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Heparin Infusion Protocol Guidelines

This document provides an intravenous unfractionated heparin infusion protocol. It recommends using a concentration of 1000 units/ml and gives loading and maintenance dose rates. It instructs monitoring APTT every 6 hours and adjusting the infusion rate based on the APTT ratio to maintain a therapeutic range of 1.5-2.5. It also recommends monitoring platelet count on alternate days due to the risk of heparin-induced thrombocytopenia.

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Alvy Syukrie
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523 views1 page

Heparin Infusion Protocol Guidelines

This document provides an intravenous unfractionated heparin infusion protocol. It recommends using a concentration of 1000 units/ml and gives loading and maintenance dose rates. It instructs monitoring APTT every 6 hours and adjusting the infusion rate based on the APTT ratio to maintain a therapeutic range of 1.5-2.5. It also recommends monitoring platelet count on alternate days due to the risk of heparin-induced thrombocytopenia.

Uploaded by

Alvy Syukrie
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

INTRAVENOUS UNFRACTIONATED HEPARIN

INFUSION PROTOCOL

Previously
concentration • Use a heparin infusion of 1,000 units/ml. No need to dilute – use
was 500 units/ml

heparin 20,000 units in 20ml ampoules.

• Unless contraindicated give loading dose of 5,000 units (5ml)

• Start infusion at rate of 1200 units (1.2ml) /hour

• Check APTT 6 hourly until stable in therapeutic range and adjust

rates to achieve a target range of 1.5-2.5


Heparin induced
thrombocytopenia
is a risk of • Monitor platelet count on alternate days
heparin treatment
Infusion adjustments
• Adjust heparin infusion as follows. described in both
units/hour and ml/hr

APTT ratio Infusion adjustment Recheck APTT


> 5.0 Stop for 1 hour and decrease 2 hours
rate by 500 units/ hour
(0.5ml/ hr)
4.1 –5.0 Decrease infusion rate by 300 6 hours
units/ hour
(0.3 ml/hr)
3.1 – 4.0 Decrease infusion rate by 200 6 hours
units/ hour
(0.2 ml/hr)
2.6 – 3.0 Decrease infusion rate by 100 6 hours
units/ hour
(0.1 ml/hr)
1.5 – 2.5 No change in infusion rate Within 12 hours

1.2 – 1.4 Increase infusion rate by 200 6 hours


units /hour
(0.2ml/hr)
<1.2 Increase infusion rate by 400 6 hours
units/hour
(0.4 ml/ hr)

Reviewed and supported by the NHS Tayside Multidisciplinary Anticoagulant Liaison


Committee.
Prepared: July 2007

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