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Generic Name Brand Name Classification/ Indication Mechanism of Action Adverse Effects Nursing Responsibilities

Isoxsuprine hydrochloride is a tocolytic agent and peripheral vasodilator used to treat uterine hypermotility disorders like threatened abortion and premature labor. It works by acting as an alpha receptor antagonist and beta receptor agonist, causing vasodilatation of blood vessels and relaxation of the uterus and heart. Common side effects include hypotension, tachycardia, dizziness, and flushing. Nurses should monitor the patient's blood pressure, hydration, and maternal and fetal heart rates during infusion.

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5K views3 pages

Generic Name Brand Name Classification/ Indication Mechanism of Action Adverse Effects Nursing Responsibilities

Isoxsuprine hydrochloride is a tocolytic agent and peripheral vasodilator used to treat uterine hypermotility disorders like threatened abortion and premature labor. It works by acting as an alpha receptor antagonist and beta receptor agonist, causing vasodilatation of blood vessels and relaxation of the uterus and heart. Common side effects include hypotension, tachycardia, dizziness, and flushing. Nurses should monitor the patient's blood pressure, hydration, and maternal and fetal heart rates during infusion.

Uploaded by

Ria Nicole
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
  • Drug Information Tables
  • Drug Information Tables Continued
  • Drug Information Tables Extended

Generic Name Isoxsuprine Hydrochloride

Brand Name Isoxilan Tablet 10mg Category C

Classification/ Indication Tocolytic Agent/Peripheral Vasodilator

Mechanism of Action soxsuprine is an receptor antagonist with -receptor agonist action. It causes peripheral and cerebral vasodilatation by directly acting on vascular smooth muscle. It also causes cardiac and uterine relaxation.

Adverse Effects Hypotension, tachycardia, palpitations, dizziness & flushing. May cause slight increase in fetal heart rate if used as IV infusion in premature labor. Hypotension, dizziness, palpitation, nausea, vomiting, abdominal distress, severe rash, flushing, tachycardia. Maternal pulmonary oedema and foetal tachycardia (IV). Hypersensitivity reactions & GI disturbances. Reversible leukopenia & thrombocytopenia, thrombocytopenic purpura, agranulocytosis, anemia, slight thrombocytosis, eosinophilia, abnormal platelet aggregation, prolonged bleeding & prothrombin time. Dizziness, headache, reversible hyperactivity & convulsions, agitation, anxiety, behavioral changes, confusion, insomnia. Increased AST & ALT, serum bilirubin & alkaline phosphatase; hepatitis, cholestatic

Nursing Responsibilities Monitor maternal BP and hydration, maternal and foetal heart rates during the infusion. May be taken w/ meals, milk or antacids to minimise GI discomfort.

Uterine hypermotility disorders: Threatened abortion, premature labor & dysmenorrhea

Co-amoxiclav

Amoclav Tablet 625mg Catergory B

Penicillins Infections due to lactamase-producing strains (where amoxicillin alone is not appropriate) genitourinary infections. Used in the systemic treatment of infections.

An antibiotic that combines amoxicillin and clavulanic acid. It destroys bacteria by disrupting their ability to form cell walls.

- Assess bowel pattern before and during treatment as pseudomembranous colitis may occur.

- Clavulanic acid blocks the chemical defence, known as beta-lactamase, that some bacteria have against penicillins. l Co-amoxiclav is active against bacterial infections that have become resistant to

- Report haematuria or oliguria as high doses can be nephrotoxic.

- Assess respiratory status.

amoxicillin.

jaundice, acute hepatic dysfunction. Acute interstitial nephritis, crystalluria, vag itching, soreness & discharge. Superficial tooth discoloration.

- Observe for anaphylaxis.

- Ensure that the patient has adequate fluid intake during any diarrhoea attack.

Patient teaching - If the patient develops a rash, wheezing, itching, fever or swelling in the joints, this could indicate an allergy and should be reported.

- Patients must ensure they take the full course of the medicine.

- The medicine must be taken in equal doses around the clock to maintain level in the blood.

- If oral contraceptives are used, use alternative contraception.

- Report diarrhoea, cramping and blood in stools as pseudomembranous colitis may occur.

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