Scribd
Upload
663 views2 pages

Pentoxifylline

Pentoxifylline is a hematologic agent used to treat intermittent claudication associated with peripheral vascular disease. It works by increasing blood flow through vasodilation and higher oxygen content. The typical dosage is 400 mg three times daily, reduced to twice daily if side effects occur. Precautions include risk of bleeding, and it should be used cautiously in pregnancy, renal impairment, or children. Adverse effects can include nausea, dizziness, chest pain, swelling and flu-like symptoms. Smoking and other medications may reduce its efficacy or increase bleeding risk.

Uploaded by

Ashley Nordstrom Collins
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
663 views2 pages

Pentoxifylline

Pentoxifylline is a hematologic agent used to treat intermittent claudication associated with peripheral vascular disease. It works by increasing blood flow through vasodilation and higher oxygen content. The typical dosage is 400 mg three times daily, reduced to twice daily if side effects occur. Precautions include risk of bleeding, and it should be used cautiously in pregnancy, renal impairment, or children. Adverse effects can include nausea, dizziness, chest pain, swelling and flu-like symptoms. Smoking and other medications may reduce its efficacy or increase bleeding risk.

Uploaded by

Ashley Nordstrom Collins
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Pentoxifylline- Apo-Pentoxyphylline (CA), Neotren (UK), Nu-Pentoxyphylline SR (CA), Pentoxil, Trental

Pharmacologic class: Hemorrheologic, xanthine derivative Therapeutic class: Hematologic agent Action- Unknown. Thought to enhance blood flow to the circulatory system by increasing vasoconstriction and oxygen concentrations. Availability Tablets (controlled-release, extended-release): 400 mg

Indications and dosages Intermittent claudication


Adults: 400 mg t.i.d. If adverse reactions occur, decrease to 400 mg b.i.d. Dosage adjustment Renal impairment Off-label uses Diabetic angiopathies and neuropathies Transient ischemic attacks Severe idiopathic recurrent aphthous stomatitis Raynaud's phenomenon Contraindications Hypersensitivity to drug or methylxanthines (such as caffeine, theophylline, theobromine) Recent cerebral or retinal hemorrhage Precautions Use cautiously in: patients at risk for bleeding pregnant or breastfeeding patients children (safety not established). Administration Give with meals to minimize GI distress. Make sure patient swallows tablets whole without crushing, breaking, or chewing. Route Onset P.O. Peak Duration

Variable 2-4 hr 8 hr

Patient teaching Instruct patient to take with meals and to swallow tablets whole without crushing, breaking, or chewing

Inform patient that drug can cause serious adverse effects. Instruct him to immediately report chest pain, swelling,
and flulike symptoms. Tell patient smoking may make drug less effective and that many over-the-counter preparations (including aspirin, NSAIDs, and herbs) increase risk of bleeding. As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

pentoxifylline
[pentoksfiln] a drug that lowers blood viscosity by making red blood cells even more flexible. indications It is prescribed for the treatment of intermittent claudication associated with chronic occlusive arterial limb disease but should not be used as a replacement for other types of medications used for peripheral vascular disease because its efficacy is marginal. There are several unlabeled uses for the drug for which decreased blood viscosity could be advantageous, including cerebrovascular disease and diabetic neuropathy. contraindications It should not be administered to patients who are allergic to xanthines or who have had recent episodes of bleeding, especially in the brain or retina, and should be used with caution if renal impairment is present.

adverse effects Among the most serious adverse effects are nausea, dyspepsia, dizziness, angina, arrhythmia, and hypotension.

You might also like