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Study Christopher Makinson

Some axons stop functioning properly, which can have catastrophic results as they seem to be a critical control point in epileptic networks. Epilepsy develops when neurons' signaling becomes dysregulated, and neurons normally fire asynchronously, but safety mechanisms can fail, causing many neurons to fire together and result in seizures. A recent study suggested that loss of a single gene in the regulatory network is enough to generate seizures.

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38 views2 pages

Study Christopher Makinson

Some axons stop functioning properly, which can have catastrophic results as they seem to be a critical control point in epileptic networks. Epilepsy develops when neurons' signaling becomes dysregulated, and neurons normally fire asynchronously, but safety mechanisms can fail, causing many neurons to fire together and result in seizures. A recent study suggested that loss of a single gene in the regulatory network is enough to generate seizures.

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“Some of the axons work well, and others stop working,” said Huguenard.

“That
failure can have catastrophic results, because this seems to be a critical control point
in some epileptic networks.”

Epilepsy develops when neuron's signaling becomes dysregulated, according to past


research. Neurons direct many parallel processes in the brain at the same time, all
the time. Despite constantly shooting off signals, neurons normally don’t fire in
synchrony. Built-in safety mechanisms keep this from happening, but when these
measures fail, many neurons fire together and seizures can occur. A
recent study from Huguenard’s lab, led by Christopher Makinson, PhD, suggested
that the loss of a single gene in this regulatory network is enough to generate
seizures.

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