PCB 6555
Introduction to Quantitative Genetics
Spring 2013
PREREQUISITE
STA6166 or equivalent
INSTRUCTOR
Dr. Salvador A. Gezan
Office: 363 Newins-Ziegler Hall
Phone: (352) 846-0133
E-mail:
[email protected]Office hours: TBA (or by appointment).
LECTURE TIME
Tuesday:
Thursday:
Period 5 (11:45 am 12:35 pm) MAEB 229
Periods 5 (11:45 am 12:35 pm) MAEB 229
COMPUTING LABS
Wednesday:
Periods 10-11 (5:10 pm 7:05 pm) NZH 222
CLASS WEBSITE
https://lss.at.ufl.edu/
COURSE DESCRIPTION Intended for students of all disciplines who are interested in
genetic principles and biometric evaluation of characters that
exhibit continuous variation in natural populations or breeding
programs.
COURSE OBJECTIVES
Introduce graduate students to concepts, theory and methods in
quantitative genetics with emphasis in applications for breeding
programs and statistical analysis of genetic experiments.
INTENDED AUDIENCE
The course is designed for both MS and Phd graduate students in
the following disciplines: plant or anuimal genetics; plant or
anumal breeding; molecular gentics or biotechnology; conservation
biology in botany, zoology or fisheries.
COURSE FORMAT
The course is structured as two one period lectures and one two
period laboratory each week. The lectures cover concepts and
theory. The laboratory section is used to reinforce and enhance the
lecture material, including: (1) presentation of additional material
on statistical methods and computer programs, (2) problem solving
and data analysis, and (3) exams.
TEXTBOOK
No text required (notes will be provided on courses webpage).
The following are some of the suggested textbooks:
WARNING
This class assumes that you have done STA6167 or an equivalent
class with some strong component of linear models, and that you
are familiar with basic matrix algebra. The course will assume that
those topics are well known. In addition, we assume that you are
self-motivated and an independent student/researched that will be
EXAMS
There will be 3 exams. No final exam will be required, but exams
will be cumulative with greater emphasis in later/newer material.
Each Exam will be worth 100 points. These will be implemented
during laboratory time. No make-up exams will be given under
ANY circumstance!
EXAM DATES
Exam 1 (5:10-7:10 pm) - Febreuary 5 NZH 222
Exam 2 (5:10-7:10 pm) - March 5 NZH 222
Exam 3 (5:10-7:10 pm) - April 5 NZH 222
HOMEWORK
There will be 6 assignments, each will be worth 20 points, and
only the best 5 will be considered for grading. Therefore, there is a
total of 100 points. Students may work together in groups, but the
report must be presented individually. Homework are due at 11:45
pm before the corresponding class and should be presented ON
PAPER (i.e. not electronically). Late homework will NOT be
accepted!
ATTENDANCE
Lecture and laboratory attendance is not obligatory, but success in
the class (together with eligibility of bonus points and/or curving)
depends, and it will depend, on attendance. In addition, some
topics relevant for exams and homework that are not included in
slides will be presented during class.
GRADING
Grades will be based on a total of 400 points, with 300 points from
the exams and 100 points from homework. The following are the
letter grades considered and their corresponding ranges
A (381-400)
B+ (347-360)
C+ (307-320)
D+ (267-280)
E (0-240)
SOFTWARE
A- (361-380)
B (334-346)
C (294-306)
D (254-266)
B- (321-333)
C- (281-293)
D- (241-253)
You will need a computer for some of the homework assignments.
The main software used will be ASReml. This statistical package
is free for educational purposes for Windows and it can be
downloaded from: http://www.vsni.co.uk/software/asreml.
Additional statistical software might be used during class to
illustrate some other aspects, and this could include SAS and R.
