UNIVERSITY OF PERPETUAL HELP SYSTEM DALTA
COLLEGE OF PHARMACY
EXERCISE NO.5
Name : Aloyodan, Sittie Fahieda G.
ZINC OXIDE WITH SALICYLIC ACID Date : November 5, 2020
PASTE Rating :________________
I. Objective
Demonstrate knowledge and understanding of the composition, advantages and
disadvantages, application/use, method of preparation, packaging, labeling and storage
of semi-solid dosage forms.
Demonstrate competence in compounding, packaging and labeling of semi-solid dosage
forms.
II. Pre-Laboratory Discussion (done in lecture)
III. Materials
Mortar and pestle
Weighing scale
Pill tile
Stainless spatula
Cornstarch
Petroleum Jelly
IV. Procedure for preparation
a. Triturate zinc oxide until fine powder is obtained
b. Triturate starch together with the zinc oxide until fine and mixed thoroughly.
c. Triturate salicylic acid until
d. Using proper spatulation technique, incorporate zinc oxide and starch in quarters to
your petroleum jelly.
e. Add your salicylic acid.
f. Make sure to incorporate all the powder mixture with your petroleum jelly evenly.
g. Transfer in an appropriate container and label properly.
Formulations:
Zinc oxide with salicylic acid paste
Zinc oxide 125g
Starch 125g
Petrolatum 250g
Salicylic acid 10g
Make 45g paste
PHARMACEUTICAL DOSAGE FORMS, DRUG DELIVERY SYSTEMS AND MEDICAL DEVICES
UNIVERSITY OF PERPETUAL HELP SYSTEM DALTA
COLLEGE OF PHARMACY
Create a Schematic Diagram of the procedure for each preparation.
Compute for the quantity of each ingredient needed for the preparation. Show your
computation below.
PHARMACEUTICAL DOSAGE FORMS, DRUG DELIVERY SYSTEMS AND MEDICAL DEVICES
UNIVERSITY OF PERPETUAL HELP SYSTEM DALTA
COLLEGE OF PHARMACY
Total weight = 125g zinc oxide + 125g starch + 250g Petrolatum + 10 g salicylic acid
Zinc oxide 125g/510g x 100% = 24.51% x 45g = 11.03g
Starch 125g/510 x 100% = 24.51% x 45g = 11.03g
Petrolatum 250g/510 x100% = 49.02% x 45g = 22.06g
Salicylic acid 10g/510 x 100% = 1.96% x 45g = 0.882g
Complete the following Table:
Zinc oxide with salicylic acid paste
Synonyms Lassar’s Paste
Category/Use This medication is used to treat and prevent diaper rash
and other minor skin irritations (e.g., burns, cuts,
scrapes). It works by forming a barrier on the skin to
protect it from irritants/moisture.
Method of preparation Trituration, spatulation, levigation
Type of container Plastic or glass container
Label color Red label
Storage temp. and condition Do not store above 25C. Keep container tightly closed.
Store in a closed container at room temperature away
from heat, moisture, and direct sunlight
Incompatibilities Zinc Oxide is incompatible with benzylpenicillin.
Complete the following table
Ingredient Physical Solubility Use (Pharmaceutical/therapeutic)
Description
Zinc oxide Odorless Insoluble in It is used to treat and
white powder water prevent diaper rash and
other minor skin irritations
Starch White, Insoluble in Used in brewing and
tasteless, and cold water thickening agents in baked
odorless Insoluble in goods and confections
powder alcohol
Petrolatum White or Insoluble in This medication is used as a
yellow water moisturizer to treat or
homogenous Freely soluble prevent dry, rough, scaly,
paste, almost in benzene itchy skin and minor skin
PHARMACEUTICAL DOSAGE FORMS, DRUG DELIVERY SYSTEMS AND MEDICAL DEVICES
UNIVERSITY OF PERPETUAL HELP SYSTEM DALTA
COLLEGE OF PHARMACY
odorless and Soluble in irritations (e.g., diaper rash,
tasteless ether skin burns from radiation
therapy).
Salicylic acid Clear and Insoluble in It is used in the treatment of
colorless water acne, dandruff, or psoriasis
crystal of an Soluble in and to remove corns,
organic acid ether, calluses and warts
benzene,
propanol,
ethanol and
acetone
References
WebMD. (n.d.). Retrieved from Lassar's Paste: [Link]
paste-topical/details
PHARMACEUTICAL DOSAGE FORMS, DRUG DELIVERY SYSTEMS AND MEDICAL DEVICES
