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Sulfinpyrazone: Uses, Dosage, and Interactions

This document summarizes the drug sulfinpyrazone, including its route, onset, peak and duration when taken orally, half-life, adverse reactions, interactions, and indications and dosages. Sulfinpyrazone is taken orally, has an onset time that is unknown, peaks 1-2 hours after administration, and has a duration of action of 4-6 hours. Its half-life is 3 hours. Common adverse reactions include GI issues, hematologic effects, and respiratory and skin issues. It can interact with probenecid, theophylline, verapamil, alcohol, aspirin, niacin, salicylates, oral anticoagulants and oral antidiabet

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Princess Bartolome
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69 views1 page

Sulfinpyrazone: Uses, Dosage, and Interactions

This document summarizes the drug sulfinpyrazone, including its route, onset, peak and duration when taken orally, half-life, adverse reactions, interactions, and indications and dosages. Sulfinpyrazone is taken orally, has an onset time that is unknown, peaks 1-2 hours after administration, and has a duration of action of 4-6 hours. Its half-life is 3 hours. Common adverse reactions include GI issues, hematologic effects, and respiratory and skin issues. It can interact with probenecid, theophylline, verapamil, alcohol, aspirin, niacin, salicylates, oral anticoagulants and oral antidiabet

Uploaded by

Princess Bartolome
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

Sulfinpyrazone Route Onset Peak Duration  Probenecid: May inhibit renal

P.O. unknown 1-2 hr 4-6 hr excretion of sulfinpyrazone. Use


( Antazone+,Anturane, Apo- together cautiously.
Sulfinpyrazone+, Novo-Pyrazone+, Nu-  Theophylline, verapamil: May
sulfinpyrazone+) Half-life : 3 hours
increase clearance of these drugs.
Pharmacologic class: Pyrazolone Adverse Reactions Use together cautiously.
derivative  Drug-lifestyle: Alcohol use: May
GI: nausea, dyspepsia, epigastric pain, decrease effectiveness.
Pregnancy category: NR reactivation of peptic ulcerations Discourage use together.

Available forms: Capsules: 200 mg and Hematologic: leucopenia,


Tablets: 100 mg, 200 mg + agranulkocytosis, thrombocytopenia,
aplastic anemia, anemia
Action: Blocks renal tubular reabsorption
of uric acid, increasing excretion, and Respiratory: bronchoconstriction in
inhibits platelet aggregation patients with aspirin-induced asthma

Indications and Dosages Skin: rash

 Intermittent or chronic gouty Interactions:


arthritis
 Drug-drug: Aspirin, niacin,
Adults: 200 to 400 mg PO daily, salicylates: may inhibit uricosuric
divided b.i.d. during the first week; effect of sulfinpyrazone. Avoid
then 400 mg PO daily divided b.i.d. using together.
Maximum dose is 800 mg daily.  Oral anticoagulants: May increase
anti-coagulant effect and risk of
 To decrease the risk of sudden bleeding. Use together cautiously.
cardiac death 1-6 months after an  Oral antidiabetics: May increase
MI effects of these drugs. Monitor
glucose level.
Adults: 300 mg PO q.i.d.

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