COMPULSORY QUESTIONS PART I
1. Barbiturates are derivatives of _____________
a).Urea b).Ethyl Alcohol c).Creatinine d).Opium
2. Dopamine is __________
a).alpha & beta agonist b).Beta agonist c).alfa agonist d).beta antagonist
3. Which antibiotic is preferably used in myasthenia gravis?
a).Cephalosporins b).Tetracyclines c).Erythromycin d).All of these
[Link] Beta-blocker with maximum local anaesthetic property is ______
a).Metoprolol b).Acebutalol c).Pindolol d).Propranolol
[Link] blockers are contraindicated in_______
a).Angina b).Asthma c).Congestive Heart Failure d).All of these
6. The anticholinergic used in treatment of bronchial asthma is ________
a).Ipratropium b).Scopolamine c).Propantheline d).Isopropamide
7. Selective Beta 1-blocker is ______
a).Nadolol b).Atenolol c).Pindolol d).All of these
[Link] most potent bronchoconstrictor is __________
a).Histamine b).Bradykinin c).Leukotrienes d).Acetylcholine
[Link] of the following can cause neutropenia?
a).Indomethacin b).Captopril c).Phenylbutazone d).All of these
[Link] diuretic which causes hypercalcemia is__________
a).Chlorthiazide b).Furosemide c).Bumetanide d).Acetazolamide
[Link] Beta-Blocker to be avoided in renal failure is__________
a).Propranolol b).Metoprolol c).Atenolol d).Oxprenolol
[Link] are avoided during pregnancy because ______
1
a). It is teratogenic b).It may affectthe bone growth of foetus
c).It causes discoloration of teeth d).All of the above
[Link] of the following function of the Mu Opioid receptors?
a).Decrese Nor-epinephrine release b).Decreases Dopamine release
c).Decrease Serotonin release d).Decrease Acetyl Choline release
[Link] of the following Anticancer drug is not obtained from plant source?
a).Paclitaxel b).Vinblastine c).Chlorambucil and Melphalan d).All of these
[Link] of choice in Penicillin induced anaphylaxis is _______
a).Antihistamines b).Adrenaline c).Corticosteroids d).Dopamine
[Link] of the following is Anti-estrogen?
a).Danazol b).Clomephene c).Tamoxifen d).Diclofenac
[Link] is caused by ___________
a).INH b).Steroids c).Chloroquin d).All of these
[Link] available anticance agents have any of underlying mechanism?
a).Improving defence mechanism of the body
b).Inhibition of cell wall synthesis
c).Receptor site blockade of cancer cell content
d).Cell growth inhibitor
[Link] of which of the following should be avoided by a patient taking Warfarin
and its congeners?
a).Cyanocobalamin b).Thiamine c).Menadione d).Tocopherol
[Link] of the following is cardiotoxic?
a).Cyclophosphamide b).Methotrexate c).Mitomycin d).Adriamycin
[Link] of choice of Gonorrhoea is ______
a).Benzyl Penicillin b).Benzathine penicillin c).Procaine Penicillin d).Penicillin V
[Link] of the following is used to treat Plasmodium vivax during
pregnancy_____
a).Chloroquine b).Chloroquine+Pyrimethamine c).Chloroquine+proguanil
d).quinine
2
[Link] is useful in poisoning_____
a).Salicylate b).Barbiturates c).Methanol d).All of these
[Link] Ceiling Diuretic is ______
a).Furosemide b).Ethacrynic acid c).Bumetanide d).Triamterene
[Link] Baby Syndrome occurs with the use of ________
a).Isoniazid b).Chloramphenicol c).Tetracycline d).Propranolol
[Link] Neuritis is a side effect of __________
a).Ethambutol b).Pyrazinamide c).Rifampicin d).PAS
[Link] of choice in ulcerative Colitis is _________
a).Sulfasalazine b).Sulfadimidine c).Sulfathiazole d).Sulfacetamide
[Link] act by_______
a).Decrease amount of glucose released into the blood
b).Muscular utilizatin of glucose by muscle is increased
c).Increase the amount of glucose released into the blood
d).Decreses the amount of glucose in the muscle
[Link] of choice in chloramphenicol resistant typhoid is _____
a).Cephalexin b).Ciprofloxacin c).Ceftazidine d).Ampicillin
[Link] of the following is hepatotoxic?
a).Isoniazid b).Ethambutol c).Pyrazinamide d).Rifampicin
[Link] action of Penicillin is due to its effect on_______
a).Cell membrane permeability b).Cell wall synthesis
c).DNA Synthesis d).Protein synthesis
[Link] of choice in Motion Sickness is _______
a).Metoclopramide b).Chlorpromazine c).Scopolamine d).Diphenhydramine
[Link] cytotoxic agent causes haemorrhagic cystitis?
