Scribd
Upload
147 views2 pages

Antiarrhythmic Agent: Class Known As Examples Mechanism Clinical Uses in Cardiology

Antiarrhythmic agents are a group of pharmaceuticals used to treat abnormal heart rhythms such as atrial fibrillation and ventricular tachycardia. They are classified into five categories based on their mechanism of action - sodium channel blockers (Class I), beta blockers (Class II), potassium channel blockers (Class III), calcium channel blockers (Class IV), and others with direct effects on cardiac tissues (Class V). Each class includes example drugs and is used to treat specific cardiac arrhythmias.

Uploaded by

MUBIERAMZI
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
147 views2 pages

Antiarrhythmic Agent: Class Known As Examples Mechanism Clinical Uses in Cardiology

Antiarrhythmic agents are a group of pharmaceuticals used to treat abnormal heart rhythms such as atrial fibrillation and ventricular tachycardia. They are classified into five categories based on their mechanism of action - sodium channel blockers (Class I), beta blockers (Class II), potassium channel blockers (Class III), calcium channel blockers (Class IV), and others with direct effects on cardiac tissues (Class V). Each class includes example drugs and is used to treat specific cardiac arrhythmias.

Uploaded by

MUBIERAMZI
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Antiarrhythmic agent are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias),

such as atrial
fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.

Class Known as Examples Mechanism Clinical uses in cardiology [1]

 Ventricular arrhythmias
fast-channel  Quinidine
(Na+) channel block (intermediate  prevention of paroxysmal recurrent atrial fibrillation (triggered
Ia blockers-affect QRS  Procainamide
association/dissociation) byvagal overactivity)
complex
 Disopyramide
 procainamide in Wolff-Parkinson-White syndrome

 Lidocaine  treatment and prevention during and immediately aftermyocardial


Do not affect QRS  Phenytoin (Na+) channel block (fast infarction, though this practice is now discouraged given the increased
Ib
complex  Mexiletine association/dissociation) risk of asystole

 Tocainide  ventricular tachycardia

 Encainide
 prevents paroxysmal atrial fibrillation
 Flecainide (Na+) channel block (slow
Ic  treats recurrent tachyarrhythmias of abnormal conduction system.
 Propafenone association/dissociation)
 contraindicated immediately post-myocardial infarction.
 Moricizine

 Propranolol
 Esmolol
beta blocking
 Timolol  decrease myocardial infarction mortality
II Beta-blockers Propranolol also shows some class I
 Metoprolol action  prevent recurrence of tachyarrhythmias
 Atenolol
 Bisoprolol

 Amiodarone K+ channel blocker


 Sotalol  In Wolff-Parkinson-White syndrome
Sotalol is also a beta
III  Ibutilide  (sotalol:) ventricular tachycardias and atrial fibrillation
blocker[2] Amiodaronehas Class I, II, III &
 Dofetilide  (Ibutilide:) atrial flutter and atrial fibrillation
IV activity
 Dronedarone
 E-4031

slow-channel  Verapamil  prevent recurrence of paroxysmal supraventricular tachycardia


IV Ca2+ channel blocker
blockers  Diltiazem  reduce ventricular rate in patients with atrial fibrillation

 Adenosine
Used in supraventricular arrhythmias, especially in Heart Failure with Atrial
 Digoxin Work by other or unknown mechanisms
V Fibrillation, contraindicated in ventricular arrhythmias. Or in the case of
 Magnesium (Direct nodal inhibition).
Magnesium Sulf
Sulfate

You might also like