Exam Questions, Hematology 169 INTRODUCTORY QUESTIONS ‘The role of éosinophils is: a. Tomake antibodies b._ To mediate hemostasis je c... To secrete the contents oftheir granules Vol. Lp. 245 To present antigens to immunoresponsive cells | See p. 224 Plasma differs from serum in that it contains: a Albumin b,. Globulin ¢.) Factor VIL je 4 Cholesterol Vol. I, p- 255 ‘Which of the following proteins is not present in . the serum? a Albumin Fibrinogen je & Gamma globulin Vol. I, p. 255 Normal serum contains platelets. T, F) iF Vol. I, p. 255 Bopha wz os stimulated by: b Neamaogebul ns like IgE. > ©. Viruses like HIV Vol. 1, p. 245 d. Bacteria [See p. 224 Basopil related wo another el ype: ‘Neutrophils ‘ ‘Macrophages Sa up.24s Lymphocytes Lp. 4. Mast cella Seep. 224 ‘Normal blood is bacteriologically sterile. T, F T ‘The 0.85% solution of sodium chloride is known as: a. Zenker’s fluid b. Bouin's fluid . Wright's buffer a Normal saline Vol. 1, p. 338 ‘An increase in eosinophils is seen in: a. Dermatologic disease b. Helminthic infections ¢, Collagen vascular disease id d.Allof the above Vol. I, p. 245170 Exam Questions, Hematology 10. 12, 13, 4 15. 16. 17, 18, ‘Which of the following achromatic objectives ‘would be an oil immersion objective? a NA.065 b NA OIZ ¢ NA 125 4 NA.030 How long does the monocyte circulate in the peripheral blood before becoming a tissue macrophage?| a. 1-3 hours b. 12 e. 3-72hours ‘Which ofthe following tests would not be included in ‘aroutine CBC? ‘Differential leukocyte count b. , Total erythrocyte count ¢. Reticulocyte count 4, Total leukocyte count Of the priera white blood cel, which ae the most efficient at phagocytosis? Neutrophils Monocytes ©. Lymphocytes 4. Eosinophils ‘A blood pressure cuff is needed to carry out the following tes) 1a.) Ivy's bleeding test b. Duke's bleeding c. Coomb’s test d. Lee & White clotting time In what ways are Kupffer cells, osteoclasts, alveolar macrophages and Langerhans cells similar? a ‘are derived from endothelial cells b. They are all forms of tissue macrophages €. They all secrete immunoglobulin antibodies Accurate platelet counts can be obtained on capillary blood. T, ‘The "LE cell" phenomenon is a useful test in clinical practice. T, F ‘An alternate test for the disease systemic lupus ‘erythematosis isto see if there are antinuclear antibodies in the patient's serum. T, F ec See p. 224 ab a Vol. I, p. 338 F Vol. I, p. 252 E See p. 224 T Vol. I, p. 337 19, 20. a. 2. 2. 6. 21. Exam Questions, Hematology 171 Blood smears prepared from whole blood which has stood for a few hours are just as satisfactory for dif- ferential counting as blood smears prepared from fresh blood, provided the specimen was kept in the reftig- ‘erator and that it was thoroughly mixed just before the smears were made. T, F ‘The tourniquet should not be released until after the needle is out of the vein. T, F F ‘The ESR testis a measure of inflammation and is dependent in parton plasma: a. Fibrinogen Sodium a © Prothrombin Vol. I, p.210 d. Protein See p. 224 Patignts who have the lupus anticoagulant are in danger| F of bleeding. T.F Seep. 224 Which of the following tests does not require the preparation of a blood smear? a” Ratculocys count b ‘cells 4. Thrombin time od Plasma volume can only be determined by using a dye |F (such as Evans blue) which forms a bond with piasma | Vol. p. 196, protein, T, F 320 See p. 224 A21 gauge needle has a bore with a wider diameter than either a 19 or a 20 gauge needle. T, F 1% HCI may be used as red cell diluting fluid. T,F | F ‘A newly described syndrome called the *Anti-Phos- pholipid Syndrome” consists of hypercoagulability, thrombocytopenia, and fetal wastage. Abnormal blood findings include: ‘a. A positive test for anti-cardiol b. A positive test for fibrinogen . A positive test for the "Lupus Anticoagulant” d._A positive test for anti F. V. antibody ac172 Bxam Questions, Hematology 28. 30. 31. 32. 35. Which of the following substances is not employed as a blood anticoagulant? a EDTA b. Sodium oxalate c. Heparin 4. Thromboplastin © Sodium citrate ‘The anticoagulant (0.5 ml. per each 4.5 ml blood) required forthe prothrombin time tests: a b, Ammonium and potassium oxalate mixture ¢. Defibrinated serum d. EDTA 3.8% sodium citrate s ‘The first polychrome stain was discovered by: a. Ehrlich .. Romanowsky cc. Wright 4. Giemsa e. Gram Methylene blue is: a. Anacid stain ‘Wright's stain contains eosin and: a. Basic fuchin b. Gentian violet c. Brilliant cresyl blue 4. Methylene blue Indicate pH range of buffer solution employed in connection with Wright's stain: I i t aPTT. T,F 4 Vol. I, p. 255 e Vol. I, p. 267 a See p. 224 37. 38. al. 42. 43. 45. 41. Exam Questions, Hematology 173 ‘When the plasma from a patient with the lupas anti- oseteed in eqeal pce wih wore plana the aPTT corrects to normal, T, F ‘The presence of the anti-cardiolipin antibody is detected in the aPTT. T, F ‘When Wright's stain is used, of smear is not required. T, liminary fixation ‘Which ofthe following blood stains is not used {for differential leukocyte counts? a. Wright's stain b. Brilliant cresyl blue c. Giemsa stain 4. May-Griinwald ‘Which of the following blood stains is used to demonstrate reticulocytes? a. Giemsa b. Wright ¢. Brilliant cresyl blue 4. May-Grunwald 1% brilliant cresyl blue is the only stain that ‘can be used for reticulocyte staining. T, F Redculocytes can be stained after tho cll a fxed Heinz bodies can be seen on Wright stained blood smears. T, F Heinz bodies can be seen on wet preparations Stained with methyl viole. Te ‘The cells of the granulocytic series, except the myeloblast, are peroxidase-positive. T, F ‘Monocytes contain specific esterases by which they can be identified. , F Wright's stain is an excellent stain for bone marrow smears. T, F fF See p. 224 IF [See p. 224174 Exam Questions, Hematology 48. Bone marrow smears usually require a longer staining ‘time than smears of peripheral blood. T, 49. In testing for F. V. Leiden one determines that normal activated Protein C does not cause a lengthening of the APTT. T,F NORMAL VALUES: 50. The diameter of a normal erythrocyte measures approximately: a. 3.0microns b. 4.5 microns ¢. 75 microns d. 10.0 microns 51. Normoblasts are frequently found in normal peripheral adult blood.T, F 52, The normal volume of the blood in males is approximately: a. liters S liters c. 7 liters d. 9 iters 53, Normal values for total volume are usually expressed ‘as ml. of blood/kilogram of body weight. T, F 54," For every 500 red cells a normal adult person has approximately the following number of white cells: a. I white cell b. 3 white cells ©. 10white cells d. 6 white cells 55. Forevery white cell there is approximately the following number of platelets 9 platelets 30 platelets 500 platelets 1,000 platelets 2/500 platelets b, e a e 56. For every $00 red cells a normal adult person has approximately the following number of platelets: iT Vol. i, p. 201 F See p. 224 b Vol. 1, p. 322 iT Vol. 1, p. 322 58. 61. 63. Exam Questions, Hematology 175 a 12platelets b. 30platelets ©. 100 platelets d. 7Splatelets b One hundred ml of normal adult male blood contains approximately the following amount of plasma: a. (20-30% G -: Vol. I, p. 196, d. 65-69% 320, 322 ‘The normal range of prothrombin concentration is: a 3030% b. 30-40% ©. 40-60% d. 60% or more ‘The normal range of bleeding time using Duke's method (ear lobe puncture) is: a 46 minutes b. 3-7 minutes c. 48 minutes 4. 5-10 minutes ‘The average platelet has a diameter of: a. 0.5-1.0 micron b. 1.0-1.5 microns ¢. 20-40 microns d. 5.0-7.0 microns a ‘Vol. 1, p. 255, 339) a Vol. I, p. 210, 260 ic Vol. Ip. 251 ‘A monocyte measures approximate a. 7.5 microns b. 15.0 microns ©. 20microns d. 32.0 microns © Vol. I, p. 245 ‘A segmented granulocyte measures approximately: a. 7.5 microns b. 10.0 microns fc. 15.0imicrons ie d. 20.0 microns ‘Vol. I, p. 243, In normal differential white cell count you would expect find the following percentage of lymphocytes a. bv. 26% ©. 20-35% ¢ d. 55-75% Vol. I, p. 247176 Exam Questions, Hematology 64. 67. ‘The normal number of neutraphils per cu. mim. is: a. 1,000-2,000 b. 1,500-2,500 c. 1,800-6,000 4. 5,000-10,000 ‘A patient is considered to be neutropenic if his il count is below: a ‘eu mm b. 3500.cu mm cc. 1800cu mm ‘A patient is lymphopenic if his absolute lymphocyte ‘count is below: a. 2500cu mm b. 1800.cumm ¢. 1200.¢umm ‘At what percentage of stab cells in the differentiated ‘white count would you expect that the patient might have an infection? a 13 b. 36 c. 1015 In a normal differential white cell count you would ‘expect to find the following percentage of segmented neutrophils: a. 10-20% b. 20-40% c. 40-60% 4 60-80% Ina normal differential white cell count you would expect to find the following percentage of band ("stab")} cells: a 0% b. 26% c. 20-35% d 55-75% Ina normal differential white cell count you would. expec ta find the following percentage ‘of eosinophils: a 12! b. 36% 68% d. 812% le Vol. 1, p- 243 le Vol. 1, p. 247, 338) c Vol. I, p. 247, 338 je Vol. I, p. 247 le Vol. I, p. 247 b Vol.1, p. 247 Vol. Lp. 248, 336 n. n. B. ". 