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Eszopiclone: Mechanism and Properties

Eszopiclone is a nonbenzodiazepine hypnotic drug used to treat insomnia. It has a molecular weight of 388.812 g/mol and binds to GABA receptors in the central nervous system to produce a calming effect. Eszopiclone is taken as a circular tablet before bedtime to help patients fall asleep faster, stay asleep longer, and reduce nighttime awakenings. Treatment periods are generally limited to 1-2 weeks and dosages are based on medical conditions and other factors.

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251 views1 page

Eszopiclone: Mechanism and Properties

Eszopiclone is a nonbenzodiazepine hypnotic drug used to treat insomnia. It has a molecular weight of 388.812 g/mol and binds to GABA receptors in the central nervous system to produce a calming effect. Eszopiclone is taken as a circular tablet before bedtime to help patients fall asleep faster, stay asleep longer, and reduce nighttime awakenings. Treatment periods are generally limited to 1-2 weeks and dosages are based on medical conditions and other factors.

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Ms.

Sorasaree Tonsiengsom Jirat Prasertmak


Chemistry 11 1101

Eszopiclone
Chemical Properties [3]
Molecularweight: 388.812 g/mol
Formal charge: 0
Dissociation constant: pKa = 5.35
IUPAC name: [(7S)-6-(5-chloropyridin-
2-yl)-5-oxo-7H-
pyrrolo[3,4-b]pyrazin-7-
yl] 4-methylpiperazine-
1-carboxylate
Physical Properties [1]
Status: Solid
Density:1.50.1 g/cm3
Colour:White to light-yellow crystalline
Vapor pressure:9.7X10-11 mm Hg at 25 deg C
Melting point: 202-204 C
Solubility: Very slightly soluble Eszopiclone is a cyclopyrrolone, nonbenzodiazepine
Flash point: 305.030.1 C and active stereoisomer of zopiclone with hypnotic and
sedative activity. Eszopiclone is able to bind to and
Application activate the omega-1 subtype of the alpha subunit of the
Eszopiclone is formed as a circular gamma-aminobutyric acid-benzodiazepine GABA
tablet which is taken before
receptor complex (GABA-A) in the central nervous
bedtime. Insomnia is efficiently
treated by the medicine. It helps system (CNS). [National Center for Biotechnology
patients fall asleep faster and stay Information, n.d.]
asleep longer, and reduces chances
to wake up during the There are limited periods of 1 to 2 weeks
night.Eszopiclone
. is in sedative- to take. The dosage is based on your
hypnotics class which acts on your medical condition, age, liver function,
brain to produce a calming effect. other medications you may be taking.[2] C17H17ClN6O3

References:
Eszopiclone. (n.d.). Retrieved May 20, 2017, from http://www.chemspider.com/Chemical-
Structure.839530.html[1]
Krystal, A. D., & Walsh, J. K. (n.d.). Sustained Efficacy of Eszopiclone Over 6 Months of Nightly
Treatment: Results of a Randomized, Double-Blind, Placebo-Controlled Study in Adults with
Chronic Insomnia [PDF].[2]
National Center for Biotechnology Information. PubChem Compound Database; CID=969472.
(n.d.).Retrieved May 17, 2017, from https://pubchem.ncbi.nlm.nih.gov/compound/96947 [3]

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