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Drug Study

Trimetazidine is an antianginal drug that works by selectively inhibiting an enzyme involved in fatty acid oxidation, improving glucose utilization and limiting acidosis and calcium overload. It is indicated for the preventive treatment of episodes of angina pectoris and can cause side effects like dizziness, headache, and abdominal pain. Citicoline is a nootropic drug that increases phosphatidylcholine in the brain to reduce tissue damage from injury and is used to treat cerebrovascular diseases.

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Lorina Lynne Apelacio
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987 views2 pages

Drug Study

Trimetazidine is an antianginal drug that works by selectively inhibiting an enzyme involved in fatty acid oxidation, improving glucose utilization and limiting acidosis and calcium overload. It is indicated for the preventive treatment of episodes of angina pectoris and can cause side effects like dizziness, headache, and abdominal pain. Citicoline is a nootropic drug that increases phosphatidylcholine in the brain to reduce tissue damage from injury and is used to treat cerebrovascular diseases.

Uploaded by

Lorina Lynne Apelacio
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd

Drug Name TRIMETAZIDINE !

astarel MR" #$ mg%tab &ID Drug classes: ANTI'AN(INA

Mechanism Of Action
Selective inhibition of an enzyme of fatty acid oxidation: the long-chain 3-ketoacyl CoA thiolase 3-!A"#$ "his inhibition results in: %eduction in fatty acid oxidation& Stimulation of glucose oxidation$ "he cou'ling of glycolysis (ith glucose oxidation is im'roved and A") 'roduction is further increased* (hile cell acidosis and Ca+, overload are limited$ "he increase in total glucose utilization has been evidenced by studies using -./D0 'ositron emission tomogra'hy )1"#$

Indication
)reventive treatment of e'isodes of angina 'ectoris$

Contraindicatio n
2y'ersensitivity$ Severe renal im'airment CrCl 334 m56min#$ 5actation$

Adverse Effect
Commonly* dizziness* headache* abdominal 'ain* diarrhea* dys'e'sia* nausea* vomiting* rash* 'ruritus* urticaria* asthenia$ %arely* 'al'itations* extrasystoles* tachycardia* arterial hy'otension* orthostatic hy'otension that may be associated (6 malaise* dizziness or fall* in 'articular in 'atients taking antihy'ertensive treatment* flushing$ Commonly* body tem'erature elevation* restlessness* headache* nausea and vomiting* diarrhea* lo( or high blood 'ressure* tachycardia* slee'ing troubles or insomnia* blurred vision* chest 'ains :ccasionally* may stimulate 'arasym'athetic effects* fleeting ? discrete

Nursing Responsibilities
Check for doctor7s order 8onitor blood 'ressure and 'ulse rate before and after giving the meds$ 9otify 'rescribing signs of heart failure such as s(elling of hands and feet or S:;$ Advise 'atient of the side effects of the drug$

CITICO)INE Z*napse" +, ml &ID Drug classes:


NE-ROTONIC./ NOOTRO0IC.

Citicoline increase a brain chemical called 'hos'hatidylcholine$ "his brain chemical is im'ortant for brain function$ <t decreases brain tissue damage (hen the brain is in=ured$ <t is usually kno(n that 'hos'holi'id* es'ecially lecithin* decreases follo(ing decline in brain activity (ith cerebral trauma$ Citicoline* (hich is a co-enzyme* accelerates the biosynthesis of lecithin in the body$ "his medication

Cerebrovascular diseases

Any allergy or hy'ersensitivity to the drug 2y'ertonia of the 'arasym'athetic nervous system >se cautiously for 'regnancy and lactation Conscious use for 'atient (ith renal and he'atic damage

Citicoline may be taken (ith or (ithout food$ "ake it (ith or bet(een meals$ "he su''lement should not be taken in the late afternoon or at night because it can cause difficulty slee'ing$ Contact the 'hysician immediately if allergic reaction such as hives* rash* or itching* s(elling in your face or hands* mouth or throat* chest tightness or trouble breathing are ex'erienced$ Citicoline thera'y should be started (ithin +@ hours of a stroke$ "he 'hysician (ill 'rescribe the correct dosage and the length of time it

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