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Contact Dermatitis Concept Map

This document summarizes the pathophysiology and clinical manifestations of contact dermatitis. It has two phases: the sensitization phase where haptens penetrate the skin and activate immune cells, and the elicitation phase where re-exposure causes a type 4 hypersensitivity reaction. Clinical features include itchiness, rash, vesicles, plaques, and scaling in exposed areas. Treatment involves antihistamines and corticosteroids.

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Alexeve Tabal
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420 views1 page

Contact Dermatitis Concept Map

This document summarizes the pathophysiology and clinical manifestations of contact dermatitis. It has two phases: the sensitization phase where haptens penetrate the skin and activate immune cells, and the elicitation phase where re-exposure causes a type 4 hypersensitivity reaction. Clinical features include itchiness, rash, vesicles, plaques, and scaling in exposed areas. Treatment involves antihistamines and corticosteroids.

Uploaded by

Alexeve Tabal
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Contact Dermatitis

Predisposing Precipitating factrs:


factors: Irritants LEGEND:
Age Allergies
Gender Occupation BROWN: Pathopysiology
GREEN: Clinical
manifestations
Sensitization Phase BLUE: Medication/treatment
(Haptens penetrates the epidermis and activate YELLOW: Laboratory Result
Langerhans cells which travel to regional lymph
nodes and activate naive T cells)

Elicitation Phase
(re-exposure to offending haptens leads to type
Patch test (weak
4 hypersensitivity reaction. Sensitized T-cells
positive)
circulate in blood and arrive at skin sites where
antigen is present)

Fever
Increase mast cells, eosinophils (6%), CD4 + / Mast cells release
(only in severe
CDB + T-cells, and inflammatory cytokines leukotrienes
ACD)

Dilation of local Stimulation of local


CD8 + T-cells cause keratinocyte apotisis
microvasculature nociceptors

Itchiness (rash) Spongiosis Burning Pruritus

Erythematous
Antihistamine Papule Vesicle plaque 9x11 on by
lateral inner thighs

Corticosteriods Chronic findings

Scaling Lichenification Excoriation

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