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The Brief Assessment of Cognition in Affective Disorders (Bac-A) : A New Instrument For Assessing Cognitive Functioning in Bipolar Disorder

This study assessed cognitive performance in 93 young adults with bipolar disorder compared to 56 healthy controls using the Brief Assessment of Cognition in Affective Disorders (BAC-A). The BAC-A measured cognitive domains including memory, verbal fluency, inhibition, and problem solving. Bipolar patients performed significantly worse than healthy controls on immediate non-affective memory and verbal fluency. Verbal memory scores correlated positively with functional and clinical measures. The results support the BAC-A as a useful tool for evaluating cognitive impairment in bipolar disorder.

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0% found this document useful (0 votes)

334 views1 page

The Brief Assessment of Cognition in Affective Disorders (Bac-A) : A New Instrument For Assessing Cognitive Functioning in Bipolar Disorder

Uploaded by

elvinegunawan

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Download as PDF, TXT or read online on Scribd

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REFERENCES

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ACKNOWLEDGEMENTS

1. Keefe R. S. E., Goldberg T. E., Harvey P. D., Gold J. M., Poe M. P., Coughenour L. The Brief
Assessment of Cognition in Schizophrenia: Reliability, sensitivity, and comparison with a
standard neurocognitive battery. Schizophrenia Research 2004;68(23):283-297.
2.Keefe R. S. E., Harvey P. D., Goldberg T. E., Gold J. M., Walker T. M., Kennel C., et al. Norms
and standardization of the Brief Assessment of Cognition in Schizophrenia
(BACS). Schizophrenia Research 2008;102(13):108-115.
3.Quraishi, S., & Frangou, S. (2002). Neuropsychology of bipolar disorder: a review. Journal of
Affective Disorders, 72(3), 209-226.

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This work was partly supported by 1R01MH085667 and Pat Rutherford, Jr Chair in Psychiatry
at UTHealth\

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CONCLUSIONS

Our results are consistent with previous reports of verbal

memory and word generation impairment in BD.
BD may be associated with inefficient learning strategies
rather than memory storage problems.
The addition of time-based tests of processing speed and
measures of sustained attention may increase the
specificity of the BAC-A for the assessment of BD patients.

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BD patients exhibited a significant impairment in immediate nonaffective memory and verbal fluency when compared to HC.
Verbal memory correlated positively with functional and clinical
scores.

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Abbreviations: STAM = short-term affective memory, STNM = short-term non-affective memory, fluency =
verbal fluency, DAM = delayed affective memory, DNM = delayed non-affective memory, PS = problem
solving (PS), and attention in bipolar patients (BD) and healthy controls (HC). *p<.05

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93 BD patients and 56 healthy controls

The BAC-A variables were summarized in eight summary
scores : visuomotor abilities, immediate affective and nonaffective memory, verbal fluency, delayed affective and nonaffective memory, inhibition, problem solving.
Profile analyses compared the cognitive performance of BD
and HC. Age was included as a covariate.
Correlational analyses were conducted to explore the
association between cognitive functioning and clinical
features.

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METHODS

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Assess cognitive performance in young adults with BD

compared to healthy controls using the BAC-A.

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OBJECTIVES

RESULTS

Cognitive impairment persists during the acute and

euthymic phases of BD.
Although cognitive impairment is a core feature of bipolar
disorder (BD) there is no established instrument of choice
for the cognitive evaluation of bipolar patients.
The Brief Assessment of Cognition in Affective Disorders
(BAC-A) is a newly developed tool that assesses cognitive
domains of interest in BD.

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*corresponding author :[email protected]

BACKGROUND

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Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX 77054, USA
2Division of Medical Psychology, Duke University, Medical Centre, Durham, NC, 27710 , USA

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E. Bauer, 2Richard S.E. Keefe, 1Robert Suchting, 1Charles Green, 1Giovana B. Zunta-Soares, 1Jair C. Soares

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1Isabelle

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