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ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

Max. Marks: 300 Model Test Paper – 4 Time: 3 hours

ROSE PHARMACY GPAT
Instructions
1. All questions are multiple choice objective, you have to select one correct answer.

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2. There are 100 questions in question paper. Each question contains three marks.
3. There will be ⅓ (one third) negative marking for each wrong answer.
Q.1 Consistency of capsule hard gelatin shell can be changed by addition of
a) Glycerin b) Sorbitol c) both a & b d) silica

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Q.2 Monsanto tester is used to test …….of the tablets.
a) Hardness b) Friability c) disintegration d) active content
Q.3 Which of the following test is not applicable on parentral preparations?

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a) Pyrogen test b) Sterility test c) Clarity test d) Uniformity test
Q.4 Which capsule has the largest capacity?
a) 0 b) 00 c) 5 d) 000
Q.5 Phenylethylamine and dicyanoamide (cyanoguanidine) are used to prepare
a) Metformin b) Phenformin c) Cycloguanil d) Chloroguanide

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Q.6 An antineoplastic agent methotrexate inhibits the enzyme dihydrofolate reductase.
they bind so tightly that their inhibition has been termed as
a) reversible b) irreversible c) pseudo irreversible d) compitative
Q.7 1-oxopenam structure and has no 6-acylamino side chain of penicillin is
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a) Clavulanic acid b)Sulbactum c) Carbpenam d) Impenam
Q.8 5, 6 methylene dioxyindole is treated with oxalyl chloride to give a keto acid
chloride. This method is useful for introducing a two carbon side chain at
a) Dioxy group of indole b) NH-group of indole c) electron rich 3-position of indole
d) 7-position of indole
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Q.9 If wave length of electromagnetic radiation is 400 nm then what will be the wave
number?
a) 20, 000 cm-1 b) 25, 000 cm-1 c) 30, 000 cm-1 d) 40, 000 cm-1
Q.10 The source of radiation used in IR spectrophotometry
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a) Nernest glower b) Sodium lamp c) Deuterium d) Tungsten

Q.11 Reduction (destruction) in the intensity of fluorescence is called as
a) suppression b)Depression c) Sedation d) Quinching
Q.12 Which of the following drugs is most likely to be effective against multidrug-
resistant strains of M. tuberculosis, including those resistant to streptomycin?
a) Amikacin b) Gentamycin c) Clarithromycin d) Meropenam
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Q.13 Streptomycin has no useful activity in the treatment of

a) Tuberculosis b) Tularemia c) Bubonic plague d) Brucellosis
Q.14 The dose limiting toxicity of amphotericin B is
a) Hypotension b) Hepatitis c) Mylosuppression d) Renal tubular acidosis
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Q.15 Which of the following drug is most likely to be responsible for acute pancreatitis?
a) Zidovudine b) Foscarnet c) Didnosine d) Saquinavir
Q.16 “Athletics foot” disease is caused by
a) Fungus b) Virus c) Bacteria d) Plasmodium
Q.17 Hesperitin is
a) 5,7,3’-trihydroxy flavones b) 5,7,3’,4’-tetrahydroxy flavone c) 3, 5,7,3’ ,4’ –

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

pentahydroxy flavonol d) 5, 7, 3’-trihydroxy-4’-methoxy flavonone

Q.18 Green fluorescence is produced by following compound when treated with borax
a) Senna b) Aloe c) Cascara d) Rubarb
Q.19 Isapgol shows color change when treated with ruthenium red
a) Yellow b) Brown c) Pink d) Voilet
Q.20 Which of the followings are biosynthesized from cinnamic acid?