a).Vinblastine b).Methotrexate c).Cyclophosphamide d).Busulfan
[Link] insulin preparation with longest duration of action is ___
a).Isophane b).protamine Zinc c).Insuline Zinc d).Crystalline Zine
3
[Link] Positive pregnancy test is caused by ________
a).Thioridazine b).Trifluropromazine c).Amitryptiline d).All of these
[Link] level estimation is most essential with________
a).Digoxin b).Lithium c).Chlorpromazine d).Aminophylline
[Link] poisoning would be best antagonized by ________
a).Pralidoxime b).Neostigmine c).Cyclopentolate HCl d).Physostigmine
38.A drug causing painful gynaecomastia and myopahty is ________
a).Lithium b).Clofibrate c).Cimetidine d).Alcohol
[Link] is lease likely with ________
a).Biguanides b).Chlorpropamide c).Glibenclamide d).Tolbutamide
[Link] of the anti neoplastic agent is metabolized by Xanthine Oxidase?
a).6-Mercapto purine b).Vinblastine c).Chlorambucil d).6-Thioguanine
[Link] drug to be avoided in a diabetic patient on insulin is _____
a).Nifedipine b).alfa-methyldopa c).Propanolol d).Atenolol
[Link] of the following is a steroidal antibiotic?
a).Bacitracin b).Nystatin c).Clindamycin d).Fusidic Acid
[Link] of the following diuretic can be used in diabetic insipidus?
a).Thiazides b).Acetazolamide c).Autothioglucose d).Indomethacin
[Link] total leucocyte count is essential in therapy with ______
a).Gentamicin b).Carbenicillin c).Chloramphenicol d).Co-trimoxozole
[Link] are used in ______
a).Anaphylaxis b).Purpura c).Bronchial Asthma d).All of these
[Link] may be caused by ______
a).Sulfonamides b).Salicylates c).Phenacetin d).All of these
[Link] can be caused by _________
a).Colchicine b).Cyclophosphamide c).Cimetidine d).All of these
[Link] occurs when alcohol is taken along with ________
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a).Phenformin b).Chlorpropamide c).Glibenclamide d).Tolbutamide
[Link] antibiotics such as amphotericin B are most likely to _______
a).Inhibit bacterial DNA Synethsis b).Binds to prokaryotic ribosomes
c).Acts as antimetabolite d).Reacts with sterols in the membrane
[Link] of the following durgs is least effective as an anti-inflammatory agent?
a).Phenylbutazone b).Acetaminophen c).Aspirin d).Indomethacin
Answers:
1 a,2 a,3 d,4 d,5 d,6 a,7 b,8 c,9 d,10 a,
11 c,12 d,13 c,14 c,15 b,16 c,17 d,18 d,19 c,20 d,
21 c,22 a, 23 d,24 a,25 b,26 a,27 a,28 b,29 b,30 b,
31 b,32 c,33 c,34 b,35 d,36 b,37 d,38 c,39 d,40 a,
41 c,42 d,43 a, 44 c,45 d,46 d,47 d,48 b,49 d,50 b
5
COMPULSORY QUESTIONS PART II
[Link] the drug has a short duration of action,the action can be prolonged by except:
a).Enteric coating and other methods to retard absorption
b).Interfering with renal excretion c).Inhibiting drug metabolism
d).Increasing dosage
[Link] drugs are rapidly absorbed from:
a).Mouth b).Stomach c).Intestine d).Rectum
[Link] drug has the maximum protein binding:
a).Phenobarbitone b).Thipentone c).Sulphadiazine d).Sulphadimethoxine
[Link] to be avoided in the first trimester of pregnancy:
a).Insulin b).Lithium c).Tinidazole d).Alpha Methyldopa
5.A bactericidal drug would be preferred over a bacteriostatic drug in a patient with:
a).Neutropenia b).Renal insufficiency c).Cirrhosis d).Hemolytic anemia
[Link] mechanism for transfer of multiple antimicrobial resistance among Gram -ve
enterobacteria is:
a).Mutation b).Transformation c).Conjugation d).Transduction
[Link] pass metabolism of following drugs is high except:
a).Pethidine b).Amitriptyline c).Theophylline d).Salbutamol
[Link] feeding is contraindicated if the mother is taking:
a).Iron tonics b).Steroids c).Crystalline Penicillin d).Phenytoin
[Link] of the following drugs has the maximum protein binding:
a).Ampicillin b).Phenylmethyl penicillin c).Clozacillin d).Methicillin
[Link] Rhythm occurs in:
a).Hepatic Microsomal activity b).Urinary excretion c).Blood volume d).Methicillin
[Link] amount of drug required to form 2.5% solution in 100 [Link]:
a)2.5 mg b)25 mg c)250 mg d)2500 mg
[Link] of a drug depends on:
6
a).Rate of excretion b).Rate of absorption c).Serum levels d).Half life
[Link] phase metabolism is seen in:
a).Digoxin b).Dicoumarol c).Propranolol d).Proctalol
[Link] Index of a drug:
a).Denotes its utility in diseases b).Denotes its margin of safety
c).Gives clue for its interaction with other drugs d).Determine potency of drug