18. 6. 71. B. Exam Questions, Hematology 177 In a normal differential white cell count you would expect to find the fellowing percentage of basophils: a b. 26% 812% d. 10-16% In a normal differential white cell count you would ‘expect to find the following percentage of monocytes: a 10-15% b. 20-30% ©. 28% d 812% In a normal differential white cell count you would expect to ind the following percentage of myelocytes: a b. 2% c 3% a 5% ‘The normal range of total white cell count (WBC) is: a. 5,000-8,000/cu mm b. 8,000-10,000/cu mm ¢. 4,000-10,000/cu mm 4. 8,000-12,000/cu mm ‘The normal range of circulating eosinophils is: 2 0.10percumm ‘cu mm ©. 50-300 per eu mm 4. 1500-2000 per cu mm peal platelet count using Rees-Ecker diluting is: ‘50,000-150,000 per cu mm b. 100,000-200,000 per cu mm ‘¢. 250,000-350,000 per cu mm 4. '350,000-500,000 per cu mm 5 : cacao ‘mean platelet volume MPV. T, F Platelet counts are the same in infants and adults. T, F Retraction of a normal clot begins in: a 1-2hours b, 20-24hours le ‘Vol. I, p. 247 Vol. I, p. 246, 36 ce iT Vol. I, p. 210 IT Vol. 1, p. 210178 Exam Questions, Hematology 80. 81. 82. 84. 86. 87. ¢. 6-12 hours 12-18 hours Retraction of a normal clot is complete wi a. 30minutes b. Thour 2-4 hours d. 36-48 hours ‘Two new low molecular weight heparins are now in use in the U.S.A. When given the recommended doses they prolong the aPTT. T, F ‘The normal range of prothrombin time is: a. 1-3 seconds b. 4-8 seconds ©. 10-12 seconds d._ 19-24 seconds ‘The normal adult female values for the ESR using Wintrobe-Landsberg or Westergren method are: a. 0-9 mnvhr b. 0-10 mabe . 020mm/nr , 40-48 mm/hr ‘The normal adult male values for the ESR using ‘Wintrobe-Landsberg or Westergren method are: 0-9 mm/h a b. 5-15 mmv/hr ce. 10-20mm/hr d 15-25 mmv/br Ifthe RBC is $ million/jl and the reticulocyte count is 1%, the absolute reticulocyte count is: eo © Stood ‘The normal absolute reticulocyte count is: a. 25,000 to 75,000/u1 b. 10,000.10 25,000/u1 © 75,000 to 150,000/p1 ‘The normal value for the prothrombin time is indepen- dent ofthe type of commercial thromboplastin used in the test. T, Vol. I, p. 252, 296 c Vol. I, p. 252, 297 e Vol. I, p. 297 b Vol. 1, p. 210 a Vol. I, p. 210 b Vol. p. 210 a Vol. I, p: 204, 210 F Vol. I, p. 297 88, 89. 91 92 93, 94, Exam Questions, Hematology 179 | ‘The normal number of grams of hemoglobin in all adult males is: a 1042 grams% b. 1242 grams% c 1342 grams% dé. 15% grams% Hemolysis of normal erythrocytes in hypotonic salt solution begins at the following sodium chloride concentration: a 48% b. .44% 40% a. 34% Hemolysis of normal erythrocytes in hypotonic salt solution is complete atthe following sodium chleride ‘concentration: a 48% b. 44% ©. 40% 4. 34% ‘The normal range of MCHC is: a. 28-32 micromicrograms b. 32-36% c. 80-94 cu microns d.1,7-25 microns ‘The normal value forthe activated partial thrombo- plastin time is: a. 26-39 sec b. 5-10 sec 40-50 sec 4. 60-90 sec With a normal rate of red cell production in adults the following percentage of circulating r.b.c. are reticulocytes: a. 09.5% b. 05-15% c. 15-20% a 20-40% ‘The normal adult female values for the red cell count (RBC) are: a. 3.5.4.5 millions/cu mm b. 50-60 millions/eu mm 4 Vol. I, 9.209, 228 b Vol. I, p. 238 a Vol. I, p.238- 240 b Vol. I, p20, 21,207 Vol. I, p. 265 b Vol. I, p. 203, © Vol. I, p. 209,180 Exam Questions, Hematology 95. 98. 100. 101. ¢: 43-55 millions/cu mm 221, 235, d. 45-60 millions/eu mm ‘The normal range of erythrocyte count (RBC) in adult males is: a 45-60 millions/ou mm b. 556.5 millions/ou mm ¢. 40-50 millions/eu mm 4. 385.4 millions/ou mm ‘The normal range of PCV in adult males is: a 33-38% Bb. 42% 42 44% to.34% ad 47% 42 ‘The normal range of MCH a. 80-94 cu. microns b. 17-25 microns c 3338% . 28-32 micromicrograms ‘The normal range of MCV is: ‘a. 28-32 micromicrograms b. 80-94 cu microns ©. 3338% ‘The normal number of grams of hemoglobin in an adult female is: a 1042 grams% b. 1242 grams% c. 1442 grams® 4. 1642 grams® Dihle bodies are: - ‘Precipitated hemoglobin in red blood cells from oxidation tS b. Blue inclusions in PMN signifying infection or inflammation cc. Iron granules in red blood cells signifying inef- ectie erythropoiesis Vol. 1, p.244,- 4. Ahallmark of acute lymphoblastic leukemia 340 With a normal rate of red cell production in a newborn infant the following percentage of circulating r-b.c. are : a 05-10% b. 10-20% 7 102, 103. 104. 106. 107. 108, Exam Questions, Hematology 18: ‘normal bone marrow smear you would expect to nd the following numberof reticulocytes: In a normal bone marrow smear you would expect to find the following number of lymphocytes: 05.0% b. 120% © 416.0% d. 18.0% Ina normal bone marrow smear you would expect to find the following number of plasma cells: a 01.0% b. 05.0% © 525.0% d. 08.0% In anormal bone marrow smear you would expect to find the following number of normoblasts: a 05.0% b. 12.0% c 23.5% 10-20% In a normal bone marrow smear you would expect to find the following number of myeloblasts: 02.0% b. $-20.0% «00.5% 6. 020% In anormal bone marrow smear you would expect to find the following number of neutrophilic myelocytes: a 05.0% b. 18.0% ©. 5-20.0% d. 02.0% In anormal bone marrow smear you would expect to find the following number of neutrophilic metamyelocytes 2. 01.0% Yol. I, p. 203, 204 ‘Vol. I, p. 299, 300 a Vol. I, p. 299, 300 ja Vol. I, p. 244, 300 a ‘Vol. I, p. 299, 300 c Vol. I, p. 299, 300182 Exam Questions, Hematology 109. 110. ML 112, 113. b, 20-25 mbkg ce. 25-35 mlhkg. d. 40-50 mV/kg ee ee HEMOCYTOMETRY ‘The total ruled area of the counting chamber covers: a. 1sqmm b. 9sqmm cc. 10sqmm 4. 12sqmm 114 11s. b. 5-10.0% 003% d. 0.40% In anormal bone marrow smear you would expect to find the following number of neutrophilic band (tab) cells: a 020% b. 03.0% 05.0% 15-35% Vol. I, p- 299, 300 Ina normal bone marrow smear you would expect to find the following number of segmented neutrophils: a 0-4.0% b. 0-50 cc. 07.0% d. 7-30.0% ‘The normal mycloid-erythroid ratio in the adult ranges from or ‘0 ‘The normal RBC mass for males is: a 10-20mblkg ‘The counting chamber has the following depth: a. 0.05 mm b. 010mm c. 020mm d 025mm ‘The counting chamber has a depth of 1/10 mm and a total ruled area which measures 3 mm on each side. ‘Therefore, the counting acea of a chamber has a ruled > Vol. I, p. 299, 300 d Vol. I, p. 299 a Vol. I, p. 299, 300 23.1 Voi. 1, p. 231, 299 Vol. I, p. 319, 322 b Vol. I, p. 336 b Vol. I, p. 336 16. 117. 119. 120. 11. 122, 123. 124. 125, 126. mn ee, See area of 9 sqmm, a depth of 0.1 mm and a volume of: a. 09cumm b. 1.0cumm ©. 05cumm a a 15cumm Vol. Ip. 336 Each of the smallest squares of the hemocytometer grating measures: 125. 125sqmm 126. 1/4 sq mm 127, 40sqmm 4 128, 1/400 sq mm Vol. I, p. 336 ‘The dilution range of a white cel pipette is: a. 1:10-1:100 a b a « Vol. I, p. 211 a 212 ‘The normal function of Protein C isto degrade F Prothrombin (FID). T, F Vol. Lp. 257 See p. 224 ‘The role of Protein S is to enhance the action of T Protein C. T,F Vol. I, p. 257 258 ‘The activation of Protein C to activated Protein C (aPC) is mediated by a reaction that takes place on endothelial] T cells. T, F ‘Vol. 1, p. 257 Endothelial cells have a substance on their surfaces |T. called thrombomodulin. T, F Vol. I, p. 258 ‘When thrombomodulin binds to thrombin (Fila), the, |. combination converts Protein C to aProteinC. T,F | Vol. I, p. 258 Once thrombin is bound to thrombomodulin itcan. | F siill clot fibrinogen. T, F See p. 224 ‘Thrombomodulin is the same as thrombospondin, T, F |F See p. 224 Aspirin works as an anti-thrombotic by interfering with | F the clotting of fibrinogen by thrombin (Fla) T,F [Vol 1p, 263 ee p. 224 Platelet-platelet interaction which leads to platelet. =| T aggregation is mediated in part by fibrinogen linking | Vol. I, p. 251, two platelets. T, F 263184 Exam Questions, Hematology 127. 128, 129. 130. 131. 132. 133. 134. ‘When you draw blood to the 1.0 mark of a WBC ree ei lugag fn tothe 11.0 mark youhave the following blood dilution: 10 ‘When you draw blood to the 0.5 mark of a WBC pipette and white cell diluting fluid tothe 11.0 mark, you have the following blood dilution: a 1:10 b. 1:20 ¢ d ‘A drug that interfers with platelet aggregation is: a Ticlopidine . . Coumadin (warfarin) ce. Nifedi It would be expected that Ticlopidine administration ‘would cause prolongation of the bleeding time. T, F HEMOGLOBIN ‘The function of hemoglobin is: a Togive red blod cels.color b. Topick up oxygen in the lungs : OTe pick up oxygen inthe lungs and release it to the tissues 4. Participate in blood clotting ‘The following may have an effect on hemoglobin concentration. Balle, & Sex 3. Disease ‘Small amounts of Hemoglobin Az are present normally Itisc ‘of two pairs of polypeptide chains alpha and delta. T.F ‘The two major globin polypeptide chains alpha (c) and a Vol. 1, p- 211, 212 Vol 1,p2t Vol. I, p.211, 212 a See p. 224 T Vol. I, p. 260 © Vol. I, p. 225, 339 od Voi. I, p. 225, 228 3 Vol. I, p. 228, 233 T beta (B) are usually synthesized in equal amounts. T, F | Vol. I, p. 225, 28 135. 