microbiology 3367
Heme 3420
EEG 3306, 3688
Lab corp (619) 295-9327
Information Technology
IT help desk 4767 (contracted o/s hospital)
Jesse Christmas (remote access): 6200
Andy Mosley (CPRS guru): 1034
Mercy
Main number (619) 294-8111
Med Ed (619) 260-7200 or 7220
th
X floor (619) 260-72X0
th
e.g. 5 floor is (619) 260-7250
th
11 floor (619) 260-7211
Med records (619) 260-7190
ER fax (619) 260-7369
Mercy Clinic (619) 260-7087
Mercy Clinic PCC nurse’s desk (3rd fl) (619) 260-7110
Intern call pager: none (will use your own pager)
nd
Intern 2 call pager: (619) 290-6866
nd
Resident 2 call pager: (619) 290-6875
MD line (619) 686-3900 or ext 4111
Pharmacies
UCSD DC (619) 543-3279
Thornton (858) 657-8610
UPAS (619) 297-1677
Hillcrest (619) 260-1010
Priority (619) 688-2222
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Most Useful Numbers and Codes
San Diego Crisis Line (24hr/7day) (888)724-7240
193
VA Numbers
Dr. Lehman 3674 or p: 619-290-4706
Dr. Rao 1270 or p: 858-347-1218
Dr. Printz 3045 or p:
2S Clerk 3005
2W Clerk 3011
Pharmacy 3490 or p: 858-347-1414
Admission Nurse c: 858-864-2684
PEC Resident x3649
194
NOTES
195
NOTES
196
NOTES
197