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a) Coumarin b) Arbutin c) Salicin d) All of these
Q.21 Baclofen is a
a) GABAA- antagonis b) GABAB- antagonist c) GABAB- agonist d) GABAA-agonist
Q.22 Non curable disease comes under

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a) Schedule- J b) Schedule- P1 c) Schedule- N d) Schedule- S
Q.23 Licence of manufacture for sell or distribution of drugs other than those specified in
Schedules C, C1 and X

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a) Form 24 b) Form 25 c) Form 26 d) Form 27
Q.24 Pharmacy Act was passed by central government in
a) 1946 b) 1947 c) 1948 d) 1949
Q.25 Bacillus stereotherophilus is biological indicator in which sterilization process?

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a) Autoclave b) Hot air oven c) Gaseous d) Radiation
Q.26 Spans are chemically
a) Polysorates b) Sorbitan esters c) liposomes d) none of these
Q.27 Enzyme-substrate kinetics is studied by
a) Noyes-whitney b) Handerson-hasslbach c) Michelis menton eq. d) Fick’s law
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Q.28 Anti-cancer drug dactinomycin acts by mechanism
a) Inhibit RNA and protein synthesis b) Intercalate between DNA strands
c) Inhibits DNA polymerase d) Inhibits DHFase
Q.29 Which of the following antibiotics is potent inducer of hepatic drug metabolizing
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enzyme?
a) Clathromycin b) Cyclosporin c) Sparfloxacin d) Rifampin
Q.30 An oral anti-diabetic drug that inhibits an enzyme in the gastrointestinal tract that
converts polysaccharides and thereby reduces postprandial hypoglycemia is
a) Rosiglitazone b) Acarbose c) Metformin d) Glimepride
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Q.31 The purity and acceptability of the propellant is tested by

a) Moisture b) Halogen c) Non volatile residue determination d) All of these
Q.32 Which one of the following is monoclonal antibiotics?
a) Beleomycin b) Polymixin B c) Trastuzumab d) Nystatin
Q.33 The statement “Store in cold place” as per I.P. means
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a) Room temperature b) between 20 to 80 or below c) between 80 to250 d) 300-400

Q.34 If the temperature of body is 39.60 C, then the reading in 0F will be equal to
a) 98.70F b) 99.40F c) 103.280F d) 105.370F
Q.35 TG 8-12% + C 5-10% + CE 35-40% + PL 20-25% +Apo Pro 20-24% is known as
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a) Chylomicron b) VLDL c) LDL d) HDL

+
Q.36 Moderately decrease dv/dt of 0 phase(Na channel blocker) Ia class drug is
a) Tocainamide b) Propafenone c) Disopyramide d) Phenytoin
Q.37 O-bromobenzylchloride + dimethylethylamine are used to prepare the drug
a) Carvedilol b) Bretylium c) Donepezil d) Mexilitine
Q.38 Compitative nondepolarizing neuromuscular blocking agent is

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

a) Trimethaphan b) Parathion c) Pancuronium d) Succinylcholine

Q.39 α2, M2, D2, 5HT1A, μ, k, δ receptor agonists act through the second messenger
a) Increase the level of Cyclic AMP b) through IP3/DAG
c) Open gate to enter Na+/Ca++ d) Decrease the level of Cyclic AMP
Q.40 [1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl-3,5 pyridine
dicarboxylate is known as

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a) Nifedifine b) Nicardipine c) Nimodipine d) Flodipine
Q.41 which one of the following is not anticholinergic aminoalcohol Class drug:
a) Biperiden b) Procyclidine c) Isopropamide d) Trihexyphenidyl
Q.42 The drug, 10-[2-(diethylamino)propyl]phenothiazine has antimuscarinic activity

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and is especially useful in the symptomatic treatment of parkinsonism, will be
a) Promethazine b) Ethopropazine c) Promazine d) Chlorpromazine
Q.43 m-Xylidine is not used in the synthesis of one of the following drug:

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a) Xipamide b) Xylocaine c) Mepivacaine d) Indapamide
Q.44 Insertion of methyl group at ortho position of phenyl ring in diphenhydramine
results in
a) Dimenhydrinate b) Pheniramine c) Orphenadrine d) Benztropine

