FITZPATRICK’S DERMATOLOGY 8th EDITION

VOLUME 1

Part 1. Introduction

Section 1. General Considerations

1. The epidemiology and burden of skin disease

2. Evidence-based dermatology
3. Global health in dermatology
4. Public health in dermatology

Section 2. Approach to Dermatologic Diagnosis

5. Structure of skin lesions and fundamentals of clinical diagnosis

6. Basic pathologic reactions of the skin

Section 3. Overview of biology development, and structure of skin

7. Development and structure of skin

8. Genetics in relation to the skin
9. Racial considerations skin of color

Part 2. Disorders Presenting in Skin and Mucous Membranes

Section 4. Inflammatory disorders based on T-cell reactivity and dysregulation

10. Innate and adaptive immunity in the skin

11. Cytokines
12. Chemokines
13. Allergic contact dermatitis
14. Atopic dermatitis (atopic eczema)
15. Nummular eczema, Lichen simplex
16. Vesicular palmoplantar eczema
17. Autosensitization dermatitis
18. Psoriasis
19. Psoriasis arthritis
20. Reactive arthritis
21. Pustular eruptions of palms and soles
22. Seborrheic dermatitis
23. Exfoliative dermatitis
24. Pityriasis rubra pilaris
25. Parapsoriasis and pityriasis lichenoides
 26. Lichen planus
27. Lichen nitidus
28. Graft-Versus host disease
29. Skin disease in acute and chronic immunosuppression

Section 5. Inflammatory diseases based on neutrophils and eosinophils

30. Regulation of the production and activation of neutrophils

31. Regulation of the production and activation of eosinophils
32. Acute febrile neutrophilic dermatosis (sweet syndrome)
33. Pyoderma gangrenosum
34. Granuloma faciale
35. Subcorneal pustular dermatosis (Sneddon-Wilkison disease)
36. Eosinophils in cutaneous disease

Section 6. Inflammatory disease based on abnormal humoral reactivity and other

inflammatory diseases

37. Humoral immunity and complement

38. Urticaria and angioedema
39. Erythema multiforme
40. Epidermal necrolysis (SSJ and TEN)
41. Cutaneous reactions to drugs
42. Pityriasis rosea
43. Erythema annulare centrifugum and other figurate erythemas
44. Granuloma annulare

Section 7. Disorders of epidermal differentiation and keratinization

45. Epidermal stem cells

46. Epidermal growth anddifferentiation
47. Skin as an organ of protection
48. Irritant contact dermatitis
49. The ichthyoses
50. Inhereted palmoplantar keratodermas
51. Acantholytic disorders of the skin
52. Porokeratosis

Section 8. Disorders of epidermal and dermal-epidermal adhesion and vesicular and

bullous disorders

53. Epidermal and epidermal-dermal adhesion

54. Pemphigus
 55. Paraneoplastic pemphigus
56. Bullous pemphigoid
57. Cicatrical pemphigoid
58. Linear immunoglobulin a dermatosis and chronic bullous disease of childhood
59. Pemphigoid gestationis (herpes gestationis)
60. Epidermolysis bullosa acquisata
61. Dermatosis herpetiformis
62. Inhereted epidermolysis bullosa

Section 9. Disorders of the dermal connective tissue

63. Collagens, elastic fibers, and other extracellular matrix proteins of the dermis
64. Morphea
65. Lichen sclerosus
66. Dermal hypertrophies and benign fibroblastic/myofibroblastic tumors
67. Anetoderma and other atrophic disorders of the skin
68. Ainhum and pseudoainhum
69. Acquired perforating disorders

Section 10. Disorders of subcutaneous tissue

70. Panniculitis
71. Lipodystrophy

Section 11. Disorders of melanocytes

72. Biology of melanocytes

73. Albinism and other genetics disorders of pigmentation
74. Vitiligo
75. Hypomelanoses and hypermelanoses

Section 12. Disorders of the oral and genital integument

76. Biology and pathology of the oral cavity

77. Disease and disorders of the male genitalia
78. Disease and disorders of the female genitalia

Part 3. Disorders of the skin appendages

Section 13. Disorders of the sebaceous glands

79. Biology of sebaceous glands

80. Acne vulgaris and acneiform eruptions
81. Rosacea
82. Perioral dermatitis
Section 14. Disorders of the eccrine and apocrine glands

83. Biology of eccrine and apocrine glands

84. Disorders of the eccrine sweat glands and sweating
85. Disorders of the apocrine sweat glands

Section 15. Disorders of the hair and nails

86. Biology of hair follicles

87. Keratosis pilaris and other inflammatory follicular keratotic syndromes
88. Hair growth disorders
89. Biology of nails and nails disorders

