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Sickle Cell Anemia Red Blood Cell Types

This document discusses red blood cell morphology in sickle cell anemia. Patients with sickle cell anemia will have target cells, Howell-Jolly bodies, basophilic stippling, schizocytes, and nucleated red blood cells present on a peripheral smear. A key finding is sickle shaped red blood cells, which are indicative of sickle cell anemia.

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Usama Sadiq
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59 views10 pages

Sickle Cell Anemia Red Blood Cell Types

This document discusses red blood cell morphology in sickle cell anemia. Patients with sickle cell anemia will have target cells, Howell-Jolly bodies, basophilic stippling, schizocytes, and nucleated red blood cells present on a peripheral smear. A key finding is sickle shaped red blood cells, which are indicative of sickle cell anemia.

Uploaded by

Usama Sadiq
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd

RED BLOOD CELL MORPHOLOGY

NORMAL RED BLOOD CELLS

SICKLE CELL ANEMIA


RED BLOOD CELL MORPHOLOGY

RED BLOOD CELL MORPHOLOGY

You will see the following types of cells in a patient with sickle cell anemia, Hemoglobin SS.

RED BLOOD CELL MORPHOLOGY


Target cells are also known as codocytes. They resemble a bulls eye. These cells are indicative of an anemia state.

RED BLOOD CELL MORPHOLOGY


Howell-Jolly bodies may be seen in sickle cell anemia. These bodies are DNA that stain dark purple within the red blood cell.

RED BLOOD CELL MORPHOLOGY


Basophilic stippling is granules of RNA seen within the red blood cell. The granules stain blue to purple.

RED BLOOD CELL MORPHOLOGY


Schizocytes are fragmented red blood cells present on the peripheral smear of sickle cell anemia. They are many shapes and sizes and may have pointed extremities.

RED BLOOD CELL MORPHOLOGY


Nucleated red blood cells. These red blood cells are released from the bone marrow early into the blood stream, due to the need for oxygen. Normal red blood cells do not contain a nucleus on a peripheral smear.

RED BLOOD CELL MORPHOLOGY


Sickle cell anemia. Note the sickle shaped red blood cell.

RED BLOOD CELL MORPHOLOGY


Sickle cell crisis.

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