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Vaccine Candidates in Development: Candidate Mechanism Sponsor Trial Phase Institution

The document lists various COVID-19 vaccine candidates in development including their mechanism of action, sponsor, and current trial phase. Candidates range from nanoparticle, DNA, mRNA, adenovirus-based vaccines to protein subunit vaccines. Major sponsors include pharmaceutical companies, research institutes, and governments. Trial phases range from Phase 1 to Phase 3 testing across various international institutions.

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0% found this document useful (0 votes)
114 views5 pages

Vaccine Candidates in Development: Candidate Mechanism Sponsor Trial Phase Institution

The document lists various COVID-19 vaccine candidates in development including their mechanism of action, sponsor, and current trial phase. Candidates range from nanoparticle, DNA, mRNA, adenovirus-based vaccines to protein subunit vaccines. Major sponsors include pharmaceutical companies, research institutes, and governments. Trial phases range from Phase 1 to Phase 3 testing across various international institutions.

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Vaccine candidates in development

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Trial
Candidate Mechanism Sponsor Institution
Phase

NVX-CoV2373 Nanoparticle vaccine Novavax Phase 3 Novavax

Anhui Zhifei Longcom Biopharmaceutical, Institute of


ZF2001 Recombinant vaccine Phase 3 Various
Microbiology of the Chinese Academy of Sciences

ZyCoV-D DNA vaccine (plasmid) Zydus Cadila Phase 3 Zydus Cadila

CVnCoV mRNA-based vaccine CureVac; GSK Phase 2b/3 CureVac

University of Melbourne and Murdoch Children’s University of Melbourne and Murdoch


Bacillus
Research Institute; Radboud University Medical Children’s Research Institute; Radboud
Calmette-Guerin Live-attenuated vaccine Phase 2/3
Center; Faustman Lab at Massachusetts General University Medical Center; Faustman
(BCG) vaccine
Hospital Lab at Massachusetts General Hospital

Center for Pharmaceutical Research,


INO-4800 DNA vaccine (plasmid) Inovio Pharmaceuticals Phase 2/3 Kansas City. Mo.; University of
Pennsylvania, Philadelphia

VIR-7831 Plant-based adjuvant vaccine Medicago; GSK; Dynavax Phase 2/3 Medicago

No name
Adenovirus-based vaccine ImmunityBio; NantKwest Phase 2/3
announced

Multitope peptide-based
UB-612 COVAXX Phase 2/3 United Biomedical Inc. (UBI)
vaccine

Abdala (CIGB
Protein subunit vaccine Finlay Institute of Vaccines Phase 2 Finlay Institute of Vaccines
66)
Trial
Candidate Mechanism Sponsor Institution
Phase

Phase Multiple study sites in Europe, North


BNT162 mRNA-based vaccine Pfizer, BioNTech
1/2/3 America and China

AdCLD-CoV19 Adenovirus-based vaccine Cellid; LG Chem Phase 1/2a Korea University Guro Hospital

Recombinant vaccine (Spike


Nanocovax Nanogen Biopharmaceutical Phase 1/2 Military Medical Academy (Vietnam)
protein)

EuCorVac-19 nanoparticle vaccine EuBiologics Phase 1/2 Eunpyeong St. Mary’s Hospital

Mambisa (CIGB
Protein subunit vaccine Finlay Institute of Vaccines Phase 1/2 Finlay Institute of Vaccines
669)

Recombinant vesicular
Hadassah Medical Center; Sheba
IIBR-100 stomatitis virus (rVSV) Israel Institute for Biological Research Phase 1/2
Medical Center Hospital
vaccine

No name
SF9 cell vaccine candidate West China Hospital, Sichuan University Phase 1/2 West China Hospital, Sichuan University
announced

Soberana 1 and 2 Monovalent/conjugate vaccine Finlay Institute of Vaccines Phase 1/2 Finlay Institute of Vaccines

VLA2001 Inactivated vaccine Valneva; National Institute for Health Research (NIHR) Phase 1/2 Multiple NIHR testing sites

No name Adjuvanted protein subunit


CEPI Phase 1/2
announced vaccine

AG0301- AnGes, Inc.; Japan Agency for Medical


DNA vaccine AnGes, Inc. Phase 1/2
COVID19 Research and Development

GX-19N DNA vaccine Genexine Phase 1/2

ARCT-021
(LUNAR- Self-replicating RNA vaccine Arcturus Therapeutics and Duke-NUS Medical School Phase 1/2 Duke-NUS Medical School, Singapore
COV19)

No name
Protein subunit vaccine Sanofi; GlaxoSmithKline Phase 1/2 Various
announced
Trial
Candidate Mechanism Sponsor Institution
Phase

West China Second University Hospital,


No name Chinese Academy of Medical Sciences, Institute of
Inactivated vaccine Phase 1/2 Yunnan Center for Disease Control and
announced Medical Biology
Prevention