Part 4. Disorders due to the environment

Section 16. Disorders due to ultraviolet radiation

90. Fundamentals of cutaneous photobiology and photoimmunology

91. Abnormal responses to ultraviolet radiation: idiopathic, probably immunologic,
and photoexacerbated
92. Abnormal responses to ultraviolet radiation: photosensitivity induced by
exogenous agents

Section 17. Skin changes due to other physical and chemical factors

93. Thermoregulation
94. Cold injuries
95. Thermal injuries
96. Skin problems in amputees
97. Skin problems in ostomates
98. Corns and calluses
99. Sport dermatology
100. Decubitus (pressure) ulcers
101. Body art

Part 5. Neurocutaneous and psychocutaneous aspects of skin disease

Section 18. Neurocutaneous and psychocutaneous skin disease

102. Neurobiology of the skin

103. Pathophysiology and clinical aspects of pruritus
104. Psychocutaneous skin disease
105. Cutaneous manifestations of drug abuse
106. Skin signs of physical abuse
Part 6. Skin changes across the span of life

Section 19. From birth to old age

107. Neonatal, pediatric, and, and adolescent dermatology

108. Skin changes and diseases in pregnancy
109. Aging of skin

Part 7. Neoplasia

Section 20. Carcinogenesis

110. Genome instability, DNA repair, and cancer

111. Chemical carcinogenesis
112. Ultraviolet radiation carcinogenesis

Section 21. Epidermal and appendageal tumors

113. Epithelial precancerous lessions

114. Squamous cell carcinoma
115. Basal cell carcinoma
116. Basal cell nevus syndrome
117. Keratoacanthoma
118. Benign epithelial tumors, hamartomas, and hyperplasias
119. Appendage tumors and hamartomas of the skin
120. Merkel cell carcinoma
121. Mammary and extramammary paget disease

Section 22. Melanocytic tumors

122. Benign neoplasias and hyperplasias of melanocytes

123. Atypical (dysplastic) melanocytic nevi
124. Cutaneous melanoma

Section 23. Tumors and hyperplasias of the dermis and subcutaneous fat

125. Malignant fibrous, fibrohistiocytic, and histiocytic tumors of the dermis

126. Vascular tumors
127. Neoplasias and hyperplasias of muscular and neural origin
128. Kaposi’s sarcoma and angiosarcoma
129. Neoplasma of subcutaneous fat
 FITZPATRICK’S DERMATOLOGY 8th EDITION

VOLUME 2

Part 8. The Skin in Systemic Disease

Section 24. Skin in nutritional metabolic, and heritable disease

130. Cutaneous changes in nutritional disease

131. Cutaneous changes in errors of amino acid metabolism
132. The porphyrias
133. Amyloidosis of the skin
134. Systemic autoinflammatory disease
135. Xanthoma and lipoprotein diseases
136. Fabry disease
137. Lipoid proteinosis and heritable disorders of connective tissue
138. Cutaneous mineralization and ossification
139. Hereditary disorders of genome instability and DNA repair
140. Tuberous sclerosis complex
141. The neurofibromatoses
142. Ectodermal dysplasias
143. Genetic immunodeficiency diseases

Section 25. Skin Manifestations of Bone Marrow or Blood Chemistry Disorders

144. Hematologic disease

145. Cutaneous lymphoma
146. Inflammatory diseases that stimulate lymphomas
147. Cutaneous Langerhans cell histiocytosis
148. Non-langerhans cell histiocytosis
149. Mastocytosis

Section 26. Skin manifestation of internal organ disorders

150. The skin and disorders of the alimentary tract, the hepatobiliary system, the
kidney, and thecardiopulmonary system
151. Diabetes mellitus and other endocrine diseases
152. Sarcoidosis
153. Cutaneous manifestations of internal malignant disease: cutaneous
paraneoplastic syndromes
Section 27. The skin in vascular and connective tissue and other autoimmune disorders

154. Mechanism of autoimmune disease

155. Lupus erythematosus
156. Dermatomyositis
157. Scleroderma
158. Sclerederma and scleomyxedema
159. Relapsing polychondritis
160. Rheumatoid arthritis, rheumatic fever, and gout
161. Sjorgen’s syndrome