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Q.45 Removal of the p-hydroxyl group from epinephrine gives one of the following the
product, which is selective for the α1-adrenergic receptor.
a) Albuterol b) Metaraminol c) Methoxamine d) Phenylephrine
Q.46 0.25 gm of a compound C10H15NO.HCl (ephedrine hydrochloride) was titrated with
0.1 M HClO4. It consumed 12.5 ml of the titrant. Calculate the percentage purity
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a) 99.85 % b) 100.85 % c) 99.15 % d) 100.15 %
Q.47 in Bragg’s equation nλ = 2d sinθ, 2θ is the angle between
a) The direction of the incident beam and the reflected beam b) the surface of the
crystal and the incident fluorescent beam c) the direction of the incident and that of
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the diffracted beam d) two incident beams

Q.48 the color which human eye perceives is not color corresponding to the wavelength
of the light
a) Reflected b) absorbed c) refracted d) diffracted
Q.49 presence of anomocytic stomata on the epidermis of pericarp and mesocarp
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containing lignified and reticulate parenchyma is microscopy characters of

a) Cardamom b) Clove c) Fennel d) Cassia cinnamomum
Q.50 quadrangular stalked portion-the hypanthium, surmounted by four divergent lobes
of Sepals which surround a globular head. Powdered drug show fragments of
hypanthium showing the epidermis and the parenchyma containing large oil glands,
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singly occurring short fibres, clusters crystals of calcium oxalate is found in

a) Cardamom b) Clove c) Fennel d) Cassia cinnamomum
Q.51 Calculate the amount of sodium chloride required to make 1.5 % solution of
Pilocarpine hydrochloride is isotonic with tear fluid is (Freezing point of 1 %
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solution of pilocarpine HCl = -0.120C and freezing point of 0.9 % NaCl = -0.5760C)
a) 0.382 % b) 0.590 % c) 0.465 % d) 0.645 %
Q.52 [2-chloro-11-(1-piperazinyl) dibenzo[b,f][1,4]oxazepine] is known as
a) Amoxapine b) Loxapine c) Doxepin d) Quetiapine
Q.53 dipyridodiazepine heterocyclic ring system is present in the following drug
a) efavirenz b) nevirapine c) didanosine d) amithopterine

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

Q54 which of the following is not 2,4,6- tri-iodo benzoic derivative organ imaging agent
a)diatizoic acid b) Ipodate c) Ioxaglate d) metrizamide
Q.55 This reaction shows the synthetic out line of a drug that contain ptridine ring
NH2
COOH
NH2 O
N +

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+ H2CBr CH2CHO H3C NH C NH CH
H2N NH2 Br CH2
N
COOH
a) Triametrine b)Methotraxate c) Leucovarine d) Folnate

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Q.56 What will be the product of the reaction?
Cl Chlorination
O

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Cl C CH3
Imidazole

a) (2,4-dichlorophenyl)Imidazole b) (2,4-dichlorophenylacyl)Imidazole
c) (2,6-dichlorobenzyl)Imidazole d) (2,6-dichlorophenylacetyl)Imidazole

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Q.57 When this product is treated with sodium borohydride and then with p-chlorobenzyl
chloride the end product will be
a) Fluconazole b) Miconazole c) Econazole d) Ketoconazole
Q.58 The main constituent in the dried ripe seeds of Colchicum luteum Baker and
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Colchicum automnale Linn. is derived from
a) Di hydroxy phenylalanine b)Tryptophan c) Ornithine d) Lysine
Q.59 Synthetic cytokinin that is in promoting lateral bud development and inhibition of
senescence
a) Zeatin b) Auxin c) Kinetin d) Gibberellic acid
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Q.60 While performing the chemomicroscopy of a drug, lignified epidermal cells of testa
of seed were observed probable drug is
a) Buchu b) Lobelia c) Nux vomica d) Mint leaves
Q.61 A common organism that causes tetanus belongs to the genus
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a) Candida b) Neisseria c) Pseudomonas d) Clostridium

