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Immunology Exam for Medical Students

This document summarizes a 152-point immunology exam given on June 4th 2012 at the Faculty of Medicine, Department of Laboratory Medicine, Children’s and Women’s Health. The exam consisted of 5 questions testing knowledge of topics like the host response to infection, complement pathways, antigen presentation, antibody and T-cell receptor structure and diversity, T-cell differentiation, and antiviral immune responses. It provides context for the exam such as credits earned and allowed resources. Contact information is provided for any issues during the exam.

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88 views3 pages

Immunology Exam for Medical Students

This document summarizes a 152-point immunology exam given on June 4th 2012 at the Faculty of Medicine, Department of Laboratory Medicine, Children’s and Women’s Health. The exam consisted of 5 questions testing knowledge of topics like the host response to infection, complement pathways, antigen presentation, antibody and T-cell receptor structure and diversity, T-cell differentiation, and antiviral immune responses. It provides context for the exam such as credits earned and allowed resources. Contact information is provided for any issues during the exam.

Uploaded by

sazzad joy
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Faculty of Medicine

Department of Laboratory Medicine, Children’s and Women’s Health

WRITTEN EXAMINATION:
MOL3005 Immunology

Tuesday June 4th 2012, 9.00 am - 1.00 pm

ECTS credits: 7.5


Number of pages (including front-page): 3

Examination support: Language dictionary (Medical dictionaries or


similar dictionaries on biology are not permitted).

Contact person during the exam: Trude Helen Flo, 91897796 / 72825331

Examination results are announced on [Link] June 26 th

1
Short answers are expected; most questions can be answered with one or a few
sentences, a list or a drawing with explanatory comments

Examination question 1 (35 points).


a) Explain the sequential steps of host defenses that are initiated when a wound gets
infected (7p)
b) What triggers activation of the three complement pathways? What are the main
biological functions of complement factor split products a? (4p)
c) Explain how Lipopolysaccharide (LPS) is recognized by an immune cell and
activates it to produce cytokines (4p)
d) How is interleukin-1 produced? (4p)
e) Explain adjuvancy (3p)
f) Natural killer cells (NK cells) express killer-cell immunoglobulin-like receptors
(KIRs). What purpose do these receptors serve? (3p)
g) How does NK-cells kill target cells? Describe the different pathways initiated in the
target cell. (10p)

Examination question 2 (15 points).


Respirable organic dust like spores and animal proteins may cause allergic alveolitis
(type III hypersensitivity reaction, hypersensitivity pneumonitis), which may be seen in
farmer’s lung, bird breeder’s lung and mushroom cultivator’s lung.
a) Explain the immunologic mechanism of allergic alveolitis (9)
b) Describe briefly the different clinical phases with major cell types of
hypersensitivity pneumonitis (6)

Examination question 3 (20 points).


a) Describe the most important differences in antigen-recognition by B-cells and T-
cells (5p)
b) Sketch and explain the differences in antigen presentation by MHC class I or MHC
class II molecules (cellular expression, type of antigens, intracellular pathways and
type of immune response that is activated) (10p)
c) What is cross-presentation of antigens? In what cells does it occur? Discuss
mechanisms for how cross-presentation can happen. (5p)

Examination question 4 (15 points).


a) Draw the structure of an antibody and indicate major functions (3p)
b) Describe the mechanism of class switching (3p)
c) Describe factors contributing to diversity for the T-cell receptor and explain/draw
the stepwise mechanism. When and where during T-cell development is this
happening (9p)

2
Examination question 5 (15 points).
a) When naïve T-cells are activated they differentiate to effector subsets. List the major
subsets (5p)
b) Describe the Th1/Th2 balance (5p)
c) What type of immune response is best for fighting virus infections? (1p)
d) Why are type I interferons efficient in antiviral defences. (4p)

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