Philadelphia University
Faculty of Pharmacy
Department of Clinical Sciences
Course Syllabus
Course title: toxicology Course code: 0510534
Course prerequisite (s) and/or corequisite (s):
Course level: 4th year
Pharmacology 2 (0510335)
Credit hours: 3 hours
Lecture time: 8:15-9:45, 9:45-11:15
, 9-10 Contact hours: 8-9. 10-11 SUN, TUS, THU
MON,WES:11-12, 2-3
Location: pharmacy faculty
Academic Staff Specifics
Office
Name Rank Office Number and Location E-mail Address
Hours
Pharmacy college, office
Ms Noor Batarseh lecturer 10-11 nbatarseh@[Link]
number 527
Course module description:
This course focuses on aspects of toxicology. Students will receive basic background
information about important areas in toxicology, which includes the principles of toxicology,
Dose- response relationships and mechanisms of toxic action.
Discuss the appropriate detoxification methods for general toxicology, the toxicological effect
of heavy metals, products like pesticides and household and different groups of medications
and compounds on human health, and commonly types of antidotes and their mechanism of
action.
Course module objectives:
At the end of this course, the student will:
1. Have basic, full knowledge about human health toxicology
2. Understand the pharmacokinetics of toxins
3. Know the appropriate general detoxification method for certain group of chemical agents
4. Know different sources of toxicants and their mechanism of toxicity
5. Be familiar with clinical presentations and the differential lab and physical examinations of
different toxicants
Course/ module components
Text book:
1. Toxicology: the basic science of poisons, casarett and doulls, 8 ed, 2013, ISBN:
978-0071769235
Clinical toxicology, principles and mechanisms, 2 ed , Frank A. Barile,2010, ISBN:
2. 978-1420092257
Teaching methods:
Classes will be held three times a week. The content of this course will be presented in a variety
of different formats:
Lectures three times a week;
Applied case studies and discussion in class.
Learning outcomes:
At the end of this module, students will be able to:
1. Understand the basic principles of toxicokinetics and toxicodynamics
2. Provide knowledge of the commonly encountered toxicants
3. Have knowledge of different types of toxicants (household/industrial, medical, and drugs of
abuse) and their mechanism of toxicity
4. Provide knowledge of the most commonly encountered antidotes, their mechanisms of actions,
routes of administration
5. Apply the knowledge obtained from this course to evaluating exposure and solving problems
associated with toxicants.
Assessment instruments
Quizzes.
Home works
Final examination: 40 marks
Allocation of Marks
Assessment Instruments Mark
First examination 20 marks
Second examination 20 marks
Final examination: 50 marks 40 marks
Research projects, Quizzes, Home works 20
Total 100 marks
Documentation and academic honesty
It is expected that all students help to maintain an environment of academic honesty. The following
behaviors are strictly forbidden during the administration of the exam: talking, wearing of hats with bills,
checking, sending, and answering of cell phone message including text messages and passing of papers or
notes. Students must keep their eyes on their own paper. All students are required to hand-in the packet
of test questions with their name and 6-digit student ID number clearly indicated on each page of the
exam.
Course/module academic calendar
Basic and support material to be covered Homework/
week Quizzes
dates
(1) Principles of Toxicology
(2) Pharmacokinetics and pharmacodynamics of toxicants
(3) Pharmacokinetics and pharmacodynamics of toxicants
(4) General approaches to the management poisoned patients Quiz 1
(5) General approaches to the management poisoned patients
First exam
(6) Pesticides toxicology Quiz2
(7) Household toxicology
(8) Heavy metals toxicology ( lead, mercury, cyanide, iron,
cadmium, arsenic, and copper)
(9) Heavy metals toxicology ( lead, mercury, cyanide, iron, Quiz 3
cadmium, arsenic, and copper)
(10) Drugs toxicology: (analgesics)Acetaminophen, Salicylates, Home work
and NSAID deadline
Second exam
(11) Drugs toxicology: Antihistamines, Digoxin toxicity , TCA
(12) Drugs of abuse: (Opioids) Quiz 4
(13) Sympathomimetics toxicology : (Nicotine, Xanthine,
Pseudoephedrine)
(14) Common antidotes
(15) Final examination
Expected workload:
On average students need to spend 3 hours of study and preparation for each 50-minute lecture/tutorial.
Attendance policy:
Absence from lectures and/or tutorials shall not exceed 15%. Students who exceed the 15% limit without a
medical or emergency excuse acceptable to and approved by the Dean of the relevant college/faculty shall
not be allowed to take the final examination and shall receive a mark of zero for the course. If the excuse
is approved by the Dean, the student shall be considered to have withdrawn from the course.
Module references
Books
Students will be expected to give the same attention to these references as given to the Module
textbook.
1. Casarett & Doull’s: Essentials of Toxicology, 2nd Ed. 2010 by Curtis Klaassen and John Watkins III
(ISBN: 978-0071622400)
Journals and Websites
1. American College of Toxicology, [Link]/
2. International journal of toxicology, [Link]/
