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Deventer Formula

This document provides instructions for using the Deventer method to calculate the recommended vaccination age for infectious bursal disease (IBD) based on Idexx ELISA antibody titre results. The method involves entering titre results from tested birds, selecting a cutoff percentage for flock response, and identifying vaccination age ranges in tables based on bird type and vaccine used. It also notes the potential need for an early vaccination of birds with low titres to prevent outbreaks before the calculated vaccination day is reached due to flock variation.

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Feliks Adi Nugroho
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2K views4 pages

Deventer Formula

This document provides instructions for using the Deventer method to calculate the recommended vaccination age for infectious bursal disease (IBD) based on Idexx ELISA antibody titre results. The method involves entering titre results from tested birds, selecting a cutoff percentage for flock response, and identifying vaccination age ranges in tables based on bird type and vaccine used. It also notes the potential need for an early vaccination of birds with low titres to prevent outbreaks before the calculated vaccination day is reached due to flock variation.

Uploaded by

Feliks Adi Nugroho
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as XLSX, PDF, TXT or read online on Scribd
  • Vaccination Age Tables
  • Deventer Method Instructions
  • Sample Numerical Data

Idexx titre

IBD vaccination age using Idexx titres, according to Deventer formula†:

Sample no. Idexx titre Age at sample: 2


1 5259
2 5310 Earliest vaccination age to allow 75%
3 5844 Vaccine: Other
4 6457 Breakthrough titre,
Idexx,Biochek 100
5 6474 T1/2 (days):
6 6652 3.0 Broiler 23
7 6669 4.5 Broiler Breeder 33
8 7191 5.5 Layer 39
9 7556
10 7638 Earliest vaccination age to allow 25%
11 8067 Vaccine: Other
12 8141 Breakthrough titre,
Idexx,Biochek 100
13 8217 T1/2 (days):
14 8223 3.0 Broiler 22
15 8532 4.5 Broiler Breeder 31
16 8909 5.5 Layer 37
17 9221
18 10237 Gap between take day of lowest 25% of the flock, & 75% take vaccination
19 Days
20 Broiler 1
21 Broiler Breeder 2
22 Layer 2
23
24
Average
7478
18%
CV

†
Adapted from de Wit 2001, COST Action 839, Working Group 3 meeting

Page 1
Idexx titre

days

of the flock to respond: 78%


D-78 228E 11% Then 78% Then (78%+3D)
or
125 700
(78%-3D) Then 78% Then (78%+3D)
22 15
31 20
37 24

of the flock to respond: 11%


D-78 228E

125 200
21 14
30 18 7478
35 22 3739
1869.5
f the flock, & 75% take vaccination day: 934.75
Days 467.375 93.475 116.8438
1 560.85 584.2188
2 654.325 701.0625
2 747.8 817.9063
841.275 934.75
934.75

Page 2
Instructions for the Deventer method calculator

1. Paste or type in the Idexx or Biochek ELISA results from the tested birds into the blue
cells on the left of the page. At least 18 results should be entered.

2. Type in the age of the birds at the time of sampling into the top blue cell on the right.

3. Select the cut-off percentage for the fraction of the flock that you want to be able to
respond to vaccination. 75% is highly recommended - a too low figure (eg, 40%) would
mean most of the birds will not take the vaccine and will not be protected. Too high a
figure (e.g., 90%) would mean you have to wait a lot longer and there is an increased risk
of an outbreak before vaccination."

4. If you wish to determine the recommended vaccination day for a product other than
Nobilis D-78 or Nobilis 228E, enter the breakthrough titer and name for that vaccine in
the cells below the cut-off percentage.

5. The vaccination age (in days) for the type of bird and the vaccine used can be found in
the red tables. Note: if it is known that the half life values ( T1/2 ) or the vaccine
breakthrough titer are different from the given values, they can be changed.

6. Check the gap period for the type of bird, in the lower red table. This is the number of
days between the age when a part of the flock with the lowest-titers can take the vaccine
and when the chosen higher proportion (usually 75%) can be vaccinated. This gap is a
result of the variation in the flock. If this gap is long, waiting for the calculated
vaccination day may expose the flock to an outbreak (starting in birds with low titers),
before vaccination day is reached. In this instance an extra vaccination, to cover the
lowest 30% of the flock, may be needed.
1485
2478
2764
2775
3144
3167
3354
3389
3470
3679
3680
3681
4178
4416
4596
4787
5463
5718

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