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Drug Name Mecahnism of Action Indication Side Effects Generic Name

Mannitol is an osmotic diuretic that works by increasing plasma osmotic pressure and inhibiting tubular reabsorption of water and electrolytes. This enhances water flow from tissues and reduces intracranial and intraocular pressures. Mannitol is indicated to test for oliguria, prevent oliguria during surgeries, reduce intracranial pressure, and for irrigation. Common side effects include headache, nausea, vomiting, and electrolyte abnormalities like hypernatremia, hyponatremia, and hypokalemia. Contraindications include active intracranial bleeding, anuria from renal disease, and progressive heart or lung issues.

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971 views2 pages

Drug Name Mecahnism of Action Indication Side Effects Generic Name

Mannitol is an osmotic diuretic that works by increasing plasma osmotic pressure and inhibiting tubular reabsorption of water and electrolytes. This enhances water flow from tissues and reduces intracranial and intraocular pressures. Mannitol is indicated to test for oliguria, prevent oliguria during surgeries, reduce intracranial pressure, and for irrigation. Common side effects include headache, nausea, vomiting, and electrolyte abnormalities like hypernatremia, hyponatremia, and hypokalemia. Contraindications include active intracranial bleeding, anuria from renal disease, and progressive heart or lung issues.

Uploaded by

hahaha
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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  • Drug Details

DRUG NAME MECAHNISM OF ACTION INDICATION SIDE EFFECTS

GENERIC NAME: Increases osmotic pressure of plasma in  Test dose for marked oliguria or CNS: dizziness, headache
mannitol glomerular filtrate, inhibiting tubular suspected inadequate renal function EENT: blurred vision, rhinitis GI: nausea,
reabsorption of water and electrolytes  To prevent oliguria during vomiting, diarrhea, dry mouth GU: polyuria,
(including sodium and potassium). These cardiovascular and other surgeries urinary retention,
BRAND NAME: actions enhance water flow from various  To reduce intracranial pressure and Metabolic: dehydration, water intoxication,
Osmitro tissues and ultimately decrease intracranial brain mass hypernatremia, hyponatremia,
and intraocular pressures; serum sodium  Irrigation during hypovolemia, hypokalemia,
CLASSIFICATION: level rises while potassium and blood urea Skin: rash, urticaria Other: chills, fever,
Osmotic diuretic levels fall. Also protects kidneys by thirst, edema, extravasation with edema
preventing toxins from forming and blocking and tissue necrosis
tubules.
DOSAGE:
75 cc

CONTRAINDICATION ADVERSE EFFECTS


ROUTES:
Parenteral  Active intracranial bleeding (except CNS: seizures
during craniotomy) Anuria CV: chest pain, hypotension, hypertension,
secondary to severe renal disease tachycardia, thrombophlebitis, heart failure,
 Progressive heart failure, pulmonary vascular overload
FREQUENCY: Metabolic: , hyperkalemia, metabolic
congestion, renal damage, or renal
Q4h dysfunction after mannitol therapy acidosis
 Severe dehydration
TIMING:
8am-12pm-4pm-8pm-12-am-4am

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