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Drug: Milrinone Presentation: Action & Indication:: 30 Weeks

Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29

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595 views1 page

Drug: Milrinone Presentation: Action & Indication:: 30 Weeks

Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29Anesth Analg 1983 Hermens 218 29

Uploaded by

SIDHARTH GOYAL
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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  • Milrinone Drug Information

DRUG:

MILRINONE

PRESENTATION:

Ampoules:

ACTION &
INDICATION:

Milrinone is a selective phosphodiesterase inhibitor which has positive


inotropic and vasodilatory activity.

1mg/mL (10mL ampoules)

Used in patients with refractory pulmonary hypertension, low cardiac


output (especially after cardiac surgery) and in septic shock.
There is some evidence for its use in preventing low cardiac output in
patients undergoing cardiac surgery.
It is for short term treatment only and should generally not be used for
longer than 72 hours.

DOSE :

Any fluid imbalance should be corrected before commencing milrinone.


The specified infusion rates are dependant upon preparing the infusion
solution exactly as described below.

< 30 weeks
Loading dose:

135 microgram/kg given over 3 hours


(ie 1.5mL/hr for 3 hours)
then
Maintenance dose: 0.2 microgram/kg/min
(ie 0.4mL/hr)
30 weeks
Loading dose:

75 microgram/kg given over 60 minutes


(ie 2.5mL/hr for 1 hour)
then
Maintenance dose: 0.5 0.75 microgram/kg/min
(ie 1 1.5mL/hr)
NB - In both regimens, consider reducing or omitting the loading dose
if the patient is at risk of hypotension.

PREPARATION:

Use solution prepared in Pharmacy if available.


Withdraw 1.5mg of milrinone per kg of babys weight (1.5mL/kg) and
dilute to 50mL with appropriate infusion fluid.
Diluent:

Sodium chloride 0.9%, Glucose 5%

ADMINISTRATION:

Intravenous infusion

ADVERSE
EFFECTS :

Hypotension, supraventricular and ventricular arrhythmias,


hypokalaemia.
Thrombocytopenia.
Use with caution in patients who have severe obstructive aortic or
pulmonary valvular disease or a history of arrhythmia.
Dosage adjustment may be required in patients with impaired renal
function.
Incompatible with frusemide.

COMMENTS:

REFERENCES:

REVIEWED:

Paediatric Pharmacopoeia, 13th ed.


BNF for Children 2009
Neofax 2008
Pediatric Dosage Handbook, 15th ed.
January 2011

DRUG: MILRINONE PRESENTATION: Ampoules: 1mg/mL (10mL ampoules) ACTION & INDICATION: Milrinone is a selective pho

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