136. 137. 138. 139, 140, 141. 142, 143, 144. 14s. Exam Questions, Hematology 185 In beta thalassemias more B chains are produced than | F chains. T,F ‘Vol. p.229 In alpha thalassemia the synthesis of ot chains less than | T the synthesis of B chains. T, F Vol. p. 229 ‘The manner by which oxygen is picked up in lungs by hemoglobin and released to the tissues is best depicted by the: ‘a. Oxyhemoglobin dissociation curve b. The myoglobin dissociation curve a €. The osmotic fragility curve Vol. I, p39 Patients who smoke a great deal (2 packs/day) may have elevated levels of: a. Oxyhemoglobin 'b. Reduced hemoglobin a ¢. Sulfhemoglobin Vol. I, p27, d. Carboxyhemoglobin 229 Reduced hemoglobin lacks loosely bound oxygen. T, F| T See p. 224 Adult A hemoglobin is cc ised of 2 pairs of poly- | F ae hr ccna ef pee atre E ns, 228 ‘Small amounts of fetal hemoglobin are normally iT present into adult life. T, F Vol. I, p. 228 Fetal hemoglobin is composed of 2 pairs of polypeptide] T chains, alpha and gamma. T, F Vol. I, p. 228 Hemoglobin ‘synthesis in adults occurs in: a Liver b. Bone marrow > c, Lungs Vol. I, p. 225, d. Heart 228 Hemoglobin is synthesized in which of the following cd a. Myeloblasts 'b. . Normoblasts ¢. Monocytes b 4. Erythrocytes Vol. I, p. 225 Bilirubin and urobilinogen are pigments derived from | T hemoglobin. T, F ae Vol. 1, p. 236186 Exam Questions, Hematology 146. 147. 148, 149. 150. 151. 152. 153, 154. 155, Most of the hemoglobin degraded each day appears in the stool in the form of urobilinogen. T, F ‘When the iron in hemoglobin is oxidized to the ferric iT Vol. I, p. 236 F form, the new compound is called ferrohemoglobin and| Vol. I, p. 228, itcan camry oxygen. T, F ‘light variations in the isoelectric points of some of the various human hemoglobins provide the basis for recognition by iontophoresis. T, F In adult life there are substitutes for normal alpha chains. T,F In adult life the two substitutes for normal B chains are alpha and gamma. T, F ‘There are both hereditary and acquired forms of, (Guch as carboxyhemoglobin) wher the hemoglobin picks up oxygen avidly but Teleases it to tissues poorly. ‘The body acts as though: ‘a. There was tissue hypoxia b. There was too much oxygen in the tissues ©. Blood flow was too rapid Drabkin’s solution contains: a, Calcium chloride b. Cyanide cc. Magnesium sulfate 4d. Sulfosalicylic acid “The major classes of fibrinolytic agents in therapeutic use are: ‘2. tPA (Tissue Plasminogen Activator) b. uPA (urine plasminogen activator or urokinase) ¢, Streptokinase 6. Allof the above ‘The copper sulfate method of hemoglobin determinat Pe eet itean be relied upon for standardization of hemoglobinometers T, F ‘The iron content of hemoglobin (method of Wong) is 0.335% iron. Therefore, to obiain grams% hemo- globin, the amount of iron in milligrams% should be divided by: a 0335 338 F Vol. I, p. 229, 230 Vol. I, p- 225, lp. 225, 228 F Vol. I, p. 225, 228 a Vol. I, p. 225, 229 b Vol. I, p- 198 207 4 Vol. I, p. 259, 284-296 F Vol. 1, p. 233, 251 156. 157. 158 159. 160, 161. 162. 163. 164. Exam Questions, Hematology 157 b. 3.335 ce 335 d 3350 ‘There are excellent laboratory tests to monitor the administration of fibrinolytic agents. , F To convert oxygen capacity to grams cf hemoglobin por 100'nf oF Hood you would multiply oxygen capacity by: a 1315 b. 0.746 ©. 0625, a 016 ‘One gram of hemoglobin can carry a. 4m. of oxygen b. 1.3 ml. of oxygen ©. 95% oxygen A patient with a hemoglobin content of 14.5 grams% ‘and an RBC of 5.0 million will have the following ‘MCH value: 10 picograms 7.25 picograms ©. 29 picograms d. 725 picograms Old red blood cells are trapped in the cells of the reticuloendothelial system. T, F T ‘There the iron is removed from the hemoglobin and returned to the peripheral blood where it circulates bound to myglobin. T, F ‘Which of the following indices expresses a relationship between the hemoglobin content and the erythrocyte count? a MCV b. MCH . MCHC Hemoglobin in plasma is usually bound by haptoglobin. T, F ‘The haptoglobin binding capacity for hemoglobin is. Trike Sede of 30 mg% hemoglobin. Ts E b F See p. 224 b Vol. I, p. 229, 339 b Vol. 1, p. 229, 339 c Vol. 1, p. 209, 221 iT Vol. I, p- 235, 236 F Vol. I, p- 235, 236 > Vol. I, p. 235 T Vol. 1, p. 336 F Vol. I, p. 336188 Exam Questions, Hematology 165. 170. m. 172, RED BLOOD CELLS Because the normal erythrocyte is shaped like a biconcave disc itis called a: a. Stomatocyte b. Echinocyte Spherocyte L) Di id Oke, Rauup as When a red cell loses membrane material from any cause, the ratio of surface area: volume: a, Increases > Decreases b c. Stays the same Vol. I, p. 235 i nt denatured globin from te Qxieus —_ Vol. I, p. 231 ic mechanisms that result in formation of a I are increased surface area or decreased cell | Hgb content. 1, F Vol. I, p.235 ‘A nucleated cell resembling a lymphocyte but which ‘has denser nuclear chromatin and an orange-pink tinted cytoplasm would probably be a: a. Normoblast a Vol. I, p. 339 ‘When the ratio of surface area to volume decreases in a| red cell it assumes one of the following shapes: a. Discocyte bs , ©. Sickled & Targetcel™ Vol. 1, p. 235 In the Coulter Counter a measure of variation of RBC |T sizes isthe RDW (Relative Dstnbuton Wid) T,F | Vol 1 p.220, In some of the hemoglobi T bemolysis the hemoglobin Nol: p.230, 173, 174, 175. 176. 177. 178. 179. 180. 181. Exam Questions, Hematology 189 Unstable hemoglobinopathies can be diagnosed by testing for their susceptibility to oxidation and pH. T, F Which are tests for unstable hemoglobinopathies? a. Heinz bodies b. Ascorbate cyanide ©. Thermolability After the marrow normoblast extrudes its nucleus, the ‘cell that remains is a reticulocyte. T, F This reticulocyte normally retains its identity for 4 days; 3 days inthe marrow and 1 day inthe peripheral blood Sickling on the peripheral smear is also seen in which Of the following disorders? a. Sickle B Thalassemia b. Sickle HbyC disease c. Homozygbus Hb C disease d. Hereditary persistence of fetal Hb: In Hb C disease the characteristic RBC finding is: a. Target cells, b. Spurcells ©. Echniocytes 4. Arcanthocytes In the Thalassemia trait disorders, one of these findings is not conrrect.The major RBC findings are: a Bj ia b. Microcytosis c. Target cells 4. Spherocytes €. Basophilic stippling Ifa patient has a Hgb value of 9.2% because of iron deficiency his RBC count will be: a. 6,000,000 2,000,000 ¢. 3,000,000 4. 4,000,000 e. $,000,000 F Vol. I, p.230 231 abe Vol. I, p. 230 231 iT ‘Vol. , p. 235 T Vol. I, p. 235 jab Vol. I, p. 340 a Vol. I, p. 229 a Vol. I, p. 229 c Vol. I, p. 331, 337 Ifa patient basa High value of 9 gm because of B trait his RBC count will be: a 2million b. 3 million190 Exam Questions, Hematology 182. 183. 184, 185, 186. 187. 188. 189. 190. cc. /4million 4. Smillion e. 6 million Reticulocyte counts are used as an index of red cell production. T, F Heinz bodies are caused by: ‘a. Immune attack on the erythrocyte b. Hypotonic conditions ¢. Oxidative attack on erythrocytes d. Lymph node enlargement Reticulocytes may appear larger and polychromatophili ‘on Wright stained smears. T, F Reticulocytes may look like adult erythrocytes in Wright stained blood smears. TF Cabot rings are made of nuclear remnants and ‘chromatin structures, TF ‘When the older erythrocytes from a patient with Hemoglobin C disease are exposed to hypertonic salt solutions, Hgb C crystals appear within the erythrocytes) T TF ‘Which of the following structures is not classified as an erythrocyte inclusion: a. Cabot rings b. Auer’s rods c. Heinz bodies 4. Howell-Jolly bodies Howell-Jolly bodies are: a. Remnants of nuclear material shaped like dots . Remnants of nuclear material shaped like a ring c. Eithera orb 4. Neither a nor b ‘An abnormally thin erythrocyte ("Ieptocyte”) presentin a bull's eye appearance in the stained smear is a: Sickle cell ‘Target cell Burr cell Crenated cell pose 4 Vol. I, p. 229 be Vol. 1, p: 235 e Vol. I, p. 231 a. Vol. I, p. 235, T Vol. I, p. 235 a Vol. I, p- 236, 335 Vol. I, p. 229 a Vor. 1, p: 236, 337 > Vol. I, p.235 191. 192. 193. 194. 195, 196. 197. 