[Link] injected drugs absorb:
a).Rapidly as compared to i.v. injection b).Rapidly as compared to [Link]
c).Slower as compared to intravenous d).Fastest
[Link] of fixed-dose combination of Sulfamethoxazole and Trimethoprim is:
a).development of greater capacity to penetrate bacterial cell wall
b).By causing sequential blockade in microbial multiplication
c).Because of adequate absorption from gut mucosa
d).Due to their slow elimination and prolonged action
[Link] of the following are inducers of hepatic microsomal enzymes except:
a).Phenytoin b).Tolbutamide c).Barbiturates d).Rifampicin
[Link] of the following cross plasma membrane except:
a).Epinephrine b).Thyroxine c).Androstenedione d).Methyldopa
[Link] pass metabolism is low in following except:
a).Verapamil b).Phenobarbitone c).Sulindac d).Thiopentone
[Link] are produgs except:
a).Proguanil b).5-Fluoro Uracil c).Sulindac d).Thiopentone
[Link] registration of Pharmacists in the various states, the Pharmacy Act provides for
constition of:
a).Registration Tribunals b).Registrar of Co-operative Societies
c).Regisrar of State Pharmacy Council d).None of the above
[Link] for wholesale of drugs specified in Schedule C and C1 are issued in the
forms:
a) 20A b)20B c) 21B d) 22A
[Link] of following is Ex-officio member of State Pharmacy Council?
a).Chief Pharmacist of Government Hospital b).Chief administrative Medical officer of
state
c).Registered Pharmacist d).Assistant Drug Controller
[Link] original licence or renewed license to sell drugs remains valid upto:
7
a).21st March rent year in which it is granted
b).20th June of following year in which it is granted
c).31st January of same year in which it is granted
d).31st December of following year in which it is granted
[Link] FF contains the list of:
a).Drugs which can be marked under generic names only
b).Drugs which are habit forming c).Standards for opthalmic preparation
d).Drugs which are exempted for certain provision applicable to mfg
[Link] Schedule in Drugs & Cosmetics Act that deals with requirement and guidelines
for
clinical trials, import and and manufacture of new drugs is:
a) Schedule 'O' b) Schedule 'M' c) Schedule 'P' d) Schedule 'Y'
[Link] cancellation of manufacturing license, the loan license is:
a).Cancelled b).Suspended c).Temporarily suspended d).None of the above
28. The person incharge of state drug laboratory is:
a).Drug controller b).Assistant drug controller c).Senior Drug inspector d).Government
Analyst
[Link] education regulation is published in official gazette by:
a).Ministry of education b).Central Govt c).Drug Controller d).President, PCI
[Link] drug personal use can be imported without permit provided, it should not
exceed:
a).100 doses b). 200 doses c).300 doses d). 50 doses
[Link] licensed for sale of drugs are inspected atleast:
a).Once in a year b).Twice in a year c).Thrice in a year d).Every month
[Link] total area required for mfg of cosmetic aerosol as per Drug & Cosmetic Act:
a). 15 sq.m b).25 sq.m c).30 sq.m d). 35 sq.m
[Link] period of drugs is dealt in:
a).Schedule 'Q' b).Schedule 'R' c).Schedule 'P' d).Schedule 'T'
[Link] form specified to obtain a licence to sell or stock the Schedule C and C1 drugs
by retail is:
a) 20 b) 20A c)21 d) 21A
[Link] of Schedule G drugs is:
a).Penicillin injection b).Penicillin Tablets C).Sulfonal d).none of the above
[Link] that arre required to be used only under supervision of registered medical
8
practitioner are dealt in:
a).Schedule G b).Schedule H c).Schedule i d).Schedule D
[Link] belongs to Schedule:
a) X b) G c) H d) M
[Link] term of patent for ordinary invention from date of patent is:
a) 7 years b).14 years c).5 Years d).10 years
[Link] of drugs means;
a).Formulation of drugs in bulk & packing in bulk for packing in small units
b).Breaking up of any drug from bulk container into small packs & labelling
c).Packing,dispensing or formulation of drugs for retail sale
d).None of these
[Link] of cosmetics intended for use on eye brow or eye lash containing Coaltar
dyes is:
a).Permitted b).Exempted c).Prohibited d).Dutyable
[Link] color is:
a).Titanium dioxide b).Caramel c).Cochineal d).Curcumin
[Link] comes under Schedule:
a).G b).H c).W d).P
[Link] should be taken under the supervision of:
a).Surgeon b).Nurse c) R.M.P. d).All of the above
