MODIFIABLE RISK FACTORS NON - MODIFIABLE RISK FACTORS
Hypertensive vascular disease Advancing age
Diabetes Mellitus Female gender @ menopausal
Obesity Genetics & racial attributes
Lifestyle
- Psychosocial stress
- Physical inactivity
- Alcohol consumption
- Increased fat intake
- Increased serum cholesterol level
MYOCARDIAL INFARCTION
Atheroma build-up Plaque formation @ coronary vessels
Rupture of vulnerable atherosclerotic
plaque
Exposure of the plaques lipid-rich core
to flowing blood
Seepage of blood into plaque, causing
LEGEND:
it to expand
RISK FACTORS
Thrombus formation
DISEASE PROCESS
Occlusion of a coronary artery
MANIFESTED SIGNS
UNMANIFESTED SIGNS
Coronary blood supply
less than demand
Anaerobic Coronary ischemia
metabolism/glycolysyis
Coronary injury
ANGINA Lactic acid
(CHEST PAIN) production
Coronary infarction Myocardial cell
death
Atypical stomach,
back, or abdominal Elevated ST
Altered segment, Q wave
pain
repolarization of the appears
myocardium
DYSRHYTHMIA Elevated CK-MB,
Myocardial irritability Release of myoglobin, and
lysosomal enzymes troponin T
Decreased cardiac
ELEVATED
contractility
TROPONIN I
Palpitations, orthopnea,
paroxysmal nocturnal Decreased cardiac
dyspnea, hypotension, output
swelling of extremities,
decreased urine output
DIZZINESS, SYNCOPE,
ALTERED MENTATION,
PALLOR, DIAPHORESIS,
SHORTNESS OF BREATH,