OUTLINE OF TOPICS (Tentative)
Topic
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
Description
Population Genetics Review
Continuous and Discrete Variation
Expected Values and Breeding Values
Variance Components in Genetics
Linear Mixed Model Theory
REML and Estimation of Variance Components
Resemblance Between Relatives: Relationship Matrix
Animal Model
Parental Model: Mating Designs and Analysis
Genetic Gains and Response to Selection
Heritability and its Inference
Genotype by Environment and Multi-Site Analysis
Multi-Trait Analysis and Selection Index
Dealing with Binomial Responses
Incorporating Molecular Data: QTL and Genomic Selection
ADDITIONAL REFERENCES
Bernardo, R. 2010. Breeding for Quantitative Traits in Plants. Second Edition. Stemma Press,
Minnesota.
Bourdon, R.M. 2000. Understanding Animal Breeding. Second Edition. Prentice Hall, New
Jersey.
Bulmer, M. G. 1980. The Mathematical Theory of Quantitative Genetics. Oxford University
Press.
Cameron, N.D. 1997. Selection Indices and Prediction of Genetic Merit in Animal Breeding.
CAB International. Wallington, UK.
Falconer, D. S. and T. F. C. Mackay. 1996. Introduction to Quantitative Genetics. Fourth
Edition, Longman, New York.
Hallauer, A.R.; Carena, M.J. Miranda Filho, J.B. 2010. Quantitative Genetics in Maize Breeding.
Springer, New York.
Henderson, C.R. 1984. Applications of Linear Models in Animal Breeding. University of
Guelph.
Kearsey, M. J. and H. S. Pooni. 1996. The Genetical Analysis of Quantitative Traits. Chapman &
Hall, New York.
Littell, R. C.; Milliken, G.A.; Strop, W.W.; Wolfinger, R.D. and O. Schabenberger. 2006. SAS
for Mixed Models. Second Edition. Cary, NC: SAS Institute Inc.
Lynch, M. & B. Walsh, 1998. Genetics and Analysis of Quantitative Traits. Sinaure Associate,
Sunderland, Massachusetts.
Mather, K. and J. L. Jinks. 1977. Introduction to Biometrical Genetics. Cornell University Press,
Ithaca, New York.
Mrode, R.A. 2005. Linear Models for the Prediction of Animal Breeding Values. 2nd Edition.
CABI Publishing. Wallingford, UK.
Van Vleck, L.D.; Pollak, E.J. and Oltenacu, E.A.B. 1987. Genetics for the Animal Sciences. W.
H. Freeman and Company, New York.
White, T.L.; Adams, W.T. and Neale, D.B. 2007. Forest Genetics. CABI Publishing, Wallington,
UK.
White, T.L. and Hodge, G. 1989. Predicting Breeding Values with Applications in Forest Tree
Improvement. Kluwer Academic Publishers. Dordrecht, The Netherlands.
UNIVERSITY POLICIES
Academic Dishonesty: All members of the University Community share the responsibility to
challenge and make known acts of apparent academic dishonesty. Acts of academic dishonesty
will not be tolerated and will be referred to the Student Honor Council.
Software use: All faculty, staff and students of the University are required and expected to obey
the laws and legal agreements governing software use. Failure to do so can lead to monetary
damages and/or criminal penalties for the individual violator. Because such violations are also
against the University policies and rules, disciplinary action will be taken as appropriate.
University support services: Resources are available on-campus for students having personal
problems or lacking clear career and academic goals which interfere with their academic
performance. These resources include:
1. University Counseling Center, 301 Peabody Hall, 392-1575, personal and career counseling
2. Student Mental Health, Student Health Care Center, 392-1171, personal counseling
3. Sexual Assault Recovery Services, Student Health Care Center, 392-1161, sexual counseling
4. Career Resource Center, Reitz Union, 392-1601, career development assistance and counseling
Accommodations for students with disabilities: Students requesting classroom
accommodation must first register with the Dean of Students Office. The Dean of Students
Office will provide documentation to the student who must then provide this documentation to
the Instructor when requesting accommodation. If you have a documented disability and wish to
discuss academic accommodations, please CONTACT ME as soon as possible.