University of Washington; National Institutes of Health


HDT-301
RNA vaccine Rocky Mountain Laboratories; HDT Bio Phase 1/2
(HGCO19)
Corp; Gennova Biopharmaceuticals

AV-COVID-19 Dendritic cell vaccine Aivita Biomedical, Inc. Phase 1b/2 Rumah Sakit Umum Pusat Dr Kariadi

PTX-COVID19-
mRNA-based vaccine Providence Therapeutics; Canadian government Phase 1
B

COVI-VAC Intranasal vaccine Codagenix; Serum Institute of India Phase 1

CORVax12 DNA vaccine (plasmid) OncoSec; Providence Cancer Institute Phase 1 Providence Portland Medical Center

Universitätsklinikum Hamburg-Eppendorf; German


Modified vaccinia virus
Center for Infection Research; Philipps University University Medical Center Hamburg-
MVA-SARS-2-S ankara (MVA) vector vaccine Phase 1
Marburg Medical Center; Ludwig-Maximilians - Eppendorf
candidate
University of Munich

Modified vaccinia virus


COH04S1 ankara (MVA) vector vaccine City of Hope Medical Center; National Cancer Institute Phase 1 City of Hope Medical Center
candidate

Multi-peptide vaccine
pVAC University Hospital Tuebingen Phase 1 University Hospital Tuebingen
candidate

AdimrSC-2f Protein subunit vaccine Adimmune Phase 1 Adimmune

Monovalent oral vaccine


bacTRL-Spike Symvivo Phase 1 Symvivo Corporation
(bifidobacteria)

Monovalent recombinant
COVAX-19 Vaxine Pty Ltd. Phase 1 Royal Adelaide Hospital
protein vaccine
Trial
Candidate Mechanism Sponsor Institution
Phase

DelNS1-2019-
Xiamen University, Beijing Wantai Biological Jiangsu Provincial Centre For Disease
nCoV-RBD- Replicating viral vector Phase 1
Pharmacy Control and Prevention
OPT1

Lazzaro Spallanzani National Institute


GRAd-COV2 Adenovirus-based vaccine ReiThera; Leukocare; Univercells Phase 1
for Infectious Diseases

UQ-CSL V451 Protein subunit vaccine CSL; The University of Queensland Phase 1

GlaxoSmithKline, Sanofi, Clover


SCB-2019 Protein subunit vaccine Biopharmaceuticals, Dynavax and Xiamen Innovax; Phase 1 Linear Clinical Research (Australia)
CEPI

Recombinant vaccine
VXA-CoV2-1 Vaxart Phase 1 Vaxart
(adenovirus type 5 vector)

AdCOVID Intranasal vaccine Altimmune Phase 1 University of Alabama at Birmingham

Massachusetts Eye and Ear; Massachusetts General


AAVCOVID Gene-based vaccine Pre-clinical
Hospital; University of Pennsylvania

ChAd-SARS- Washington University School of


Adenovirus-based vaccine Washington University School of Medicine in St. Louis Pre-clinical
CoV-2-S Medicine in St. Louis

MGH Vaccine and Immunotherapy


HaloVax Self-assembling vaccine Voltron Therapeutics, Inc.; Hoth Therapeutics, Inc. Pre-clinical
Center

LineaDNA DNA vaccine Takis Biotech Pre-clinical Takis Biotech

MRT5500 mRNA-based vaccine Sanofi, Translate Bio Pre-clinical

No name Ii-Key peptide COVID-19


Generex Biotechnology Pre-clinical Generex
announced vaccine

University of Saskatchewan Vaccine and


No name University of Saskatchewan Vaccine and Infectious
Protein subunit vaccine Pre-clinical Infectious Disease Organization-
announced Disease Organization-International Vaccine Centre
International Vaccine Centre
Trial
Candidate Mechanism Sponsor Institution
Phase

No name Chulalongkorn University’s Center of Excellence in


mRNA-based vaccine Pre-clinical
announced Vaccine Research and Development

No name University of Miami Miller School of


gp96-based vaccine Heat Biologics Pre-clinical
announced Medicine

No name
Inactivated vaccine Shenzhen Kangtai Biological Products Pre-clinical
announced

Recombinant protein subunit


PittCoVacc vaccine (delivered through UPMC/University of Pittsburgh School of Medicine Pre-clinical University of Pittsburgh
microneedle array)

T-COVIDTM Intranasal vaccine Altimmune Pre-clinical

No longer
LNP-
Self-amplifying RNA vaccine Imperial College London being Imperial College London
nCoVsaRNA
studied

No longer
Recombinant vaccine
V590 Merck; IAVI being
(vesicular stomatitis virus)
studied

No longer
University of Pittsburgh; Themis
V591 Measles vector vaccine University of Pittsburgh’s Center for Vaccine Research being
Biosciences; Institut Pasteur"
studied

Showing 1 to 57 of 57 entries

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