198. Exam Questions, Hematology 191 ‘The term schistocyte is used to describe a variation in red blood cell stage. Synonyms include: a. Helmet cells 'b. Microangiopathic red ceils lab ¢. Target cells Vol. I, p.237, 4. Hypochroma 338 When hydroxyurea is usd to treat patients with sickle cell anemia, the MCV fails. T, F Echinocytes are not called: a. Burrcells '. Spiculated red blood cells 4 .Prickle red blood cells ‘Vol. I, p.235, 4. Target cells 236 ‘A test to determine maximum capacity of erythroc} {3 Witsand hypotonic stress bet me ‘a. Osmotic fragility test b. Mechanical fragility test c. Thomtest 4. Rumpel-Leede test ‘When fresh blood is mixed with 0.85% salt solution the a Vol. I, p. 199 id ‘Vol. I, p. 199 In relation to body fluids, the salt solution employed in the osmotic fragility test of erythrocytes may be said to be: ‘a. Isotonic b. Hypotonic cc. Hypertonic Which of the following cells is most resistant to hemolysis by hypotonic salt solution? erythrocyte b Vol. I, p. 199 a. Normal: & S © Pha or leptocyte Curge” cet) ¢ dQ Spurcell Vol, p. 199 st are: BS. Rodets wit pure . ls and e with Red Red projections Red cells with cup shapes having lost half of their |192 Exam Questions, Hematology 199. biconcavity ‘The PCV can be accurately determined only by means of ahematocrit tube. T, F Homocysteine is an essential amino acid found in blood} TF Hyperhomocysteinemia is a hereditary disease. T, F Hyperhomocysteinemia causes a bleeding state. T, F ‘The primary factors measured by sedimentation rate determinations are: 4. Plasma albumin content ». Fibrinogen-globulin concentration ¢. Rouleaux formation 4. Blood specific gravity ‘The longer the column of blood the faster the ESR. T, ‘The presence of sickle cells on the peripheral smear ‘means that the patient has: : ‘2. Sickle cell anemia (homozygous SS disease) b. Sickle cell tait (AS) ©. Bither of the above ‘An increase in temperature will: ‘a. Decrease the ESR b. Increase the ESR cc. Have no effect on the ESR cc. Have no effect on the ESR Elongated cigar shaped erythrocytes are called: a. Target cells b, © hipones ‘The presence of elliptocytes means thatthe patient bas hemolytic anemia. T, F Vol. 1, p. 340 IT Vol. I, p- 336 ae IT See p. 224 IF See p. 224 be Vol. 1, p. 199, 210 T Vol. 1-199, 210 Vol. I, p. 340 jo Vol. 1, p. 199, 210? b Vol. I, p. 199, 210 ic Vol. I, p. 339 F Vol. I, p. 339 210. 2a. 212. 213. 214. 215. 216. 217. 218. Exam Questions, Hematology 193 Basophilic stippling means that there is persistent, ribosomal RNA remaining in young erythrocytes. T, F ‘The percent dilution of the blood in Westergren ‘method is: a 0 b 04 « 10 d 20 ‘The percent dilution of the blood in Wintrobe method is a 0 b 04 ce 10 d. 20 Basophilic stippling in erythrocytes can be seen in: a poisoning Uremia :. Thalassemia trait d. Allof the above ‘A Westergren tube is graduated between: a. 0-18mm b. 050mm ¢. 0-100mm d 0-200mm ‘A Wintrobe tube is graduated between: a 018mm b. 050mm ¢. 0-100mm dé. 0-100mm Erythrocytes that have lost membrane material and become microspherocytic will have increased osmotic fragility. T, F Hb F can also be detected by electrophoresis and radioimmunoassay. T, F ‘The frequency of variants of alpha (a) Thalassemia trait in Black Americans is: a 5% b. 10% e 15% 30% T ‘Vol. 1, p. 303 a Vol. I, p. 199, 210 a Vol. I, p. 199, 210 4 Vol. I, p. 303 a Vol. I, p. 199, 210 ¢ Vol. I, p. 199, 210 T Vol. I, p. 199 Tr Vol. 1, p. 228, 230 a ‘Vol. 1, p. 229194 Exam Questions, Hematology 219. 220. 221. 22. 23. 224. 225. 226. 227. 228 229. ‘Normally four genes control the synthesis of an ct globulin. A deficiency of one gene produces what findings on the blood smear? a. Hypochromic RBC b. Microcytic RBC . Normal RBC d.Spherocytic RBC Fetal hemoglobin is resistant to alkali denaturation and thus can be detected in the Kleinhower-Betke stain. LE In chronic severe iron deficiency the red blood cells will be; a. Macrocytic b. Spherocytie . Elliptocytic d.Hypochromic and microcytic WHITE BLOOD CELLS Lymphoblasts are peroxidase-positive: T, F Lymphocytes are peroxidase-positive. T, F Basophils are peroxidase-negative. TF Monocytes can pass through blood vessel walls and become fixed to tissues. T, F ‘Monocytes contain a variety of esterases which can be used to identify them. T, F Eosinophils are granulocytes. T, F ‘Acute stress or electric shock may cause the white blood cell count to: a. Increase b. Decrease ©. Stay the same In immunophenotyping one uses specific mono- clonal antibodies to detect molecules on the cell surface| je Vol. I, p.229 T Vol. I, p. 228, 230 4 Vol. 1, p. 325 329 F Vol. Ip. 204 , 243 F Vol. I, p. 204, 243 F Vol. 1, p.245 T Vol. I, p. 245 r Vol. I, p. 245 T Vol. I, p. 245 Vol. I, p. 248 T Vol. 1, p. 310, 230. 231. 232. 233. 235. 236. 237. 238. Exam Questions, Hematology 195 of the leukemia cells that are known to indicate the cells lineage. T,F ‘One can also use the technique of immunophenotyping to quantify the number of helper T lymphocytes in @ patient with AIDS. T, F ‘A deficiency of two ofthe fou alpha globin gens produces what findings on the peripheral smear? a. Hypochromia b. Microcytosis ec. Normal RBC dd. Target cells {A deficiency of three alpha globin genes produces severe hemolytic anemia and is known as HF disease. TF Hb His: a 02 Ba barn ©. ard a. bs Monocytes can settle in the tissue to produce the following macrophages: pulmonary alveolar macrophages and hepatic Kupfer cells. T, F ‘The most immature cell in the plasmacytic series is the: a. Plasmacyte b. Plasmablast ¢. Lymphoblast dd. Megakaryoblast ‘The most immature cell in the granulocytic series is thes a. Monocyte b. Myeloc ¢. Myeloblast 4. Monoblast Al granulocytes contain the enzyme: a Li : ©. Pryalin d. Peroxidase All leukocytes are capable of phagocytosis. T, F 31 T Vol. I, p. 310, 311 abd Vol. I, p.229 F Vol. 1, p.229 ja Vol. 1, p.229 fr Vol. I, p.245 b Vol. 1, p. 246 e Vol. 1, p. 243, 246 a Vol. I, p. 243+ 246 F ‘Vol. p. 244194 Exam Questions, Hematology 219. 20. 221, 202. 23. 224, 225. 226. 227. 228. 229. Normally four genes control the synthesis of an a. globulin, A deficiency of one gene produces what findings on the blood smear? Hypochromic RBC Microcytic RBC :. Normal RBC 4. Spherocytic RBC c Vol. I, p. 229 Fetal hemoglobin is resistant to alkali denaturation |T and thus can be detected in the Kleinhower-Betke stain. Vol. I p. 228, TE 230 In chronic severe iron deficiency the red blood cells. b Meco 4 5. Spheroeytic ©. Elliptocytic Vol. 1, p. 325 4. Hypochromic and microcytic 329 WHITE BLOOD CELLS Lymphoblasts are peroxidase-positive: T, F FE aaah Vol. Lp. 204 , 243 Lymphocytes are peroxidase-positive. T, F E me a Vol. I, p. 204, 243 Basophils ae peroxidase-negative. T, F F _] Vo. 1, p.245 Monocytes can pass through blood vessel walls and. | T become fixed to tissues. T, F Vol. I, p. 245 Monocytes contain a variety of esterases which can be |T used to identify them. T, F Vol. I, p. 245 Eosinophils are granulocytes. T, F T Vol. I, p. 245 ‘Acute stress or electric shock may cause the white blood cell count to: a Increase b. Decrease a ©. Stay the same Vol. I, p.248 In immunophenotyping one uses specific mono- T clonal antibodies to detect molecules on the cell surface] Vol. I, p. 310, 230, 231. 232, 233. 234. 235. 236. 237. 238, Exam Questions, Hematology 195 of the leukemia cells that are known to indicate the cells lineage. T,F ‘One can also use the technique of immunophenotyping to quantify the number of helper T lymphocytes in @ patient with AIDS. , F ‘A deficiency of two of the four alpha globin genes ‘produces what findings on the peripheral smear? c. 4. Target cells A deficiency of three alpha globin genes produces severe hemolytic anemia and is known as HOF disease. TF Hb His: a 02 Ba b. a2yp c. andy d. bg Monocytes can setle inthe tissue to produce the following macrophages: pulmonary alveolar ‘macrophages and hepatic Kupfer cells. T, F ‘The most immature cell in the plasmacytic series is the: a. Plasmacyte b. Plasmablast c. Lymphoblast dd. Megakaryoblast ‘The most immature cell in the granulocytic series is the: ‘a. Monocyte b. Myeloc; c. Myeloblast dd. Monoblast All grumloeytes contain the enryme: a. Lipase b. Phosphatase cc. Pryalin d. Peroxidase All leukocytes are capable of phagocytosis. T, F 31 T Vol. I, p. 310, 31 abd Vol. 1, p. 229 F Vol. I, p. 229 a ‘Vol. 1, p. 229 iT ‘Vol. 1, p. 245 b Vol. 1, p. 246 e Vol. I, p. 243, 246 a Vol. I, p. 243+ 246 F Vol. I, p. 244196 Exam Questions, Hematology 239. 241. 242, 243. 245. 247. ‘When someone says that the PMN contains toxic granules it means that there is persistence of the primary azurophil granules from the promyelocyte stage. T. F In patients with AIDS, neutropenia is uncommon. T, F Monocytes are actively phagocytic. T, F Plasma cells can usually be seen in peripheral blood smears. T, F Lymphocytes possess phagocytic properties. T, F ‘The formation of lymphocytes takes place in the fone marow exclusively. GE Which of the following cells is largest and possesses sprawling” nucleus? ‘Small lymphocyte b. Large lymphocyte ©. Neutrophilic segmented cell 4. Monocyte Lymphocytes derived from the thymus or T= lymphocytes: ‘a. Produce antibodies b. Are involved in cell mediated immune responses like tuberculin hypersensitivity ce. Can undergo phagocytosis ‘T-lymphocytes can be further subdivided into which of the following? Helper cells Suppressor cells Natural killer cells, Macrophages Antibody secreting cells ‘The receptor sites on the basophil membrane are for which of the following? a IgD b. IgA c bE iT ‘Vol: I, p. 244 F Vol. I, p.247 338 See p. 224 T Vol. I, p. 244 F Vol. I, p. 246 FE Vol. I, p.245 F Vol. I, p. 245 Vol. I, p. 244 ’ Vol. I, p. 245 abe Vol. I,p. 245 249, 251. 252. 253 254. 255. 256. 257. 258. Exam Questions, Hematology 197 4. IgM Albumin A platelet fanctonal defect is defined as a circumstance) ‘where a patient has a platelet count of over 100,000/mm? and an abnormal template bleeding time. fap B TF ‘Which of the following cells is characterized by a number of bluish-black coarse cytoplasmic granules? a. Monécyte b.