RAYNAUDS DISEASE
PATHOPHYSIOLOGY
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In most cases, the first symptom is extreme pain of the lower arms and legs while at rest. Affected individuals may also experience cramping in the legs when they walk that, in rare cases, may cause limping (claudication). In addition, affected individuals may have sores (ulcers) on the extremities, numbness and tingling and a lack of normal blood flow to the fingers and/or toes when exposed to cold temperatures (Raynaud's Phenomenon), and/or inflammation and clotting of certain veins (thrombophlebitis). In severe cases, individuals with Buerger's disease may exhibit tissue death (gangrene) of affected limbs.
Intermittent claudication
Cramping of leg muscles that may : stop a person from doing normal daily activities or exercise. starts with walking and stops with rest
Pallor (whiteness): in response to spasm of the arterioles and the resulting collapse of the digital arteries. Cyanosis (blueness) appear because the fingers or toes are not getting enough oxygen-rich blood. The fingers or toes may also feel cold and numb. Rubor (redness):as the arterioles dilate (relax) and blood returns to the digits As the attack ends, throbbing and tingling may occur in the fingers and toes.
Raynauds episode can last from several minutes to an hour or more. It can take up to 15 minutes for blood flow to return to normal
Recurrent superficial thrombophlebitis marked by redness and tenderness over the affected vain, can occur in arm, leg or the foot. The symptoms usually disappear over 2-3 weeks, leaving behind blackish-brown pigmentation. "Phlebitis migrans" is characteristic of Buergers disease,
Ulceration and gangrene in the extremities
caused by poor circulation
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