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Bulk Density and CCI of Paracetamol

This document describes an experiment to determine the bulk density, tapped density, and Carr's consolidation index of paracetamol powder. The bulk density, tapped density, and Carr's index were calculated according to standard formulas. The bulk density was found to be 0.69 ± 0.02 g/ml, tapped density was 0.99 ± 0.075 g/ml, and Carr's index was 30.3%, indicating the paracetamol powder has poor flowability.

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AKHIL PADHA
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205 views3 pages

Bulk Density and CCI of Paracetamol

This document describes an experiment to determine the bulk density, tapped density, and Carr's consolidation index of paracetamol powder. The bulk density, tapped density, and Carr's index were calculated according to standard formulas. The bulk density was found to be 0.69 ± 0.02 g/ml, tapped density was 0.99 ± 0.075 g/ml, and Carr's index was 30.3%, indicating the paracetamol powder has poor flowability.

Uploaded by

AKHIL PADHA
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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INDUSTRIAL PHARMACY PRACTICAL

Akhil Padha
BPH/10001/19
August 18, 2021

EXPERIMENT NO.: 02
Aim
: To perform the bulk density, tapped density and calculate the carr’s con-
solidation index ( % CCI) of paracetamol.

Reference:
1. Martin’s physical pharmacy and pharmaceutical sciences, Physical Chem-
ical and Biopharmaceuticals principles in the Pharmaceutical Sciences 6th
edition; page no.: 461 and 463.
2. The theory and practice of industrial Pharmacy by Lachmen and Lieber-
menn Page number 183 to 184.

APPARATUS AND CHEMICALS


Tap Density tester, Drug sample, graduated cylinder, spatula.

THEORY
1) Bulk density : The mass of a powder divided by the bulk volume. The
bulk density of a powder depends primarily on particle size, distribution,
particle shape and the tendency of the particle to adhere to one another.
2) True density : It is the density of the material itself exclusion of the voids

1
and intra- particle pores larger than the molecular or atomic dimension in
the crystal lattice.
3) Carr’s Consolidation Index: It is the indication of the compressibility of
the powder. It is named after the scientist Reph I Carr Jr. It is frequently
used in the pharmaceutical as an indication of the flow ability of powder.

%compressibility = PtP−P
t
o
× 100
where, Pt = T apdensity
Po = Bulkdensity.

Carr’s consolidation index


Percentage Compressibility Flowability
5-15 Excellent
12-16 Good
18-21 Fair
23-35 Poor
33-38 very poor
less than 40 very very poor

PROCEDURE
a) Bulk Density : 1) Pre-seived 40 mesh drug was poured in graduated
cylinder via a large funnel.
2) The weight and volume of drug was measured.
3) The bulk density was determined by using the given formula.
Bulkmass
Bulkdensity = BulkV olume

B) For Tapped Density : 1) The measuring cylinder was placed in mechanical


tapper.
2) It was tapped 100 times.
3) Again volume was noted using the given formula:
T apdensitymass
T appedDensity = T apvolume

2
0.1 Calculations
A) For Bulk density

Mass of Drug (gm) Volume(ml) Bulk Density Bulk Density ±standarddeviation


70 100 0.7 0.7 ±0.02
60 90 0.67 0.67 ±0.02
70 100 0.7 0.7 ±0.02
- Mean=0.69 -

B) For Tapped density

Mass of Drug (gm) Volume(ml) Tapped Density Tapped Density ±Standarddeviation


70 70 1 1 ±0.075
60 65 0.92 0.92 ±0.075
70 65 1.067 1.06 ±0.075
- - Mean= 0.99 -

Result
1)BulkDensity = 0.69 ± 0.02
2)T appeddensity = 0.99 ± 0.075

0.1.1 Carr’s Consolidation Index


T appedDensity−BulkDensity
= T appedDensity
= 0.99-0.69 0.99×100
= 30.3 %
Therefore CCI = 30.3 %

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