-Newrophi Eosinophil a Besoptt ‘Which ofthe following cells is characterized numerous large brilliant red eytoplasmic gram B Neutrophil . Eosinophil 4. Basophil Lymphocytes derived from the bone marrow: a. Can produce antibodies b. Are involved in cell mediated immunity c. Become phagocytes ‘The presence of toxic granulation and Dole bodies suggests thatthe patient has infectious or inflammatory | T disease. T,F Vol. Ip. 244 ‘The segmented cell precedes the band cell. T, F ¢ Vol. I, p. 245 4 Vol. I, p.245 c Vol. I, p. 245 a Vol. I, p. 245 ‘The lupus anticoagulant can be seen with some frequency in patients with AIDS. T, F [See p. 224 ‘The normal adult neutrophil has 4 lobes. TF F Vol. I, p.243 ‘There are at least two functional classes of I ‘They are called: ‘Teells bs Reells c. Beells ac Yells Vol. I, p. 245 Antibody producing lymphocytes can, under SinnanaLd, sade ceded er a. Plasma cells b. Monocytes a198 Exam Questions, Hematology 259. 261. 262, 263. 264. 265. 266. 267. 268. 270. cc. Monoblasts Eosinophils generally have two lobes. T, F Neutrophiis and monocytes can ingest red blood cells coated with specific antibodies. T, F ‘Monocytes are derived from cells that normally grow in the bone marrow. T, F ‘The monoblast is derived from the same precursor cell that gives rise to the myeloblast. T, F Patients with HIV infections have high lymphocyte counts. T, F Fresh frozen plasma is the best treatment for patients ‘who have classical hemophilia (F. VIII def) and are bleeding. T, F ‘The blood cell that is the precursor cell for fixed tissue ‘macrophages is the monocyte, T,F PLATELETS ‘The immediate precursor of the platelet a. Promegakaryocyte b. Megakaryocyte ©. Megakaryoblast ‘A test of platelet function is the prothrombin time. ‘TF Platelets can release ‘Serotonin Epinephrine Norepinephrine Cholesterol ADP Aspirin can bind to platelets, interfere with their normal function, and prolong the bleeding time even though the platelet count remains normal. T, F (On a well stained blood smear of a normal plasma person there should be how many platelets iri each, Vol. 1, p. 245 iT Vol. 1, p. 245 T Vol. I, p. 243, 245 T Vol. 1, p. 244, 245 T Vol. 1, p. 245 FE See p. 224 FE See p. 224 T Vol. 1, p. 245 » Vol.1, p.251 F Vol. I, p.210 abe Vol. I, p. 256 T Vol. I, p. 266 an. 2. 273. 274, 215. 276. am. 278. Exam Questions, Hematology 199 oil immersion (900X) field? BLEEDING AND COAGULATION ‘The role of the platelet De Topo te coagulation is: hemostatic plug at a break. b. Tocontribute platelet lipid required for coagulation in the intrinsic system . Tocontrol clot retraction 4. Allof the above ‘There are two pathways in coagulation. These are call a. The inferior system b. The extrinsic system ¢, The intrinsic system 4. The superior system In the intrinsic system all the coagulant factors are found in circulating blood. T, F In the extrinsic system all the coagulant factors are found in circulating blood. T, F ‘The difference between Factor V and Factor Va is that: a. Factor V has been de 'b. Factor V has been activated ¢, Factor V has been amalgamated d. Factor V has been aggravated ‘The von Willebrand Factor. to circulate in the form of huge complexes. T, ‘The function of von Willebrand Factor is: a. Toconvert Factor X to Factor Xa b. To cause the adhesion of platelets to the wall of damaged vessels To convert Factor IX to Factor [Xa To inhibit thrombin ae a Vol. 1, p. 253, a ‘Vol. I, p. 251 be Vol. I, p. 256, 257 T Vol. I, p. 256, 257 IF Vol. 1, p. 256, 257 b Vol. I, p. 255 iT Vol. I p. 251, 263, 340 ‘Thrombin is also known as: a. Factor la200 Exam Questions, Hematology 279. 280. 281. 282, 283. 284. 285. 286, 287. Factor Ta Factor Ila Factor Va Factor Xa In von Willebrands disease the template bleeding time is: a. Normal b. Short c. Long Factor X, inthe presence of Factor V, Ca++ and platelet snd phospholipid, can catalyze the conversion bf prothrombin (i) into thromboplastin. T, F Blood also contains factors that antagonize coagulation. TF ‘When blood clots the fibrinogen of the plasma becomes converted to: ‘a. Thromboplastin b. Thrombin c. Fibrin d. Prothrombin ‘A test which determines the rate of fibrin formation ‘under a standardized set of conditions is the: a. Bleeding time : b. Partial jastin time ¢. Clot retraction time d._ Thorntest ‘The actions of thrombin are: a. Toconvert fibrinogen to fibrin bi To activate plasminogen to plasmin ¢, Toactivate Factor XII 4. Aggregate and fuse platelets ‘The activity of the plasminogen-plasmip system can be assayed in the: a ‘Whole blood clot lysis time b. The euglobulin clot lysis time ce. TheP&Ptime Quick prothrombin time ‘Aplastic Anemia can be caused by infection with ‘several of the hepatitis viruses. , F Plasmin is a proteolytic enzyme that can lyse fibrin- b Vol. I, p. 266 lc Vol. Ip. 251, 263, 340, F Vol. I, p- 256 iT Vol. I, p. 255 © Vol. 1, p.255. b Vol. I, p. 264 abd Vol. I, p. 255, 266 ab Vol- I, p. 259, 286.292 T Vol. 1, p. 335 T 288. 289. 290. 291. 292. 293. 295. 296. Exam Questions, Hematology 201 ogen and fibrin. T, F Fibrin split products may be detected in the serum by adding materials like ethanol or protamine to serum. to allow fibrin monomers to precipitate out. T, F ‘The longer the prothrombin time the greater the prothrombin concentration. T, F BaSO, or A1(OH); adsorbed plasma contains the following procoaguf&nts: a. Factor VIII b. Factor V ©. Factorl 4d. Factor XI Serum contains all but one of the following. procoagulants: Factor VIL b. Factor IX ©. Factor X . Factor XI ‘Vitamin K is required for the adequate provision of all but one of the following procoagulant factors: a Factor VIL b. Factor VIIT ©. Factor It dd. Factor IX ‘The procoagulant factors: in, Factor IX, Factor X, Factor VIL, and fibrinogen are made in the: a. Pancreas b. Liver ©. Bone marrow d. Ovary ‘The bleeding time is only abnormally protonged i the case of thrombocytopenia. T, F Jn modem transfusion practice screening for HIV has ‘brought the incidence of post-transfusion infection to Tess than 1/200,000. T, F ‘The warfarin/coumadin anticoagulants suppress the activity of which procaogulants? a. Factor Il b. Factor VIE Vol. I, p. 286- 292) lee ‘Vol. 1, p. 286- 292 F ‘Vol. I, p. 267 abcd Vol. 1, p. 255 a Vol. 1, p. 255 b Vol. I, p. 338 b Vol. I, p. 338 F ‘Vol. 1, p. 260 IT202. Exam Questions, Hematology 297. 298. 299. 301. 303. 208. cc, Factor IX a Factor X results of the Prothrombin Time are now usually eed boll in seconds as compared (othe normal Control and as the Internationalized Normalized Ratio. TF ‘The commercial sources of thromboplastin regularly used give strikingly different results for the bin for patients anticoagulated with vitamin K, VF ‘The major crossmatch is being replaced in many blood banks with the type and screen. T, F hemolytic disease of the newborn, maternal ‘dbody against Rh (Ant-D) can eross the placenta and hemolyze Rh + (D+) neonatal RBC. T, F The mechanisms for controlling hemostasis are all except which of the following? ability of endothelial cells to generate in b. le of the protein AT I © The ole of Protein C and Protein S 4. The ability of Factor XII to cross link fibrin ‘The function of AT IIT - antithrombin Il isto: a. Interact with naturally occurring heparins thereby enhancing its action wb. Rancng and deatoying Faso Xa and Factor Ta Attacking and destroying platelets Attacking and iysing Pastor Villa and Factor Va ‘There are different platelet antigen subgroups. T, F f the protein C - Protein S system is 7 Neosalize Factor Villa and Factor Va 'b. Block the platelets release reaction ¢, Interact with naturally occurring heparins ,_ tract wih platelet produced thromboxane Hemorrhagic state ; ¢. A tendency to develop leukemia Occult blood > Elevated lymphocyte count Vol: I, p.247 @. Hematuria Vol. 1, p. 336 317. Ahigh total white cell count is called: 324, The presence of free tiemoglobin in the urine i called: ‘a. Exythrocytosis, a jobinemia b. Leukocytosis ‘ % Soca bood ©, Leukopenia © inuria d._ "Shift to the left” Vol. 1, p. 248 d, Hematuria Vou. 1, p. 336 318. White blood cell formation is also called: 325. When the hemoglobin content of cells is decreased the a. Erythropoiesis central pale area of erythrocytes becomes larger b. Leukemia and paler. This condition is known as: ¢, Leukopoiesis o a. Hypochromia 4. Leukocytosis Vol. I, p- 337 b. Hyperchromia g Anicchromia 7 319. The term "pleocytosis” refers to: |. Normochromia . a. A variation in shape of red cells . eee . An increase in the number of CSF lymphocytes 326. Sickle cells are also called: Erythrocyte basophilia a. Ovalocytes A condition characterized by the presence of | b. Target cells oval-shaped erythrocytes Vol. Ip. 339, ¢. Burrcells a 4. Drepanocytes Vol. I, p. 340 320, When the total number of red cells in the blood ‘ becomes excessive the condition is known as: 327. When basophilic stippling is seen it must be in: a. Leukemia a. Old red blood cells b. Polycythemia b. Young red blood cells b Anemia be ©. Allages of red blood cells - Vol. Ip. 336 Vol. I, p.235, : 336 328. "Schizocytes" are: a. Larger than normal erythrocytes 321. In the case discussed above, if one made the diagnosis ._ Fragments of erythrocytes > before delivery what would one do? ¢. Smaller than normal erythrocytes Vol. 1, p. 236, ‘a. Treat mother with corticosteroids and hope they d. Normal size erythrocytes 336 :206 Exam Questions, Hematology 329. 