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Durie-Salmon Staging of Myeloma

The document describes the Durie and Salmon staging system for multiple myeloma, which classifies patients into stages based on criteria including cell mass measurements, hemoglobin and calcium levels, bone lesions, paraprotein levels, and renal function. Stage I indicates a low myeloma cell mass of 600 billion or less, stage II is intermediate with 600-1200 billion cells, and stage III represents a high cell mass of over 1200 billion cells. Stages are further divided into A or B categories depending on normal or abnormal renal function.

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Meldy Muzada Elfa
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153 views1 page

Durie-Salmon Staging of Myeloma

The document describes the Durie and Salmon staging system for multiple myeloma, which classifies patients into stages based on criteria including cell mass measurements, hemoglobin and calcium levels, bone lesions, paraprotein levels, and renal function. Stage I indicates a low myeloma cell mass of 600 billion or less, stage II is intermediate with 600-1200 billion cells, and stage III represents a high cell mass of over 1200 billion cells. Stages are further divided into A or B categories depending on normal or abnormal renal function.

Uploaded by

Meldy Muzada Elfa
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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TABLE 4: THE DURIE AND SALMON STAGING SYSTEM

STAGE CRITERIA MEASURED MYELOMA CELL MASS


(myeloma cells in billions/m2)*

STAGE I (low cell mass)

All of the following: Hemoglobin value >10g/dL  Serum calcium value normal or <10.5mg/dL  Bone x-ray, normal bone structure (scale 0), or solitary bone plasmacytoma only  Low M-component production rates IgG value <5g/dL; IgA value <3g/dL  Urine light chain M-component on electrophoresis <4g/24h Fitting neither Stage I nor Stage III

600 billion*

STAGE II (intermediate cell mass) STAGE III (high cell mass)

600 to 1,200 billion*

*myeloma cells in whole body

One or more of the following: Hemoglobin value <8.5g/dL Serum calcium value >12mg/dL Advanced lytic bone lesions (scale 3)  High M-component production rates IgG value >7g/dL IgA value >5g/dL Bence Jones protein >12g/24h  A: relatively normal renal function (serum creatinine value) <2.0 mg/dL  B: abnormal renal function (serum creatinine value) >2.0 mg/dL Examples: Stage IA (low cell mass with normal renal function) Stage IIIB (high cell mass with abnormal renal function)

>1,200 billion*

SUBCLASSIFICATION (either A or B)

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