Common Equations Used In Renal Physiology
Name Clearance
[P]x Clearance Ratio = Cx
Equation
Cx = [U]xV
Units
ml/min
Comments
x is any substance Also means fractional excretion of x
Clearance Ratio
Cinulin RPF = [U]PAHV
None
Renal plasma flow
[RA]PAH - [RV]PAH Effective RPF =[U]PAHV
ml/min Underestimates RPF by 10% Equals CPAH RBF = RPF
Effective renal plasma flow Renal Blood Flow
[P]PAH
ml/min
ml/min 1 - Hct GFR = [U]inulinV
1 - Hct is fraction of blood volume that is plasma Equals Cinulin
Glomerular Filtration Rate
[P]inulin FF = GFR
ml/min
Filtration Fraction
RPF
None
Filtered Load
Filtered Load = GFR x [P]x
mg/min
Excretion Rate Reabsorption or Secretion Rate
Excretion = V X [U]x
mg/min If positive, net reabsorption If negative, net secretion If positive, free water is excreted ml/min If negative, free water is reabsorbed
Reabsorption or secretion = filtered load - excretion
mg/min
CH2O = V - Cosm
Free-Water Clearance