330, 331. 332 333, 334, 335. 336. 337. 338, ‘The spliting up of a nucteys is known as: a. Mononucleosis b. Karyorthexis ¢, Anisocytosis 4. Polychromatophilia A small red cell is a: Metarubricyte Macrocyte Microcyte Reticulocyte large red cell is a: Poikilocyte Normocyte Macrocyte Microcyte erge> ange If one decided to do in utero transfusions in the case above you would use father’s platelets. T, F ‘The measurement of platelet associated IgG or IgM is critical for the diagnosis of ITP. T, F Polychromatophilia is also called: a. Poikilocytosis b. Polychromasia c. Erythroblastosis dd. Neutrophilia ‘A young woman in the 3rd trimester of her first pregnancy is found to have a platelet count of 89,000. She is otherwise well, you immediately start her on treatment with prednisone. T, F In Idiopathic Aplastic Anemia, the cause seems to be immune attack on marrow progenitor cells. T, F ‘The bone marrow in pernicious anemia is: a. Hypocellular b. Hypercellular c. Normocellular ‘The major defect of Pemnicious anemia that leads to the ‘anemia is: a, Hemolysis in the peripheral blood b. Blood loss c. Ineffective erythropoiesis b Vol. I, p. 337 Vol. I, p. 338 ec Vol. 1, .338 F See p. 225 FE See p. 225 b Vol. I, p. 339 F See p. 225 T See p.225 b Vol. I, p. 337 Vol. I, p. 337 339, 341. 342, 343. 345. 346. 347. 348. Exam Questions, Hematology 207 If one treats Pernicious anemia with vitamin By2 the first thing one gets is: a. Areticulocyte increase b. Platelet increase . Disappearance of hypersegmented neutrophils | 338 (One can use the Schilling test to distinguish between ‘Pemicious anemia and other causes of vitamin B12 ‘malabsorption by: a. Administering "Co, vitamin By> LV. and orally b. Administering "Co-vitamin Bj and "'Co-vitamin ‘Bz complexed to intrinsic factor orll b ¢. Alternatively administering 5"Co-vitamin By, and_| Vol. I, p. 337, 38Co-vitamin By 338 Infection with parvovirus predominantly affects, erythroid precursors in marrow. T, F fa patient who has sickle cell anemia is infected with the parvovirus he/se wil likely have anaplastic crisis. T, T with parvovirus one sees decreased ery giant vacuolated proerythroblasts. T, F (One would treat such a patient with: a. Corticosteorids b. Antibiotics ce. LV.-IgG d. Acyclovir In order to calculate this absolute reticulocyte count youmultiply the RBC count by the reticulocyte percent 5 ks ‘When erythropoietin is given to a patient to increase his hgb or hct, the peripheral smear will frequently show "skip macrocytes’. T, F In the presence of extensive polychromatophilia the reticulocyte count will be: a. Normal Decreased > d. None of the above If the haptoglobin-combining capacity of the plasma for hemoglobin is exceeded, free hemoglobin appears | a Vol. 1, p. 337, iT See p. 225 T Vol. I, p. 345 See p. 225 © See p. 225 iT See p. 225 Vol. 1, p. 339208 Exam Questions, Hematology in the urine in a condition known as hemoglobinuria. TF. 349. Some drugs can produce a blood picture resembling folic acid deficiency- they are: a. Methrotrexate b. Penicillin ¢. Bactrim or Septra 4. Dilantin ‘ABNORMAL HEMATOLOGY Red Cells 350. Which of the following animal parasites cannot be present in a blood smear? a Plasmodium Microfillaria c. osoma a. Schistosoma 351, Pemnicious anemia is caused by a deficiency of: itamin K Vitamin Bis ¢. Vitamin C 4 Vitamin A 352. Another vitamin deficiency that is similar to Pemicious anemia in that it anemia, ‘macrocytic r.b.c., and megaloblasts in the marrow is: a. Folic acid deficiency b. Vitamin D deficiency . Vitamin B deficiency 4. Vitamin K deficiency 353. In anemia due to vitamin By2 deficiency or folic acid deficiency the reticulocyte count is high. T, F 354, Hypochromia is seen in: a. Iron deficiency anemia b. Thalassemia c. The anemia of chronic disease d. Allof the above 355, Heinz bodies occur in .b.c. in which of the following. conditions? a. Drug-induced hemolysis Vol. I, p. 336 acd Vol. I, p. 337, 338 4 Vol. 1, p.248 b Vol. 1, p. 337 a Vol. 1, p. 337, 338 F Vol. I, p.337, 338 a ‘Vol. I, p. 337 356. 387. 358, 359, 360. 361. 362. 363. Exam Questions, Hematology 209 b. Hemolysis associated with the unstable hemoglobins cc. Hemolysis associated with hereditary deficiency a. oflneese 6 phosphate dehydrogenase ‘The osmotic fragility testis increased in hereditary spherocytosis and in the autoimmune anemias. T, F In addition to macrocytic anemia patients with folic acid and Vitamin Bj deficiencies are also neutropenic and thrombocytopenic. T, F A low PCV indicates anemia. T, F Both RBC and PCV are increased in : a. Anemia b. Leukemia ¢. Polycythemia vera 4d. Dehydration ‘The direct Coombs test can detect which molecules In order to distinguish between folic acid deficiency and Vitamin B 2 deficiency in a case of macrocytic ‘megaloblastic anemia one could order: a. Ared blood cell folate level ¢. A serum Vitamin B12 level 4. A Schilling test ‘A Schilling test measures: ‘a. The presence of megaloblasts in the marrow 'b. The absorption of Vitamin B12 cc. | The adsorption of folic acid d. The action of lead on erythrogenesis In severe or acute anemia very large polychromatophili RBC appear in the blood. T, F abe Vol. I, p. 228, 228, 331 be Vol. I, p. 238- 240 bs Vol. I, p. 337 ir Vol. I, p. 235, 336 ed Vol. I, p. 235, 336 ab Vol. 1, p.336 abcd Vol. I, p. 332 b Vol. 1, p. 337 T ‘Vol. I, p. 338‘210 Exam Questions, Hematology 364. 366. 367. 368. 370. 3m. 372, 323. ‘These large RBC are called: a. Shift macrocytes a Vol. I, p. 338 ‘marocytes represent the occurrence of skipped ‘Tiistons ia the marrow normoblass inorder 10 deliver RBC to the blood more quickly. T, F ‘Target cells re found in some ofthe hereditary hemoglobinopahties T, T Vol. I, p. 338 iT Vol. Lp. 236, 337, 340 The’ jobinopathies one associates with target cells include: ‘a. Hemoglobin C disease “ abc, : Hemoglobin SC disease Voi. I, p. 236, 4. Hemoglobin G 337, 3 . ie it rincan |T Sete Rt enbgopine. TE (Seon 25 na case of obstructive jaundice you would expect the erythrocyte fragility to be: Tncreased ib es Vol. I, p. 238- e. Normal a Ina case of hereditary spherocytosis you would expect the erythrocyte fragility to be: A a. Increased Vol. I p. 238- ° a ba In cases of sickle cell anemia the red cells become sickle-shaped when: a» Oxygen ie fe Vol. 1, p- 236, d. Cell fragility is decreased 340 Only deoxy sickle hemoglobin can undergo the Zoya sickling process. T,F You tp 236 ing cannot be diagnosed unless basoptilic | F sintae ison ooytes can be comonstaed Vol. I, p-237 374. 375. 376. 377. 378. 379. 380. 381. Exam Questions, Hematology 211 When sickle cell erythrocytes have been deoxygenated and have undergone sickling, restoration of oxygen to the system causes most of the erythrocytes to resume a ‘normal shape. T, F Inceversibly sickle cells are erythrocytes that retain their sickle shape even after oxygen is restored and the cells contain only oxy sickle hemoglobin. T, F ‘The peripheral blood smear of a patient with auto- immune hemolytic anemia usually shows sickled erythrocytes and the diagnosis can be confirmed by requesting a test for sickling. T, F ‘The sedimentation rate is usually increased in the following condition(s): ‘a. Pregnancy b. Infectious mononucleosis ¢. Rheumatic fever d. Cancer ‘The situations wherein reduced r.b.c. contents lead to target cell formation include: a. Thalassemia b. Iron deficiency anemia &. Some forms of hemoglobinopathy (C disease) 4d. Pernicious anemia ‘The situations wherein increased surface area leads to the formation of target cells occurs in: a. Obstructive jaundice b. Renal failure ¢. Hereditary spherocytosis d. Shock ‘Spur cells are r-b.. with long projections. They are seen associated with hemolytic states in: a. Overwhelming hepatic failure b. Pneumonia . Infectious mononucleosis d. Acquired autoimmune hemolytic anemia Schizocytes or burr cells are characteristically seen in: Microangiopathic hemolytic anemia Hereditary spherocytosis Disseminated intravascular coagulation Sickle cell anemia Hemolysis associated with prosthetic heart valves T Vol. 1, p. 236, }240, $40 iT Vol. 1, p. 240 F Vol. I, p. 241 abcd Vol. 1, p. 199, 210 abe ‘Vol. I, p. 236, 337, 340 a Vol. I, p. 236 ace Vol. 1, p. 236212. Exam Questions, Hematology jocytes are cup-shaped rb.c. that have a slit 382. Sromaance on Wright-stamned smears, They aze seen in 2. Hemolysis with alcoholic cirrhosis bb. Hemolysis in certain hereditary conditions c In Thalassemia : ._Iniron deficiency anemia hereditary red blood cell disorder that. . 