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Drug Study Ziprasidone

1. Ziprasidone, sold under the brand name Geodon, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It works by selectively blocking serotonin and dopamine receptors in the brain. 2. Common side effects include neurological effects like tremors, cardiovascular effects like prolonged QT interval, and gastrointestinal effects like nausea. It can interact with other drugs in dangerous ways, like increasing the risk of arrhythmias. 3. Nurses monitor patients taking ziprasidone and watch for signs of serious adverse reactions like neuroleptic malignant syndrome.

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3K views2 pages

Drug Study Ziprasidone

1. Ziprasidone, sold under the brand name Geodon, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It works by selectively blocking serotonin and dopamine receptors in the brain. 2. Common side effects include neurological effects like tremors, cardiovascular effects like prolonged QT interval, and gastrointestinal effects like nausea. It can interact with other drugs in dangerous ways, like increasing the risk of arrhythmias. 3. Nurses monitor patients taking ziprasidone and watch for signs of serious adverse reactions like neuroleptic malignant syndrome.

Uploaded by

Arnzz Agbulos
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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Drug Stud#

Drug Data Generic Name: Ziprasidone rade Name: Geodon Ma!imum Dose: 80 mg twice daily Minimum Dose: 10 mg/day A"ailabilit#: Capsules: 20 mg, 40, 60, 80 mg Lyophilized powde !o in"ection: 20 mg/#ial Route: $%, &' Classification $harmacologi c: (enziso)azole de i#ati#e herapeutic: *ntipsychotic $regnanc# Categor#:C Mechanism of Action +electi#ely ,loc-s se otonin and dopamine ecepto s in the mesoco tical t act o! the C.+, the e,y supp essing psychotic symptoms/ A: 60 0 a,so ,ed !ollowing o al administ ation1 100 0 a,so ,ed ! om $% sites/ D: un-nown M % E: 220 meta,olized ,y the li#e 1 3 10 e)c eted unchanged in u ine &alf' life: &' 4 5 h 1 $%: 267 h Route (nset $%: within h s &': apid $ea) $%: 168 days &': 60 min Duration 9n-nown Indication To treat schizophren ia To treat acute manic or mixed episodes of bipolar disorder As adjunct to lithium or valproate for maintenanc e treatment of bipolar I disorder Contraindications Concu ent use o! othe d ugs that p olong :; inte #al, histo y o! a hythmia, hype sensiti#ity to zip asidone o its components, histo y o! p olonged :; inte #al, ecent acute %$, uncompensated hea t !ailu e Drug Interactions: antihypertensives: *dditi#e antihype tensi#e e!!ects carbamazepine: &ossi,ly dec eased ,lood zip asidone le#el CNS depressants: $nc eased C.+ dep ession dopamine agonists levodopa: <ec eased the apeutic e!!ects o! these d ugs drugs that prolong !T interval "including #uinidine dofetilide pimozide sotalol thioridazine and sparfloxacin$: $nc eased is- o! p olonged :; o :;c inte #al, to sades de pointes, and sudden death %etoconazole: &ossi,ly inc eased ,lood zip asidone le#el *((DS all foods: $nc eased zip asidone a,so ption Side Effects CNS: neu oleptic malignant synd ome, pa esthesia, pe sonality o speech diso de , se otonin synd ome, somnolence, syncope, suicidal ideation, ta di#e dys-inesia, t emo C+:p olonged :; o :;c inte #al, tachyca dia, th om,ophle,itis , #asodilation EEN : *,no mal #ision, d y mouth, END(: <ysmeno hea, hype glycemia GI: *,dominal pain, ano e)ia, G,: & iapism, u ina y incontinence &EME: *g anulocytosis, leu-openia, neut openia MS: * th algia, ,ac- pain, dysa th ia, myalgia RES$: Cough, pulmona y em,olism, uppe espi ato y t act in!ection Nursing Responsibilities -efore: Chec- !o docto =s o de Chec- #ital signs Con!i m patient=s identity and ight dose and oute & otect zip asidone #ials ! om light During: Gi#e medication at the ight oute Gi#e the ight medication at the ight dosage Gi#e %edication at the ight time >econstitute ,y adding 1/2 ml ste ile wate !o in"ection to #ial and sha-ing #igo ously until d ug is dissol#ed Gi#e only ,y $/%/ oute/ >econstituted d ug may ,e sto ed 24 hou s p otected ! om light o up to 5 days i! e! ige ated and p otected ! om light/ *dministe $/%/ !o m cautiously to patients with impai ed enal !unction/ After: immediate documentation a!te medication administ ation %onito patient closely !o anaphyla)is *ssess ca diac hythm in patients with hypo-alemia o hypomagnesemia/ $mmediately epo t e#idence o! neu oleptic malignant synd ome, a a e ,ut potentially !atal ad#e se eaction including hype py e)ia, muscle igidity, alte ed mental status, i egula pulse, ,lood p essu e changes, tachyca dia, diapho esis, a hythmia, myoglo,inu ia monito patient closely !o suicidal tendencies

Source:

+i,ley, <onnelly/ .u se=s < ug ?and,oo;enth @dition Aones B (a tlett Lea ning, LLC 2011

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