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Agbl1 ATP/GTP binding protein-like 1 [ Mus musculus (house mouse) ]

Gene ID: 244071, updated on 8-Feb-2025

Summary

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Official Symbol
Agbl1provided by MGI
Official Full Name
ATP/GTP binding protein-like 1provided by MGI
Primary source
MGI:MGI:3646469
See related
Ensembl:ENSMUSG00000025754 AllianceGenome:MGI:3646469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccp4; Nna1-l1; EG244071; D430020F16
Summary
Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in C-terminal protein deglutamylation and protein side chain deglutamylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to human AGBL1 (AGBL carboxypeptidase 1). [provided by Alliance of Genome Resources, Feb 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Agbl1 in Genome Data Viewer
Location:
7 D1; 7 43.87 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (75879311..76774446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (76229591..77124698)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19235 Neighboring gene predicted gene, 51413 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:83373966-83374075 Neighboring gene predicted gene, 51518 Neighboring gene STARR-seq mESC enhancer starr_19236 Neighboring gene STARR-seq mESC enhancer starr_19237 Neighboring gene thymine DNA glycosylase pseudogene Neighboring gene VISTA enhancer mm1397 Neighboring gene predicted gene, 30774 Neighboring gene predicted gene, 33069 Neighboring gene STARR-seq mESC enhancer starr_19238 Neighboring gene STARR-seq mESC enhancer starr_19239 Neighboring gene STARR-seq mESC enhancer starr_19240 Neighboring gene STARR-seq mESC enhancer starr_19241 Neighboring gene STARR-seq mESC enhancer starr_19242 Neighboring gene STARR-seq mESC enhancer starr_19244 Neighboring gene STARR-seq mESC enhancer starr_19245 Neighboring gene STARR-seq mESC enhancer starr_19246 Neighboring gene proliferating cell nuclear antigen pseudogene Neighboring gene predicted gene, 23239

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Wang T, et al. Mol Cell Neurosci, 2006 Oct. PMID 16952463
  2. A novel subfamily of mouse cytosolic carboxypeptidases. Kalinina E, et al. FASEB J, 2007 Mar. PMID 17244818
  3. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Liu B, et al. Nat Commun, 2017 Aug 10. PMID 28794449, Free PMC Article
  4. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Tort O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103237, Free PMC Article
  5. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Xia P, et al. Nat Immunol, 2016 Apr. PMID 26829768

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallocarboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in C-terminal protein deglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in C-terminal protein deglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein side chain deglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein side chain deglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytosolic carboxypeptidase 4
Names
protein deglutamylase CCP4
NP_001186153.1
XP_017177740.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199224.2 → NP_001186153.1  cytosolic carboxypeptidase 4

    See identical proteins and their annotated locations for NP_001186153.1

    Status: VALIDATED

    Source sequence(s)
    AC093474, AC115830, AC121812, AC121971, AC123792, AC132333, AC154104
    Consensus CDS
    CCDS85321.1
    UniProtKB/Swiss-Prot
    Q09M05, Q8C768
    UniProtKB/TrEMBL
    D3Z1M2
    Related
    ENSMUSP00000119721.3, ENSMUST00000156166.8
    Conserved Domains (1) summary
    cl11393
    Location:742 → 1018
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    75879311..76774446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322251.2 → XP_017177740.1  cytosolic carboxypeptidase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q09M05, Q8C768
    Conserved Domains (2) summary
    cd06906
    Location:753 → 1018
    M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
    pfam18027
    Location:595 → 729
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

RNA

  1. XR_004934099.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172902.2: Suppressed sequence

    Description
    NM_172902.2: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09M05.3 GenPept UniProtKB/Swiss-Prot:Q09M05

Gene LinkOut

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