Section 28. The skin in inflammatory and other vascular disorders

162. Endothelium in inflammation and angiogenesis

163. Cutaneous necrotizing venulitis
164. Systemic necrotizing arteritis
165. Erythema elevatum diutinum
166. Adamantiades-Bechet disease
167. Kawasaki disease
168. Pigmented purpuric dermatoses
169. Cryoglobulinemia and cryofibrinogenemia
170. Raynaud Phenomenon
171. Malignant atrophic papulosis (Degos Disease)
172. Vascular malformations
173. Cutanaeous changes in peripheral arterial vascular disease
174. Cutaneous changes in peripheral venous and lymphatic insufficiency

Part 9. Disease due to microbial agents, infestations, bites, and stings

Section 29. Bacterial disease

175. General considerations of bacterial diseases

176. Superficial cutaneous infections and pyodermas
177. Gram-positive infections associated with toxin production
178. Non-necrotizing infections of the dermis and subcutaneous fat: cellulitis and
erysipelas
179. Necrotizing soft tissue infections: necrotizing fasciitis, gangerenous cellutitis,
and myonecrosis
180. Gram-negative coccal and bacillary infections
181. The skin in infective endocarditis, sepsis, septic shock, and disseminated
intravascular coagulation
182. Bartonellosis
183. Miscellaneous bacterial infections with cutaneous manifestations
 184. Tuberculosis andinfections with atypical mycobacteria
185. Actinomycosis, nocardiosis, and actinomycetoma
186. Leprosy
187. Lyme borreliosis

Section 30. Fungal diseases

188. Superficial fungal infection

189. Years infections: candidiasis, tinea (pityriasis) versicolor, and Malassezia
(pityrosporum) folliculitis
190. Deep fungal infections

Sections 31. Viral and rickettsial disease

191. General considerations of viral disease

192. Exanthematous viral diseases
193. Herpes simplex
194. Varicella and herpes zoster
195. Poxvirus infections
196. Human papillomavirus infections
197. Human T-lymphotrophic viruses
198. Cutaneous maniestations of human immunodeficiency virus disease
199. The rickettsioses, ehrlichioses, and anaplasmoses

Section 32. Sexually Transmitted Diseases

200. Syphilis
201. Endemic (nonvenereal) treponematoses
202. Chancroid
203. Lymphogranuloma venereum
204. Granuloma inguinale
205. Gonorrhea, mycoplasma, and vaginosis

Section 33. Infestations, bites, and stings

206. Leishmaniasis and other protozoan infections

207. Helminthic infections
208. Scabies, other mites, and pediculosis
209. Bites and stings of terrestrial and aquatic life
210. Arthropod bites and stings
Part 10. Occupational Skin Diseases and Skin Diseases Due to Biologic Warfare

Section 34. Occupational skin diseases

211. Occupational skin diseases due to irritants and allergens

212. Occupational noneczematous skin diseases due to biologic, physical, and
chemical agents: introduction

Section 35. The skin in bioterrorism and biologic warfare

213. Cutaneous manifestations of biologic, chemical, and radiologic attacks

Section 36. Topical therapy

214. Principles of topical therapy

215. Pharmacokinetics and topical applications of drugs
216. Topical corticosteroids
217. Topical retinoids
218. Topical antibiotics
219. Topical antifungal agents
220. Topical and intralesional cytotoxic agents
221. Topical immunomodulators
222. Other topical medications
223. Photoprotection

Section 37. Systemic therapy

224. Systemic glucocorticoids

225. Dapsone
226. Aminoquinolines
227. Cytotoxic and antimetabolic agents
228. Retinoids
229. Antihistamines
230. Antibiotics
231. Antiviral drugs
232. Oral antifungal agents
233. Immunosuppresive and immunomodulatory drugs
234. Immunobiologicals, cytokines, and growth factors in dermatology
235. Antiangiogenic agents
236. Drug interactions
Section 38. Physical treatments

237. Phototherapy
238. Photochemotherapy and photodynamic therapy
239. Lasers and flashlamps in dermatology
240. Radiotherapy

Section 39. Complementary and alternative dermatology

241. Complementary and alternative medicine in dermatology

Section 40. Surgery in dermatology

242. Anatomy and approach in dermatologic surgery

243. Excisional surgery and repair, flaps, and grafts
244. Mohs micrographic surgery
245. Nail surgery
246. Cryosurgery and electrosurgery
247. Surgical complications
248. Mechanism of wound repair, wound healing,and wound dressing
249. Treatment for varicose and telangiectatic leg veins

Sections 41. Cosmetic dermatology

250. Cosmetics and skin care in dermatology

251. Ablative lasers, chemical peels, and dermabrasion
252. Cosmetic application of nonablative lasers and other light devices
253. Liposuction
254. Soft tissue augmentation
255. Botulinum toxin
256. Hair transplantation and alopecia reduction