7 Ate Vol. I, p. 237 384, Sickle cell disease is a hereditary disease which ‘affects blacks predominantly. ‘T, F 385. Sickle cell trait and sickle cell anemia are one and the same condition. T, F Ey Vol. I, p.236 F ‘Vol. I, p. 236 the seventh month of pregnancy a woman may have |"T 386. tyever ‘38 and still have a normal or even sli Vol. I, p. 209, jnereased total red cell mass. TT, F 221 387. An important factor in plasma that determines the ESR is: b &.Fibnoses Rau. 1p.199 c. Prothrombin 210 16 SUS} the diagnosis of glucose-6-phosphate 388. Gf yrogenase deficiency, te test that can make the diagnosis include: 1. Direct enz b ‘Use ot Ets where he action of the enzyme decolorizes a dye c. Osmotic fragility test d. Coombs test 389. The difference between polycythemia vera and ‘erythremia is that polycythemia vera is due to primary marrow disease and is associated with increases in RBC and platelet count. , F 390, Fetal hemoglobin can be detected by: Sickle Pre yest ‘Osmotic b. Qicasuring akall-resistant hemoglobin Looking for basophilic stippling. 391 392. 393, 394, 395. 396. 397. 398, 399. 400. Exam Questions, Hematology 213 In a case of classical sickle cell anemia about 90% of _ | T the hemoglobin would be S or sickle hemoglobin. T, F | Vol. I, p. 236 ‘The remaining hemoglobin is usually: a. Hemoglobin A b. Hemoglobin A, c c. Fetal hemoglobin Vol. I, p. 236 All of the hemoglobin found in sickle cell trait F (C"sicklemia") is of the "S" variety. T, F Vol. I, p. 236 In sickle trait what per cent of the hemoglobit hemoglobin? sickle a 45% b. 10% a ©. 85% Vol. I, p. 236 The hemoglobin concentration of blood may be increased in: a. Anemia b. Polycythemia vera ¢. Dehydration bed 4. Exythremia secondary to cardiac or pulmonary | Voi. I, p. 235, disease 336 ‘The total body hemoglobin is increased in: a. Anemia b. Polycythemia vera b c. Leukemia Vol. I, p. 235, 4. Dehydration 336 Polycythemic blood is more viscous than normal whole} T. blood. TF Vol. I, p. 235, 336 In B-thalassemis trait the diagnosis would be confirmed by finding elevated values of: a. Fetal hemoglobin b. Az hemoglobin ab ¢. Sickle hemoglobin 4. G hemoglobin Vol. 1, p. 229, 233 "8" hemoglobin may be separated from other hemoglobins by electrophoresis and by density F gradients. T, F. Vol. I, p. 240 ‘When a patient with AIDS is being treated with AZT. (azido-thymidine) what changes would you expect in214 Exam Questions, Hematology his RBC? olychromasia Macrocytosis Microcytosis Fragmentation Hypochromia eerge b Vol. 1, p.338 White Cells ‘401. Awhite blood cell differential count which contains jnoreased numbers of stab forms and myelocytes is said to: ‘a. Beshifted to the right b, Be normal c ¢. Be shiftedto the left Vol. I, p. 247 402. In Acquired Immunodeficiency Syndrome (AIDS) the ‘total number of lymphocytes is: a, Increased b, Decreased ec. Normal b Vol. I, p. 245 403, Other abnormal blood findings in Acquired Immunodeficiency Syndrome (AIDS) are: a b. Neutropenia ¢, Hypersplenism with pancytopenia 4. Megaloblastic anemia abe Vol. I, p. 244, 251, 339 404. A.white blood count of 3,500 where there are 15% PMN and 85% lymphocytes indicates that the patient has: a. Balanced leucopenia , Absolute lymphocytosis Neutropenia 4, Allof the above © Vol. 1, p- 247, 338 405, In ordet to be sure that the cause of your patients thrombocytopenia is heparin induced thrombocytopenia) fyou would do atest in which platelet aggregation (a Be blocked by heparin in the presence of patient's |T_ plasma. T,F See p.225 406. ‘The HIT syrdrome is probably caused by an antibody directed against a complex of heparin and platelet £4 (which comes from platelet and endothelial cell granules). T, F 407 408. 410. aul. 412. 413. 44. 41s. 416. ‘Exam Questions, Hematology 215 In whooping cough peripheral blood smears show ahigh lymphocyte count. T, F Vout». 248, 338 Acute infectious lymphocytosis affect a be a Aa Vol. I, p. 248, 338 ‘Acute infectious lymphocytosis and infectious F mononucleosis are one and the same condition. T,F, ‘| Vol. Ip. 248, 246 ° © Vol. I. p. 246, 337 ‘An osinophilic leucocytosis . A distinct increase in atypical lymphocytes > © Decreased numberof basophils Yet 4p. 246, Atypical lymphocytes are really lymphocytes that have been transformed by contact with vires or | coon Vol. I, p. 246 Ins infectious mononucleosis ‘= oem sa bepfl esti: | 5. Monospot c. White count Yoh Lp. 246, ‘When the body is invaded by i Crom a eam by pyogenic bacteria thre a. Circulating eosinophils b. Circulating neutrophils b . Small lymphocytes d._Large lymphocytes, ol fp. 248, ‘The white blood cell count infections. T, F a In the presence of inflammation or infecti bay bee a a. Toxic granulation Bb. Doble bodies ab216 Exam Questions, Hematology 417. 418. 419. 420. 421. 422. 423. 424. 425. cc. Auer rods ‘The presence of Auer Rods is diagnosis of: a. Infectious mononucleosis b. Chronic myeloid leukernia cc. . Acute myeloid leukemia “The percent number of eosinophils is increased in: a. Brucellosis b. Asthma c. Hay fever d._ Parasitic infections ‘The circulating monocyte is the precursor of the fixed tissue macrophages. T, F ‘The total white cell count is always high in leukemi TF ‘The combined French-American-British study on the morphology of acute leukemias found that the PAS stain did NOT distinguish between acute myeloid. Jeukemia and acute lymphoblastic leukemia. T, F ‘A patient with a white blood count of 3,500 and a differential count of 65% PMN, 5% monocytes, and 30% lymphocytes has: ‘a, Balanced leucopenia b. Aleftshift ¢, Neutropenia ._ Lymphocytosis In typhus, brucellosis, tuberculosis, and monocytic Jeukemia you would expect the monocytes to be: a. Increased b. Decreased ¢. Normal in number ‘In mumps and whooping cough you would expect the lymphocytes to be: a. Increased b. Decreased ¢. Normal in number Cll ofthe granulocyte series have primary granules that appear at the promyelocyte stage. T, bod Vol. I, p. 248, 336 by Vol. 1, p. 245 F iT Vol. I, p. 249, 337 a Vol. 1, p-247 a Vol. I, p. 245 a Vol. I, p. 248, 338 IT 426. 427, 428. 429. 430, 43. 432. 433, Exam Questions, Hematology 217 ‘At what stage in development of the granulocyte line dh the specific or secondary granules spear? a. Myeloblast b. Promyelocyte c. Myelocyte ‘Toxic granulation represents persistence of the primary granules of the neutrophils. T, F In the disease multiple myeloma there is a malignant infiltrate of which cells in the marrow? a: Myeloblasts b. Plasma cells cc. Lymphoblasts d. Osteoblasts ‘A finding that is characteristic of chronic granulocytic leakemia is the presence in erythroid and myeloid precursor cell of: a. Auer Rods b. Toxic granules ¢. Doble bodies d._ The Philadelphia chromosome ‘The percent number of monocytes is increased in: a. Whooping cough b. Tuberculosis, c. Typhus fever d. Hay fever A real increase in the absolute numbers of small mature lymphocytes occurs in: a. Systemic lupus ©. Chronic lymphocytic leukemia ©. Hodgkins disease ‘Atypical lymphocytes are seen in the following tions: a. Infectious mononucleosis b. Toxoplasmosis ©. Cytomegalovirus infection 4. Infectious hepatitis In some forms of lymphosarcoma abnormal Iympho- cytes and lymphoblasts can be seen in the peripheral blood smear. T, F © Vol. I, p. 243- 246 T Vol. I, p. 244, 340 b Vol. I, p. 246, 299) Vol. I, p. 300, 301, 312, be Vol. I, p. 245, b Vol. 1, p. 248, 338218 Exam Questions, Hematology 434. 435. 436, 437. 438, 439. 44. In which of the myeloproliferative diseases would you ‘expect to find-on the peripheral smear fishtailed erythrocytes, nucleated erythrocytes, myeloid immaturity and giant dysplastic platelets? a. Chronic granulocytic leukemia 'b. Polycythemia vera ¢. Agnogenic myeloid metaplasia 4d. Essential thrombocythemia In Vitamin B12 deficiency and folic acid deficiency a Useful clue to the diagnosis is the presence of hypersegmented PMN (more than 4 lobes) in the peripheral smear. T, F Older people in the geriatric aged groups (>75) will always have a neutrophilic leucocytosis if they have pneumonia. T, F In searching for a donor for allogeneic bone marrow transplantation in acute leukemia one can use any sibling the patient has. , F In order to identify the type of leukemia a patient has, cone can use which of the following techniques? Staining of peripheral blood and bone marrow wi ‘b. Immunophenotyping €. Searching for patterns of enzymes in the leukemia WBC like myeloperoxidase with biochemical stain 4d. Cytogenetics analysis looking for specific ¢ Vol- I, p. 338 T Vol. I. p. 337 FE See p. 225 See p. 225 abod Vol. I, p. 249, ‘chromosomal translocations or deletions or additions 337 ‘Before heparin can exert its anticoagulant effect it ‘must interact with which protein in the blood? a. Fibrinogen b. Gamma globulin ¢. Antithrombin IIT dd. Factor VII In aplastic anemia you would expect the platelet count tobe: a. High b. Low ¢. Normal Aspirin and some of the newer non-steroidal anti- inflammatory agents may interact with platelets and le Vol. I, p. 337 b Vol. I, p. 335 Exam Questions, Hematology 219 cause bleeding due to this acquired platelet dysfunction] ‘One way to determine if the patient has a platelet functional defect is to do: ‘a. PTT and acuglobulin lysis time b. PT and thrombin time © cc, Template bleeding time and a platelet count Vol. 1, p. 210 4d. "Whole blood clotting time 260 442. 443. 