Q.62 Angiotensin I is
a) a steroidal hormone b) serotonin derivative c) a decapeptide d) a lipoprotein
Q.63 In WHO guidelines for the herbal drugs contaminants include
a) Purines and pyrimidine bases b) Amino acids c) Pentoses
d) Pesticidal residues, heavy metals, microbial load
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Q.64 Glutamate  GABA is converted by the enzyme

a) Glutamate decarboxylase b) Kinase c) Maelic dehydrogenase d) HMG-CoA
Q.65 Rat holding is problem during manufacturing of tablets is due to
a) Poor design of hoper b) Higher granule moisture content
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c) Air entrapment d) Higher processing temperature or humidity

Q.66 The strips are coated with glucose oxidase, peroxidase and o-toludine. Any glucose
in the test solution, when exposed to the strips, gets oxidized leading to the release of
hydrogen peroxide, the latter in turn oxidizes o-toludine to yield a blue color.these are
diagnostic strips and are used to monitor the disease
a) Myocardial infarction b) diabetes c) Cancer d) none of these

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

Q.67Abrasive compound used in the formulation of toothpaste is

a) Dicalcium phosphate b) Sodium lauryl sulphate c) Sorbitol syrup d) Tragacanth
Q.68 How much of 90 % and 20 % alcohols are required to produce 350 ml of 60 %
alcohol?
a) 250 ml, 100 ml b) 300 ml, 50 ml c) 200 ml, 150 ml d) 150 ml, 200 ml
Q.69 G-CSF a myeloid growth factor

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a) Exhibits action similar to that of folic acid b) has a remarkable ability to mobilize
hemopoietic stem cells c) is activated by t-PA d) activates plasminogen to plasmin
Q.70 Aminotransferase is directly involved in the biosynthesis of
a) Palmitate b) Alanine c) Oleate d) 3-phosphoglycerate

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Q.71 Add a solution of potassium permanganate & warm; yields an odor of benzaldehyde
a) Etoposide b) Sumatra benzoin c) Ergot powder d) Papaverine
Q.72 South American arrow poison is obtained from chondodendron tomantosum contain

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a) Curare alkaloids b) Tropane alkaloids c) Quinoline alkaloids d) Ergot alkaloids
Q.73 β-subunit of heamoglobin is defected in disease
a) Haemolytic anemia b) β-Thalassemia c) Scrapie d) phenylketonurea
Q.74 A solution of the drug was freshly prepared at concentration of 600 mg/ml. After 20

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days of storage at 250C, the drug concentration in the solution was found to 200mg/ml.
The drug can be assumed to undergo zero order kinetics. The rate constant is
a) 20 mg/ml/day b) 15 mg/ml/day c) 12.0 mg/ml/day d) 7.5 mg/ml/day
Q.75 Half life of the drug solution under these conditions is
a) 12 days b) 20 days c) 10 days d) 15 days
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Q.76 Which type of sample is used in gas chromatography?
a) Solution b) Crystal c) Solid, liquid or gas d) Liquid or gas
Q.77 Albendazole I P is assayed by
a)Cerric ammonium sulphate b)Sodium nitrite c) Perchloric acid d) Potassium bromate
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Q.78 Splitting of electron’s magnetic energy occurs in

a) ESR Spectrometer b) IR Spectrometer c) Mass Spectrometer d) UV Spectrometer
Q.79 Benzophenone derivative-topical sun screening substance is
a) Colestipole b) Clebopride c) Cilazapril d) Mexenone
Q.80 When benzaldehyde is treated with acetophenone to form chalcone in presence of
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dilute sodium hydroxide is known as

a) Claisen Schmidt condensation b) Michael condensation
c) Friedel-Craft acylation d) Oppenauer oxidation
Q. 81 Influence of temperature on degradation of drug product is studied by
a) Stokes equation b)Arrhenius equation c)Young eq. d)Micaelis-Menton eq.
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Q.82 Homogenisation of emulsion is done with

