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Codeine-Dexketoprofen Pain Study

This study investigated the effects of sub-analgesic doses of codeine-dexketoprofen association on somatic and visceral pain in mice. The researchers found that while low doses of codeine or dexketoprofen alone did not influence nociceptive reactivity, the combination of low doses of codeine and dexketoprofen induced a significant increase in latency response to thermal pain and an important decrease in the number of pain-induced writhes. The results suggest that treatment with sub-analgesic doses of codeine and dexketoprofen together produced antinociceptive effects in both somatic and visceral pain models in mice.

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29 views1 page

Codeine-Dexketoprofen Pain Study

This study investigated the effects of sub-analgesic doses of codeine-dexketoprofen association on somatic and visceral pain in mice. The researchers found that while low doses of codeine or dexketoprofen alone did not influence nociceptive reactivity, the combination of low doses of codeine and dexketoprofen induced a significant increase in latency response to thermal pain and an important decrease in the number of pain-induced writhes. The results suggest that treatment with sub-analgesic doses of codeine and dexketoprofen together produced antinociceptive effects in both somatic and visceral pain models in mice.

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EXPERIMENTAL RESEARCHES ON THE EFFECTS OF LOW DOSES OF

CODEINE-DEXKETOPROFEN ASSOCIATION IN NOCICEPTIVE REACTIVITY

Authors: Ana Damaschin, Andrei Damaschin


Scientific coordinator: Assist. lecturer Beatrice Rozalina Buca MD, Assoc. prof. Liliana
Mititelu-Tarţău MD, PhD
’’Grigore T. Popa’’ University of Medicine and Pharmacy, Iasi, Romania
Department of Pharmacology, Clinical Pharmacology and Algesiology

Abstract: The natural opioid agonist, codeine, is a phenanthrene derivative, used as


painkiller and cough suppressant drug. The non-steroidal anti-inflammatory drug
dexketoprofen is the dextro-rotatory enantiomer of ketoprofen, indicated in the treatment of
post-operative pain, dysmenorrhea, low back pain, arthritis and toothache. We aimed to
investigate the effects of sub-analgesic doses of codeine-dexketoprofen association in somatic
and visceral pain models in mice. Material and method: The experiment was carried out
with white Swiss mice (20-25g), distributed into 4 groups of 6 animals each, treated
intraperitoneally, with only one dose, as follows: Group I (Control): distilled water
0,1ml/10g body weight; Group II (COD): codeine 100mg/kbw; Group III (DEX):
dexketoprofen 1.5mg/kbw; Group IV (COD+ADEX): codeine 100mg/kbw+dexketoprofen
1.5mg/kbw. Tail immersion test was used to assess somatic nociception in mice. The tail
withdrawal response (seconds) was counted before, 15, 30, 60 and 90 minutes after the
substances administration. Visceral sensitivity was evaluated using writhing test with acetic
acid 0.6%. The behavior modifications (writhes) were scored every 5 minutes during 30
minutes. Data were analyzed using SPSS software for Windows version 17.0 and ANOVA
method. Experimental protocol was implemented according to recommendations of our
University Committee for Research and Ethical Issues, in concordance with the international
guidelines, regarding the handling of laboratory animals. Results: The administration of
100mg/kbw of codeine or 1.5mg/kbw of dexketoprofen did not influence the nociceptive
reactivity in tail immersion test, nor in writhing test in mice. The combination of low doses of
codeine and dexketoprofen induced significant increase in the latency time response to
thermal noxious tail stimulation. The use of codeine and dexketoprofen combination was
associated by an important decrease in the number of writhes. Conclusions: The treatment of
sub-analgesic doses of codeine and dexketoprofen association, determined antinociceptive
effects in both somatic and visceral pain models in mice. Keywords: codeine, dexketoprofen,
tail immersion, writhing test.

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