HARAMAYA UNIVERSITY
HARAMAYA INSTITUTE OF TECNOLOGY
DEPARTMENET OF CHEMICAL ENGINEERIMG
Course outline
Course Code ChEg3124
Course Name Introduction to Biochemical Engineering
Degree Program [Link]. in Chemical Engineering
Instructor’s Workisa .B (workisabacha@[Link])
ECTS Credits 5
Student work load per Lecture Tutorial Lab/practice Home study
Week
3 2 0 3
Student work load per 48 32 0 48
Semester
Mode of Delivery Parallel ( Semester wise)
Course Objectives & This course has the objective of acquainting the students
Competences to be with typical biochemical processes, enzyme kinetics and
Acquired industrial application, cell kinetics and fermenter design.
Upon completion of the course, the students will able to
explain uses of major industrial enzymes &
enzyme reactor designs
exercise on biomass production and application
design bio process and biochemical processes, and
use bio-organisms on chemical processes
Course 1. Biotechnology and Biochemical Engineering
Description/Course Applications of Biotechnology
Contents Typical Biological Processes
2. Enzyme Kinetics
Commercial Applications of Enzymes
Simple Enzyme Kinetics
Evaluation of Kinetic Parameters
Enzyme Reactor with Simple Kinetics
Inhibition of Enzyme Reactions and Other
influences on Enzyme Activity
3. Immobilized Enzyme
Immobilization Techniques
Effect of Mass-Transfer Resistance
4. Industrial Applications of Enzymes
Carbohydrates
Starch Conversion
Cellulose Conversion
5. Cell Kinetics and Fermenter Design
Growth Cycle for Batch Cultivation
Stirred-tank Fermenter
Multiple Fermenters Connected in Series
Cell Recycling
Alternative Fermenters
Structured Model
6. Sterilization
Sterilization Methods
Thermal Death Kinetics
Design Criterion
Batch, Continuous and Air Sterilization
7. Agitation and Aeration
Basic Mass-Transfer Concepts
Correlation for Mass-Transfer Coefficient
Shear-Sensitive Mixing
8. Downstream Processing
Solid-Liquid Separation
Cell Rupture
Recovery and Purification
Pre-requisites ChEg3121 (Reaction Engineering I)
Semester Year III, semester II
Status of Course Compulsory
Teaching & Learning Classroom contact/Lecture, group work, interactive
Methods tutorial sessions (group and pair work/discussions) and
individual work (independent learning)
Assessment/Evaluation Continuous assessment ---------------------------50%
Quizzes ------------------------- 10%
Assignments ------------------- 15%
Group works--------------------15%
Tests ------------------------------10%
Final exam----------------------------------------------50%
Course Policy Attendance: As per the harmonized academic policy
Assessments: Students are supposed to handle all the
assessments on time.
Cheating/ Plagiarism: It is strictly forbidden and any
miss con duct is accountable as per the student’s code of
conduct.
Literature Text Book:
1. James Lee, Biochemical Engineering, prentice hall,
2ed, 1992
Reference Books:
2. Baily James E and Olli’s David F; Biochemical
Engineering Fundamentals