Generic Name: Senna
Brand Name: Senokot, Ex-lax, Senexon, Senna-Gen
Drug Classification: Pharmacotherapeutic: G.I. stimulant
Clinical: Laxative
Mechanism of Action: Senna contains sennosides which act as a stimulating intestinal
cells, producing contractions in intestine, water influx to
the intestines and bowel movement.
Suggested dosage: Syrup (Senokot): 8.8 mg/5 ml. Tablets (Senexon, Senna-Gen,
Senokot): 8.6 mg. (Ex-Lax, Perdiem): 15 mg.
Indication:
Constipation
PO (Tablets): ADULTS, ELDERLY, CHILDREN 12 YRS AND OLDER: 2
tablets at bedtime. Maximum: 4 tablets twice daily. CHILDREN 6–11 YRS:
1 tablet at bedtime. Maximum: 2 tablets twice daily. CHILDREN 2–5 YRS:
½ tablet at bedtime. Maximum: 1 tablet twice daily. PO (Syrup): ADULTS,
ELDERLY, CHILDREN 12 YRS AND OLDER: 10–15 ml at bedtime.
Maximum: 15 ml twice daily. CHILDREN 6–11 YRS: 5–7.5 ml at bedtime.
Maximum: 7.5 ml twice daily. CHILDREN 2–5 YRS: 2.5–3.75 ml at
bedtime. Maximum: 3.75 ml twice daily.
Bowel Evacuation
PO: ADULTS, ELDERLY, CHILDREN OLDER THAN 1 YR: 75 ml
between 2 pm and 4 pm on day prior to procedure.
Contraindication: Undiagnosed abdominal pain, appendicitis, intestinal obstruction or
perforation, nausea, vomiting. Cautions: Prolonged use
(longer than 1 wk) may lead to dependency, fluid and electrolyte
imbalance, vitamin and mineral deficiency.
Side Effects: Frequent: Red, brown discoloration of urine. Occasional: Some degree
of abdominal discomfort, nausea, mild cramping, faintness.
Adverse Effects: Long-term use may result in laxative dependence, chronic
constipation, loss of normal bowel function. Prolonged
use/overdose may result in electrolyte, metabolic
disturbances (e.g., hypokalemia, hypocalcemia, metabolic acidosis
or alkalosis), vomiting, muscle weakness, persistent diarrhea,
malabsorption, weight loss.
Drug Interaction: DRUG: May decrease transit time of concurrently administered oral
medications. HERBAL: None significant. FOOD: None
known. LAB VALUES: May increase serum glucose. May
decrease serum potassium.
Nursing Responsibilities:
Encourage adequate fluid intake.
Assess bowel sounds for peristalsis.
Monitor daily pattern of bowel activity, stool consistency.
Assess for GI disturbances.
Monitor serum electrolytes in pts exposed to prolonged, frequent,
excessive use of medication.