Generic Name amphetamine sulfate
Trade Name Adderall
Classification CEREBRAL STIMULANT; ANOREXIANT
Dose 10mg
Route 10mg
Time/frequency Morning
Peak 1-5h
Onset Rapid
Duration Up to 10h
Why is your patient getting this medication To control obesity
Normal dosage range Narcolepsy Adult: PO 560 mg/day divided q46h in 23 doses Child: PO Older than 12 y, 10 mg/day, may increase by 10 mg at weekly intervals; 612 y, 5 mg/day, may increase by 5 mg at weekly intervals Attention Deficit Disorder Adult/Adolescent: PO 10 mg extended release once daily in a.m.; may increase by 510 mg at weekly intervals if needed to max of 30 mg/day. Child: PO 6 y, 5 mg 12 times/day, may increase by 5 mg at weekly intervals (max: 40 mg/day); 35 y, 2.5 mg 12 times/day, may increase by 2.5 mg at weekly intervals; 10 mg extended release once daily in a.m.; may increase by 510 mg at weekly intervals if needed to max of 30 mg/day. Obesity Dosage Adjustment Adult: PO 510 mg 1 h before meals For IV meds, compatibility with IV drips and/or solutions
Mechanism of action and indications (Why would this med be ordered) . Marked stimulant effect on CNS thought to be due to action on cerebral cortex and possibly the reticular activating system. Acts indirectly on adrenergic receptors by increasing synaptic release of norepinephrine in the brain and by blocking reuptake of norepinephrine at presynaptic membranes. CNS stimulation results in increased motor activity, diminished sense of fatigue, alertness, wakefulness, and mood elevation. Anorexigenic effect thought to result from direct inhibition of hypothalamic appetite center, as well as mood elevation.
Nursing Implications (what to focus on) Contraindications/warnings/interactions Monitor for S&S of toxicity in children. Response to this drug is more variable in children than adults; acute toxicity has occurred over a wide range of dosage. Monitor for S&S of insomnia or anorexia. Report complaints to physician. Dosage reduction may be required. Monitor diabetics closely for loss of glycemic control. Monitor growth in children; drug may be discontinued periodically to allow for normal growth. Drug's excitatory and euphoric effects are associated with a high abuse potential. Common side effects Body as a Whole: Allergy, urticaria, sudden death (reported in children with structural cardiac abnormalities). CNS: Irritability, psychosis, restlessness, nervousness, headache, insomnia, weakness, euphoria, dysphoria, drowsiness, trembling, hyperactive reflexes. CV: Palpitation, elevated BP; tachycardia, vasculitis. Urogenital: Impotence and change in libido with high doses. GI: Dry mouth, anorexia, unusual weight loss, nausea, vomiting, diarrhea, or constipation.
Interactions with other patient drugs, OTC or herbal medicines (ask patient specifically) N/A
Lab value alterations caused by medicine Elevations in serum thyroxine (T4) levels with high amphetamine doses.
Nursing Process- Assessment (Pre-administration assessment)
Be sure to teach the patient the following about this medication Keep physician informed of clinical response and persistent or bothersome adverse effects. This drug exerts a stimulating effect that masks fatigue; after exhilaration disappears, fatigue and depression are usually greater than before, and a longer period of rest is needed. Report insomnia or undesired weight loss. Do not drive or engage in potentially hazardous tasks until response to drug is known. Rinse mouth frequently with clear water, especially after eating, to relieve mouth dryness; increase fluid intake, if allowed; chew sugarless gum or sourballs. Meticulous oral hygiene is required because decreased saliva encourages demineralization of tooth surfaces and mucosal erosion. Avoid caffeine-containing beverages because caffeine increases amphetamine effects. Note that drug is usually tapered gradually following prolonged administration of high doses. Abrupt withdrawal may result in lethargy, profound depression, or other psychotic manifestations that may persist for several weeks. Assessment Evaluation Why would you hold or not give this med? Check after giving