Name of drug Dosage, Route, Indication Contraindication Mechanism of Drug-to-drug Adverse effects Nursing
and Frequency action interaction responsibilities
Generic name PO 15–30 mg Adjunct to diet in Hypersensitivity Results in insulin Pioglitazone may Body as a Whole: BEFORE
Pioglitazone once daily (max: the treatment of to pioglitazone, sensitivity by decrease serum Headache, >Monitor signs
Hydrochloride 45 mg q.d.) type 2 diabetes troglitazone, affecting insulin levels for oral myalgia, edema. and symptoms of
mellitus. rosiglitazone, receptors. contraceptives; CV: Edema, fluid hypoglycemia
Brand name: englitazone; type Decreases ketoconazole retention,
Actos 1 diabetes, or hepatic glucose may increase exacerbation of >Monitor closely
treatment of DKA; output and serum levels of heart failure. GI: for signs and
Therapeutic active liver increases insulin- pioglitazone. Tooth disorder. symptoms of CHF
classification: disease or ALT dependent Ginseng may Respiratory: or exacerbation of
Hormones and levels >2.5 times muscle glucose potentiate Upper respiratory symptoms with
synthetic normal limit; uptake in skeletal hypoglycemic tract infection, preexisting CHF.
substitutes; pregnancy muscle and effects sinusitis,
antidiabetic; (category C), adipose tissue. pharyngitis. >Monitor weight
thiazolidinedione lactation. Metabolic: and notify
Hypoglycemia, physician of
mild anemia. development of
edema.
DURING
>Discontinue
drug if ALT >3
times ULN or
patient has
jaundice
>Use or all barrier
contraceptive if
using hormonal
contraception
>May need
adjustment for
other antidiabetic
drugs to avoid
hypoglycemia
AFTER
>Emphasize the
importance of
adhering to
nutritional
guidelines and
the need for
periodic
assessment of
glycemic levels.
>Educate patient
about symptoms
of hyperglycemia