Figure 3.
12 Receptor-mediated Endocytosis
Process Diagrams Step-by-Step
Copyright 2007 by John Wiley & Sons, Inc.
1 Binding Receptor-LDL complex LDL particle Receptor
Plasma membrane
Clathrin-coated pit
Invaginated plasma membrane
1 Binding Receptor-LDL complex LDL particle Receptor
Plasma membrane
Clathrin-coated pit
Invaginated plasma membrane 2 Vesicle formation Clathrin-coated vesicle
1 Binding Receptor-LDL complex LDL particle Receptor
Plasma membrane
Clathrin-coated pit
Invaginated plasma membrane 2 Vesicle formation Clathrin-coated vesicle 3 Uncoating
Uncoated vesicle
1 Binding Receptor-LDL complex LDL particle Receptor
Plasma membrane
Clathrin-coated pit
Invaginated plasma membrane 2 Vesicle formation Clathrin-coated vesicle 3 Uncoating
Uncoated vesicle 4 Fusion with endosome
Endosome
Transport vesicle
1 Binding Receptor-LDL complex LDL particle Receptor
Plasma membrane
Clathrin-coated pit
Invaginated plasma membrane 2 Vesicle formation Clathrin-coated vesicle 3 Uncoating
Transport vesicle
Uncoated vesicle 4 Fusion with endosome
5 Recycling of receptors to plasma membrane
Endosome
Transport vesicle
1 Binding Receptor-LDL complex LDL particle Receptor
Plasma membrane
Clathrin-coated pit
Invaginated plasma membrane 2 Vesicle formation Clathrin-coated vesicle 3 Uncoating
Transport vesicle
Uncoated vesicle 4 Fusion with endosome
5 Recycling of receptors to plasma membrane
Endosome
Transport vesicle
6 Degradation in lysosome
Digestive enzymes
Lysosome