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Non-ST Elevation Myocardial Infarction Factors

Pathophysiology of Acute Coronary Syndrome - Non-ST elevation Myocardial Infarction (NSTEMI) VS Unstable Angina

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Jerom Yamat
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874 views2 pages

Non-ST Elevation Myocardial Infarction Factors

Pathophysiology of Acute Coronary Syndrome - Non-ST elevation Myocardial Infarction (NSTEMI) VS Unstable Angina

Uploaded by

Jerom Yamat
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Non-Modifiable Factors: Age Men > 45 years of age Sex Male has higher incidence Family History Father

her with Hx of MI and Hypertension - 1st degree family member before age of 55 years old for men.

Modifiable Factors: Elevated Cholesterol Level Cigarette Smoking Hypertension

Cholesterol and other fatty substances attach to the endothelial lining of the Coronary Arteries Plaque Formation Possible Injury to Plaque Natural Cause of Injury Hypertension Plaque Rupture Chemical Injury Nicotine from Cigar Subendothelium releases collagen (potent platelet agonist)

se of Serotonin (platelet agonist)

Platelet Activation

Conformational Shape Change of Arterial Lumen

constriction of Coronary Artery

Platelet Aggregation Coagulation Cascade activated Production of Thrombin

Decreased diameter of coronary artery lumen

eased blood flow to Myocardial Cells

Thrombin stimulates further platelet recruitment and aggregation

Thrombin catalyzes generation of Fibrin

Forms the main protein component of the thrombus

Thrombus Formation

Occluding thrombus in the Coronary Artery

Degree of Occlusion: Intermittent/Partial Working Diagnosis: Non-ST elevation Myocardial Infarction VS Unstable Angina

Decreased myocardial oxygen supply Decreased myocardial contractility Imbalance of myocardial oxygen supply and demand

Decreased Cardiac Output

Decreased myocardial perfusion Fatigue Decrease Cerebral Tissue Perfusion

Angina Pectoris

ed Cardiopulmonary Perfusion

Chest Pain radiating to arm, shoulder, mandible and neck

Shortness of Breath

Dizziness

Myocardial Ischemia Further decrease in blood flow to the heart Myocardial Infarction

Release of Cardiac Biomarkers

Myocardial Infarction

Myocardial Infarction

Final Diagnosis: Non-ST elevation Myocardial Infarction

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