Medications for Arrest Rhythms
Vasopressors:
VF and Pulseless
A. Epinephrine- Increase coronary and cerebral
perfusion.
Dose: 1mg IV every 3-5 mins
2-2.5mg + 10ml NSS/ET
B. Vasopressin- Peripheral vasoconstrictor.
Dose: 40 u IV single dose-(may replace either 1 st or 2nd
dose of epinephrine.
• Asystole/ Pulseless electrical activity.
A. Epinephrine and Vasopressin-(same as above)
B. Atropine- reverses cholinergic mediated decrease in heart rate,
systemic vascular resistance and blood pressure. A case series of
adults in cardiac arrest documented conversion from asystole to
sinus rhythm in 7 of 8 patients.
-1st line of drug for acute symptomatic bradycardia.
Dose: 1mg IV every 3-5mins (max. total of 3 doses or3mg) or
0.04mg/kg
• Antiarrhythmics
A. VF and pulseless VT
a. Amiodarone- Affects Na, K and Ca channels as well as
alpha and beta adrenergic blocking properties.
-If VF and Pulseless VT unresponsive to
shock delivery, CPR and vasopressor.
Dose: Initial 300mg IV + 20-30 ml NSS or
D5water x 1-2 mins if consistent may
give 150mg IV over 10mins.
Max dose: 2.2g/day
b. Lidocaine- Alternative antiarrhythmic.
-Considered alternative treatment to
amiodarone.
Dose: 1-1.5mg/kg IV then 0.5-0.75 mg/kg IV.
May repeat after 5-10 mins. Interval.
Max. dose: 3mg/kg.
Via ET: 2-4mg/kg
c. Magnesium- when VF/ pulseless VT associated
with torsdes de pointes.
Dose: 1-2gm in 10ml D5water IV push
typically over 5-20mins.
Torsades with pulse
Dose: 1-2 gm in 50-100ml D5water over 5-
60mins.
• SVT
A. Adenosine- Dose: 6mg rapid IV push; if no
conversion give 12mg rapid IV push and may
repeat 12 mg dose once.
THANK YOU
AND HAVE
ANICE DAY!