[Link] categories of drugs introduced in Drug & Cosmetic Act in 1982 were:
a) 2 b) 4 c) 6 d) 10
[Link] Standard as per provision of DCA includes:
a).Drugs complying with standards of official pharmacopoeia
b).Drugs complying with standards of Drug & Cosmetic Act
c).Drugs with international standards
d).Drugs complying with standards of all pharmacopoeias
[Link] amendment in DCA was made in:
a). 1975 b). 1982 c). 1985 d).1986
[Link] and propriotary medicines can be imported to some extent in:
a).Crude conditions b).Multidose vials c).bulk form d).Unit containers
[Link] retail sale licences are issued by:
a).Drug Controller of India b).Union Health Minister
c).Drugs Controller authorities of states d).Director of helath Services
9
[Link] belongs to Schedule:
a) E b) X c) G d) H
[Link] and its preparation belong to Schedule:
a) P b) Q c) C 1 d) L
Answers:
1-D, 2-B, 3-D, 4-B, 5-A, 6-C, 7-C, 8-D, 9-C, 10-D,
11-D, 12-D, 13-c, 14-B, 15-C, 16-B, 17-B, 18-c,19-A 20-D
21-C 22-C 23-B 24-D 25-C 26-D 27-A 28-D 29-B 30-A
31-B 32-A 33-C 34-A 35-D 36-A 37-C 38-B 39-B 40-C
41-B 42-B 43-C 44-B 45-B 46-B 47-D 48-C 49-A 50-C
[Link] Arain
(Hospital/clinical pharmacist)
The University of Faisalabad; Madina
University P a k i s t a n
10
Multiple Choice Question (MCQs) of
Organic Pharmaceutical Chemistry
1. The analgesic action of aspirin is removed, if
a. Carboxyl group is removed
b. Acetoxy group is removed
c. Carboxyl group is not attached on ortho position
d. All of the above
--------------------
2. Diastereoisomerism and enantiomorphism is shown in
a. Ephedrine and pseudoephedrine
b. D and L-ephedrine
c. Ephedrine & pseudoephedrine and D & L-ephedrine respectively
d. D & L-ephedrine and Ephedrine & pseudoephedrine respectively
--------------------
3. Caffeine is presented as a/an
a. Purine derivative
b. Pyrimidine derivative
c. Imidazole derivative
d. both b and c
--------------------
4. A group that can donate an electron pair is
a. Bronsted acid
b. Bronsted base
c. Lewis acid
d. Lewis base
--------------------
5. Hendersen-Hasselbalch equation is represented by
a. Ka = [A][H+]/[HA]
b. pKa + pKb = 14
11
c. pKa = pH + log [HA]/[A-]
d. both a and c
--------------------
6. Which of the following is through space-effects on polarizability due to
electronegativity differences?
a. Field effect
b. Inductive effect
c. Resonance effect
d. Polarizability
--------------------
7. Which of the following is the ease of distortion of the electron cloud?
a. Field effect
b. Inductive effect
c. Resonance effect
d. Polarizability
--------------------
8. Which of the following occurs as a result of electronegativity differences?
a. Field effect
b. Inductive effect
c. Resonance effect
d. None of the above
--------------------
9. Which of the following involves the actual movement of electrons through a
pie-bond system?
a. Field effect
b. Inductive effect
c. Resonance effect
d. None of the above
--------------------
10. The movement of electrons through a conjugated system allows for charges
to be dispersed over several atoms. This phenomenon is
a. Localization
12
b. Delocalization
c. Polarization
d. Depolarization
--------------------
11. Which of the following is less influenced by distance?
a. Field effect
b. Inductive effect
c. Resonance effect
d. both a and c
--------------------
12. Which of the following is a carbonyl based group?
a. esters
b. nitro-
c. alcohols
d. ethers
--------------------
13. Which of the following shows electron withdrawing groups?
a. phenyl
b. ethers
c. amines
d. alkyl groups
--------------------
14. Which of the following shows electron donating group?
a. amides
b. esters
c. ketones
d. amines
--------------------
15. Which of the following has minimum pKa value or maximum acidic strength?
a. imide
b. sulphonamide
c. N-arylsulfonamide
13
d. sulfonimide
--------------------
16. sigma-bonding electrons, especially those from C-H bonds can be donated in
a process known as
a. conjugation
b. hyperconjugation
c. polarization
d. depolarization
--------------------
17. Which of the following has neutral pKa value?
a. Water
b. Ether
c. Amide
d. All of the above
--------------------
Answers
1. d
2. c
3. a
4. d
5. c
6. a
7. d
8. b
9. c
10. b
11. c
12. a
13. a
14. d
15. d
16. b
17. d
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