a) Coulter-counter b) Ultrasonifier c) Chilsonator d) Accela cota
Q.83 Fibrous and crude drugs are milled by
a) Cutter mill b) Revolving mill c) Roll mill d) Fluid energy mill
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Q.84 Iron content in gelatin should be not more than

a) 5 ppm b) 10 ppm c) 15 ppm d) 20 ppm
Q.85 Powder drug + bromine water + dil ammonia solution  Emerald green color in
a) Vital-morin reaction b) Van Urk test c) Thalleoquine test d) Klunge test
Q.86 ephedrine + water + dil. HCl treated with cupper sulphate & NaOH gives
a) Voilet color b) Purple color c) Pink color d) yellow color

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

Q.87 The percentage of acid insoluble ash can be determined by treating total ash with
a) water b) Sulphuric acid c) hydrochloric acid d) none of these
Q.88 Cluster crystals of calcium oxalate and unicellular clothing lignified trichomes are
the characteristic of which adulterant of atropa belladonna
a) Phytolacca decandera b) Ailanthus glandulosa c) Solanum nigrum d) none of these
Q.89 Opium is juice of paper someniferum contains morphine content

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a) 5 % b) 10 % c) 15 % d) 3 %
Q.90 Red color of capsicum is due to pigment
a) Capsiacin b) Capsanthin c) Quassin d) none of these
Q.91 In polarography any change in diffusion current is denoted by

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a) Nernest equation b) Ilkovic equation c) Handerson Haschalbatch eq. d) Stoke eq.
Q.92 In NMR, spinning of nucleus is perpendicular to the applied field and it is known as
a) Momentum b) frequency c) Precision d) Oscillation

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Q.93 In the near IR instrument, radiation source is
a) Nernest glower b) Globar source c) Incandescent d) none of these
Q.94 Which detector is used in UV spectroscopy?
a) Barrier layer cell b) Photo emissive cell c) Photomultiplier tube d) All of these

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Q.95 Which spraying agent is used for carbohydrate in Thin layer chromatography?
a) Mercuric nitrate b) Aniline phthalate c) Antimony trichloride d) diphenyl carbazone
Q.96 Polystyrene film is used for calibration of
a) IR spectrophotometer b) UV spectrophotometer c) NMR spectrometer d) none
Q.97 Calculate the λmax of given structure
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a) 293 nm b) 303 nm H3C

c) 313 nm d) 343 nm
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Q.98 2-[4-(2-furoyl) Piperzin-1-yl]-6,7-dimethoxyquinazolin-4ylamine hydrochloride is

chemical name of drug
a) Terazosin b) Prazosin c) Dioxazosin d) Trimethoprim
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Q.99 The tablet of above drug is analyzed by

a) Non-aqueous titration b) HPLC c) Spectrophotometery d) Potentiometery
Q.100 Karl-fisher reagent does not contain one of the following constituents
a) Pyridine b) Iodine c) Sulfur dioxide d) Ethanol

Answer Key
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1.c 2.a 3.d 4.d 5.b 6.c 7.a 8.c 9.b 10.a 11.d 12.a 13.d
14.d 15.c 16.a 17.d 18.b 19.c 20.d 21.c 22.a 23.b 24.c 25.a 26.b
27.c 28.b 29.d 30.b 31.d 32.c 33.b 34.c 35.c 36.c 37.b 38.c 39.d
40.c 41.c 42.b 43.d 44.c 45.d 46.b 47.c 48.a 49.c 50.b 51.b 52.a
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53.b 54.b 55.b 56.b 57.c 58.a 59.c 60.b 61.d 62.c 63.d 64.a 65.a
66.b 67.a 68.c 69.b 70.b 71.b 72.a 73.b 74.a 75.d 76.d 77.c 78.a
79.d 80.a 81.b 82.b 83.a 84.c 85.c 86.a 87.c 88.b 89.b 90.b 91.b
92.c 93.c 94.d 95.b 96.a 97.d 98.b 99.b 100.d

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