447. Bleeding & Coagulation Ifa platelet count is below 50,000/cu.nm. you would expect the bleeding time to be: Decreased Increased > | Bither aor b Vol. I, p. 210, . Neither a nor b 260 Ifa platelet count is low you would expect the clot retraction time to be b Vol. I, p. 252 ‘Measurement of fibrinolysis include: a. The whole blood clot lysis time b. The euglobulin lysis time abjod ©. FDP/fdp Vol. I, p. 259, d. Thrombin time 285, 292 If you have a patient with hereditary bleeding and a low| Factor VmI coagulant level which ofthe fllowing findings would favor the diagnosis of von Willebrand's disease over classical hemophilia? ‘a. Long template bleeding time b. Abnormal ristocetin platelet aggregation cc. Low vwF antigen 4. A family history indicating that female members hhad clinically significant bleeding ‘Aspirin modifies platelets so that their ability to adhére to-wound surfaces and release their granular contents | T is impaired. T,F Vol. I, p. 263 ‘Hemorrhagic discase of newbom is often due to hypo- prothrombinemia. This condition may be prevented by giving expectant mothers adequate doses of: a Vitamin A i b. Vitamin C 4220 Exam Questions, Hematology 448. 449. 430. 431. 452. 453. 434, c. Vitamin D Vitamin K In hemophilia you would expect the platelet court to be} a. Deere b. Increased cc. Neither anor b ‘During heparin anticoagulation which of the following, tests are used to monitor therapy? a. Prothrombin time >. PIT ¢. Thrombin time 4d. Activated whole blood clotting time Bleeding may occur when the plasma concentration ‘of prothrombin drops below: a. 50% of normal b. 40% of normal ©. 20% of normal Vitamin K absorption cannot take place in the absence of: a. Bile b. Carotene ¢. Prothrombin ¢. Insulin Vitamin K absorption is also impaired in disease of the: a, Small intestine b. Lungs c. Spleen d. Bone marrow {All ofthe following apply to vitamin C except a. prevents scary b. Its used inthe formation of prothrombin. €. This used inthe formation of capillary walls @._ Citrus and other fruits are excellent source If the bleeding time is abnormal in a patient who is thought to have hemophilia, he may Vol. I, p. 255, 257, 339 Vol. I, p. 336 be Vol. I, p. 257 c Vol. I, p: 255. 339 a Vol.1, p. 257 a Vol. 1, p. 257 > Vol. I, p. 257 abc a. Be taking aspirin a Have von Willebrand's disease and not hemophilia c. Have uremia ._ Have nothing else wrong since the bleeding time is] always abnormal in hemophilia Vol. I, p.260 455. 456. 497. 458. 459. 461. 462. 463. Exam Questions, Hematology 221 Presence of any amount of the following in the circu- lating blood is abnormal: a. Fibrinogen b. Fibrin c. Neutral fat d. ‘Cholesterol ‘After dicumarol or warfarin administration the prothrombin time: a. Increases b. Decreases cc, Remains unchanged: « ‘Warfarin administration reduces the following In classical hemophilia the PTT is increased as a result itamin K deficiency b. Inadequate synthesis of prothrombin ©. Deficiency of active Factor VIII 4. Allow platelet count ‘A firbinogen deficiency may bring about extensive hemorrhage. T, F ‘Tests particularly useful in detecting intravascular coagulation include everyone but: a. Lee & White clotting time 'b. Measurement of plasma fibrinogen ©. Thrombin time 4. Platelet count ‘The best test for making the diagnosis of hemophilia is the clotting time. T,F Tn a suspected case of hemophilia you would fist do a partial thromboplastin time and, if t was abnormal you ‘would then proceed to assays of the following Factors VIL, IX, XI. T,F “The principle of the Russel Viper Venom testis that the venom activates: a. Factor It b. Factor X b Vol. I, p. 259, 266, 278 Vol. Ip. 267 abd Voi. I, p. 257, 257, 267, Vol. I, p. 336 IT Val. I, p. 259 F Vol. I, p.336 iT Vol. I, p. 336222 Exam Questions, Hematology 464. 465. 461. 470. an. cc, Factor VII d. Factor IX In classical hemophilia the prothrombin time is prolonged. T, F b Vol. i, p. 257 F Vol. I, p.336 ‘The prothrombin time tests: a! Factor IL b. Factor V ¢. Factor VI abc 4. Factor VIL Vol. I, p- 267 In the presence of normal numbers of platelets the Ivy bleeding time may be prolonged in the following condition(s) a. Hemophilia b. Uremia ‘e._ Hereditary platelet functional disorders 3. Acquired platelet functional disorders bod Vol. I, p. 260 In disseminated intravascular coagulation fibrit Thonomers and fibrin degradation products appear in the serum. T, F It. Vol. I, p. 278, 335 In disseminated intravascular coagulation the following Coagulation components are frequently depleted: fa. Platelets b. Factor Ill acd c. Factor Vill ‘Vol. 1, p.278, 4. Factor I 335 In the condition of intravascular coagulation both the coagulation system and the fibrinolytic system are activated. T, F iT Vol. I, p. 278, 335 ‘During anticoagulant therapy the prothrombin time is usually kept between: a. Sand 15 seconds . 10and 13 seconds ¢. 15.and 20 seconds © Vol. I, p. 255, 335 If meticulous HLA & DRA matching is not done in the ‘case described above, the recipient may develop a syndrome of wasting, pancytopenia, diarrhea and liver disease. This is called: ‘2. Graft vs. Host Disease bb. Autoimmune Panniculitis ¢, Auto erythrocyte purpura 472, 473, 474, 475. 476. 477. 478. ‘Exam Questions, Hematology ‘Bone Marrow In order to prevent Gr VHD foll meee lowing all ImaOW tatplanaion heh ef Be tees troop b. Methotrexate cs d. Allof: the Above In vitamin Bp def megaloblastgcyahecea yt bone marrow shows = id hyperplasia. T, F Yyelosporine, a drug used microangiopathic hemolysis, Pre ection Canc Inthe di nthe : - Blatt savin OMDORY ope purpura the Short e. Normal Platelet survival can be a ‘measured by: Paging te lait win Scr” Te Platelet with '"In G TeBeiNs the platelet with Re 'agging the platelets with 5’Co-vitamin B, The plasma volume @ he iasma volume can be accurately . aban radioscopic dilution study with Stee, adio iodinated se : = Doing a rated serum albumis & Bogs 7co-Viamin Bi dlaion sud 98 8 Technitium bone sean ty ‘A recently approved drug. desi ange ene ese signed to improve the ong onal anioay dace a i essentially a i Vol. I, p. 320 integrin GPOB/IIA, Y, 3¢ platelet moeisine nt ‘ou Wal T ing this agent to have along Blcedingrae’ T. F Vol 1 p.251 time. T, \ 7224 Exam Questions, Hematology 2, 35. 36. 37. re 49. 118, 123, 124. 125. 129. 139, HEMATOLOGY ANSWERS “The eosinophils release their granules in response to specific signals from parasites. eee bare sugges Sic Tel and whan minal ne SOP Base mamul controls to cause allergic rhinitis and hives ther granals ommon ancestor and the contents of their eranules are similar. Simla ch it becomes a fixed tissue macrophage whose function ‘depends on it site (nerves, lung, liver, spleen) depends on i sigced by more senate and specific tests Vike Nahorescent anti-nuclear antigen” or FANA ‘luorescet 2a gute pase reactant that causes RBC 10 rouleaus and thus sediment quickly. ss et donglant rarely is associated with bleding, More ofen dhe antociation is with a hypercoagulable state, Other methods for measuring plasma volume include: a Ragjrodine or techniium labeled sen albumin t GBT agged rb.c. with correction for plasmacrit TK long aPTT is frequently the frst sign ‘A long of correction is characteristic ofthe lupus anticoagulant ‘A specific antibody test is required A specie andpody ‘sins clude: Janus goon, Nile-bve sulfate and N Protein Wnje modified on thromborodulin and can clot Fibres Fae aad has very different roles in phagocytosis and platelet interaction. ‘Aspirin interferes with platelet function eine a newer ani-thrombotic drug blocks platelet aggreBAtio” by interfering with platelet-fibrinogen interaction sere tlegin i a conjugated cheme + globin) protein. Heme Conroe Homogietne ferrous state and can unite with oxygen (o form Neykemoglobin. Without this loosely bound oxygen it's “reduced hemoglobin.” hemoglobin etiable methods that distinguish desirable thrombolysis from dangerous fibinolysis. Hydroxyurea causes a uniform increase MCV usually 100. Hydro yt ed rarely as the homozygous form and more commonly ‘as the heterozygous variant, esduces a hypercoagulable state involving arteries and weit TW Proetin most patients with AIDS and in aboot 8% of patients who are HIV positive Ttusually disappears spontancously a eee tparacterized by suppression of T-helper Iymphoctes ‘The disc ate either recombinant FVIII or # monoclonal afiniy fied preparation free of HIV. " positive is much more common. 310. 332, 333. 335. 336, 341. 343. 344, 346. 368, 405. 436, 437, Exam Questions, Hematology 225 The disease is called N ise Neonatal Alloimmun pect nce | Alloimmune Thrombocytopenia and it f rng sng the anol wou postive plate. You would we mote plaice nn eeemuement har aba shown to have clinical utility. siete ara tpenia, Tt has no clinical significance ‘The therapy is based on immunosuppression with ATG, cyclosporine {tan produce transient ertroblastopen hese are the typical findings ™_ Because the pooled LV IgG will have an-parvovirus antibodies EPO causes an inctease in erythropoiesis and a skipped dscns angele Pn Tse standard tet nkng or hep eae an ase for heparin induced inhibition of n inhibit Dider people seem to be unable to gen be generate the same neutrophi ‘The sibling donor must eae hang Re pa aL and DRA ses. The